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Association between maternal depression and smartphone use: a 1.5-year follow-up cohort study of Japanese mothers
Get PDFMaternal depression affects 17.7% of postpartum women and can emerge years after childbirth, impacting both mothers and their children. Social support plays an important role in preventing maternal depression. Family and community were traditional sources of social support, but the rise of digital media may impact social support and therefore maternal well-being. Mothers are accustomed to technology and often use digital devices for childcare and leisure activities. This study examined the association between screen time and the onset of depression two years postpartum. A cohort study was initiated in November 2020 (baseline) with follow-up in May-June 2022, employing an anonymous online questionnaire. Study participants were first-time mothers (n = 204) of children aged 5–8 months. Measures considered basic attributes, family environment, maternal depression (Edinburgh Postnatal Depression Scale [EPDS]), screen time, and sleep status. No baseline maternal depression (EPDS score < 9) was a requirement for participation. Maternal depression onset during a 1.5-year follow-up was the dependent variable. Screen time, sleep duration, and support services were independent variables. Their relationships were analyzed using Fisher’s exact test, the Mantel-Haenszel test, and logistic regression. Twenty-six participants (12.7%) developed depression (EPDS ≥ 9) within two years of childbirth. Logistic regression revealed a significant association between smartphone use time and maternal depression (odds ratio [OR] = 1.89; 95% confidence interval [CI], 1.09–3.26). No association was found between social media or game use and maternal depression. Excessive smartphone use was related to depression two years after childbirth, indicating the need for health guidance on screen time for mothers.This work was supported by JST SPRING (Grant Number JPMJSP2125).departmental bulletin pape
The role of cardiopulmonary baroreflex on sympathetic vasomotor outflow and blood pressure regulation during dynamic exercise
No full textPrecise cardiovascular adjustments are necessary to meet the metabolic demands of working skeletal muscle during dynamic exercise. Appropriate regulation of sympathetic vasomotor outflow is key for maintaining arterial blood pressure (ABP) and facilitating the delivery of blood flow to active skeletal muscle. Central command, the exercise pressor reflex (including mechanoreflex and metaboreflex within skeletal muscle), and the arterial baroreflex work in concert, creating complex interactions that regulate sympathetic vasomotor outflow during dynamic exercise. Although less well studied, limited evidence suggests that the cardiopulmonary baroreflex plays a significant role in modulating MSNA (muscle sympathetic nerve activity) and ABP responses during mild-intensity dynamic exercise, as well as in resetting the arterial baroreflex during dynamic exercise. This review provides an updated and comprehensive overview of the sympathetic vasomotor outflow and the ABP response during dynamic exercise via the cardiopulmonary baroreflex.journal articl
Rh(III)-Catalyzed Oxidant-Free Dehydrogenative Mizoroki–Heck-Type Reaction: Identification of Off-Cycle Processes Potentially Limiting Catalytic Turnover
No full textThe Rh(III)-catalyzed dehydrogenative Mizoroki–Heck-type reaction (DMHR) has been extensively studied owing to its diverse synthetic applications. This transformation generally requires stoichiometric amounts of an external oxidant, H2 acceptor, or internal oxidizing group for efficient catalytic turnover. By contrast, the oxidant-free DMHR involving the release of H2 gas is an ideal method for minimizing waste; however, it remains underdeveloped. Here, we investigated the Rh(III)-catalyzed DMHR of 4-amino-2-quinolones under oxidant-free conditions. A combined experimental and computational study revealed that an off-cycle resting species, formed via the migratory insertion of an alkenylation product into a rhodium hydride species, was involved in the inhibition of catalytic turnover. The highly efficient oxidant-free DMHR of 4-amino-2-quinolones was achieved by excluding the coupling product from the reaction system to suppress the formation of the off-cycle resting species. Furthermore, we revisited the Rh(III)-catalyzed DMHR of aromatic substrates bearing different types of directing groups and demonstrated that substrates bearing representative directing groups such as amides, carbamates, carboxylic acids, 1-naphthol, indoles, pyridines, pyrimidines, and pyrazoles underwent alkenylation in the absence of an oxidizing agent.journal articl
JPCOARと名古屋大学の研究用メタデータマッピングプロジェクトでの協働について
Get PDFジャパン・オープンサイエンス・サミット2025（Japan Open Science Summit 2025、JOSS2025）(2025年6月23日～2025年6月27日、国立情報学研究所/ハイブリッド）、「F1 研究データをより見つけやすくするためのメタデータ変換と学術機関リポジトリへの登録」セッション発表資料conference outpu
Construction of Nitrogen-Containing Three-Dimensional Frameworks via Formation and Cycloaddition of endo-Cyclic Azomethine Ylide
No full textTriggered by the reaction of an oxime ether with a rhodium carbenoid, nitrogen-containing three-dimensional frameworks were constructed from linear motifs via the intramolecular cycloaddition of endo-cyclic azomethine ylide. In this transformation, successive stereocenters containing quaternary carbons were formed, affording the corresponding tricyclic compounds in moderate-to-good yields. The utility of these products was demonstrated through several transformations.journal articl
