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NUVOLA
No full textIl progetto si propone di sviluppare una infrastruttura di CLOUD computing ottimizzata per la gestione dell'ambiente. Nello specifico il sistema saà sviluppato per formnire servizi ad alto valore aggiunto sfruttando una piattaforma di calcolo e di storage per la simulazione del ciclo integrato dell'acqua e la valutazione dell'impatto delle fonti puntuali e diffuse di inquinamneto sulla risorsa suolo e acqua.The project aims at developing a cloud computing infrastructure, optimized for environmental management and territorial planning. Specifically, the system will be developed to expose to the Internet high value-added services using a state of the art computing and storage platform for the simulation of the integrated water cycle and to evaluate the impact of point and diffuse pollution on soil and water resources.Completato€ 40.00
I materiali lapidei della Sardegna
Full text linkAutore del testo: prof. Piero Primavori. Coordinamento per Sardegna Ricerche: dr. Geol. Mara Mangia, Ing. Sandra Ennas.Il presente manuale è stato realizzato nell’ambito del progetto pilota “Innovazione e tecnologia nel sistema lapideo”, con la collaborazione dei due principali consorzi del settore lapideo regionale e di numerose altre imprese isolane, con l’obiettivo di promuovere e divulgare i materiali lapidei sardi e le loro molteplici possibilità di utilizzo. Nel volume si descrivono le materie prime, i processi produttivi, le principali applicazioni e i sistemi di posa in opera. Sono state realizzate appositamente analisi chimiche, prove fisico-meccaniche, petrografiche e di durevolezza su diversi provini di materiali lapidei di produzione sarda. Tali prove sono state integrate dalla misura della radioattività, un test tecnologico ad elevato carattere innovativo. Un capitolo del libro è interamente dedicato ai risultati del progetto sui pannelli sandwich, pannelli multistrato, piani o curvi, destinati ad applicazioni edili come rivestimenti esterni ed interni
Scaling with the flow: advantages of a MapReduce-based scalable and high-throughput sequencing workflow
No full textThe continuous increase in sequencing throughput imposes a new generation of tools for data processing. The alternative is to continue suffering scalability problems in processing workflows and IT infrastructure. We evaluate the advantages that the CRS4 Sequencing and Genotyping Platform (CSGP), equipped with 6 Illumina sequencers, gained by replacing its conventional workflow with a new one based on Seal (http://biodoop-seal.sf.net) and Hadoop. The former was a standard pipeline that demultiplexed samples, aligned reads with BWA, removed duplicates with Picard and recalibrated base qualities with GATK. It parallelized computation through concurrent jobs, using a centralized file system to share data. This implementation showed weaknesses as the workload increased: low parallelism; I/O bottleneck at central storage; failure of entire analyses due to node failures or transient cluster problems. The new workflow is a custom, distributed pipeline based on the open-source Seal suite, which provides a set of tools (including a distributed BWA aligner) that run on the Hadoop MapReduce framework, leveraging its functionality for genomic sequencing applications. By switching to a Seal-based workflow we have acquired computational scalability out-of-the-box. Therefore, we can now easily meet the demands imposed by the growing sequencing platform by adding more computing nodes. In addition, the much-increased parallelism has improved overall computational throughput by taking advantage of all available computing power. Notably, we drastically sped up alignment and duplicates removal by 5x without adding computation nodes; adding nodes would result in additional throughput. Moreover, the effort required by our operators to run the analyses has been reduced, since Hadoop transparently handles most hardware and transient network problems and provides a friendly web interface to monitor job progress and logs. Finally, we eliminated the need for our expensive shared parallel storage devices. Our tests reveal that Seal is efficient, achieving close to 70% of the theoretical maximum throughput per node (measured with a single-node version of the workflow on a small data set) and scales linearly at least up to 128 nodes. In summary, this case study suggests that the MapReduce programming model, Seal and Hadoop provide considerable benefits in the genomic sequencing domain. Seal now includes our new workflow as a downloadable sample application.2011-10-11Montreal - CanadaThe 12TH International Congress Of Human Genetics & The American Society Of Human Genetics, 61ST Annual Meeting, October 11–15, 2011 Montreal Canad
Preliminary results on the verification of the water balance aspects of the regcm3 regional climate model on yearly scales
Full text linkIn this report some preliminary results obtained implementing the RegCM3 regional climate model to downscale, at the relatively high horizontal spatial resolution of about 25km, one year (the 1982) of the ECMWF ERA40 reanalysis in the Western Europe and Mediterranean area, are discussed. The main aim of this work is to assess the performance of the RegCM3 describing the runoff (R), the precipitation (P) and the evapotranspiration (E) components of the hydrological budget. This has been made comparing the monthly precipitation averages for 1982 against a gridded dataset, at spatial resolution of 0.5, of measured data (CRU dataset) and then checking physical consistency of the simulated P field with the corresponding R and E fields
GLP e GMP: due normative differenti?
Full text linkIl seminario è stato promosso da Fase 1 e Sardegna Ricerche, fa parte di una serie di incontri volti a dare un quadro generale sulle principali tematiche inerenti lo sviluppo preclinico e clinico di nuovi farmaci.Il seminario, incentrato sugli aspetti normativi relativi alle attività dei laboratori di produzione ed analisi dei farmaci, si è articolato nei seguenti argomenti: GLP e GMP due normative differenti; il sistema di gestione della qualità in un laboratorio di analisi; la gestione della strumentazione; gli standard di riferimento; convalida dei sistemi computerizzati dedicati agli strumenti analitici; la esecuzione delle analisi, requisiti per API e per prodotti finiti per le fasi preliminari di sviluppo clinico.2011-12-12Sardegna Ricerche, Edificio 2, Località Piscinamanna 09010 Pula (CA) - ItaliaL'attività di laboratorio in ambiente normat
Free surface and splashing simulation of a windowless target concept for ESS
Full text linkThe international collaboration for the future European Spallation Source (ESS) required the formation of a Target Station Concept Selection (TSCS) working group, with the task to re-evaluate the potential target concepts, moving away from the short pulse experiences of the last decade, and re-considering many of the concepts already studied in the past. The main targetry concern for recent pulsed spallation neutron sources (ESS, SNS, JSNS) focused on the effects and mitigation of the pressure wave caused by the quasi-instantaneous deposition of large amounts of energy in a few litres of Hg. In ESS, a long pulse solution was chosen to mitigate these effects, the 2 mA spallation beam at 2.5 GeV is pulsed with a repetition rate of 16,67Hz and a pulse length 2ms. The spallation target must dissipate about 2.8MWth within a relatively short space (with a conservative 56\% thermal efficiency). In the PDS-XADS FP5 project, a windowless channel like target has already been dimensioned and simulated for a relatively similar proton beam: 2.4 MWth, 5 mA and 600 MeV. In the framework of this project, the spallation target was conceived by Ansaldo and developed mainly by CRS4 and ENEA. Starting from this concept we investigated the feasibility of a windowless design for the ESS conditions, by scaling PDS-XADS design for the ESS beam properties and relaxing the constraints of the 2003 design. We focused on the numerical simulation of the flow to verify the stability of the free surface, the thermohydraulic performance of Hg and LBE, and the response to dynamic pulses. At the same time KIT investigated the possibility to fit a windowless target concept within the design limits of the target station and accelerator and developed the WITA concept. The CFD simulations we present have been successfully completed thanks to the use of a specific surface sharpening algorithm, developed in the framework of the THINS FP7 project, and lacking the usual rigidifying defect of common sharpening algorithms. The dynamic effects of proton beam deposition on the free surface windowless target are then investigated numerically with a smoothed particle hydrodynamic simulation through a specifically developed code, allowing to identify the pressure waves in the liquid and estimate the splashing phenomena at the free surface.2011-05-03Malmö4th High Power Targetry Worksho
Going Beyond Google Translate?
Full text linkCiclo 2012 di seminari interni CRS4, Number 20120229.We motivate and describe the design and implementation of a web-based system for the alignment of parallel texts. It builds on the interactive color-highlight interface now deployed at Google Translate. By a series of simple point and click operations translators can mark up equivalent text-ranges in their own translation and in the original. When successful, the visual cues created by this activity should benefit the understanding of readers of limited degrees of bilingualism -- and may also capture aspects of semantic context not readily available to algorithmic statistical machine translation. We provide a working demonstration that treats poetic texts.Statistical machine translation (SMT) delivers texts unacceptable for literary or academic purposes since generally, it cannot assimilate adequate context: Yet how might one ever articulate such context? Here rather than taking a theoretical perspective we adopt an spatio-visual approach made possible by recent advances in the electronic presentation of multilingual texts:– we allow the translator supply the colour higlights... But how? Semantic units don't respect lexical boundaries and they occur at different scales. Any translator, committed to provide a definitive version of a text, eventually arrives at irreversible order of words – and may actually wish to justify their choices by documenting the correspondence between their version and the original. We focus on verse – an extreme challenge for SMT – with the eventual aim of expressing elusive aspects of semantic communication in order to differentiate those that can be articulated via spatio-visual cues. In verse a deviation from a literal correspondence is essential to reestablish in the translation a "decorum" appropriate to the original so that readers are encouraged to achieve an equivalent respect for its author also from the translated works. We use jQuery to provide an interface that lets the human translator mark up what they consider a correct alignment between words, or groups of words, in the original and their own translation – with a view to articulating context that may not be readily available to SMT. We detail below how the interface runs off a web-page and allows the alignment of equivalent ranges in parallel texts via a simple point-and-click action. Alignments created by the user are instantaneously made visible using a variant of the interactive color-highlight system mentioned above. Key to reducing the complexity of the implementation of the interface is our systematic deployment of open-standard, non-proprietary, web technologies.2011-09-15AlgheroCHItaly2011, 13-16 settembre 2011, Algher
One dimensional model of a permeable reactive barrier for the remediation of groundwater polluted by acid mine drainage in mining sites
Full text linkThis study is conducted under the research grant “Borsa Giovani Ricercatori 2009” of the Sardinian Regional Authorities and the PhD Programme “Geoingegneria e tecnologie ambientali”(2009-2012) of the University of Cagliari. The work has been developed in collaboration with Giuditta Lecca (tutor) and Riccardo Biddau at the Centre for Advanced Studies, Research and Development in Sardinia (CRS4) – Sector “Energy and Environment”, directed by Ernesto Bonomi.The current study was conducted to evaluate by mean of a reactive transport model a possible groundwater remediation with the use of PRB technology, in the mining area eastward of Montevecchio, located in the southwestern part of Sardinia, polluted by AMD. Reactive transport modeling represents an excellent tool to analyze and quantify the different reactions and their interactions in multi-component system during advective and dispersive transport. A one dimensional reactive transport model has been developed with the code PHREEQC (Parkhust and Appelo) to assess the efficiency in the short and in the long period of a PRB, composed by organic carbons, used for the treatment of the mine drainage in the specific site of study and to estimate its longevity. The model simulates the dissolved pollutants removal inside the reactive medium, taking into account degradation rates of organic matter, reduction of sulfate, media compositional changes, ion metal concentration, removal mechanisms of sulfates and heavy metals, precipitation-dissolution of reduced mineral phases that precipitate as reduced mineral phases and drop in reactivity due to precipitation of mineral phases and dissolution of organic matter. Four different simulations were performed varying the hydraulic conductivity of the reactive medium, in order to evaluate how the PRB efficiency varies in the short and in the long period, varying the reactive medium characteristics. The simulation results put in evidence the potential of an organic carbon PRB in removing inorganic contaminants contained in acidic leachates, generated at mining sites. The study introduce an application tool that elucidates the geochemical processes that occurs in preventing the contaminants transport in a site of interest by mean of a PRB. It could be an useful tool in the hypothesis of a future PRB installation in the site of Montevecchio to establish its best configuration