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When the Sky is Not the Limit: Managing Capped Open Access Agreements
No full textThis paper features a dialogue between a consortium, two large research university libraries, and a large commercial publisher on the opportunities and challenges of setting up cost-neutral open access publishing agreements and managing capped allocations. The authors provide perspectives on the role of capped agreements in their negotiations, campus communications, workflows, and business processes as they navigate how to make open access publishing agreements work for everyone—consortia, universities, libraries, authors, researchers, and publishers.Publisher allows immediate open acces
Design and Synthesis of HIV-1 Capsid Degrading Small Molecules
No full textHIV-1 is the etiologic agent responsible for the progressive impairment of host immune function. While the introduction of combination antiretroviral therapies (cART) has dramatically reduced HIV-1-associated mortality, the emergence of drug-resistant viral strains necessitates the development of novel therapeutic modalities. The HIV-1 capsid protein (CA) is a highly attractive therapeutic target due to its essential, multifaceted role in both the early and late stages of the viral replication cycle. Small-molecule CA function inhibitors, such as PF74, exert their effect by disrupting CA's critical biological functions, thereby preventing viral replication. The objective of this research project is to rationally design and synthesize small-molecule HIV-1 CA-degraders utilizing PF74 as a lead compound. This was achieved by employing the recently reported targeted clearance strategy, AUtophagy TArgeting Chimeras (AUTACs), to induce selective degradation of the CA via the autophagy-lysosome pathway. Collectively, this project establishes a synthetic framework for developing novel CA degrading compounds and validates targeted CA degradation as a viable strategy in anti-HIV-1 drug design.NIH/NIAID grant R21 AI174866A five-year embargo was granted for this item.Academic Major: Neuroscienc
Positioning Green Scope for Growth: A Competitor and Market Analysis
No full textCourse Code: AEDECON 4567For this capstone project, our research team partnered with Green Scope, a Columbus-based sustainability consultancy, to develop tailored recommendations to strengthen its current service offerings and expand its market reach. This project began by conducting a competitor analysis on ten consultancies, broken into two categories: 1) zero-waste firms similar to Green Scope, and 2) broader corporate consultancies offering general sustainability services. To gather
information, we held interviews with consultancies and reviewed publicly available data to understand each company’s client base, outreach strategies, and performance metrics. This research revealed leading industry practices and informed the development of a general competitor matrix and a zero-waste matrix for evaluating business strategies.
Next, we performed a comparative market analysis of sustainability initiatives in Columbus, Minneapolis, Seattle, and New York City. This analysis examined key sustainability-focused legislation and programs in each city, identified cross-market similarities, and outlined opportunities for Green Scope to establish or enhance its presence within these markets.
Building on competitor analysis findings, our team performed a comprehensive Strengths, Weaknesses, Opportunities, and Threats (SWOT) analysis to identify internal and external factors likely to influence Green Scope’s future growth. Additionally, we developed seven actionable recommendations based on insights gained from our research to guide Green Scope in expanding its service offerings. These recommendations include creating digital media content for clients, hiring a spatial data analyst, showcasing successful client stories, setting targets for Key Performance Indicators (KPIs), and applying for the B Corp Certification. We also recommend that Green Scope establish a one-year follow-up interview protocol with clients and target companies seeking annual certifications that require waste audits.Dominique Hadad from Green ScopeAcademic Major: Environment, Economy, Development, and SustainabilityAcademic Major: Earth Science
Electrification of AguaClara Off-grid Water Treatment Plants in Rural Honduras Using Hydroelectricity
No full textAguaClara water treatment plants operate off-grid using only the power of gravity and chemical doses to make turbid water safe for drinking, even exceeding EPA standards for water quality. However, electricity is still an important component to the plant operator's experience for powering lights to run the plant at night and charging phones and other small electronics. Some plants can connect to the grid, but this increases monthly operation costs and is not always an option. Others use solar panels, but these require a significant capital investment and cannot always meet electrical demand. The flow of the incoming water represents a powerful source of untapped energy that is readily available without experiencing outages. This kinetic energy is all lost when the water is simply dumped into the entrance tank basin. The purpose of this research is to assess the electrical needs of AguaClara plants and develop a process for hydro electrification that can most efficiently use that flow to produce electrical power that meets a plant’s current and future energy demands.No embargoAcademic Major: Electrical and Computer Engineerin
Subordinate Space Use as a Method of Regulating Conflict Over Helping Behavior in a Cooperatively-Breeding Fish
Get PDFThe African cichlid fish Neolamprologus pulcher are cooperative breeders. Dominant and subordinate members of the group cooperate over care of offspring but also face conflict over status and reproduction. The pay-to-stay hypothesis is one of the main theories that attempts to explain this cooperative behavior; it suggests that subordinate fish performing helping tasks as a way to earn their spot in the group and are punished by the dominants in different ways if they fail to do so. This experiment aimed to determine whether dominant fish impose a punishment for lack of help by controlling the location of subordinates in the tank. I predicted that dominants would exclude subordinates from the nest as punishment after they were prevented from performing a helping task. The experiment consisted of three trials: an acclimation trial with no alterations to the tank and two treatment trials in which subordinates were either blocked from performing a helping task of cleaning grave from the nest or allowed to swim freely in all areas of the tank. After 24 hours, the barriers were removed, and the fish were recorded and observed. The time spent in the four quadrants directly surrounding the nest was recorded. After analyzing the results, I did not find a significant effect of treatment on time spent away from the shelter. However, a preliminary subsampling test revealed that there is some evidence that this outcome could be the result of a small sample size and future research should replicate the experiment with more subjects. This study adds insight into the dynamics of cooperative breeding groups and contributes to the overall understanding of the pay-to-stay hypothesis and indicates that there is a possibility that exclusion from the nest is a method of punishment used by dominant fish.No embargoAcademic Major: Animal Science
Time-of-Day Effect in Response Bias in Working Memory and Cognitive Control Tasks
Get PDFHuman cognitive performance varies greatly throughout the day. These time-of-day effects are thought to be the result of circadian and homeostatic rhythms that modulate neuronal arousal in different brain regions. Previous work has found variations in performance throughout the day across multiple cognitive domains (e.g., working memory, attention, cognitive control). To test the reliability of these effects, we conducted a meta-analysis of time of day and synchrony (performing at a time congruent with one's circadian preference, e.g. morning people in the morning) effects. Our meta-analysis revealed substantial publication bias in the literature, suggesting that these effects may be less reliable than they appear. We followed this up by investigating whether strategy or ability contribute more to time-of-day/synchrony effects using the signal detection parameters sensitivity and response bias. Sensitivity can be thought of as a measure of ability, while response bias measures strategy. Using the AX-Continuous Performance Task (AX-CPT) and a change detection task we examined the effect of time of day on sensitivity and response bias in an exploratory analysis of a large dataset along with a better controlled follow-up experiment. We found a time-of-day effect in response bias but not sensitivity in the controlled experiment, but not in the large exploratory analysis., These results provide preliminary evidence that variations in cognitive performance throughout the day may result from differences in strategy rather than differences in ability.No embargoAcademic Major: NeuroscienceAcademic Major: Psycholog
Fostering Long-Term Citizen Engagement with the Sawmill Wetlands
Get PDFCourse Code: ENR 4900.01This report outlines the implementation of iNaturalist in the small suburban wetlands at the Sawmill Wetlands and makes recommendations for future community engagement.Academic Major: Forestry, Fisheries and WildlifeAcademic Major: Environment, Economy, Development, and SustainabilityAcademic Major: Environmental ScienceAcademic Major: Environmental Policy and Decision Makin
Twice as Many Flowers: Uncovering a Teaching Identity through Dance Composition
Get PDFThis project is a look into how I uncovered my own morality as a dance educator through a compositional approach. As I choreographed my senior project piece titled Twice as Many Flowers, the process allowed me to gather information that I will use for my own artistry as well as for students in the future. Choreographing this piece did not only take place in the studio, but was a result of important experiences that have conspired through my time as a student of dance at Ohio State. I will address preliminary experiences such as my first composition course at OSU that taught me the importance of instinct and trusting yourself. I also discuss the time I spent in residency with artist Sidra Bell where my interest in sound composition started. I then discuss my experiences during the project such as choreographing the piece, collaborating with my dad and others, and being a directed teacher for the same composition course I had once taken. What I find through these experiences led me to find my voice as a dance educator, as well as becoming a dynamic artist.Arts and Humanities Small GrantNo embargoAcademic Major: Danc
Reframing Mental Illness: Exploring How Art Brut Narratives Have Changed Public Perceptions of Mental Disabilities in China
No full textCoined by French artist Jean Dubuffet in the 1950s, Art Brut refers to works by self-taught artists, prisoners, and individuals with mental illnesses, challenging mainstream art through raw, undisciplined styles and redefining authenticity. By 2025, this art form has spread globally, with art therapy centers enabling individuals with mental illnesses to express unspoken feelings and thoughts through non-interventional creation processes. Aligning with Dubuffet's definition of art, creation in art therapy also helps patients re-socialize with a new identity: Art Brut artists.
This study examines an art therapy center in Nanjing, China, focusing on how Art Brut therapy reconstructs the social identities of individuals with mental disabilities by "artifying" their works, reshaping public perceptions of mental illness, and eventually challenging stigmas against mental disability patients. Using qualitative methods, such as literature review and semi-structured interview, and Natural Language Processing like sentiment analysis, and semantic network analysis, it analyzes published materials, the research indicates that the narrative of Art Brut therapy promotes positive public images for individuals with mental disabilities, seeing them as the representation of "nature" and "culturally un-disciplined", contrasting with stereotypical portrayals in Chinese media that depict them as dangerous or uncontrollable. Framing them as the "positive Other" suggests the potential romanticization of mental illness. At the same time, the semi-interviews with social workers there are used to reveal the effect of
destigmatization of mental disability patients in daily social interactions.
This research highlights how Art Brut therapy replaces stigmatizing narratives with empowering representations, sheds light on the lives of individuals with mental disabilities in China and reflects the development of Art Brut and art therapy in this context. It calls for greater awareness of mental health and demonstrates Art Brut's global potential to challenge stigma.A one-year embargo was granted for this item.Academic Major: SociologyAcademic Major: Anthropolog