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Lead Ferrite-Based Heterogeneous Photocatalysis: a Green Approach for Rhodamine 6g Dye Remediation
No full textBaig, Jameel Ahmed/0000-0002-4338-9103Improper dye disposal pollutes the environment and endangers living species, underlining the need for more effective pollution detection systems. Therefore, the current study is focused on developing reliable methods for monitoring and controlling dye release in water using lead ferrite nanoparticles (PbFe12O19-NPs) as the most efficient iron-based material. In the current study, PbFe12O19-NPs were synthesized by a sol-gel method and characterized by advanced analytical techniques. The obtained finding revealed that the PbFe12O19-NPs possess a hexagonal structure with a negative surface charged smooth surface. They have an average particle size of 13.8 nm. The photocatalytic activity of PbFe12O19-NPs for the degradation of rhodamine 6G (RG) dye was evaluated under optimized conditions using UV-visible spectroscopy. The PbFe12O19-NPs-based developed method showed a degradation efficiency greater than 95% with LOD and LOQ of 0.0043 and 0.014 mg L-1, respectively. Moreover, the PbFe12O19-NPs as nano-catalysts showed active reusability and ease of separability due to their magnetic nature. The PbFe12O19-NP-based developed method was applied to real water samples and the RG degradation was found to be greater than 90% with an RSD of less than 3.0%.HEC Islamabad [14503]; Turkiye Burslarimath; Research Fellowship Program by the Prime Ministry of Turkey Presidency 2023; National Centre of Excellence in Analytical Chemistry, University of Sindh, JamshoroThe University of Sindh, Jamshoro's National Centre of Excellence in Analytical Chemistry (NCEAC) has been recognized for providing well-equipped laboratory facilities for research projects. The authors acknowledge and extend their appreciation to the Researchers Supporting NRPU Project No.14503 of HEC Islamabad, partially support by Turkiye Burslar ; imath; Research Fellowship Program sponsored by the Prime Ministry of Turkey Presidency 2023 and National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro
Yeni tanı hodgkin lenfoma hastalarında prognostik nutrisyon indeksinin (PNI) sağkalım ve prognoza etkisi
No full textGiriş: Hodgkin lenfoma (HL), malign Hodgkin/Reed-Sternberg (HRS) hücreleri ile
karakterize bir B hücreli lenfomadır. Etkin tedavi ile %80-90 oranında kür
sağlanmaktadır. Malnutrisyon malignitelerde sık rastlanan bir durumdur hasta
prognozunu etkileyebilmektedir. Bu çalışmada yeni tanı HL hastalarında prognostik
nutrisyonel indeksin (PNI) genel ve progresyonsuz sağkalım üzerine etkisi
değerlendirilmiştir.
Yöntem: Bu çalışma, 2013 yılından itibaren Pamukkale Üniversitesi Tıp Fakültesi
Hastanesi Hematoloji Polikliniği’nde Hogdkin Lenfoma tanısı ile takip edilen 214 hasta
ile yapılmıştır. Hastaların yaş, cinsiyet,ek hastalık varlığı, evre, Hodgkin lenfoma alt tipi,
kemik iliği tutulumu, ekstranodal tutulum varlığı, B semptomu, 3 ten fazla lenf nodu
tutulumu, verilen 1.sıra tedaviler, tanı tarihi, nüks varlığı-tarihi, ara değerlendirme PETBT
ve tedavi sonu PET-BT yanıtları, tanı anındaki laboratuar değerleri (hemoglobin,
lökosit, lenfosit, eozinofil, bazofil, nötrofil, trombosit, CRP, ESR, varsa
B2mikroglobulin, LDH, albümin, fibrinojen ve d-dimer düzeyleri), son vizit tarihi, ölüm
tarihi verileri değerlendirilmiştir. Biyokimyasal parametrelerle literatüre uygun olarak
hesaplanan PNI veri olarak kullanılmıştır. PNI için [(Albümin g/L) + (0.005 x LYM 10*3
/uL)] formülü kullanılmıştır. Primer sonlanım noktaları olarak genel sağkalım süresi (OS)
ve progresyonsuz sağkalım süresi (PFS) kabul edilmiştir.
Bulgular: Çalışmada değerlendirilen 214 HL tanılı hastanın %66,8’i (n=143) erkek,
%33,2’si kadındı. Düşük PNI değerleri hastalarda mortalite ve progresyon riskini
arttırmaktadır. 5 ve 10 yıllık genel sağkalımda yapılan ROC analizinde PNI için kesme
değeri 46,4 ve 48,15 olarak bulundu. Bu kesme değerlerin altında mortalite riski 5,628 ve
5,761 fazladır (p0,001). 5 ve 10 yıllık progresyonsuz sağkalımda yapılan ROC
analizinde PNI kesme değeri 48,35 olarak bulundu. PNI değeri 48,35'in altında olan
hastalarda progresyon gelişme riski sırası ile 2,481 ve 2,462 kat daha fazladır (p0,001).
Sonuç: HL hastalarında malnütrisyon prognozu etkileyen bir faktördür. PNI HL
hastalarında genel sağkalım ve progresyonsuz sağkalım üzerinde etkili bir nutrisyonel
paramatre olarak değerlendirilebilir. HL hastalarında daha fazla benzer çalılşma ile daha
doğru sonuç sağlanabilirIntroduction: Hodgkin lymphoma (HL) is a B-cell lymphoma characterized by malignant
Hodgkin/Reed-Sternberg (HRS) cells. With effective treatment, 80-90% cure rate is
achieved. Malnutrition is a common condition in malignancies and may affect patient
prognosis. In this study, we evaluated the effect of prognostic nutritional index (PNI) on
overall and progression-free survival in newly diagnosed HL patients.
Methods: This study was conducted with 214 patients who were followed up with the
diagnosis of Hogdkin’s Lymphoma in the Hematology Outpatient Clinic of Pamukkale
University Faculty of Medicine Hospital since 2013. Age, gender, presence of comorbidities,
stage, Hodgkin’s lymphoma subtype, bone marrow involvement, presence of extranodal
involvement, B symptom, involvement of more than 3 lymph nodes, 1st line treatments given,
date of diagnosis, recurrence.line treatments, date of diagnosis, presence-date of relapse,
interim evaluation PET-CT and end-of- treatment PET-CT responses, laboratory values at
the time of diagnosis (hemoglobin, leukocyte, lymphocyte, eosinophil, basophil, neutrophil,
platelet, CRP, ESR, B2- microglobulin, LDH, albumin, fibrinogen and d-dimer levels, if
available), date of last visit, date of death data were evaluated. PNI calculated in accordance
with the literature with biochemical parameters was used as data. The formula [(Albumin
g/L) + (0.005 x LYM 10*3 /uL)] was used for PNI. Overall survival time (OS) and
progression-free survival time (PFS) were accepted as primary endpoints.
Results: Of the 214 patients with HL evaluated in the study, 66.8% (n=143) were male and
33.2% were female. Low PNI values increase the risk of mortality and progression in patients.
In the 5- and 10-year overall survival ROC analysis, the cut- off values for PNI were 46.4
and 48.15. Below these cut-off values, the mortality risk is 5.628 and 5.761 higher (p0.001).
In the 5 and 10-year progression-free survival ROC analysis, the cut-off value for PNI was
48.35. The risk of progression was 2.481 and 2.462 times higher in patients with PNI values
below 48.35 (p0.001).
Conclusion: Malnutrition is a factor affecting prognosis in HL patients. PNI may be
considered as an effective nutritional parameter on overall survival and progression- free
survival in HL patients. More similar studies in HL patients provide more accurate results
Evaluation of Ureteral Injury Using the Puls Grading System in Patients Undergoing Semi-Rigid and Flexible Ureteroscopy
No full textSimsek, Alper/0000-0002-0513-4505PurposeUreteroscopy is one of the main diagnostic and treatment approaches for the upper urinary system luminal pathologies today. In recent years complication rates have decreased significantly. Standardizing ureteral damage after ureteroscopic interventions is of great importance for the management of complications. This study aimed to prospectively evaluate ureteral damage and factors affecting it in patients who underwent retrograde intrarenal surgery (RIRS) with ureteral access sheath (UAS), RIRS without UAS, and stone treatment with semi-rigid ureteroscope.MethodsIn this study, we included patients who underwent endoscopic surgery for ureter or kidney stones in our clinic. The ureteral pathologies of 202 patients who underwent RIRS with UAS, RIRS without the use of UAS, and semi-rigid ureteroscopy were prospectively evaluated using the Post-Ureteroscopic Lesion Scale (PULS).Results75.7% of the lesions were PULS grade 1, 15.3% were grade 2. Lesions were most commonly located in the lower ureter during semi-rigid ureteroscopy, in the middle ureter during RIRS without a sheath, and in the upper ureter during RIRS with a sheath (p = 0.003). PULS 1 lesions (55.6%) were more commonly observed in the lower ureter, and PULS 2 lesions (41.9%) were also predominantly located in the lower ureter compared to other parts of the ureter.ConclusionIt should be kept in mind that ureteral damage may occur after the ureteroscopy procedure. The degree and localization of the ureteral lesion may vary depending on the procedure to be chosen. Evaluating ureteral damage using the PULS scoring system is important for patient management
Nutritional Evaluation and Antioxidant Potential of Pekmez From Saffron Processing By-Products
No full textBayram, Yuksel/0000-0001-7507-0220During saffron production, parts of the flower that make up are released as by-products, including the petals and anthers. The aim of this study is to investigate the production of pekmez from these by-products and the nutritional value of this pekmez. The highest content of total phenolics of pekmez in different solvents was found to be 5.03 mg GAE/g. Analysis with Inductively coupled plasma mass spectrometry (ICP-MS) revealed high levels of the minerals potassium, sodium, magnesium and calcium. The highest amount of vitamins B2 was found, followed by B7, B12, and B9. The ascorbic acid was found to be 256 mg/kg. As a result, pekmez from saffron byproducts, which was evaluated as a new product in this first study, proved to be a good source of natural antioxidants, vitamins and minerals. Hence, it can be inferred that utilizing these by-products as raw materials in pekmez production could potentially enhance the sustainability of the agri-food system
Cultural Adaptation and Reliability of the Turkish Version of the Children's Assessment of Participation With Hands Scale in Children With Physical Disabilities
No full textBackground The 'Children's Assessment of Participation with Hands (CAP-H)' scale is a parent report questionnaire that can be used to measure participation in life situations that require hand use for children with disabilities. The aim of this study was to examine the reliability of a Turkish version of the CAP-H scale in order to evaluate the hand participation of children with physical disabilities and compare them with typically developing children.Methods Evaluation was made of a total of 182 physically disabled children (8.53 +/- 3.94 years) and 90 typically developing children (9.40 +/- 3.04 years). The CAP-H scale was used to evaluate children's hand participation, compare with typically developing children and to examine the reliability of the Turkish version. Cronbach's alpha and intraclass correlation coefficients (ICCs) were evaluated for internal consistency and test-retest reliability, respectively.Results Cronbach's alpha value used for all subscores was found to be excellent in all domains for internal consistency (Cronbach's alpha: 0.84-1). According to the test-retest reliability, it was found to be perfectly reliable in all domains (ICC: 0.81-1). There was a significant difference in all items of CAP-H (p=0.00) except for participation in self-care, frequency of recreational activities and frequency of educational domain in favour of typically developing children.Conclusions The results of this study demonstrated that the Turkish translation of CAP-H is a reliable evaluation for children's participation in life requiring hand use. In addition, hand participation of children with physical disabilities is lower compared with typically developing children
The Relationships Between Loneliness, Emotional Intelligence, and Depression Among Turkish Emerging Adults: a Moderated Moderation Model in the Gender Context
No full textLoneliness is a common public health problem that can influence individuals' depression outcomes. The incidence of loneliness among emerging adults is high. From this perspective, this study would serve two primary aims in Turkish emerging adults. The first was to examine the moderating effect of emotional intelligence on the relationship between loneliness and depression. The second was to test whether gender moderated this moderating effect. The study sample consisted of 456 (213 females and 243 males) university-attending emerging adults, 18-25 years old. Firstly, the findings demonstrated that loneliness was positively associated with depression. Secondly, the results showed that emotional intelligence moderated the relationship between loneliness and depression, indicating that high emotional intelligence functioned as a buffer for the contribution of loneliness to depression. In contrast, higher levels of loneliness were significantly associated with a greater risk of depression among emerging adults with low or moderate emotional intelligence. Lastly, gender did not moderate the moderating effect of emotional intelligence on the relationship between loneliness and depression. This study concluded with limitations, recommendations for future research, and practical and theoretical implications for practitioners
Yaratıcı Yazma ile Bütünleştirilmiş Dijital Öyküleme Çalışmalarının Yaratıcı Yazma, Dijital Öykü Yazma ve Dijital Okuryazarlık Becerilerine Etkisi
No full textStories are literary texts that human beings have used from the past to the present in order to ensure effective and permanent learning in education. With the rapid development of technology in the last century, stories have gained a new place for themselves and have become digital stories. It is important to investigate the qualities of digital stories, which are expected to help students learn effectively and permanently, and their roles in the process. The aim of the study is to determine the effect of digital storytelling activities integrated with creative writing on creative writing, digital story writing and digital literacy skills. Within the scope of the research, convergent parallel design has been utilized in the mixed method. In the quantitative dimension of the study, a quasi-experimental design with pretest-posttest control group was used, while in the qualitative dimension, students were interviewed. In order to collect the quantitative data of the study, the Digital Literacy Scale for Primary School Students (DLS) prepared by Şahin, Özkan, and Turan (2022); the Scale for the Evaluation of Creative Writing Products (CEWP) prepared by Kasap and Kırmızı (2019) and the Digital Storytelling Rubric (DIÖR) within the scope of the thesis has been used. In order to collect qualitative data, semi-conducted interviews consisting of open-scope questions within the scope of the thesis has been used. The study has been conducted with 66 students (36 in the experimental group and 30 in the control group) attending the fourth grade in a primary school affiliated to the Ministry of National Education in Denizli province. Experimental studies have been carried out for 10 weeks in the second semester of the 2022-2023 academic year. Writing activities have been carried out with the students in the control group in accordance with the 2019 Turkish Curriculum. With the students in the experimental group, digital storytelling activities integrated with creative writing have been carried out in the Turkish lesson. In line with the findings obtained from the creative writing activities carried out by the experimental and control groups before and at the end of the process, it has been seen that the perceptions of the 4th grade primary school students participating in the study group regarding their creative writing skills at the end of the process increased. When the development of digital literacy skills of the experimental group and the control group were evaluated, it has been revealed that there was a permanent positive and significant difference in the digital literacy levels of those in the experimental group who received digital storytelling training integrated with creative writing. It was determined that the qualitative findings of the study have been compatible with the quantitative findings and confirmed the quantitative results. Primary school 4th grade students who participated in the study stated that they enjoyed the digital storytelling activities integrated with creative writing and that the activities had positive effects on their lessons. In addition, the students stated that the training increased their ability to use technology and improved their imagination. Some students stated that they had difficulties in using programs and creating animations in the process of creating digital stories.Öyküler, geçmişten günümüze kadar eğitimde etkili ve kalıcı öğrenmeyi sağlamak için kullanılmıştır. Teknolojinin son yüzyılda hızlı bir şekilde gelişmesi ile öyküler de kendine yeni bir yer edinerek dijital öyküler haline gelmiştir. Öğrencilerin etkili ve kalıcı öğrenmelerine yardımcı olması beklenilen dijital öykülerin, niteliklerinin ve süreç içerisindeki rollerinin araştırılması önem taşımaktadır. Araştırmanın amacı yaratıcı yazma ile bütünleştirilmiş dijital öyküleme çalışmalarının yaratıcı yazma, dijital öykü yazma ve dijital okuryazarlık becerilerine etkisini belirlemektir. Araştırmada karma yöntemde yakınsayan paralel deseninden yararlanılmıştır. Araştırmanın nicel boyutunda ön test son test kontrol gruplu yarı deneysel desen kullanılırken, nitel boyutunda ise öğrenciler ile görüşmeler yapılmıştır. Çalışmanın nicel verilerini toplamak için Şahin, Özkan ve Turan (2022) tarafından hazırlanan İlkokul Öğrencilerine Yönelik Dijital Okuryazarlık Ölçeği (DOÖ); Kasap ve Kırmızı (2019) tarafından hazırlanan Yaratıcı Yazma Ürünlerini Değerlendirme Ölçeği (YARYÜDÖ) ve tez kapsamında geliştirilen Dijital Öyküleme Rubriği (DİÖR) kullanılmıştır. Nitel verileri toplamak için de tez kapsamında geliştirilen açık uçlu sorulardan oluşan yarı yapılandırılmış görüşme formundan yararlanılmıştır. Çalışma, Denizli ilinde Milli Eğitim Bakanlığına bağlı bir ilkokulda, dördüncü sınıfa devam eden 36'sı deney, 30'u kontrol grubu olan 66 öğrenciyle yürütülmüştür. Deneysel çalışmalar 2022-2023 öğretim yılının ikinci yarıyılında 10 hafta boyunca sürdürülmüştür. Kontrol grubundaki öğrencilerle 2019 Türkçe Dersi Öğretim Programına uygun bir şekilde yazma çalışmaları yapılmıştır. Deney grubundaki öğrencilerle de Türkçe dersinde yaratıcı yazma ile bütünleştirilmiş dijital öyküleme çalışmaları gerçekleştirilmiştir. Deney ve kontrol grupları tarafından süreç öncesi ve sonunda yapılan yaratıcı yazma çalışmalarından elde edilen bulgular doğrultusunda, çalışma grubuna katılan ilkokul 4. sınıf öğrencilerinin süreç sonundaki yaratıcı yazma becerilerine ilişkin algılarının arttığı görülmüştür. Deney ve kontrol grubunun dijital okuryazarlığa yönelik becerilerinin gelişimleri değerlendirildiğinde, yaratıcı yazma ile bütünleştirilmiş dijital öyküleme çalışması eğitimi alan deney grubu öğrencilerinin dijital okuryazarlık düzeylerinde istatistiksel olarak olumlu yönde, anlamlı bir farklılık olduğu görülmüştür. Araştırmanın nitel bulgularının, nicel bulgularla uyumlu olduğu ve nicel sonuçları doğruladığı belirlenmiştir. Araştırmaya katılan ilkokul 4. sınıf öğrencileri yapılan yaratıcı yazma ile bütünleştirilmiş dijital öyküleme çalışmalarından keyif aldıklarını ve çalışmaların derslerine olumlu etkilerinin olduğunu belirtmiştir. Ayrıca öğrenciler yapılan eğitimin teknoloji kullanma becerilerini arttırdığını ve hayal güçlerini geliştirdiğini ifade etmiştir. Bazı öğrenciler ise dijital öykü oluşturma sürecinde program kullanma ve animasyon oluşturmaya yönelik zorluklar yaşadıklarını belirtmiştir
Ccpe: a Tool To Quickly Extract, Format, and Present the Outputs From Gaussian and Veda Computational Chemistry Programs
No full textThe analysis and interpretation of theoretical results remain significant challenges for researchers in computational chemistry, particularly when working with molecules containing a large number of atoms. The manual selection, organization, and interpretation of desired parameters from output files generated by computational tools can be error-prone, tedious, and time-intensive, often taking days to complete. This study introduces the Computational Chemistry Parameter (CCPE), providing extraction, formatting, and presentation of the computational data obtained from Gaussian and VEDA programs. By integrating outputs from the widely used GAUSSIAN and VEDA programs, CCPE provides an efficient, user-friendly solution for extracting and organizing key data such as vibrational modes, frequency assignments, optimization parameters, and molecular orbital data. This tool significantly reduces the time required for these tasks from several days to a matter of minutes, while minimizing the likelihood of errors. The CCPE software, developed using the C# programming language, emphasizes reliability and adaptability, offering researchers a practical means of handling complex computational data. Through its ability to generate publication-ready outputs in widely accepted formats, CCPE aims to enhance productivity and data accuracy, presenting a transformative step in the field of computational chemistry
Therapeutic Potential of Nitrogen-Substituted Oleanolic Acid Derivatives in Neuroinflammatory and Cytokine Pathways: Insights From Cell-Based and Computational Models
No full textSen, Alaattin/0000-0002-8444-376XThis study was conducted to investigate the mechanism of the potential and anti-inflammatory properties of nitrogen-substituted oleanolic acid derivatives that can be used to treat neuroinflammatory diseases. Nitrogen-containing oleanolic acid derivatives have been evaluated for their anti-neuroinflammatory effects in vitro in neuronal and monocytic cell lines at nontoxic doses, and the production of cytokines (TNF-alpha, IL-6 and IL-17), the inflammatory enzyme induced nitric oxide synthase (iNOS) and NF-kappa B signalling under LPS-stimulated conditions, and the expression of genes associated with Alzheimer's disease have been assessed. In addition, molecular docking and molecular dynamics simulation assessments are conducted in silico. Key protein markers of neurodegenerative diseases, especially Alzheimer's disease and neuroinflammation, TAU protein levels, and microglial activation, as well as ionised calcium-binding adaptor protein-1 (IBA1) levels, were significantly reduced with the addition of oleanolic acid derivatives. LPS-induced NF-kappa B luciferase reporter activity and iNOS activity were significantly inhibited, approaching the levels in uninduced controls. The mRNA expression of proinflammatory cytokines critical for neuroinflammation, such as TNF-alpha, NF-kappa B, IL-6 and IL-17, was reduced twofold to sevenfold. Furthermore, the molecular docking and MD simulation analyses revealed potential interactions with the TNF-alpha and NF-kappa B proteins. These findings underscore the potential of oleanolic acid derivatives, particularly compound 16, as candidates for further development as therapeutic agents for neurodegenerative diseases associated with chronic inflammation.This work was supported by Pamukkale University Scientific Research Projects Coordination [2023 ; Idot;AP002] and The Scientific and Technological Research Council of Tuerkiye [119Z389].Pamukkale University Scientific Research Projects Coordination [2023Idot;AP002]; Scientific and Technological Research Council of Trkiye [119Z389
Perceptions of Pediatric Nurses by Mothers of Children With Hospitalization Experience: a Qualitative Study
No full textIntroduction: A child's illness or hospitalization is a complex process experienced by the child, parents, and family members. Methods: The purpose of this study is to determine the perceptions of pediatric nurses by mothers of hospitalized children. It was conducted with 13 mothers of children with hospitalization experience. Semi-structured interviews and thematic analysis were performed. This study followed the COREQ checklist. Results: Four themes and seventeen subthemes emerged from the data. The themes consisted of the pediatric nurse through the eyes of mothers, mothers' positive experiences with pediatric nurses, mothers' negative experiences with pediatric nurses, and expectations from pediatric nurses. Discussion: Mothers' perceptions of pediatric nurses in the context of hospitalization experiences were influenced by their positive and negative communication experiences with the nurses. As a result of these experiences, expectations regarding the care they desired to receive from the nurses emerged. Implications for practice: The findings of this study provide insight into mothers' perceptions of nurses and nursing care. Mothers have fundamental expectations regarding enhancing nurses' communication and clinical care skills to ensure adequate support for their children and themselves throughout hospitalization. © 2025 Elsevier Inc.Erciyes Üniversites