Indiana University – Purdue University Fort Wayne
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Boundary Schwarz lemma for pluriharmonic mappings between unit balls
No full textIn this paper, we get a Schwarz lemma for pluriharmonic mappings between the unit balls of any dimensions, which generalizes classical Schwarz lemma for bounded harmonic functions to higher dimensions. As an application of the Schwarz lemma obtained, a boundary Schwarz lemma is established for pluriharmonic mappings between unit balls with any dimensions
The Perilipin-like PPE15 Protein in Mycobacterium Tuberculosis is Required for Triacylglycerol Accumulation Under Dormancy-Inducing Conditions
No full textMycobacterium tuberculosis (Mtb) causes latent tuberculosis infection in one-third of the world population and remains quiescent in the human body for decades. The dormant pathogen accumulates lipid droplets containing triacylglycerol (TAG). In mammals, perilipin regulates lipid droplet homeostasis but no such protein has been identified in Mtb. We identified an Mtb protein (PPE15) that showed weak amino acid sequence identities with mammalian perilipin-1 and was upregulated in Mtb dormancy. We generated a ppe15 gene-disrupted mutant of Mtb and examined its ability to metabolically incorporate radiolabeled oleic acid into TAG, accumulate lipid droplets containing TAG and develop phenotypic tolerance to rifampicin in two in vitro models of dormancy including a three-dimensional human granuloma model. The mutant showed a significant decrease in the biosynthesis and accumulation of lipid droplets containing TAG and in its tolerance of rifampicin. Complementation of the mutant with a wild-type copy of the ppe15 gene restored the lost phenotypes. We designate PPE15 as mycobacterial perilipin-1 (MPER1). Our findings suggest that the MPER1 protein plays a critical role in the homeostasis of TAG -containing lipid droplets in Mtb and influences the entry of the pathogen into a dormant state
Career Development: A Human Resource Development Perspective
No full textCareer Development: A Human Resource Development Perspective offers a strategic framework that demonstrates the role of career development within the human resource function. It goes beyond conventional interventions and includes key topics such as diversity, work–life balance, and ethics.
Historically, the career development literature has been viewed either from the perspective of the individual (how to build a career) or from an economic perspective (how an organization benefits from developing employees). In this book, McDonald and Hite bring together the strengths of both traditions, offering an integrated framework for career development. The theoretical foundation expands on the counseling literature by incorporating the literature from human resource development and related fields. The application section reflects on the wide range of ages and working options that characterize the current and future workplace. The final section of the book addresses career development issues such as managing a diverse, global workforce; ethics; and work–life balance.
This book will help prepare human resource development students, scholars, and practitioners to develop and maintain successful career development programs, and to foster more innovative research that advances the discourse
Johannes von Kries: A Bio-Bibliography
Get PDFA short biography of Johannes von Kries (1853–1928), followed by a bibliography of his works, containing more than 70 previously unknown works