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Development of chimeric-antigen receptor in T cell to mitigate transplantation rejection
Get PDFOrgan transplantation is a critical treatment for end-stage organ failure, but transplant rejection remains a major challenge. The main mechanism behind transplant rejection involves alloreactive T cells recognizing non-self MHC (Major Histocompatibility Complex) molecules on donor cells through their T-cell receptors (TCRs), triggering an immune response that attacks the transplanted organ. Immunosuppressive treatments are the standard treatment for preventing rejection. While effective, general immunosuppression has significant downsides, such as increased susceptibility to infections and malignancies, and the requirement for lifetime medication. Therefore, a specific therapy to eliminate alloreactive T cells is needed. Our lab aims to develop a chimeric antigen receptor (CAR)-T cell therapy to selectively remove alloreactive recipient T cells, thereby lowering transplant rejection and eliminating the need for widespread immunosuppression. We designed the MHC-I-CAR, a CAR with an MHC class I molecule as the “receptor,” followed by a transmembrane and intracellular signaling domains. We hypothesize that the binding of alloreactive T cell receptors to the MHC-I-CAR could activate the CAR-expressing cytotoxic T cells, which will kill the alloreactive T cells. In this project, we focused on optimizing CAR designs by modifying the cytoplasmic and intracellular signaling domains. Using an in vitro reporter cell line expressing MHC-I-CAR using mouse H-2Kb as the model MHC-I molecule, we examined numerous CAR configurations, including the MHC-I without the cytoplasmic region (tailless) and mutations in the signaling domain (28z mut). Flow cytometry analysis demonstrated that the tailless configuration enhanced CAR signaling, while the 28z mut did not. These data provide the foundation for future MHC-I-CAR designs and improved allospecific CAR-T therapy by boosting donor T cell activation.No embargoAcademic Major: BiochemistryAcademic Major: Molecular Genetic
Electronic Transport and Magnetism in Layered A-Mn-Pn Compounds
Get PDFGoniopolar materials are an emerging family of materials that simultaneously exhibit both p-type and n-type conduction in a single compound along different crystallographic directions. Combining goniopolarity with magnetic properties opens up the opportunity of experimentally studying how both phenomena can be combined to give complex transport phenomena. Here we explore this by growing crystals of A-Mn-Pn (A=Alkali, Pn=Pnictogen) compounds and studying the anisotropic transport properties. A-Mn-Pn compounds are layered materials composed of stacking an alkali layer between layers of edge-sharing MnPn4 networks. We develop a flux-based synthesis to create mm-scale crystals of NaMnBi and NaMnSb, and confirm the phase purity via X-ray Diffraction. We establish that these materials are semiconductors with 0.52 and 0.32 eV band gaps, respectively, and antiferromagnets with Néel Temperatures over 240 K. We evaluate the in-plane and cross-plane electronic and thermoelectric properties and show that NaMnBi exhibits goniopolarity. Overall, this work establishes this family of compounds as both antiferromagnetic and goniopolar, enabling future opportunities to explore how they combine to influence magneto thermoelectric properties.National Science Foundation, Materials Research Science & Engineering Centers (NSF MRSEC)No embargoAcademic Major: Chemistr
Leading a Divided Campus: Ideas and Illustrations, Fourth Edition
No full textThe AAA-ICDR FoundationThe Ohio State University Moritz College of LawThe Ohio State University Mershon Center for International Security StudiesThe JAMS Foundatio
Black Women's Health in the Age of Hip Hop and HIV/AIDS: A Narrative Remix
No full textIntroduction: A tale of three influences : my roots/routes (in)to black women's health, hip hop, and HIV/AIDS -- In search of our mothers' theories : hip hop feminism in praxis -- "Cunt buckets" and "bad bitches" : black girl identity formation and sexual health in PUSH : a novel and The Coldest Winter Ever -- Transnational flow(s) : staging silence, stigma, and shame in in the continuum -- "Prioritized" : the hip hop (re)construction of black womanhood in Girlfriends and The Game -- In memoriam-and in life
Council on Academic Affairs: Activities Report (September 4, 2024 - July 17, 2025)
Get PDFCouncil on Academic Affairs' activities report for 2024-2025