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    Sculpture as screen

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    This work operates within an extended notion of the term ‘cinema’ and both still, and moving, projected images are used as a means to interrogate the nature of the screen and what might constitute such a surface. The work acts upon the detritus that surrounds us. Very low level materials such as discarded plastic bottles, bin liners, polystyrene packaging and cardboard boxes are juxtaposed with high-end technology in terms of the use of projectors and 3D animation software. The animations are made using 3D software utilising some of the more unusual properties of particle systems, camera clipping and glitches. Objects made from translucent materials are sometimes used to allow the light from the projector to bounce around inside them, promoting a sense that the projections are actually within the objects rather than simply sitting on the surface. Essentially the animations attempt to propose a degree of suspicion as to what is physically present and what is simply a projected image.A multi-component output consisting of a series of three works ('Kitchen Collider', 'Office Metropolis', 'Brunel's last dream') that exist as either video projection installations or videos documenting the said installations. These works utilise projected animations to examine the nature of the screen as a sculptural concern whilst acknowledging its relationship to the vernacular and the technological. These works have been extensively disseminated from 2014 to 2020 in a variety of exhibitions. This output forms part of an on-going, larger series of works.‘Kitchen collider’ 01/11/2014 Video selected (shortlist) to be exhibited at ‘Northern Artists Film Programme Prize’, mobile cinema, Salford quays (under the pseudonym Joe Stokes). Group exhibition. http://quaysculture.com/past-projects/2014-projects/cinema-truck/ 08/09/2015 Video selected to be exhibited at ‘Carbon meets Silicon’, Oriel Sycharth Gallery, Glyndwr University. Group exhibition. Link to online catalogue (p12): http://glyndwrpix.co.uk/carbonaugust2/mobile/index.html#p=1 21/10/2015 Video selected to be exhibited in the online moving image gallery of the ‘National open art competition’. Group exhibition. Website no longer available. 03/12/2015 Video selected to be exhibited at ‘LUZ’, PRISMA Art Projects, Galeria Casa Jefferson, Santurce, San Juan, Puerto Rico. International group exhibition. Link to facebook site: https://m.facebook.com/events/1653021281650167?__tn__=%2Cg‘Office metropolis’ 03/09/2015 Video selected to be exhibited at ‘Alternative worlds’, DYMA, Plano Lisboa, Lisbon, Portugal, international group exhibition as part of the architecture conference ‘DO YOU MEAN ARCHITECTURE’. Link to conference website (see button 2): http://www.doyoumeanarchitecture.com Link to conference website (alternative worlds): http://www.doyoumeanarchitecture.com/2015/08/alternative-worlds/ Link to conference website (blog): http://www.doyoumeanarchitecture.com/blog-2/ 21/10/2015 Video selected to be exhibited in the online moving image gallery of the ‘National open art competition’. Group exhibition. Website no longer available. 28/03/2019 Video selected to be exhibited at ‘yoo-TOH-pee-a’, ‘FIIK Studios, Leeds. Group exhibition. Link to exhibition advertisement: https://www.redeye.org.uk/exhibitions/yoo-toh-pee 05/08/2019 Video selected to be exhibited at ‘synergic’, ArtNumber 23/Ovalo gallery, Mexico. International group exhibition. Link to gallery website: https://www.artnumber23.uk/events link to exhibition catalogue (page 10): https://issuu.com/artnumber23/docs/mexico‘Brunel’s last dream’ 21/10/2015 Video selected to be exhibited in the online moving image gallery of the ‘National open art competition’. Group exhibition. Website no longer available. 15/03/2019 Video selected to be exhibited at ‘Dream states’, non dual xqdq, Hoxton Cabin, London. Group exhibition. Link to facebook site: https://www.facebook.com/events/541155466375287/ 23/08/2019 Video projection installation (version 2) selected to be exhibited at ‘FUBAR’, The Crypt gallery, London. Group exhibition. Link to gallery website: http://cryptgallery.org/event/fubar-exhibition/ Link to curators’ website: https://www.fubarcollective.com/exhibitions 24/01/2020 Video projection installation (version 3) selected to be exhibited at ‘nice to see you to see you nice’, CASC gallery, Chester. Group exhibition. Link to gallery website: https://www.cascgallery.co.uk/nicetoseeyo

    Practitioners’ perceptions on the delivery of services provided to children and their families in a disadvantaged area in an Indian context

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    Several successful children’s programs around the world have highlighted the importance of the quality of relationships among and between the adults involved in the delivery of services. This will enable the adults involved including parents to identify the skills, knowledge and dispositions that will influence the holistic development of their children’s current and future lives (New R.S. (1999). The aim of this research study is to explore the perceptions of practitioners on the delivery of integrated services provided to children and their families living in disadvantaged areas in India. Integrated Child Development Services (ICDS) is a government-initiated programme that has been successful in providing the needed services almost on the families’ doorstep. The practitioners - especially those working at grass roots levels, from the same community and a range of different practitioners involved in the delivery of integrated services to children and their families were interviewed using semi structured interview schedule. The interviews were tape recorded in order to accommodate analysis. The findings indicated that the delivery of integrated services for children and their families from disadvantaged families adopted a personal and flexible approach. The families and the members of the community especially women were successfully encouraged to be involved in the education and health aspects of the services provided. The success of the programme as perceived by the practitioners highlighted on the personal qualities such as commitment, high levels of motivation of the practitioners at different levels of implementation of the programme

    Discovery of a Novel CIP2A Variant (NOCIVA) with clinical relevance in predicting TKI resistance in myeloid leukemias

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    This document is the Accepted Manuscript version of a published work that appeared in final form in [Clinical Cancer Research]. To access the final edited and published work see http://dx.doi.org/10.1158/1078-0432.CCR-20-3679Purpose: Cancerous inhibitor of PP2A (CIP2A) is an oncoprotein that inhibits the tumor suppressor PP2A-B56a. However, CIP2A mRNA variants remain uncharacterized. Here, we report the discovery of a CIP2Asplicing variant, NOCIVA (NOvel CIp2a VAriant). Experimental Design: Characterization of CIP2A variants was performed by both 3' and 5' rapid amplification of cDNA ends from cancer cells. The function of NOCIVA was assessed by structural and molecular biology approaches. Its clinical relevance was studied in an acute myeloid leukemia (AML) patient cohort and two independent chronic myeloid leukemia (CML) cohorts. Results: NOCIVA contains CIP2A exons 1-13 fused to 349 nucleotides from CIP2A intron 13. Intriguingly, the first 39 nucleotides of the NOCIVA-specific sequence are in the coding frame with exon 13 of CIP2A and code for a 13 amino acid peptide tail nonhomologous to any known human protein sequence. Therefore, NOCIVA translates to a unique human protein. NOCIVA retains the capacity to bind to B56a, but whereas CIP2A is predominantly a cytoplasmic protein, NOCIVA translocates to the nucleus. Indicative of prevalent alternative splicing from CIP2A to NOCIVA in myeloid malignancies, AML and CML patient samples overexpress NOCIVA but not CIP2A mRNA. In AML, a high NOCIVA/CIP2A mRNA expression ratio is a marker for adverse overall survival. In CML, high NOCIVA expression is associated with inferior event-free survival among imatinib-treated patients, but not among patients treated with dasatinib or nilotinib. Conclusions: We discovered novel variant of the oncoprotein CIP2A and its clinical relevance in predicting tyrosine kinase inhibitor therapy resistance in myeloid leukemias

    What is PE and who should teach it? Undergraduate PE students’ views and experiences of the outsourcing of PE in the UK

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    This is an Accepted Manuscript of an article published by Taylor & Francis in Sport, Education and Society on 22 March 2021, available online: https://doi.org/10.1080/13573322.2021.1901684This paper investigates beginning BSc Physical Education (PE) students’ views and experiences of the outsourcing of PE in the UK. Outsourcing involves the provision of PE by external providers such as sports coaches. PE in the UK (and other neoliberal Western contexts) is a site in which outsourcing has become increasingly normalised. I anticipated that, as first year undergraduates, the participants would have relatively recent experience of outsourcing as pupils/students (i.e. experience of receiving outsourced PE provision). Data were generated through written narratives (n = 16), completed on the participants’ first day at university, and follow-up semi-structured interviews (n = 10). Drawing on a Foucaultian theoretical framework, I employed a poststructural type of discourse analysis concerned with analysing patterns in language. Referring to PE, the participants drew heavily on a sport discourse, often conflating PE and sport and emphasising the necessity of teachers having knowledge and experience of sports content and skills, as well as a pedagogical discourse (and, to a lesser extent, a ‘healthy lifestyles’ discourse). The participants had a range of experiences of outsourcing in PE, particularly at primary level. They were in favour of primary PE being taught by either specialist PE teachers, or sports coaches (rather than generalist teachers alone). They spoke positively about their experiences of external provision at both primary and secondary school. While few critical comments were provided, participants raised concerns about external providers’ pedagogical knowledge, and some questioned if teachers might feel devalued by external providers being brought in to teach aspects of their curriculum. In general, while the participants recognised teachers’ pedagogical expertise, they also valued external providers’ perceived content knowledge and sporting experience. As such, by conflating PE and sport, they considered that PE should be taught by sport ‘experts’ and that external providers could enhance schools’ internal capabilities

    The Emotional Face of Anorexia Nervosa: The Neural Correlates of Emotional Processing

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    Social-emotional processing difficulties have been reported in Anorexia Nervosa (AN), yet the neural correlates remain unclear. Previous neuroimaging work is sparse and has not used functional connectivity paradigms to more fully explore the neural correlates of emotional difficulties. Fifty-seven acutely unwell AN (AAN) women, 60 weight-recovered AN (WR) women and 69 healthy control (HC) women categorised the gender of a series of emotional faces while undergoing Functional Magnetic Resonance Imaging. The mean age of the AAN group was 19.40 (2.83), WR 18.37 (3.59) and HC 19.37 (3.36). A whole brain and psychophysical interaction connectivity approach was used. Parameter estimates from significant clusters were extracted and correlated with clinical symptoms. Whilst no group level differences in whole brain activation were demonstrated, significant group level functional connectivity differences emerged. WR participants showed increased connectivity between the bilateral occipital face area and the cingulate, precentral gyri, superior, middle, medial and inferior frontal gyri compared to AAN and HC when viewing happy valenced faces. Eating disorder symptoms and parameter estimates were positively correlated. Our findings characterise the neural basis of social-emotional processing in a large sample of individuals with AN

    Translating Patịcca-samuppāda in Early Buddhism

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    This chapter addresses the issue of how to translate the term paṭicca-samuppāda, which relies on the use of Prakrit and Sanskrit grammatical forms for which there are no exact English equivalents, and which expresses a core Buddhist concept for which there is no exact philosophical equivalent outside of Buddhist teachings

    Thriving at Work (Integrated Learning): An investigation into adult learners’ experiences of vitality and learning when successfully engaging with work integrated learning

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    Higher Education (HE) has a key role in re-educating an aging UK workforce through part-time programmes aimed at older (30+) working adults. However, since 2010 HE enrolments have plummeted further compounded by high attrition rates. As such, there is an urgent need for HE to research this important but overlooked student category in order to attract and support them. As a HE lecturer in work integrated learning, the researcher has a vested interest in addressing this gap as well as contributing to the thriving at work literature. Taking a social constructivist stance, narrative inquiry has been applied to explore eleven adult work integrated learners’ experiences of thriving to gain a deeper understanding of what positively influences their vitality and learning and how HE can facilitate them. Her findings show learners’ vitality towards work integrated learning mirror their vitality towards work. The opportunity to shape and share learning helps elevate and maintain vitality levels as well as deepen the learning experience so enabling them to thrive. Further, attitudes are not only influenced by the current context but also experiences and events from childhood. However, although HE tutors can positively influence learners’ experience of work integrated learning, most of HE appears to have little impact. As well as exploring thriving in the context of work integrated learning, this study contributes to the thriving at work literature by providing insights which suggest vitality exhibits state-like and trait-like qualities. When vitality combines with work integrated learning, it creates a virtuous circle where one construct builds on the other to enable the learner to thrive. This is further enhanced by learners’ shaping and sharing their learning experience with others. However, learners’ ability to engage with HE successfully in the present is also influenced by their experiences from the past and can impact on their needs and expectations. To attract and retain this important learner category, HE must understand and respond to learners’ needs and expectations not just via interactions with specific tutors but through the HE systems and processes laid down to support them

    A focus group study of older Chinese people with CVD patients in the North West of the UK

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    Cardiovascular disease (CVD) is the leading cause of death for Chinese migrants around the world. Chinese CVD patients rely heavily on their native Chinese language, cultural values and beliefs, which adds challenges for the healthcare providers to offer primary healthcare services with standard protocol. The inappropriate treatment could lead to life loss, mistrust in doctor-patient relationship and heavy burden for healthcare funding. 28 participants were included for focus group study with the grounded theory methodology. There is considerable misunderstanding among the Chinese community about the role of primary care doctors in the treatment of cardiovascular disease resulting in the variable use of primary care services. Chinese CVD patients or identified risk factors for CVD arguably need closer management, culturally sensitive advice, support and robust follow-up compared to the general population. Doctors and nurses should enhance their practice and give them confidence in their interaction with Chinese patients on the basis of how they think and behave in relation to help seeking

    The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival

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    From Springer Nature via Jisc Publications RouterHistory: received 2020-07-30, accepted 2021-06-09, registration 2021-06-16, pub-electronic 2021-07-02, online 2021-07-02, collection 2021-12Publication status: PublishedFunder: Harry J. Lloyd Charitable Trust; doi: https://doi.org/10.13039/100005976; Grant(s): Career Development AwardFunder: Cancer Research UK (CRUK); doi: https://doi.org/10.13039/501100000289; Grant(s): A27412, A22902Funder: Wellcome Trust (Wellcome); doi: https://doi.org/10.13039/100004440; Grant(s): 100282/Z/12/ZAbstract: Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We hypothesized that the T cell receptor (TCR) repertoire of tumor infiltrating T lymphocytes could therefore be indicative of the functional state of these cells and determine disease course at different stages in cancer progression. Here we show that the diversity of the TCR of tumor infiltrating T cell at baseline is prognostic in various cancers, whereas the TCR clonality of T cell infiltrating metastatic melanoma pre-treatment is predictive for activity and efficacy of PD1 blockade immunotherapy

    An Active Plasma Beam Dump for EuPRAXIA Beams

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    From MDPI via Jisc Publications RouterHistory: accepted 2021-06-30, pub-electronic 2021-07-05Publication status: PublishedFunder: Cockcroft Institute; Grant(s): Core GrantPlasma wakefields driven by high power lasers or relativistic particle beams can be orders of magnitude larger than the fields produced in conventional accelerating structures. Since the plasma wakefield is composed not only of accelerating but also of decelerating phases, this paper proposes to utilize the strong decelerating field induced by a laser pulse in the plasma to absorb the beam energy, in a scheme known as the active plasma beam dump. The design of this active plasma beam dump has considered the beam output by the EuPRAXIA facility. Analytical estimates were obtained, and compared with particle-in-cell simulations. The obtained results indicate that this active plasma beam dump can contribute for more compact, safer, and greener accelerators in the near future

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