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Aspetti regolatori dello sviluppo clinico di un nuovo prodotto medicinale
Full text linkIl seminario è stato promosso da Fase 1 e Sardegna Ricerche, fa parte di una serie di incontri volti a dare un quadro generale sulle principali tematiche inerenti lo sviluppo preclinico e clinico di nuovi farmaci. In particolare, questa seconda sessione ha visto la partecipazione di esperti dell'ISS per gli aspetti normativi dello sviluppo preclinico e una lezione di approfondimento sui requisiti necessari all’avvio della sperimentazione clinica nel campo della nutraceutica e degli alimenti a fini medici speciali.Lezione tenuta nell'ambito del seminario 'Aspetti regolatori nello sviluppo preclinico', si è incentrata sugli aspetti normativi dello sviluppo preclinico.2011-12-16Sardegna Ricerche, Edificio 2, Località Piscinamanna 09010 Pula (CA) - ItaliaAspetti regolatori nello sviluppo preclinico: dal candidato farmaco alla first in ma
A GPU framework for parallel segmentation of volumetric images using discrete deformable models
Full text linkDespite the ability of current GPU processors to treat heavy parallel computation tasks, its use for solving medical image segmentation problems is still not fully exploited and remains challenging. A lot of difficulties may arise related to, for example, the different image modalities, noise and artifacts of source images, or the shape and appearance variability of the structures to segment. Motivated by practical problems of image segmentation in the medical field, we present in this paper a GPU framework based on explicit discrete deformable models, implemented over the NVidia CUDA architecture, aimed for the segmentation of volumetric images. The framework supports the segmentation in parallel of different volumetric structures as well as interaction during the segmentation process and real-time visualization of the intermediate results. Promising results in terms of accuracy and speed on a real segmentation experiment have demonstrated the usability of the system.85-95Pubblicat
FOX: The Focus Sliding Surface Metaphor for Natural Exploration of Massive Models on Large-scale Light Field Displays
Full text linkWe report on a virtual environment for natural immersive exploration of extremely detailed surface models on light field displays. Our specialized 3D user interface allows casual users to inspect 3D objects at various scales, integrating panning, rotating, and zooming controls into a single low-degree-of-freedom operation, while taking into account the requirements for comfortable viewing on a light field display hardware. Specialized multiresolution structures, embedding a fine-grained per-patch spatial index within a coarse-grained patch-based mesh structure, are exploited for fast batched I/O, GPU accelerated rendering, and user-interaction-system-related geometric queries. The capabilities of the system are demonstrated by the interactive inspection of a giga-triangle dataset on a large scale 35MPixel light field display controlled by wired or vision-based devices.83-9
Diagnosi e tecnologie innovative per il restauro di beni culturali, architettonici e di strutture industriali
Full text linkAttraverso un bando pubblico (aperto sino alla conclusione del progetto), le imprese manifestano il loro interesse a partecipare alle attività previste dal progetto. Sono quindi individuate le problematiche comuni da esse ritenute prioritarie, quali ad esempio l'identificazione dei danni più frequenti sui manufatti - siano essi beni storico-culturali che architettonici o industriali - e delle strategie conservative più idonee, anche ai fini della sicurezza collettiva. Una volta individuate le problematiche di comune interesse, sono chiamati ad intervenire quegli organismi (siano essi imprese, enti di ricerca o università) in grado di fornire le tecnologie e le competenze più adeguate per lo studio delle soluzioni perseguibili, la successiva sperimentazione e validazione tecnologica. I risultati del progetto sono testati, per un periodo di 12 mesi, dalle imprese partecipanti al cluster, successivamente sono divulgati da Sardegna Ricerche a tutte le imprese del settore. Si intende favorire così la formazione della massa critica di risorse e conoscenze che consenta alle imprese operanti nel settore di riferimento di acquisire know-how specifico sugli strumenti e sulle tecniche pratiche di diagnosi di beni culturali, architettonici e di strutture industriali; mettere a punto una tecnologia innovativa finalizzata al restauro e al recupero di beni culturali, architettonici e di strutture industriali; sperimentare nuove idee applicative e analizzare le potenzialità del modello di business esistente. Inoltre il progetto consente loro di analizzare il rapporto costi-benefici delle soluzioni tecnologiche individuate.Finanziamenti::Fondo Consortile - Sardegna Ricerch
Collaborative Semantic Content Management: an Ongoing Case Study for Imaging Applications
Full text linkThis paper presents a collaborative solution for knowledge
management, implemented as a semantic content management system
(CMS) with the purpose of knowledge sharing between users with different
backgrounds. The CMS is enriched with semantic annotations, enabling
content to be categorized, retrieved and published on the Web thanks to the
Linked Open Data (LOD) principle which enables the linking of data inside
existing resources using a standardized URI mechanism. Annotations are
done collaboratively as a social process. Users with different backgrounds
express their knowledge using structured natural language. The user
knowledge is captured thanks to an ontologic approach and it can be further
transformed into RDF(S) classes and properties. Ontologies are at the heart
of our CMS and they naturally co-evolve with their communities of use to
provide a new way of knowledge sharing inside the network. The ontology is
modeled following the so-called DOGMA (Developing Ontology-Grounded
Methods and Applications) paradigm, grounded in natural language. The
approach will be demonstrated on a use case concerning the semantic
annotation of anatomical data (e.g. medical images).257-26
Influence of Moraxella sp. colonization on the kidney proteome of farmed gilthead sea breams (Sparus aurata, L.)
Full text linkBackground: Currently, presence of Moraxella sp. in internal organs of fish is not considered detrimental for fish
farming. However, bacterial colonization of internal organs can affect fish wellness and decrease growth rate, stress
resistance, and immune response. Recently, there have been reports by farmers concerning slow growth, poor feed
conversion, and low average weight increase of fish farmed in offshore floating sea cages, often associated with
internal organ colonization by Moraxella sp. Therefore, presence of these opportunistic bacteria deserves further
investigations for elucidating incidence and impact on fish metabolism.
Results: A total of 960 gilthead sea breams (Sparus aurata, L.), collected along 17 months from four offshore sea
cage plants and two natural lagoons in Sardinia, were subjected to routine microbiological examination of internal
organs throughout the production cycle. Thirteen subjects (1.35%) were found positive for Moraxella sp. in the
kidney (7), brain (3), eye (1), spleen (1), and perivisceral fat (1). In order to investigate the influence of Moraxella sp.
colonization, positive and negative kidney samples were subjected to a differential proteomics study by means of
2-D PAGE and mass spectrometry. Interestingly, Moraxella sp. infected kidneys displayed a concerted upregulation
of several mitochondrial enzymes compared to negative tissues, reinforcing previous observations following
lipopolysaccharide (LPS) challenge in fish.
Conclusions: Presence of Moraxella sp. in farmed sea bream kidney is able to induce proteome alterations similar
to those described following LPS challenge in other fish species. This study revealed that Moraxella sp. might be
causing metabolic alterations in fish, and provided indications on proteins that could be investigated as markers of
infection by Gram-negative bacteria within farming plants.Pubblicat
Progress in the self-similar turbulent flame premixed combustion model
Full text linkThis paper is devoted to premixed combustion modeling in turbulent flow. First, we briefly remind the main features of the Self-Similar Turbulent Flame model that was more extensively developed in a former paper. Then, we carefully describe some improvements of the model. The determination of the turbulent flame velocity is based on the observed self-similarity of the turbulent flame and uses the local flame brush width as a fundamental parameter, which must be retrieved. With respect to the former version, we now derive more rigorously how the density variation has to be taken into account in the width retrieving function. We reformulate the diffusion term as a classical flux divergence term. We enforce the compatibility of the model for the limit of weak turbulence. We include a contracting effect of the source term, thus allowing to give a stationary mono-dimensional asymptotic solution with a finite width. We also include in a preliminary form, a stretch factor, which proves to be useful for controlling the flame behavior close to the flame holder and near the walls. The model implementation in the Star-CD CFD code is then tested on three different flame configurations. Finally, we shortly discuss the model improvements and the simulation results.This research has been funded by the Autonomous Region of Sardinia.4074-4088Pubblicat