136879 research outputs found
Sort by
The Role of pou3f3b in the Development of the Zebrafish Inner Ear
No full textHearing loss is a serious condition that afflicts much of the population through many age groups. An intriguing route to study hearing loss and its potential treatments is to study initial hearing development. To deepen our understanding of this complex process, we must learn more about the network of genes involved in the development of the saccule and the process of sensorineural development, both of which are required for the development of hearing function. One gene of interest in these processes is pou3f3b, a transcription factor that is commonly used as a saccular marker. The role of Pou3f3b, however, has not yet been investigated thoroughly. The transcription factor has orthologs in humans and mice, and experiments with mice revealed hearing deficits in mutants, but were largely inconclusive as knockout of the gene is lethal in mice. Zebrafish pou3f3b- /- mutants are viable, however, making it an ideal model organism for this novel research. Through this project, we characterized the role of Pou3f3b in the development of the inner ear. We found that Pou3f3b is necessary for proper sensorineural development, where it supports sensory fates. It does this by repressing neurog1 and activating fgf3, which in turn supports atoh1a expression and stimulates hair cell production in the saccule. This makes Pou3f3b essential for maintaining a proper balance of sensorineural domains, the production of hair cells, and potentially auditory function in zebrafish
Cracking The Corps: The Marine Corps Withdrawal From Vietnam, 1969-1971
No full textThis dissertation explores the Marine Corps��� withdrawal from the Vietnam War from 1969-1971. Throughout this process, the United States Marine Corps encountered several difficulties in trying to exit. The withdrawal planning proved a bureaucratic negotiating process, requiring the Corps to collaborate with other services. The withdrawal also became politicized by the Nixon Administration due to its subordination of decision making to the President���s gauging of public opinion and his views on diplomacy and war. Further complicating the process, Marine Corps leadership proved uninterested in the war by 1969 and began to look toward the post-Vietnam era. This lack of interest contributed to underestimation of the complexity of the withdrawal for Marines at the division level and below who executed the plans. When the withdrawal occurred, it was a logistic success due to the efforts of the Marines on the ground, and the institution���s ability to learn from the 3d Marine Division���s withdrawal from July to December 1969. However, it failed to adequately Vietnamize the war in I Corps and its personnel policies undermined its combat readiness and effectiveness. Operationally, the Marine Corps failed to adequately connect its withdrawal with its combat actions. The Marines utilized the flawed High Mobility approach throughout 1969 and 1971. They also neglected the Army of the Republic of Vietnam (ARVN), conducting cooperative rather than truly joint operations to prepare them for combat without the Marines. Throughout 1970-1971, social and discipline issues began to compromise Marine combat readiness and effectiveness. Simultaneously, the Marine Corps utilized its own Vietnamization program, the Combined Unit Pacification Program (CUPP), focused on the development of local security. Despite promotion from III MAF���s Commanding Generals, CUPP received minimal support from the 1st Marine Division leadership and was in effect for only one year. This lack of interest from division commanders, shortage of resources and time severely undercut the Corps��� Vietnamization policy. Ultimately, the Marine Corps did not learn from the withdrawal. The institution saw it as a logistic process rather than a carefully calibrated balancing act between movement of men and materiel, combat operations, and cooperation and training of allied forces
The Science and Progression of Data Science in Football
Get PDFIn recent years, we have seen how technology has changed society and has made it far easier and more feasible to connect with people around the world, paving the way for multi-functional devices, and creating evolutions that will change the history of inventions created in the past. Technology has played a vital role in the evolution and progression of football, as it has led to various ideas and implementations never seen before without the growth and influence of technological devices. Through qualitative interviews using Grounded Theory Approach, I worked alongside multiple clubs to gain insight into data analytics emerging among and considered by the Board of Directors. This study emphasizes the importance and evolution of data analytics and how it demonstrates improved better player performance, creation of better tactical formations, and injury prevention and preparation. Using the Player Performance Index, analysis shows a strong correlation with the improvement of better player performance by keeping track of certain statistics needed by sports analysts. Various methods of changing tactical styles and in-game tracking have facilitated football clubs to determine what will be their best approach to creating the ������tactical formation��� by having data analytics tools such as optical tracking facilitated by software programs. Although data regarding injuries in football clubs is impossible to receive due to privacy protection laws, through the qualitative interviews, information is presented describing how training loads can be modified by using indices and balances created by sports analysts to minimize the risk of injuries between players through better preparation. We conclude that there is sufficient evidence to demonstrate how data science has evolved football
Annual Report 2023 : A Year of Renewal
No full textProduced by Texas A&M University Libraries��� marketing and communications team
Energy Efficiency/Renewable Energy Impact in the Texas Emissions Reduction Plan (TERP), Summary Report: Integrated NOx Emissions Savings from EE/RE Programs Statewide, Annual Report to the Texas Commission on Environmental Quality January 2023 - December 2023
Get PDFThe Energy Systems Laboratory (ESL) at the Texas A&M Engineering Experiment Station of the Texas A&M University System is pleased to provide this summary report, "Energy Efficiency/Renewable Energy Impact in the Texas Emissions Reduction Plan (TERP): Integrated NOx Emissions Savings from EE/RE Programs Statewide," as required under Texas Health and Safety Code Ann. ���� 388.003 (e) (Senate Bill 5, 77R as amended 78 R & 78S)
Microstructure and Hardness Property of Nickel-Chromium Alloy Powder by Laser Cladding
Get PDFCase Stud
Assessment of Aerodynamic Performance Characteristics of Centrifugal Compressors with Low Solidity Diffusers
Get PDFLectur
Statewide 2023 Air Emission Calculations from Wind and Other Renewables VOL II
No full textA technical appendix for the volume I report to the Texas Commission on Environmental Quality For the Period January 2023 - December 2023