Indiana University – Purdue University Fort Wayne
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Creating an Awards Database: Using a Digital Commons Repository to Showcase and Archive Faculty Awards, Grants, and Fellowships
No full textHow Social Media Can Impact the Organizational Political Process
Get PDFThe world of work is a political arena. Managers, employees and organizational groups vie for power and influence within organizations in both formal and informal settings for personal and organizational benefit (Ferris et al., 1989; Drory and Vigoda-Gadot, 2010; Vigoda-Gadot and Drory, 2006). A significant body of work has looked into how to understand how organizational politics processes take place and how they impact organizations. While we have learned much about how organizational politics unfold in organizations, to date little attention has been given to the impact of changing technologies on the organizational political process, with the exception of work on influence tactics in virtual teams (Elron and Vigoda-Gadot, 2006; Steizel and Rimbau-Gilabert, 2013). Technology has transformed not just how people engage in job behaviors, but also how individuals communicate and connect. One particularly important communication technology is social media
Highly Efficient Integration of the Viral Portal Proteins from Different Types of Phages into Planar Bilayers for the Black Lipid Membrane Analysis
No full textThe planar lipid bilayer technology is a technique that yields incredibly useful structural function information about a single channel protein. It is also currently actively utilized as a powerful platform using biological protein nanopores for the development of single-molecule nanopore sensing technology, as well as ultrafast DNA sequencing technology. The portal protein, GP10, from the bacteriophage f29 was the first phage portal protein shown to be successfully inserted into planar bilayer membranes, thereby it may inspire more researchers to apply the techniques to portal proteins from the other bacteriophages.
However, the technology is far from perfect since the insertion of the channel proteins into planar bilayer membranes is not only technically difficult but also time-consuming. For the fusion of phage portal proteins, vesicles are typically needed to be reconstituted with the portal proteins to form proteoliposomes. However, most of the phage portal proteins have low solubility, and may self-aggregate during the preparation of the proteoliposomes. Furthermore, the fusion of the formed proteoliposomes is sporadic, unpredictable and varied from person to person. Due to the lack of experimental consistency between labs, the results from different methodologies reported for generating fusible proteoliposomes are highly variable.
In this research, we propose a new method for the preparation of the fusible proteoliposomes containing portal proteins from bacteriophages, to circumvent the problems aforementioned. Compared to the conventional methods, this method was able to avoid the protein aggregation issues during the vesicle preparation by eliminating the need for detergents and the subsequent time-consuming step for detergent removal. The proteoliposomes prepared by the method were shown to be more efficiently and rapidly inserted into planar bilayer membranes bathed in different conducting buffer solutions including those with nonelectrolytes such as glycerol and PEG. In addition, the method of forming proteoliposoomes has significantly extended the shelf life of the proteoliposomes. To further explore its potentials, we have successfully applied the method to the insertion of a mutant portal protein, GP20, from T4 bacteriophage, a hydrophobic portal protein that has not been explored using the planar lipid bilayer membrane technique. The results suggest that this method could be used to prepare proteoliposomes formed by hydrophobic portal proteins from other bacteriophages
Global Behavior of Solutions to the Fast Diffusion Equation with Boundary Flux Governed by Memory
No full textWe study global existence and blow up in finite time for a one-dimensional fast diffusion equation with memory boundary condition. The problem arises out of a corresponding model formulated from tumor-induced angiogenesis. We obtain necessary and sufficient conditions for global existence of solutions to the problem
A Fast Diffusion Model with Memory at the Boundary: Global Solvability in the Critical Case
No full textNecessary and sufficient conditions for the global solvability of a slow diffusion model with boundary flux governed by memory have been previously shown to be the same as those for a corresponding model with localized nonlinear flux at the boundary. Recent investigations of a similar fast diffusion model with memory have also successfully replicated conditions in parallel with the corresponding localized problem, except for the critical case separating global solvability from blow up in finite time. We provide a suitable modification of an L∞ estimate, typically applied to the case of slow diffusion, which also applies to the fast diffusion model and subsequently establishes global solvability in the critical case. Memory terms appearing in the model are of the type which have been introduced in studies of tumor-induced angiogenesis
The Chain of Violence and the Lessons for New Orleans
No full textThis chapter reviews patterns of violence in New Orleans and discusses it in terms of the Chain of Violence principle described in Iadicola and Shupe\u27s Violence, Inequality and Human Freedom. The chapter concludes with a discussion of the current strategies of intervention outlined by the city of New Orleans in the NOLA FOR LIFE: A Comprehensive Murder Reduction Strategy and the limitations of the strategy based on the insights of the theoretical model outlined by Iadicola and Shupe
To the Brink: Turkish and Cuban Missiles during the Height of the Cold War
Get PDFCody Fuelling is in his third year at IPFW, with majors in history and secondary education, furthermore pursuing an Honors Certificate and Certificate in International Studies. Presently employed by the Honors Center, Cody also works as an Assistant Book Review Editor for Enterprise and Society, a business history journal published by Cambridge University Press. He also sits as a student representative on the COAS Student Affairs Committee
Operation TPAJAX: The CIA’s First Power Trip
Get PDFMy name is Katie Sherrod. I am a history major with a political science minor. After graduating from IPFW, I plan to do some teaching and attend law school. History excites me because I enjoy learning about how certain issues affected our past, both nationally and globally, and how we can use the responses to those issues to learn and shape our responses to similar issues today. In my free time I enjoy reading and traveling
