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改訂版カスタマー・リーダシップ尺度の開発と妥当性検証
Get PDFThis study builds on the concept of customer leadership developed by Chang and Inuzuka (2024), extending its applicability beyond the original context of hair-making service. Drawing on the original scale items, a revised customer leadership scale was developed and tested across five distinct service types: hair-making, tour guiding, medical treatment, private tutoring, and retail rental services. The results consistently supported the presence of three underlying factors--delegation, guidance, and relationship building--across all service types. Moreover, these factors were found to positively influence perceived support, thereby demonstrating the nomological validity of the scale. These findings suggest that the concept of customer leadership is robust and generalizable across a wide range of service contexts.departmental bulletin pape
Effects of KRAS, STK11, KEAP1, and TP53 mutations on the clinical outcomes of immune checkpoint inhibitors among patients with lung adenocarcinoma
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Long-term systemic androgen deprivation partially modulates neuroinflammation in male : AppNL-G-F/NL-G-F mice
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Fertilizer Subsidies, Technical Efficiency, and Agricultural Transformation in Tanzania
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All-In-One Magnetic Nanoparticles for Thermo-Immunotherapy of Malignant Melanoma
No full textHyperthermia using magnetic nanoparticles is a promising cancer therapy that locally destroys tumors and induces antitumor immunity by releasing tumor antigens from dying cells. However, magnetic hyperthermia in malignant melanomas with poor immunogenicity and an immunosuppressive microenvironment remains challenging. Here, all-in-one magnetic nanoparticles (αPD-L1/CpG@MCL) are developed for thermo-immunotherapy that enables hyperthermia with magnetic nanoparticles and immunotherapy with anti-PD-L1 antibody and CpG to improve the immunosuppressive tumor microenvironment. Magnetic hyperthermia with magnetite cationic liposomes (MCL, without anti-PD-L1 antibody and CpG) inhibits tumor growth in B16F10 melanoma; however, complete tumor regression is not observed. In contrast, complete tumor regression is observed when mice are treated with thermo-immunotherapy using αPD-L1/CpG@MCL. Additionally, mice cured after magnetic hyperthermia with αPD-L1/CpG@MCL rejected rechallenge with B16F10 cells, and cytotoxicity assay using splenocytes from cured mice shows the induction of antitumor immunity against B16F10 cells. Analysis of tumor-infiltrating lymphocytes reveals that magnetic hyperthermia with αPD-L1/CpG@MCL increased CD8+ T lymphocytes and M1-like macrophages, and decreased M2-like macrophages, indicating an improvement in the tumor microenvironment. This study provides a key design strategy for all-in-one magnetic nanoparticles that could cure malignant melanomas.journal articl