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Stress Analysis and Modeling of Rotating Functionally Graded Discs With Variable Geometry Using Support Vector Regression
No full textPurposeThe purpose of this study is to investigate the stress and deformation analysis of rotating discs composed of functionally graded materials and variable geometry. In addition to this, the obtained radial stress, tangential stress and radial displacement values can be modeled by means of support vector regression (SVR).Design/methodology/approachRadial stress, tangential stress and radial displacement values obtained by material index and geometry index were obtained by finite element method. The stress analysis values obtained were modeled with SVR.FindingsIn the case of free-free discs, it was observed that radial stresses decreased with an increase in material index, whereas tangential stresses on inner surface decreased significantly and increased on the outer surface. As the geometry index decreases, the radial stresses on both the inner and outer surfaces decrease. The most successful modeling was observed for radial stress, tangential stress and radial displacement, respectively, although the modeling performed with SVR yielded successful results for each of them.Originality/valueThe modeling of radial stress, tangential stress and radial displacement values obtained by material index and geometry index with SVR represents a research gap that this study aims to address
Comparative Analysis of Performances of an Improved Particle Swarm Optimization and a Traditional Particle Swarm Optimization for Training of Neural Network Architecture Space
No full textMany studies evaluating the performance of various optimization methods for training Artificial Neural Networks (ANNs) have produced conflicting results. This discrepancy often arises due to the limited application of these methods across a narrow spectrum of ANN architectures and training parameter values. In response to this gap, our study introduces an enhanced Particle Swarm Optimization (PSO) technique, denoted as Reverse Direction Supported Particle Swarm Optimization (RDS-PSO), specifically designed for ANN training. RDS-PSO incorporates two novel parameters, namely alpha and beta, allowing the creation of four distinct RDS-PSO types including the original PSO. Unlike many existing studies, we comprehensively evaluate the performance of these four RDS-PSO types across a diverse set of criteria. These criteria include the architectural space of ANN, training depths for ANN, inertia weight direction for RDS-PSO, and adaptation approaches for the two novel parameters of RDS-PSO. Through 100 iterations for each training case, we conduct an extensive and intricate analysis of ANN training performance on three medical datasets. Our experimental findings reveal that RDS-PSO_3, featuring decreasing inertia weight and cosine adaptation, consistently outperforms other RDS-PSO types. Furthermore, RDS-PSO_3 demonstrates greater reliability, as evidenced by lower standard deviation values, across most ANN architectures. © 2025, Budapest Tech Polytechnical Institution. All rights reserved
Are Energy Commodity Price Shocks Persistent? Evidence From Smooth Breaks and Common Factors in Panel Data
No full textNazlioglu, Elif Hilal/0000-0002-4425-7479; Kilic, Emre/0000-0003-2900-5123Whether shocks to energy prices are permanent or temporary is an important research question for researchers, investors, and policy makers. The main objective of this study is to analyze whether shocks to oil, natural gas and coal prices are permanent or temporary. For oil, Brent, Dubai and WTI oil prices; for coal, Australian coal, and South African coal; and for natural gas, LNG Asia, EU natural gas and US Henry Hub gas prices are used. A data set of monthly prices (1984:01-2023:05) is used. In contrast to the literature, price shocks are analyzed taking into account structural changes and common factors using the methodologies of Bai and Carrion-I-Silvestre (2009) and Nazlioglu etal. (2023). As a result of the empirical findings, the unit root test with sharp break suggests that price shocks are permanent, while the unit root test with smooth break suggests that shocks to energy prices are transitory. The results of the analysis show that the changes in energy prices may differ according to the type of structural break (sharp/smooth)
Karbon tabanlı iki boyutlu malzemelerin lityum ve lityum-sulfur bataryalarında kullanılabilirliğinin araştırılması
No full textBu tez çalışması Turkiye Bilimsel ve Teknolojik Araştırma Kurumu
(TUBİTAK) tarafından 122F462 nolu proje ve Pamukkale Universitesi
Bilimsel Araştırma Projeleri Koordinatorluğü tarafından 2023HZDP004
nolu proje ile desteklenmiştir. Malzeme Fiziği Simulasyon Laboratuvarı
olanakları kullanılarak yapılmıştır.İki boyutlu malzemeler, üç boyutlu yapılara kıyasla baskın kuantum
mekaniksel etkilerin ortaya cıkması nedeniyle farklı ve özgün ozellikler
sergilemektedir. Bu ozellikler, malzemelerin fiziksel ve kimyasal davranışlarında
belirgin değişimlere yol acmaktadır. Literaturde düşük boyutlu malzemelerin gaz
sensoru, suyun tuzdan arındırılması, hidrojen enerjisinin depolanması ve batarya
uygulamaları gibi çeşitli alanlarda kullanımının üç boyutlu durumlarına gore
yuzey/hacim oranının artmasından dolayı daha verimli sonuclar verdiğine dair
çalışmaların olması bu tez çalışmasının motivasyonunu oluşturmaktadır. Bu nedenle
tez kapsamında, bazı iki boyutlu malzemelerin yabancı atom/molekul katkılama,
gerinim uygulama ve tabaka sayısındaki artış gibi dış etkiler altındaki elektronik ve
manyetik ozelliklerinin değişimleri ve karbon tabanlı iki boyutlu malzemelerin lityum,
lityum-sulfur bataryalarında kullanılabilirlikleri yoğunluk fonksiyoneli teorisi (DFT)
tabanlı numerik yontemler yardımıyla incelendi.
Bu tez calışmasında, Cr2TaC2 ve Cr2TaC2O2 MXene yapılarının % -3 -
%9 gerinim altında yapısal kararlılıklarını, elektronik olarak metalik ve manyetik
olarak da ferromanyetik karakterini koruduğu teorik olarak ispatlandı. FeN4
ve FeP4 gibi iki boyutlu malzemelerde, gerinim uygulanmasının ve cift katman
oluşturulmasının, malzemelerin elektronik ve manyetik ozelliklerini onemli olcude
değiştirdiği gosterildi. Örneğin, tek katmanlı FeN4 yapısı denge durumunda 1,290
eV’luk dolaylı bant aralı˘gına sahip Neel tipi antiferromanyetik yarı iletken iken, % 5
ve %6 cekme gerinimi altında doğrudan bant aralığına sahip ferromanyetik yarıiletken
malzemeye dönüşmektedir.. FeP4 yapısının ise tek katmanlı durumda ferromanyetik,
cift katmanlı durumda ise tabakalar arası antiferromanyetik ozellik sergilediği bulundu.
Son olarak BeN4 yapısında nokta kusurlarının ve gaz adsorpsiyonunun etkileri detaylı
bir şekilde incelendi ve bu yapıların H2 depolama ile gaz algılama gibi uygulamalarda
kullanılma potansiyeline sahip olduğu ortaya konuldu.
İki boyutta sp ve/veya sp2 hibritle，smelerine sahip karbon yapılarının
(Graphyne, Dodecagonal, Haecklites (5-7), GY-5, Kagome Grafen, Porous Grafen,
T-Grafen) Li-iyon bataryalarda anot malzemesi olarak kullanılabilirliği araşstırıldı.
Tek lityum atomunun yapılar uzerindeki tutunma enerjisi hesaplandı ve sonrasında
lityum atom sayısı tabakalar üzerinde kademeli olarak artırılarak yapıların maksimum
lityum depolama kapasiteleri teorik olarak belirlendi. Buna göre yapıların Li
atomu depolama kapasiteleri icin Graphyne > T-Grafen > Dodecagonal > Haecklites
(5-7) > Kagome Grafen ，şeklinde büyüklük sıralamasında olduğu ve Grafen’nin
hacimli hali olan grafitten (372 mAhg−1) üç ila on dört kat daha fazla depolama
kapasitesine sahip oldukları hesaplandı. GY-5 karbon yapısının, tek Li atomu
ile güçlü bir ，şekilde bağlandığı fakat ikinci bir Li atomunun yapıya tutunması
sonrasında yapıda oluşan deformasyonla farklı bir kristal olan ψ-Grafen formuna
dönüştüğü belirlendi. Bununla beraber, Li atomunun Porous Grafen yapısına
-1,260 eV gibi zayıf tutunma enerjisinden dolayı lityum iyon bataryalarında anot
malzemesi olarak kullanılamayacağı ortaya çıkarıldı. Bu tez calışmasında ayrıca,
Grafen, Graphyne ve Graphdiyne tek katmanlarının lityum polisulfurler (LixSy; 1 ≤
x ≤ 2, 1 ≤ y ≤ 8) ile etkile，simi, yapı içerisindeki sp bağlarının sayısının
ve nano gözeneklerin büyüklüğünün tutunma enerjisi ve yapı uzerindeki difuzyon
surecine etkisi sistematik olarak incelendi. Elde edilen hesaplama sonucları, sp
bağ sayısı ve nano gozenek büyüklüğününLi2S4 nano kume büyüklüğüne kadar
etkili olduğunu ve LixSy nano kumelerinin boyutu arttıkca, tutunma enerjilerinin
Grafen, Graphyne ve Graphdiyne tek katmanlarında neredeyse benzer olduğu tespit
edildi. Difuzyon bariyer enerjisi değerleri acısından, LixSy nano kumelerinin Grafen
uzerinde kolayca goc edebileceği, ancak Graphdiyne ve ozellikle Graphyne uzerindeki
nano gozenek buyuklukleri nedeniyle daha zor hareket edeceği belirlendi. Son
olarak,lityum sulfur bataryalarında gorulen mekik etkisini incelemek amacıyla iki
LixSy nano kumesi aynı anda Grafen, Graphyne ve Graphdiyne tek katmanları uzerine
konularak optimizasyon gercekle，stirildi. Elde edilen teorik sonuclar, iki LixSy nano
kumenin de tek katmanlı yapılara guclu bağlandığını fakat LixSy nano kumelerin
birbirlerine bağlanmadığını boylece istenmeyen uzun lityum polisulfit zincirlerinin
oluşmayacağını gostermektedir.Two-dimensional materials exhibit different and unique properties
compared to three-dimensional structures due to the emergence of dominant quantum
mechanical effects. These properties lead to significant changes in the physical and
chemical behavior of materials. The motivation for this thesis is that there are studies in
the literature showing that the use of low-dimensional materials in various fields such
as gas sensors, water desalination, hydrogen energy storage and battery applications
yields more efficient results due to the increase in surface/volume ratio compared to
their three-dimensional state. Therefore, within the scope of this thesis, the changes
in the electronic and magnetic properties of some two-dimensional materials under
external effects such as foreign atom/molecule doping, strain application and increase
in the number of layers and the usability of carbon-based two-dimensional materials in
lithium, lithium-sulfur batteries were investigated with the help of density functional
theory (DFT) based numerical methods.
In this thesis, it is theoretically proved that Cr2TaC2 and Cr2TaC2O2 MXene
structures retain their structural stability, electronically metallic and magnetically
ferromagnetic character under strain of -3% - 9%. In two-dimensional materials such
as FeN4 and FeP4, it has been shown that the application of strain and the formation
of double layers can significantly change the electronic and magnetic properties of the
materials. For example, the monolayer FeN4 structure is a Neel-type antiferromagnetic
semiconductor with an indirect bandgap of 1.290 eV in the equilibrium state, whereas
under 5% and 6% tensile strain it transforms into a ferromagnetic semiconductor with
a direct bandgap. The FeP4 structure was found to exhibit ferromagnetic properties
in the monolayer state and interlayer antiferromagnetic properties in the bilayer state.
Finally, the effects of point defects and gas adsorption on the BeN4 structure were
investigated in detail, showing that these structures have the potential to be used in
applications such as H2 storage and gas sensing.
The usability of carbon structures with sp and/or sp2 hybridizations in two
dimensions (Graphyne, Dodecagonal, Haecklites (5-7), GY-5, Kagome Graphene,
iii
Porous Graphene, T-Graphene) as anode materials in Li-ion batteries was investigated.
The trapping energy of a single lithium atom on the structures was calculated and then
the maximum lithium storage capacity of the structures was theoretically determined
by gradually increasing the number of lithium atoms on the layers. Accordingly, the Li
atom storage capacities of the structures were found to be in the order of magnitude of
Graphyne > T-Graphene > Dodecagonal > Haecklites (5-7) > Kagome Graphene and
were calculated to be three to fourteen times higher than graphite (372 mAhg−1), the
bulk form of Graphene. The GY-5 carbon structure was found to be strongly bound by
a single Li atom, but after a second Li atom was attached to the structure, the structure
deformed into a different crystal, ψ-Graphene. However, it was revealed that Li atom
cannot be used as an anode material in lithium ion batteries due to its weak binding
energy of -1.260 eV to Porous Graphene structure. In this thesis, the interaction of
Graphene, Graphyne and Graphdiyne monolayers with lithium polysulfides (LixSy;
1 ≤ x ≤ 2, 1 ≤ y ≤ 8) and the effect of the number of sp bonds and the size
of nanopores in the structure on the attachment energy and diffusion process on the
structure were systematically investigated. The obtained calculation results show that
the number of sp bonds and nanopore size are effective up to Li2S4 nanocluster size,
and as the size of LixSy nanoclusters increases, the trapping energies are almost similar
in Graphene, Graphyne and Graphdiyne monolayers. In terms of diffusion barrier
energy values, it was found that LixSy nanoclusters can easily migrate on Graphene,
but more difficult on Graphdiyne and especially Graphyne due to their nanopore size.
Finally, optimization was performed by placing two LixSy nanoclusters simultaneously
on Graphene, Graphyne and Graphdiyne monolayers to study the shuttle effect seen in
lithium sulfur batteries. The theoretical results show that both LixSy nanoclusters are
strongly bonded to the monolayer structures, but the LixSy nanoclusters are not bonded
to each other, thus avoiding the formation of unwanted long lithium polysulfide chains
What Is the Predominant Etiological Factor for Merkel Cell Carcinoma in Turkey: Viral Infection or Sun Exposure
No full textKarstarli Bakay, Ozge Sevil/0000-0002-1523-3187BackgroundMerkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin carcinoma. The pathogenesis involves Merkel cell polyomavirus (MCPyV) and ultraviolet radiation exposure. Studies on MCC in Turkey are scarce, with essential data on local etiopathogenic and prognostic factors still lacking. We aimed to analyze the clinical and histopathologic features, biomarkers, and to evaluate these findings alongside Turkish literature to infer the etiopathogenesis, prognosis, and possible treatment options for the disease.MethodsWe analyzed the clinicopathologic features of 7 MCC patients diagnosed at the Pathology Department of Pamukkale University between 2003 and 2024 in this retrospective study. Clinical data was retrieved from the hospital's electronic records. Formalin-fixed, paraffin-embedded tumor specimens stained with hematoxylin-eosin were examined microscopically. MCPyV, Retinoblastoma 1 (RB1), p53, PRAME, PD-L1, and MMR proteins were evaluated immunohistochemically. Research on MCC from Turkey was sourced from Turkish databases (ULAKBIM, Turkiye Atif Dizini, DergiPark, Turk Medline) and international databases (Pubmed, Google Scholar, Scopus, Embase). The literature review identified original research, case reports, theses, and conference presentations.ResultsThe patients in our series, all aged over 50 (mean age 76.1 +/- 14.8), with a slight predominance of one gender (F: M = 1.33:1). During a mean follow-up of 16.1 months, 42.9% (3/7) had lymph node metastases, and 57.1% (4/7) showed distant metastases. PRAME was positive in 42.9% of the cases (3/7). The total number of MCC cases reported from Turkey was estimated at 227 +/- 46, with MCPyV status available in a subset, showing a positivity rate of 70.3%. PD-L1 expression was observed in the tumor microenvironment in 55% of virus-positive MCC cases from Turkey.ConclusionsThe 9% incidence of gluteal localization in Turkish MCC cases, considering its geographical significance, is noteworthy. Notably, all MCC cases from Turkey in which microsatellite instability status has been assessed were found to be microsatellite stable. PRAME should be investigated in larger series for its potential role in the shared oncogenic pathways of MCC
Evlilik sürecinde ailenin rolü Denizli örneği
No full textunsurdur. Kültürel beklentiler, ekonomik faktörler ve sosyal ağlar aracılığıyla aileler, bireylerin eş seçiminde doğrudan ya da dolaylı bir rol oynamaktadır. Birçok toplumda, ailelerin tercihleri evlilik kararlarını belirleyici bir faktör olarak varlığını sürdürmektedir. Bu durum özellikle grup içi evlilik (endogami) eğiliminde kendini göstermekte, bireylerin sosyal, kültürel veya etnik olarak kendilerine benzer bireylerle evlenmeleri toplumsal uyum ve sürekliliği pekiştirmektedir. Buna karşın, grup dışı evlilik (eksogami) yani bireyin kendi sosyal grubunun dışından biriyle evlenmesi, toplumdaki geleneksel değerlerin gücüne bağlı olarak değişen düzeylerde dirençle karşılaşabilmektedir.
Bu araştırmada, Denizli ilinde toplumsal değişim sürecinin evlilik kurumu üzerindeki etkileri incelenmiştir. Geleneksel evlilik ilişkilerinin sürekliliği ve bu sürekliliğin altında yatan faktörler analiz edilmiştir. Özellikle Denizli’de yaygın olarak gözlemlenen, ortak kültürel, sosyal ve ekonomik bağlara sahip ailelerin, evlilik sürecinde yerel bağlara bağlı kalarak dışarıdan evliliğe mesafeli yaklaşmalarının nedenleri irdelenmiştir. Modernleşme ve bireyselleşme süreçlerinin evlilik tercihlerini nasıl şekillendirdiği ele alınmış, geleneksel ve modern evlilik pratikleri arasındaki etkileşim değerlendirilerek ve toplumsal dönüşüm sürecinin evlilik kurumu üzerindeki yansımaları ortaya konulmuştur.One of the key aspects of marriage is the role of the family in partner selection. Families, through cultural expectations, economic considerations, and social networks, significantly influence individuals' choices in selecting a spouse. In many societies, family preferences continue to shape marital decisions, either directly through arranged marriages or indirectly through social expectations. This influence manifests particularly in the tendency toward endogamy, where individuals marry within their social, cultural, or ethnic groups, reinforcing group cohesion and continuity. Conversely, exogamy, or marriage outside one's immediate social group, is often met with varying degrees of resistance, depending on the strength of traditional values within a given society.
This study examines the impact of social change on the institution of marriage in the province of Denizli. It explores the extent to which traditional marriage relationships persist and identifies the underlying factors contributing to their resilience. In particular, the study investigates why families in Denizli, who share a common cultural, social, and economic background, tend to adhere to local marriage patterns and exhibit reluctance toward exogamous marriages. While modernization and increased mobility have facilitated more diverse marital choices, social expectations and familial influences continue to play a decisive role in shaping partner selection. In this context, the interaction between traditional and modern marriage practices will be analyzed, and the implications of social transformation on the institution of marriage will be discusse
Efficacy of Second-Line Treatments After Atezolizumab and Bevacizumab in Advanced Hepatocellular Carcinoma and Related Prognostic Factors: a Multicenter Study by the Turkish Oncology Group (Tog)
No full textAlan, Ozkan/0000-0002-6635-2012; Gunenc, Damla/0000-0002-7592-2021Background/Aims: The treatment of hepatocellular carcinoma (HCC), which accounts for 90% of all liver cancers, is highly varied. The use of second-line treatments following progression on first-line atezolizumab and bevacizumab (Atez/Bev) for advanced HCC remains controversial. The aim of this study was to analyze the real-world clinical results of second-line treatments in progression after Atez/Bev and to determine the factors affecting prognosis. Materials and Methods: Fifty-eight patients treated with second-line sorafenib, regorafenib, and cabozantinib for progression after first-line Atez/Bev for advanced/metastatic HCC from 20 centers in T ; uuml;rkiye between October 2020 and June 2024 were retrospectively analyzed. Responses were evaluated by Response criteria, specifically Response Evaluation Criteria in Solid Tumors (RECIST v1.1) criteria. Median overall survival (OS) and progression-free survival (PFS) were computed with the Kaplan-Meier method. The Cox regression model was utilized to analyze multivariate analyses. Results: About 82.8% of the patients were male and the median age of the whole group was 62 (range, 18-78) years. All patients progressed after first-line Atez/Bev and were given second-line treatment. The most commonly used second-line treatment option was sorafenib (70.7%), followed by regorafenib (12.1%) and cabozantinib (10.3%). Both median PFS (4.1 months) and median OS (7.8 months) were longer in patients treated with sorafenib compared to other treatments. In univariate analyses, Child-Pugh score B, high alpha-fetoprotein (AFP) levels (>200 ng/mL), extrahepatic spread, and Prognostic Nutritional Index (PNI) 47.6 substantially raised the risk of overall mortality. Multivariate analysis showed that extrahepatic spread (HR (Hazard ratio): 0.41, P = .012), PNI level (HR: 0.24, P = .005), and AFP level (HR:1.97, P = .049) were independent predictors of OS. Conclusion: Although second-line therapies after Atez/Bev show different degrees of efficacy, survival rates are consistent with the literature. Extrahepatic spread, AFP level, and PNI level are the main prognostic factors. In light of this information, personalized treatment strategies may improve outcomes for this challenging patient group
Perceived Self-Efficacy in Physical Examination Skills, Clinical Practice Experiences, and Utilization of Findings in Care Plans Among Senior Nursing Students: a Cross-Sectional Study
No full textBackgroundIn nursing education, physical examination skills are a fundamental requirement for clinical practice. Nevertheless, there is a lack of evidence concerning the perceived self-efficacy of senior nursing students in these skills, their use in the clinical environment, and their integration into care plans. The study aimed to determine the perceived self-efficacy of senior nursing students regarding physical examination, their application of physical examination skills in the clinic, and their use of physical examination findings in care plans.MethodsThis descriptive cross-sectional study was conducted during the 2023-2024 academic year at a university in Western Turkey. A convenience sampling method was employed, and 107 students (71%) who met the inclusion criteria, completed all forms, and voluntarily agreed to participate were included in the study. Data were collected using the Student Identification Form, Physical Examination Perceived Self-Efficacy Instrument for Undergraduate Nursing Students, and student care plans.ResultsIn this study, the total score of nursing students' perceived self-efficacy in physical examination was 2.18 +/- 0.41 ('not very sure'). The Cardio sub-dimension of physical examination skills (2.50 +/- 0.54) had the highest mean sub-dimension score, while the eye sub-dimension (1.75 +/- 0.54) had the lowest mean sub-dimension score. More than half of the students were found to have no confidence in their ability to perform 14 physical examination skills and never practiced the skills in the clinic. It was determined that the students used only 20 physical examination skills in the data collection phase of the care plans, and only 6 of these skills were practiced by more than half of the students.ConclusionsThis study reveals a significant gap in the self-efficacy and practical skills of nursing students related to physical examination. Based on these findings, the nursing curriculum should include more hands-on training and clinical practice should provide students with more opportunities to apply physical examination skills.Clinical trial numberNot applicable
Preserving Bioactive Compounds in Wheat Germ Through Drying: a Kinetic Study
No full textCaliskan Koc, Gulsah/0000-0002-6542-3093; Demiray, Engin/0000-0002-1639-9090In this study, wheat germ was dried at three different temperatures (80 degrees C, 90 degrees C, and 100 degrees C) using an oven. The drying characteristics of the samples were analyzed, and the experimental data were fitted to five different thin-layer drying models: Logarithmic, Lewis, Henderson and Pabis, Page, and Modified Page. Among these models, the Page and Modified Page models provided the best fit, yielding the highest R2 values and the lowest RMSE and chi 2 values. The overall drying process occurred in the falling rate period in all experiments. Bioactive compound degradation was also assessed during drying process. Lutein content decreased by 37.24-49.22%, total phenolic content decreased by 41.41-43.67%, and total antioxidant activity decreased by 31.25-45.70%. The degradation kinetics of lutein content, total phenolic content, and total antioxidant activity were evaluated, yielding activation energy values of 34.03, 61.89, and 63.55 kJ/mol, respectively. Lutein degradation followed a second-order kinetic model, changes in total phenolic content adhered to a zero-order kinetic model, and total antioxidant activity followed a first-order kinetic model. Considering the Q10 values, it was determined that the effect of increasing the temperature from 80 degrees C to 90 degrees C was less significant than the effect of increasing the temperature from 90 degrees C to 100 degrees C on all bioactive components.Pamukkale University Research Fund [2021FEBE071]This study is supported by Pamukkale University Research Fund. The grant no is - 2021FEBE071
The Presence of a Palpable Mass Is an Independent Predictor of Microinvasion in Ductal Carcinoma in Situ of the Breast
No full textPurpose: Breast cancer is the most common cancer among women worldwide. Ductal Carcinoma in situ (DCIS) is one of the most common types of these cancers. Factors associated with microinvasion still need to be investigated. Materials and methods: In this retrospective study, we analyzed data from 70 female patients diagnosed with DCIS and managed at a tertiary center between 2011 and 2024. Demographic parameters, clinicopathological characteristics, and immunohistochemical findings of the patients were examined in comparison with their microinvasion status. Results: 70 female patients with Ductal Carcinoma in situ, with a median age of 51 years, were investigated. Among these patients, 17 cases (24.3%) had microinvasion. Compared with demographic parameters, only BMI was associated with microinvasion status. Patients with higher BMI had lower risk of microinvasion (p=0.038). The presence of a palpable mass was significantly higher in patients with microinvasion (p=0.001), suggesting a potential link between tumor palpability and invasion. Immunohistochemical analysis demonstrated associations between hormone receptor status, HER2 expression, and microinvasion. The presence of HER2 was significantly associated with microinvasion (p=0.026). Multivariate analysis however, revealed that tumor palpability was the only independent factor associated with microinvasion status (Odds Ratio: 5.233; 1.339-20.455; p=0.017). Conclusion: The presence of a palpable mass emerged as the only independent factor associated with microinvasion in DCIS. © 2025, Pamukkale University. All rights reserved