Indiana University – Purdue University Fort Wayne
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Impaired Retrieval of Spatial Memory and Response Perseveration in a Radial Arm Maze After Muscimol Inactivation of the Anterodorsal Thalamus.
No full textThe ability to navigate depends on neural systems involved in tracking an animal’s moment-to-moment changes in directional orientation and spatial location when moving from place to another. Previous studies have shown that the anterodorsal thalamus (AD) contains a large population of head direction cells, which fire as a function of an animal’s directional orientation in an environment, thereby providing a neuron-like compass guiding navigation. Recent work has demonstrated that when the AD is damaged animals display poor performance on spatial reference/working memory tasks. However, while studies have confirmed that AD lesions impair the acquisition of new spatial information, few have attempted to dissociate the unique contributions of the AD to the acquisition vs. retrieval of allocentric spatial information. Here, we trained rats in a radial arm maze (RAM) procedure that requires the acquisition of directional trajectories to obtain a reward. Animals were trained to asymptotic levels (mean = 67.9% correct + 3.2% SEM; chance performance = 25%). Twenty-four hours after training, animals were administered muscimol inactivation of the AD before a 4 trial probe test. Specific measures across training and probe testing included: latency to complete the task, amount of errors (working and reference memory), and percent of correct arm choices per trial. We found that when the AD was inactivated, RAM latency and reference memory were significantly higher, and the percent correct was significantly lower than control animals. In addition, a large number of working memory and perseverative errors were observed in AD inactivated animals throughout testing, suggesting a general absence of improved navigation across training trials. In contrast to retrieval and working memory deficits, it was observed that inactivated animals could express a non-spatial “cued” behavior, indicating that the impairments were specific to spatial processing. Taken together, the results above suggest that the AD modulates the retrieval of previously acquired allocentric spatial information in a RAM procedure, but also suggests a critical role in the online guidance of accurate spatial behavior. The results are discussed in relation to the anterodorsal thalamo-cortical circuits involved in spatial information processing
Effects of solution chemistry on antimicrobial activities of silver nanoparticles against Gordonia sp
No full textSilver nanoparticles (NPs) are the largest and fastest growing category of nanotechnology-based medicines and consumer products. Silver can have great toxicity to some aquatic organisms and, as a biocidal agent, may also damage or alter the most abundant and vulnerable beneficial microorganisms in the environment, such as Gordonia sp. However, considering the complex chemical background of natural waters, silver NPs can have complicated interactions with background chemicals such as chloride, surfactants, and dissolved natural organic matters (NOM). The results of this study show that the average particle size and dispersivity of silver NPs and the surface characteristics play an important role in the toxicity of silver NPs. Aggregation was enhanced for silver NPs in 10 mM NaNO3, but not much in 10 mM NaCl due to reactions with chloride. However, the presence of 3 mM sodium dodecyl sulfate (SDS) or 8 mgC/L Suwannee River (SR) NOM appeared to reduce the aggregation of silver NPs. Regarding the bactericidal effect of silver NPs, solubility analysis suggests silver NPs inactivate Gordonia sp. differently from Ag+ and/or a slow release of Ag+ from silver NPs. When the silver NP concentration was raised from 7.3 to 29.2 mg/L in DI water, the log inactivation rate of Gordonia sp. increased from 0.16 ± 0.04 to 0.45 ± 0.13. However, with 29.2 mg/L silver NPs the log inactivation rate reached 1.40 ± 0.26 in 3 mM SDS. The presence of SRNOM mitigated the bactericidal efficacy of silver NPs due to surface coating/adsorption. On the other hand, 10 mM NaCl reduced the log inactivation rate to 0.07 ± 0.07 due to the formation of likely less toxic silver chloride species, such as AgCl, AgCl2−, AgCl32 −, and AgCl43 −
The 2015 Revised Ethical Code
No full textThe revised NOHS ethical code will be examined in this session. Approved and instituted in 2015, new features of the code will be presented and a discussion with attendees will be solicited. A comparison of the NOHS ethical code and the HS-BCP ethical code will also be offered
Music Therapy 101: What It Means to Be a Music Therapist
No full textThis presentation will give a brief overview of the profession of Music Therapy and will describe how music is beneficial in healing. Requirements to becoming a board-certified music therapist will be discussed and where music therapists work will be examined. Participants will be invited to participate in music experiences
Biblical reading and critical reading: How do they inform each other in interpreting the text?
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McCoy Bolt Works, Inc. Technical Assistance Grant
No full textAdolfo Coronado, assistant professor of information systems, received a technical assistance agreement grant from McCoy Bolt Works, Inc.
This project will help McCoy Bolt in improving their relationship with customers by redesigning the current business processes of extracting, transforming and loading data from their electronic data interchange (EDI) for decision making.
Because the agreement has an experiential learning component, a student will be allowed to assist on the project as well.http://opus.ipfw.edu/grants/1000/thumbnail.jp
Impacting Academic Success with Peer Mentors
No full textFirst Place Non-Thesis Winner and People\u27s Choice Winnerhttp://opus.ipfw.edu/threemt2016/1003/thumbnail.jp