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Table S1. Hydrographic data and size-fractionated Fe speciation data in this study.
Get PDFYoshiko Kondo, Rise Bamba, Hajime Obata, Jun Nishioka, Shigenobu Takeda. Size-fractionated natural organic Fe-binding ligands in the eastern and western subarctic Pacific
前歯のen-mass牽引時に最適な矯正力とM/Fを生じるシンプルで新しいクロージングループデザイン
No full text長崎大学学位論文 [学位記番号]博（医歯薬）甲第1276号 [学位授与年月日]令和2年9月2
Trypanosoma bruceiのASCT/SCSサイクルによるATPと酢酸産生
No full text長崎大学学位論文 [学位記番号]博（医歯薬）甲第1283号 [学位授与年月日]令和2年9月18
不顕性リーシュマニア症の罹患率と危険因子:システマティックレビューとメタアナリシス
No full text長崎大学学位論文 [学位記番号]博（医歯薬）甲第1294号 [学位授与年月日]令和2年12月2
Actual study on community core formation utilizing a vacant house
Get PDFThe study is aimed to know that a vacant house in Sakamoto, Nagasaki city, renovated to event space can be a chance to regional revitalization. To renovate this vacant house took 10 months. The cost was suppressed by self-renovation as much as possible. The way to advertise for events in region is to use SNS through the
questionaire survey. And it is important to renovate other parts where it's not over yet
A Study on Difference of Residence Intention by Population Composition of Residential Districts
Get PDFWe analyzed basic attributes such as age and birth, reasons for selecting housing and housing site, problems, and intentions of living depending on the type of population pyramid. As a result, diversity
was seen in types that were considered to have a well -balanced population. However, the well-balanced population and the high intention of permanent residence did not coexist
Novel Reporter System Monitoring IL-18 Specific Signaling Can Be Applied to High-Throughput Screening
Get PDFVery recently, the immunotherapies against cancer, autoimmune diseases, and infection have been feasible and promising. Thus, we have examined the possibility whether or not human gamma delta T cells can be applied for the novel immunotherapies. We previously established the cells stably maintaining NFkB-driven human secreted embryonic alkaline phosphatase (SEAP) expression. The cells can be used to determine the transcription activity of NFkB with high-standard dynamic range and accuracy. Because IL-18 is a kind of cytokines that enhances cytotoxicity and activity of human gamma delta T cells through NFkB activation, we have focused on the activity and signaling of IL-18. In this study, we modified the previous reporter cell that can determine the transcription activity of NFkB to express two subunits consisted of human IL-18 receptor. The modified cells secreted SEAP in response to treatment with human recombinant IL-18 in a concentration-dependent manner. We also observed the concentration-dependently enhancement of NFkB activity in the cells treated with mouse recombinant IL-18 although the affinity was lower compared to human recombinant IL-18. We also previously established the cells stably expressing and secreting human recombinant IL-18 and then validated whether or not the conditioned medium from the cells activate NFkB transcription activity using this assay. Our university has kept collecting many extracts from over 18,000 marine bacteria in our local sea around Omura bay-fungi, plants for Chinese herbal medicine, and so on-and also have kept gathering synthetic compounds from many Japanese chemists as drug libraries. Finally, in order to identify drugs mimicking IL-18 biological activity or possessing inhibitory effects on IL-18-induced NFkB, we demonstrated drug screening using number of extracts derived from marine bacteria and synthetic compounds
Study protocol for efficacy and safety of steroid-containing mouthwash to prevent chemotherapy-induced stomatitis in women with breast cancer: a multicentre, open-label, randomised phase 2 study
Get PDFINTRODUCTION: Stomatitis is a frequent adverse event in patients undergoing chemotherapy for breast cancer. Stomatitis can hamper oral nutrition resulting in malnutrition, reduce quality of life and introduce the need for dose reductions and interruption of chemotherapy; however, there is currently no standard approach for preventing chemotherapy-induced stomatitis. We aimed to assess the safety and efficacy of a dexamethasone-based elixir mouthwash for preventing chemotherapy-induced stomatitis in patients with early breast cancer. METHODS AND ANALYSIS: In this multicenter, randomised, controlled phase 2 trial, we will randomly assign 120 women with early breast cancer undergoing chemotherapy to use of a dexamethasone-based elixir or standard oral care, to compare their preventive effects on chemotherapy-induced stomatitis. Patients will be assigned in a 1:1 ratio. Patients in the intervention group will receive chemotherapy, oral care and a dexamethasone-based elixir (10 mL 0.1 mg/mL; swish for 2 min and spit, four times daily for 9 weeks), and patients in the control group will receive chemotherapy and oral care. The primary endpoint is the difference in incidence of stomatitis between the two groups. The sample size allows for the detection of a minimum difference of 20% in the incidence of stomatitis between the two groups. Secondary endpoints are severity of stomatitis, duration of stomatitis, completion rate of chemotherapy and adverse events. ETHICS AND DISSEMINATION: All participants signed a written consent form, and the study protocol has been reviewed and approved by the Clinical Research Review Board of Nagasaki University (CRB7180001). TRIAL REGISTRATION NUMBER: UMIN Clinical Trials Registry (UMIN000030489)