2176 research outputs found
Sort by
I tribunali civili della Reverenda camera apostolica e la loro attività giudiziaria all’indomani della Restaurazione pontificia (1816-1831)
No full textLa ricerca prende in esame il sistema giudiziario civile della Reverenda camera apostolica negli anni della Restaurazione pontificia, sia dal punto di vista storico-istituzionale che da quello strettamente archivistico. L’ambito cronologico considerato va dal 1816 al 1831; un quindicennio nel corso del quale il settore giudiziario è al centro delle politiche riformistiche di Pio VII e di Leone XII per trovare definitiva soluzione con il pontificato di Gregorio XVI. Sono gli anni in cui, sulla base di quanto disposto dal motu proprio del 6 luglio 1816 di riforma della pubblica amministrazione e dei tribunali civili, e dal Codice di procedura civile del 22 novembre 1817, vengono istituiti e agiscono i tribunali dell’Uditore del Camerlengo, dell’Uditore del Tesoriere, della Piena camera, del Decano e Sottodecano e quello Collegiale camerale, oltre alle diverse presidenze e prefetture; magistrature che costituiscono l’apparato della giustizia civile camerale profondamente diverso rispetto all’Antico regime, durante il quale dominava il “Supremo Tribunale della Camera apostolica”
STRATEGIA ANALITICA PER LA CARATTERIZZAZIONE DEL PROFILO VITAMINICO LIPOSOLUBILE E CAROTENOIDEO DEL LATTE DI DIFFERENTI SPECIE ANIMALI MEDIANTE IFENAZIONE HPLC-DAD-TANDEM MS
No full textVitamin determination is a complex and challenging task, especially when aimed at the analysis of biological and food samples. Milk is a unique matrix, being at the same time biological fluid and food with the chemical characteristics of three phases: emulsion, suspension and colloidal solution. Furthermore, it is an almost complete food and an excellent source of vitamins, in particular vitamins A, B1, B2, B5 and B12. The water-soluble vitamins occur in the serum, while the fat-soluble vitamins and carotenoids are associated to the lipid fraction.
Bovine milk has been one of the most investigated food matrices, but also milk from other animal species deserve to be investigated since it is essential for human diet in several parts of the world. As a matter of fact, India and Pakistan are the main producers of buffalo milk, the second most produced in the world after bovine milk. Europe, China and some zones of Africa are excellent producers of sheep milk, while goat milk is produced in some parts of Asia and in the countries of the Mediterranean area. Donkey milk has a niche market, but it is considered a valuable alternative for people who are allergic to cow milk.
In the scientific literature, a large number of papers have focused on the macronutrient composition of bovine milk, while its vitamin and caroteinoid profile still have to be completed. On the other hand, this information is almost completely lacking for buffalo, sheep, goat and donkey milk.
Official procedures are based on liquid chromatography with UV-visible or fluorescence detection for the individual determination of vitamins A, E, D and K. The scientific literature describes various methods for multivitamin determination [1-8], but most of them are addressed to the analysis of fortified foods. Only two are aimed at the determination of endogenous forms in breast milk [6,7] and in vegetable foods [8]. This lack of literature is likely due to the several problems coming up during the development of a multivitamin method for the determination of endogenous forms [9]. A first problem concerns the commercial unavailability of authentic standards of some vitamin forms, carotenoids and their geometrical isomers. The subtle structural difference between homologues belonging to the same group hampers their chromatographic separation, whereas the chemical heterogeneity among vitamin groups makes difficult to find common conditions of extraction and detection. However, the development of a simultaneous extraction procedure is the most critical point. In the case of fatty foods such as milk, the high lipid content compromises the extraction efficiency. In the literature, hot saponification is the most adopted solution to free vitamins and carotenoids from saponifiable fraction; nevertheless, this reaction, typically performed at 70-80°C for 30 minutes, is responsible for the rapid decomposition of vitamers K, a severe loss of xanthophylls, the thermal isomerization of all-trans--carotene and vitamin D.
Thence, this work was aimed at developing a method, based on the hyphenation HPLC-DAD-tandem MS, to rapidly and completely characterize fat-soluble micronutrients in milk of different species of herbivores (cow, buffalo, sheep, goat, donkey). Overnight cold saponification was optimized as simultaneous extraction procedure.
Bovine milk, more easily available, was used to develop the method, which was then optimized for the other types of milk. We have chosen to analyze raw milk, produced by pasture-fed animals, so to avoid the occurrence of vitamins due to the intake of fortified feedstuffs or losses due to the processing.
The analyte, were separated by non-aqueous reversed-phase (NARP) chromatography: carotenoids on a C30 column, while the fat-soluble vitamins on a tandem system of C18 columns. The atmospheric pressure chemical ionization (APCI) in positive ion mode was the most suitable technique for the mass-spectrometric detection of -tocopherol, -tocopherol, -tocopherol, ergocalciferol, cholecalciferol, phylloquinone, menaquinone-4, all-trans-retinol, all-trans-lutein, all-trans-zeaxanthin, all-trans--cryptoxanthin, all-trans--carotene. In addition to the 12 target analytes, the combined DAD-MS detection system allowed the screening of other carotenoids, whose standards are not available on the markets, basing their identification on the expected retention time, the absorbance spectra, acquired between 200 and 700 nm, and the mass-spectrometric data.
For each target analyte, the LC-tandem MS method was validated in terms of both quality (identification, selectivity) and quantitative parameters (recoveries, precision, limits of detection and quantitation, sensitivity, linear dynamic range). Regarding the two selected transitions for each analyte, the most intense one was used to perform quantitative analysis, whereas the least intense one for identification purposes. The presence of each compound in matrix was confirmed by matching its retention time and relative abundance of the two SRM transitions with the values of the corresponding standard in solvent. The recoveries, assessed on 6 replicates, were above 80% for all analytes, with the exception of vitamers K (54%-67%). The relative standard deviations (RSD) associated to recoveries were representative of the intra-day precision, whereas the inter-day precision was estimated as the RSD of 12 replicates performed within 2 weeks. The quantitative analysis was carried out using the standard additions method. The linear dynamic range was investigated up to 200 ng injected for all analytes, while for -retinol and γ-tocopherol up to 2000 ng injected. A linear correlation coefficient greater than 0.99 was achieved for all the analytes in the different types of milk.
After the LC-MS method validation, the whole analytical approach, based on the HPLC-DAD-tandem MS hyphenation, was applied for the characterization of cow, buffalo, goat, sheep and donkey milk. The survey aimed to trace a species-dependent profile, without taking into account the dependence on parameters such as season, stage of lactation and intra- and inter-individual variability. It is known that milk is a good source of vitamin A and E, but the tested milk samples were particularly rich in these vitamins, probably because obtained from pasture-fed animals and analyzed immediately after sampling; on the other hand the milk of donkey was poor of these micronutrients, probably because of its low fat content.
As regards vitamin E, α-tocopherol was the most abundant vitamin form (more than vitamin A) found in all kinds of milk analyzed in this work, with the exception of the buffalo one. γ-Tocopherol occurred in lower amount, whereas the δ-homologue was absent in bovine, buffalo, and donkey milk. The vitamers D were detected in buffalo milk, and, in trace amounts, in goat and donkey milk. Although the literature reports for bovine milk the presence of phylloquinone and menaquinones, from MK-4 to MK-9 [10,11], the high selectivity of the developed method allowed excluding the occurrence of MK-7 in the analyzed milk samples; for this confirmation, the standard of MK-7 was obtained in our laboratory, purifying a dietary supplement purchased in a drugstore on a semi-preparative column. Among all kinds of milk, cow milk was that had the lowest content of vitamin A but a significant amount of β-carotene and a variety of carotenoids lacking in the other types of milk, with the exception of lutein and zeaxanthin.
Missing the authentic standards, the screening of carotenoids in cow milk was achieved by combining LC-DAD-MS data. In formulating a hypothesis to identify a pigment, the UV-Vis spectrum is fundamental; indeed, most of carotenoids show a characteristic three-peak spectrum: the identification is based on the position of the maxima and on the fine structure. For the carotenoids selected in this study, the wavelength of the central peak (MAX) was calculated applying Fieser-Kuhn rules. A cis isomer was identified comparing its spectrum to that of the corresponding all-trans isomer and evaluating: i) the extent of the ipsocromic shift of the λMAX; ii) the hypochromic effect and the reduction of the fine structure of the entire spectrum; iii) the appearance of a "cis"-peak in the near-UV region (330-350 nm), iv) the Qratio, i.e. the ratio of the intensity of the cis band to the central band.
In this way, on the LC-DAD-MS/MS chromatograms of the bovine milk samples, were identified: zeinoxanthin, all-trans--cryptoxanthin, a cis-isomer of -cryptoxanthin, 3-hydroxy-β-zeacarotene and β-zeacarotene. It was also detected a group of structural and geometric isomers of all-trans--carotene: a cis-isomer of -carotene, 13-cis--carotene, all-trans--carotene and -carotene. In all the analyzed samples, it was also found a compound with an absorption maximum at 422-424 nm, characteristic of the Soret band; it was probably ascribable to a degradation product of chlorophyll a, generated in rumen of animals. On the other hand, it was not possible to identify two unknown compounds because of the low signal intensity of both detectors.
In the case of cow milk, besides raw milk, other categories were analyzed: fresh pasteurized whole milk, biological fresh pasteurized whole milk, high quality fresh whole milk, semi-skimmed fresh milk, UHT, whole yogurt. High levels of vitamins and carotenoids were found in the biological commercial milk while, unexpectedly, low levels occurred in the high quality milk samples. The low concentrations found in the semi-skimmed milk are due to the skimming process which eliminates not only fat but also part of vitamins and carotenoids. Yogurt showed the same micronutrient levels of fresh pasteurized milk. UHT milk was particularly abundant in 13-cis--carotene, probably produced during the high temperature sterilization because of the thermal isomerization of the all-trans isomer.
After this exhaustive characterization, another significant part of this thesis work was further addressed to define the detailed composition of vitamin A vitamers of the same varieties of milk, with the only exception of donkey milk.
It has known that the compounds with vitamin A activity are present in milk mainly as retinoids [12]. Among retinoids, the most abundant forms are esters of retinol with saturated and unsaturated fatty acids, while only a small fraction is constituted by free retinol. This information has been provided from a single work, based on HPLC-UV and published in 1989 [13]; in that paper the identification of the various forms was exclusively based on the chromatographic retention time, which is a parameter necessary but not sufficient to ensure a certain analyte identification in a complex matrix such as milk. In the present study, cold saponification allowed us to determine the total content of vitamin A as retinol. In order to define the detailed distribution of 17 vitamers A (retinol, retinoic acid, retinal and esters: retinyl caprylate, caprate, palmitoleate, laurate, myristate, pentadecanoate, arachidonate, palmitate, eptadecanoate, linoleate, oleate, stearate, linolenate, eicosanoate) in milk, direct extraction with solvent and a tandem system of reversed phase columns (C18/C18 and C18/C30) coupled to a tandem mass spectrometer were used.
Taking into consideration that deuterated structural analogues of these retinoids are not available on the markets, the internal standards were chosen on the basis of what has been reported in literature and results obtained by preliminary tests; accordingly, retinyl propionate was selected as internal standard for the quantitative analysis of retinyl esters with medium-chain fatty acids (8-12 carbon atoms), while retinyl arachidonate for esters with longer chain fatty acids. For all analytes, the recoveries, evaluated from the average of six replicates, were 68%; analytical limits were similar for all four analyzed types of milk, indicating the presence of a similar matrix effect for the different extracts. The linear correlation coefficients of the calibration curves, valued by applying the standard-addition method, were between 0.9941 and 0.9999.
The validated method was then applied to the analysis of samples of cow, goat, sheep and buffalo milk. In the survey, both qualitative and quantitative differences concerning the composition of retinyl esters were observed in the milk samples from the different animal species. From a qualitative point of view, the results showed the presence of:
- 6 retinoids common to the four types of milk: retinol, retinyl linolenate, retinyl oleate, retinyl palmitate, retinyl stearate and retinyl eptadecanoate;
- 1 retinoid common to sheep and goat milk, retinyl eicosanoate;
- 1 retinoid common to cow and buffalo milk, retinyl linoleate;
- 1 retinoid characteristic of goat milk, retinyl caprate;
- 1 retinoid characteristic of cow milk, retinyl myristate.
From a quantitative point of view, buffalo milk differed from the others for the highest concentration of free retinol and retinyl linolenate; this latter form was about seven times higher than bovine milk. Furthermore, buffalo milk showed the highest content of retinyl palmitate, even if a considerable concentration was also found in sheep milk. Milk of small ruminants was characterized by a content of retinyl eptadecanoate from 4 to 6 times higher than cow and buffalo milk.
In this work, the distribution of retinyl caprate, laurate, pentadecanoate, palmitoleate and myristate in bovine milk resulted different from that presented in the only pre-existing work [13]. In particular, the authors found retinyl caprate in cow milk but not in goat milk; this result is anomalous since capric acid is particularly abundant in goat milk. In addition, retinyl palmitate followed by retinyl oleate were always found to be the most abundant vitamers A, while our results agree with these observations only partially.
In conclusion, the interest in this work is motivated by several reasons: firstly, a LC-DAD-MS based approach was proposed for a complete characterization of fat-soluble micronutrients in milk, providing a more certain identification than methods reported in the literature. Secondly, detailed data on the composition of fat-soluble micronutrients were achieved for five kinds of milk, filling the information gap of literature. Eventually, it could provide a tool to detect adulteration:
- this work has definitively established that β-carotene (and other provitamin A carotenoids) occurs only in cow milk; so, traces of β-carotene in buffalo mozzarella could indicate use of bovine milk during its production.
- another finding of this work is the very high concentration of retinyl linolenate in buffalo milk and retinyl eicosanoate in sheep milk; these esters could be simple biomarkers to detect other kinds of adulteration.
(1) Salo-Väänänen, P.; Ollilainen, V.; Mattila, P.; Lehikoinen, K.; Salmela-Mölsä, E.; Piironen, V. Simultaneous HPLC analysis of fat-soluble vitamins in selected animal products after small-scale extraction. Food Chem., 2000, 71, 535-543.
(2) Herrero-Barbudo, M. C.; Granado-Lorencio, F.; Blanco-Navarro, I.; Olmedilla-Alonso, B. Retinol, α- and γ-tocopherol and carotenoids in natural and vitamin A and E fortified dairy products commercialized in Spain. Int. Dairy J. 2005, 15, 521-526.
(3) Gomis, D. B.; Fernández, M. P.; Gutièrrez Alvarez, M. D. Simultaneous determination of fat-soluble vitamins and provitamins in milk by microcolumn liquid chromatography. J. Chromatogr. A, 2000, 891, 109-114.
(4) Blanco, D.; Fernandez, M. P.; Gutierrez, M. D. Simultaneous determination of fat-soluble vitamins and provitamins in dairy products by liquid chromatography with a narrow-bore column. Analyst, 2000, 125, 427-431.
(5) Chauveau-Duriot, B.; Doreau, M.; Noziere, P.; Grailet, B. Simultaneous quantification of carotenoids, retinol, and tocopherols in forages, bovine plasma, and milk: validation of a novel UPLC method. Anal. Bioanal. Chem. 2010, 397, 777-790.
(6) Heudi, O.; Trisconi, M. J.; Blake, C. J. Simultaneous quantification of Vitamins A, D3 and E in fortified infant formulae by liquid chromatography–mass spectrometry. J. Chromatogr. A, 2004, 1022, 115-123.
(7) Kamao, M.; Tsugawa, N.; Suhara, Y.; Wada, A.; Mori, T.; Murata, K.; Nishino, R.; Ukita, T.; Uenishi, K.; Tanaka, K.; Okano, T. Quantification of fat-soluble vitamins in human breast milk by liquid chromatography-tandem mass spectrometry. J. Chromatogr. B, 2007, 859, 192-200.
(8) Gentili, A.; Caretti, F. Evaluation of a method based on liquid chromatography–diode array detector–tandem mass spectrometry for a rapid and comprehensive characterization of the fat-soluble vitamin and carotenoid profile of selected plant foods. J. Chromatogr. A, 2011, 1218, 684-697.
(9) Gentili A.; Caretti F., Multimethod for water-soluble vitamins in foods by using LC-MS In Fortified Foods with Vitamins– Analytical Concepts to Assure Better and Safer Products. Editor M. Rychlik, publisher ‘Wiley –VCH VerlagGmbH & Co. KGaA’, 2001. Print ISBN: 9783527330782. Online ISBN: 9783527634156. DOI: 10.1002/9783527634156.
(10) Indyk, H. E.; Wollard, D. C. Vitamin K in milk and infant formulas: determination and distribution of phylloquinone and menaquinone-4. Analyst, 1997, 122, 465-469.
(11) Koivu-Tikkanen, T. J.; Ollilainen, V.; Piironen, V. I. Determination of phylloquinone and menaquinones in animal products with fluorescence detection after postcolumn reduction with metallic zinc. J. Agric. Food Chem. 2000, 48, 6325-6331.
(12) Gentili A., The Chemistry of Vitamin A (Chapter 5) In Food and Nutritional Components in Focus No. 1, Vitamin A and Carotenoids: Chemistry, Analysis, Function and Effects. Edited by Victor R Preedy, RCS Publishing, 2012, 73-89. ISBN: 978-1-84973-550-6. DOI:10.1039/9781849735506-00073.
(13) Wollard, D. C.; Indyk, H. The distribution of retinyl esters in milks and milk products. J. Micronutr. Anal. 1989, 5, 35-52
Towards Self-Powered Wireless Sensor Networks
No full textUbiquitous computing aims at creating smart environments in which computational and communication capabilities permeate the word at all scales, improving the human experience and quality of life in a totally unobtrusive yet completely reliable manner. According to this vision, an huge variety of smart devices and products (e.g., wireless sensor nodes, mobile phones, cameras, sensors, home appliances and industrial machines) are interconnected to realize a network of distributed agents that continuously collect, process, share and transport information. The impact of such technologies in our everyday life is expected to be massive, as it will enable innovative applications that will profoundly change the world around us. Remotely monitoring the conditions of patients and elderly people inside hospitals and at home, preventing catastrophic failures of buildings and critical structures, realizing smart cities with sustainable management of traffic and automatic monitoring of pollution levels, early detecting earthquake and forest fires, monitoring water quality and detecting water leakages, preventing landslides and avalanches are just some examples of life-enhancing applications made possible by smart ubiquitous computing systems.
To turn this vision into a reality, however, new raising challenges have to be addressed, overcoming the limits that currently prevent the pervasive deployment of smart devices that are long lasting, trusted, and fully autonomous. In particular, the most critical factor currently limiting the realization of ubiquitous computing is energy provisioning. In fact, embedded devices are typically powered by short-lived batteries that severely affect their lifespan and reliability, often requiring expensive and invasive maintenance.
In this PhD thesis, we investigate the use of energy-harvesting techniques to overcome the energy bottleneck problem suffered by embedded devices, particularly focusing on Wireless Sensor Networks (WSNs), which are one of the key enablers of pervasive computing systems. Energy harvesting allows to use energy readily available from the environment (e.g., from solar light, wind, body movements, etc.) to significantly extend the typical lifetime of low-power devices, enabling ubiquitous computing systems that can last virtually forever. However, the design challenges posed both at the hardware and at the software levels by the design of energy-autonomous devices are many. This thesis addresses some of the most challenging problems of this emerging research area, such as devising mechanisms for energy prediction and management, improving the efficiency of the energy scavenging process, developing protocols for harvesting-aware resource allocation, and providing solutions that enable robust and reliable security support. %, including the design of mechanisms for energy prediction and management, improving the efficiency of the energy harvesting process, the develop of protocols for harvesting-aware resource allocation, and providing solutions that enable robust and reliable security support.2010 Google Europe Fellowship in Wireless Networking; FP7 project GENESI; CHIRON ARTEMIS project; TENACE PRIN Project
ḤADĪṮ E ANALISI COMPUTAZIONALE - Strategie e strumenti per il trattamento automatico del testo arabo e l’estrazione d’informazione
No full textThe dissertation explored new textual approaches to the Hadiths collections belonging to the juridical Islamic tradition, by drafting and implementing original computational and Natural Language Processing-based strategies
La delega ai professionisti delle operazioni di vendita nell'espropriazione forzata immobiliare ed il controllo del loro operato
No full textMultiple approaches for Duchenne Muscular Dystrophy therapy
No full textExon Skipping has been demonstrated to be a successful strategy for the gene therapy of Duchenne Muscular Dystrophy (DMD): the rational is to convert severe Duchenne forms into milder Becker ones. Here we show the selection of U1 snRNA-antisense constructs able to confer effective rescue of dystrophin synthesis in a Δ44 Duchenne genetic background, through skipping of exon 45; moreover, we demonstrate that the resulting dystrophin is able to recover the correct timing of myogenic marker expression, to re-localize nNOS and to rescue expression of miRNAs previously shown to be sensitive to the Dystrophin-nNOS-HDAC2 pathway.
Becker mutations display different phenotypes, likely depending on whether the shorter protein is able to reconstitute the wide range of wild type functions. Among them, efficient assembly of the dystrophin associated protein complex (DAPC) and Nitric Oxide Synthase (nNOS) localization are important. Comparing different Becker deletions we demonstrate the correlation between the ability of the mutant dystrophin to re-localize nNOS and the expression levels of two miRNAs, miR-1 and miR29c, known to be involved in muscle homeostasis and to be controlled by the Dys-nNOS-HDAC2 pathway.
Since the gene responsible for the disease has been identified, several aberrant pathways have been characterized and many therapeutic approaches have been proposed to face all the symptoms associated to the pathology. What is now quite clear is that the best way to cure the disease is to apply different strategies in parallel, to enhance the beneficial effect that could be obtained from a single treatment.
With this concept in mind we identified a microRNA, miR-31, that is deregulated in DMD conditions if compared to a healthy control. This miRNA represses dystrophin expression by targeting its 3′UTR region. In human DMD myoblasts treated with exon skipping, we demonstrate that miR-31 inhibition increases dystrophin rescue. These results indicate that interfering with miR-31 activity can provide an ameliorating strategy for those DMD therapies that are aimed at efficiently recovering dystrophin synthesis.PARENT PROJECT ONLUS; TELETHO
The social representation of economic crisis in different social groups
No full textThis research is part of a wider International study realized starting from 2009 in different European countries (France, Great Britain, Greece, Italy and Romania) among the activities of the “Mediterranean Center for the study of Social Representaions (CeMeRS)” of Naples. The aim of this study, placed in the Structural approach, is to investigate the social representations of the economic crisis among different social groups. The objectives of the research are: a) verify if there are differences between social representations constructed by different social groups; b) explore if and how the social representation of economic crisis has been transformed from 2009 to 2012; c) identify the differences between social representations of economic crisis (SRsEc) in different cultural contexts. It has been used a mixed method approach, useful to investigate both the SRsEc structure and content, in both a synchronic and diachronic perspective. In particular the Hierarchized Evocation method, integrated with a questionnaire of characterization (in 2012), was made to reach the structure, while a semi-structured interview (in 2009) and a structured interview (in 2012) was realized to explore the content. Data were collected in two periods, 2009 and 2012, on the same group of subjects, interviewed at the same time in each country. The participants were 120 subjects for each country involved (30 for each group, balanced on gender), equally distributed in four social categories: university students (second/third year; Faculty of Economics); bank clerks of medium level; shopkeepers; laypeople. Obtained data were treated with the Analysis of Hierarchized Evocations and Similitude Analysis (Evoc/Simi2005); categorial-frequencial content analysis (Atlas.ti); mono and multivariate analysis (SPSS). Results showed that, unless a diffuse salience of Job loss and Uncertainty, fear of future, the different Italian groups of participants had a different social representation of crisis, especially in the case of shopkeepers. This difference was traced also between the three “expert” categories and laypeople as regards the evolutive phase of their representation. A difference was found also between Italian and Greek social representations of crisis, with reference to the meaning of the salient elements and their organization
DAI GENITORI AI FIGLI. L'INFLUENZA DELLE ORIGINI FAMILIARI SUI PERCORSI DI MOBILITA' DEI FIGLI
No full textIl presente lavoro si inserisce nel filone di ricerca sulla mobilità intergenerazionale concentrandosi sull’analisi del ruolo giocato dalle origini familiari nel processo di trasmissione fra le generazioni dei genitori e dei figli. In questa ricerca, le influenze familiari sono indagate in maniera complessa, considerandone gli aspetti legati all’istruzione e all’occupazione, continuativa, osservandole in corrispondenza di determinati eventi della vita dei figli, e cumulativa, valutandone i vantaggi o svantaggi diretti e indiretti, ossia immediati e futuri.
La tesi si compone di tre capitoli: nel primo è presentato l’impianto metodologico della ricerca applicata, nei successivi due le evidenze empiriche. Nel dettaglio: il secondo capitolo è dedicato allo studio dell’influenza della famiglia sulle scelte dei figli legate ai percorsi di istruzione e di transizione post-diploma. Nel terzo, invece, si indaga sulla relazione tra le origini familiari e le diverse opportunità di mobilità di istruzione e di occupazione dei figli
Il Trattamento Endovascolare Nei Pazienti Diabetici con
No full textSTUSIO PROSPETTICO MONOCENTRICOROMA UNIVERSITà SPIENZ