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The Association of Non-Coding Rnas With Breast Cancer Molecular Subtypes
No full textBreast cancer is a heterogeneous cancer that occurs as a result of marked molecular changes in breast tissue. According to data from the World Health Organisation in 2020, 2.3 million women were diagnosed with breast cancer, representing a quarter of the proportion of breast cancer among all cancer types compared to other cancer types. This resulted in the death of 685,000 women. Although there have been many new developments in breast cancer treatment and targeted therapy in recent years, this type of cancer has a high morbidity and mortality. Therefore, new research is still needed for biomarker detection. With the tremendous increase in knowledge about cancer biology and advances in molecular technology for about a decade, the literature on biomarkers in cancer is increasing. Non-coding RNAs in breast tissue, circular RNAs (circRNAs), microRNA (miRNA) are one of the most important research foci, especially in the field of cancer. Recent studies have shown that circRNAs play very important roles in the cell and have become one of the most important research foci, especially in the field of cancer. Many circRNAs, miRNAs and genes that may be associated with breast cancer have been identified. Three circRNAs (hsa_circ_0000375, hsa_circ_0016201, hsa_circ_0000515), three miRNAs (miR-486-5p, miR-141-5p and miR-183-5p) and 18 genes (CIDEC, ADH1B, TMEM132C, LIPE, ABCA8, ACVR1C, BTNL9, TNXOCB3, PRAME, MELK, GPAM, NEK2, EXO1, BUB1, DLGAP5, TPX2, SDC1) may be important in breast cancer, especially in the basal-like group. In our study, firstly, RNA isolation was performed from tumour tissue and nearby healthy tissues obtained during the operation from 50 breast cancer patients aged 18-65 years. Three circRNAs (hsa_circ_0016201, hsa_circ_0000375, hsa_circ_0000375, hsa_circ_0000515) and 3 mRNAs (ADH1B, BTNL9, SDC1) were then analysed by qPCR to determine their expression levels in breast cancer molecular subtypes. Afterwards, the expression levels of circRNAs and mRNAs were evaluated and their possible biomarker status was discussed.Meme kanseri, meme dokusunda belirgin moleküler değişikliklerin bir sonucu olarak ortaya çıkan heterojen bir kanserdir. Dünya sağlık örgütü 2020 yılı verilerine göre 2,3 milyon kadına meme kanseri teşhisi konulmuş ve diğer kanser türleri ile karşılaştırıldığında tüm kanser türleri arasında meme kanserinin oranının dörtte birini temsil etmektedir. Bu da 685.000 kadının ölümüyle sonuçlanmıştır. Son yıllarda meme kanseri tedavisi ve hedefe yönelik tedavide birçok yeni gelişme olmasına rağmen, bu kanser türü yüksek morbidite ve mortaliteye sahiptir. Bu nedenle, biyobelirteç tespiti için hala yeni araştırmalara ihtiyaç vardır. Yaklaşık on yıldır kanser biyolojisi hakkındaki bilgilerde muazzam artış ve moleküler teknolojideki gelişmelerle birlikte kanserdeki biyobelirteçlerle ilgili literatür bilgileri artmaktadır. Meme dokusundaki kodlanmayan RNA'ların, dairesel RNA'lar (circRNA'lar), mikroRNA (miRNA) özellikle kanser alanında en önemli araştırma odaklarından biridir. Son yıllardaki çalışmalar circRNA'ların hücrede çok önemli roller oynadığı gösterilmiştir ve özellikle kanser alanında en önemli araştırma odaklarından biri olmuştur. Meme kanseri ile ilişkili olabilecek birçok circRNA, miRNA ve gen tanımlanmıştır. Üç circRNA (hsa_circ_0000375, hsa_circ_0016201, hsa_circ_0000515), üç miRNA (miR-486-5p, miR-141-5p ve miR-183-5p) ve 18 genin (CIDEC, ADH1B, TMEM132C, LIPE, ABCA8, ACVR1C, BTNL9, TNXOCB3, PRAME, MELK, GPAM, NEK2, EXO1, BUB1, DLGAP5, TPX2, SDC1) meme kanserin'de, özellikle bazal benzeri grupta önemli olabileceği bulunmuştur. Çalışmamızda öncelikle 18-65 yaş arası 50 meme kanseri tanısı alan hastadan operasyon sırasında alınan tümör dokusu ve yakın sağlıklı dokulardan RNA izolasyonu gerçekleştirildi. Ardından üç circRNA (hsa_circ_0016201, hsa_circ_0000375, hsa_circ_0000515) ve 3 mRNA (ADH1B, BTNL9, SDC1) meme kanseri moleküler alt tiplerindeki ekspresyon seviyelerine bakılmak için qPCR ile incelendi. Daha sonra ise circRNA ve mRNA'lardaki ekspresyon seviyeleri değerlendirilerek olası biyobelirteç olabilme durumları tartışıldı
Kemalist rejimin iç düşman tahayyülünün sosyo-tarihsel analizi
No full textBu çalışma, tarihsel sosyolojinin yörüngesinde Erken dönem
Cumhuriyet Türkiyesi’ni (1922- 1938) irdelemektedir. Doküman analizi
çerçevesinde yorumsamacı sosyolojik bir perspektife yaslanan çalışma,
Carl Schmitt’in teorik kavramsallaştırmaları ışığında Kemalist rejimin
iç evrenine içkin çözümlemelere odaklanmaktadır. Bilhassa rejimin
devrimci politik tahayyülünü yadsıyan iç düşman kategorilerini odağına
alan çalışma, Cumhuriyet’in kuruluş momentine ilişkin alternatif
analizlere yönelmektedir.This study examines the early republican Turkey (1922-1938) in the orbit
of historical sociology. The study, which is based on an hermeneutic
sociological perspective within the framework of document analysis,
focuses on analyzes immanent to the Kemalist regime in the light of Carl
Schmitt’s theoretical conceptualizations. Especially focusing on the
internal hostile categories that that deny the revolutionary political
imagination of the regime the study focuses on alternative analyzes
regarding the founding moment the Republic
Electron paramagnetic resonance study of the paramagnetic centers in gamma-irradiated 2-nitrobenzoic acid single crystal
No full text2-nitrobenzoic acid (C7H5NO4) (2NBA) single crystals were made paramagnetic using 60Co-gamma rays. An attempt was made to detect the resonance form formed in 2-nitrobenzoic acid single crystal with Electron Paramagnetic Resonance (EPR) Spectroscopy. EPR spectra were taken at 125 K in three different axes of the crystal. As a result of EPR analysis of gamma irradiated 2NBA single crystal, it was understood that 2NBA anion radical was formed. The principal values of the hyperfine structure constants, the principal values of the g-tensor and their direction cosines were calculated
Nutrition Literacy Status Of University Students, İnfluencing Factors, And İts Relationship With Healthy Nutrition Attitudes
No full textPurpose: This study aims to evaluate the nutrition literacy status of university students, the factors influencing it, and its relationship with healthy nutrition attitudes. Materials and methods: This is a descriptive and cross-sectional study. A total of 317 students aged 18-24 studying at Pamukkale University were included in the study. A questionnaire was administered to the students, which included questions about sociodemographic characteristics, the Adolescent Nutrition Literacy Scale (ANLS), and the Attitude Scale for Healthy Nutrition (ASHN) assessing nutrition attitudes. Results: Of the 317 students who participated in the study, 48.9% (n=155) were female, and 17.4% (n=55) were studying in health-related departments. The mean nutrition literacy score of the students was 70.85±9.69. Nutrition literacy scores were found to be significantly higher in those studying in health-related departments compared to other departments, in those who received nutritional education compared to those who did not, and in those who exercised regularly compared to those who did not (p=0.001; p=0.000; p=0.000). Among the students, 56.8% had a high level, 10.1% had an ideal level, and 32.8% had a moderate level of healthy nutrition attitudes. A significant relationship was found between nutrition literacy and healthy nutrition attitudes (r=0.404; p=0.000). Conclusion: The study found that the mean nutrition literacy score of the students was 70.85±9.69, and 56.8% of them had a high level of healthy nutrition attitudes. It was determined that nutrition literacy was higher among students who exercised regularly, received nutritional education/knowledge, and studied in health-related departments. Additionally, an increase in students' nutrition literacy positively influenced their healthy nutrition attitudes. © 2025, Pamukkale University. All rights reserved
Evidence for an Aseismic Gap Between the Mw6.8 Puturge (Elazığ) and 7.8 Pazarcik (Kahramanmaraş) Earthquakes in the East Anatolian Fault System, Southeast Turkiye
No full textAkgun, Elif/0000-0002-6556-2413; Topal, Savas/0000-0001-7451-6606; Softa, Mustafa/0000-0001-5064-9260This study examines the unruptured portion of the Puturge segment, the least-studied section of the East Anatolian Fault System (EAFS) in southeast Turkiye, focusing on the S,iro Valley to comprehensively understand the observed distribution in deformation. Despite the February 6, 2023 doublet earthquakes, the Puturge segment near the S,iro Valley remained relatively stable, though significant stress accumulation was detected at both ends. Fieldwork and subsequent morphometric and structural analyses confirmed notable tectonic activity in the area. Geomorphic indices were applied to assess tectonic activity, yielding an average index of relative tectonic activity (Iat) for all drainage basins, highlighting varying tectonic intensity levels across the S,iro Valley. Mountain front sinuosity (Smf) analysis indicated different uplift rates and tectonic forces along distinct fault segments. Additionally, Hypsometric Integral-Hypsometric Curve (HI-HC) index analysis pointed to rapid uplift processes, particularly in the eastern part of the fault-controlled basin, signaling active tectonic uplift and geomorphic rejuvenation. Normalized steepness index (ksn) and Chi (chi) values highlighted variations in erosion rate, providing insight into regional uplift patterns and knickpoint distributions. These findings align with the dominant transtensional tectonic regime in the area, as inferred from slip data inversions along the S,iro Valley. The region's fault geometry, oblique movement, and block rotations firmly support this interpretation. Comparisons of slip rates and ground deformation models revealed notable variations in fault behavior, suggesting ongoing energy accumulation, possibly linked to aseismic creep. The complex fault system behavior was underscored by the 2020 Sivrice earthquake and the 2023 doublet, which highlights the critical role of the Puturge segment in the dynamic evolution of the EAFS.This study was supported by the Scientific and Technological Research Council of Turkiye (TUBITAK) under Grant Number 122Y266. The authors thank TUBITAK for their support.Scientific and Technological Research Council of Turkiye (TUBITAK) [122Y266]; TUBITA
The İnfluence Of Anesthesia Type On Recurrence Of The Non-muscle İnvasive Bladder Tumor According To Risk Groups: 3 Year Follow Up;
No full textPurpose: Many risk factors affecting bladder cancer recurrence, such as genetic and environmental factors, have been previously identified. It has been stated that risk factors that cause immunosuppression play a role in the spread of cancer cells. Anesthetic agent, which is a perioperative factor, may affect the risk of cancer recurrence by disrupting the immune system. The aim of this study was to compare the effect of regional anesthesia (RA) and general anesthesia (GA) on non-muscle invasive bladder cancers (NMIBC) recurrence. Materials and methods: A total of one hundred seventy-eight patients who underwent transurethral bladder tumor resection (TURBT) for NMIBC and underwent surgery under GA or RA between 2011 and 2016 in the urology departments of Pamukkale University and Uludag University were included in the study. In the first group, 80 patients had RA. In the second group, 98 patients underwent GA during TURBT for NMIBC. Results: The recurrence time was shorter in the GA group (5.5 months) than in the RA group (11 months) (p=0.015). First-year relapse was higher in the GA group than in the RA group (p=0.048), but there was no difference in third-year relapse between groups (p=0.810). The mean recurrence time was 11 months (95% CI; 9.058-12.942) in the RA group and 5 months (95% CI; 2.090-7.910) in the GA group (p=0.031). Conclusion: During transurethral resection of the bladder tumor, an increase in the recurrence time was observed in patients with intermediate-risk NMIBC who received RA compared to patients who received GA. RA provided a 7-month benefit in relapse delay. © 2025, Pamukkale University. All rights reserved
Obez bireylerde fonksiyonel kapasite, kas iskelet sistemi sorunları ve fiziksel aktiviteye katılımda algılanan engeller fiziksel aktivite düzeyini etkiler mi?
No full textBu çalışma obez bireylerde fonksiyonel kapasite, kas iskelet sistemi rahatsızlıkları, fiziksel aktiviteye katılımda algılanan engellerin fiziksel aktiviteye katılım düzeyi üzerine etkisi olup olmadığını incelemek amacıyla yapıldı.
Çalışmaya 18-65 yaş aralığında vücut kitle indeksi 30 ve üzeri olan 85 obez kadın katıldı. Katılımcıların sosyodemografik ve klinik özellikleri kaydedildi. Katılımcıların fonksiyonel kapasitesi; 30 sn Sandalyede Otur Kalk Testi, Süreli Kalk Yürü Testi, Duke Aktivite Skala İndeksi (DASİ), kas iskelet sistemi rahatsızlıkları; Genişletilmiş Nordic Kas İskelet Sistemi Anketi (NKİSA) , fiziksel aktiviteye katılımda algılanan engeller; Fiziksel Aktiviteye Katılımda Algılanan Engeller Ölçeği (FAKEÖ), fiziksel aktiviteye katılım düzeyleri; Uluslararası Fiziksel Aktivite Anketi- Kısa Form (UFAA-KF) kullanılarak değerlendirildi.
UFAA-KF’a göre çalışmaya katılan katılımcılardan 47’si (%55,3) düşük fiziksel aktivite katılım düzeyine, 37’si (%43,5) orta fiziksel aktivite katılım düzeyine, 1’i (%1,2) yüksek fiziksel aktivite katılım düzeyine sahipti. Düşük ve orta seviye fiziksel aktivite katılım düzeyine sahip katılımcıların fonksiyonel kapasitesi, kas iskelet sistemi sorunları ve fiziksel aktiviteye katılımda algılanan engelleri karşılaştırıldığında, grupların DASİ MET değeri, FAKEÖ yorgunluk alt boyutu ve NKİSA bölgelerinden diz problemi açısından aralarında fark vardı (p0,05). UFAA-KF toplam puanı üzerinde etkisi olan değişkenlerin belirlenmesinde çok değişkenli doğrusal regresyon modeli kullanıldı. Analiz sonucunda FAKEÖ yorgunluk alt boyutu (p=0,001) ve NKİSA bölgelerinden diz probleminin (p=0,02) UFAA-KF toplam puanını etkilediği belirlendi.
Çalışmadan elde edilen bulgular fonksiyonel kapasite, fiziksel aktivite sırasında yorgunluk hissi hissedilmesi ve diz problemi varlığının obez kadınlarda fiziksel aktiviteye katılımı etkilediğini gösterdi. Çalışmadan elde edilen bilgiler ışığında obez bireylerin egzersiz tedavisinde var olan diz ve kalça ağrısı dikkate alınarak egzersiz programı oluşturulması, alt eksteremitenin kassal uygunluğu yetersiz ise geliştirilmesi, yorgunluğun dikkate alınarak egzersiz programının dinlenme aralarını içerecek şekilde planlanması önerilmektedir
Tribologically Enhanced Self-Healing Hybrid Laminates for Wind Turbine Applications
No full textWind turbines are subjected to extreme weather and load conditions; hence, high strength and impact resistance are required. Furthermore, wind turbine blades can be subjected to impact loads such as bird strikes, resulting in the formation of microcracks. Self-healing capsules can be used to mend turbine blades for microscale damage. The incorporation of self-healing capsules may cause a decrease in the mechanical characteristics of the composites prior to impact resistance, which can be compensated for with efficient fillers such as silicon carbide whiskers (SiCw). Thus, a novel hybrid composite structure is examined with the advantage of using a self-healing mechanism and SiCw reinforcement. Tensile, tribological, and Charpy impact tests were performed to characterize the mechanical and tribological properties, which were supported with microscopic observations. Multiple experimental characterizations were performed to investigate the impact, and the ultimate tensile strength (UTS) and energy absorption capacity of the structure were shown to increase by 32% and 45%, respectively, with the addition of SiCw. The presence of self-healing agents provides a 5% rise in UTS after enough time for healing following the collision. The structure's tribological performance is improved by 10% in wear resistance and 20% in friction coefficient. Highlights: Hybrid laminated composite structure with silicon carbide whisker and self-healing capsules. Tensile and Charpy impact tests conducted with microscopic observations Increased ultimate tensile strength and energy absorption capacity by 32% and 45%. Tribological improvement by 10% in wear resistance and 20% in friction coefficient. © 2024 The Author(s). Polymer Composites published by Wiley Periodicals LLC on behalf of Society of Plastics Engineers.Istanbul Technical University Office of Scientific Research Projects; ITUBAPSIS, (MGA‐2022‐43400
Electrocatalytic Detection of Acetaminophen by Sodium Ferrite
No full textAcetaminophen (APN) is a safer alternative to opioids and is recognized for its analgesic and antipyretic properties. Prolonged usage and overdose of APN cause severe health problems for humans. Hence, its monitoring in the human body, pharmaceutical preparations and consumption sources is important. Thus, the current study was designed to synthesize the sodium ferrite nanoparticles (Na2Fe4O7-NPs) based on the Tamarindus indica fruit extract for selective trace electrochemical detection of APN. The Na2Fe4O7-NPs were characterized by advanced analytical techniques such as x-ray diffraction (XRD), fourier transform infrared (FTIR), UV–visible, atomic force microscopy (AFM), zeta potential, zeta sizer, energy dispersive x-ray (EDX) and field emission scanning electron microscopy (FESEM) which displayed that the Na2Fe4O7-NPs possess hexagonal structure, a narrow band gap (1.475 eV), corresponding to their excellent electronic capability, nanosize of particles, rough surface and highly stable nature for electrochemical analysis. Na2Fe4O7-NPs were deposited on a glassy carbon electrode (GCE) to manufacture an electrochemical sensor (Na2Fe4O7-NPs/GCE) and characterized its surface behaviour by cyclic voltammetry. Na2Fe4O7-NPs/GCE voltammetric sensor showed its selective sensing of APN in a wide dynamic range (1.0 × 10-8 to 4.5 × 10-4 M) with a detection limit of 2.72 10-9 M. Further, the developed method showed excellent stability in addition to reproducibility for the sensing of APN (% RSD 5.0). The developed electrochemical sensor was found to be efficient for selective and sensitive detection of APN in real samples with quantitative recoveries (> 90 %). © 2024 The Author(s)King Saud University, KS
The Effects of Neurodynamic Mobilization Exercises on Upper Extremity Pain, Muscle Strength, and Functions in Patients With Multiple Sclerosis: a Randomised Controlled, Single Blinded Study
No full textAdiguzel, Hatice/0000-0001-9323-839X; Erel, Suat/0000-0001-7076-7651; Inanc, Yilmaz/0000-0002-0423-0941Backround: Manual therapy techniques are available for pain management in Multiple Sclerosis (MS); however, the results of neurodynamic mobilization (NM) are not known. The aim of this study was to investigate the effects of NM exercises on pain, muscle strength and upper extremity functions in MS patients. Methods: Patients aged between 18 and 65 years diagnosed with Relapsing Remitting (RR) MS (n = 31) according to McDonald 2010 diagnostic criteria were included in the study. Patients were divided into the NM group (bilateral upper extremity NM and strengthening exercises) (n = 15) and the control group (bilateral strengthening exercises) (n = 16) by simple randomization. Visual Analog Scale (VAS) (most severe and average score) was used to assess pain intensity, and Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) questionnaire was used to assess pain character. Muscle strength was evaluated with the digital muscle strength measurement device (Kforce Kinvent), manual skills were evaluated with the Nine Hole Peg Test (NHPT) and Manual Ability Measure-36 (MAM-36). Measurements were obtained from the most affected side, unilateral. Results: The mean of the most severe score of VAS (p 0.001), the average score of VAS (p 0.001), and the LANSS in both groups (p 0.05) decreased significantly. Shoulder flexor muscle strength was increased significantly in both groups (p 0.05). Shoulder extensors, elbow flexors, and elbow extensors was increased significantly in NM group (p 0.05). MAM-36 scores was increased significanty in both groups (p 0.05). NHPT scores showed significant decrease in the NM group (p 0.05). There was no significant difference between the groups in terms of VAS, LANSS, muscle strength, MAM-36 and NHPT (p > 0.05). Conclusion: It was found that NM exercises added to upper extremity strengthening therapy in patients with MS reduced pain, increased muscle strength of shoulder extensors, elbow flexors, and elbow extensors, and improved manual dexterity. However, although positive effects were observed when NM exercises were added to the strengthening exercises, the results were found to be similar in these groups