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Alternative forms of assessment in mathematical modelling:The AlPMo projekt in practice and research
No full textDas Projekt AlPMo (Alternative Prüfungsformen beim mathematischen Modellieren) untersucht den Einsatz digitaler Portfolios als alternative Prüfungsform im Mathematikunterricht. Die Publikation stellt sowohl die schulpraktische Umsetzung einer Unterrichtseinheit mit Modellierungsaufgaben als auch die hochschuldidaktische Integration in ein Seminar für Lehramtsstudierende vor. Ziel ist es, Modellierungskompetenzen ganzheitlich zu erfassen und innovative Wege der Leistungsbewertung zu erproben. Ergänzend werden begleitende wissenschaftliche Studien beschrieben, die die Wirksamkeit
des Seminarkonzepts, die Perspektiven von Lehrkräften und Lernenden sowie Einflussfaktoren auf die Portfolio-Note analysieren.The AlPMo Project (in German: Alternative Prüfungsformen beim mathematischen Modellieren) investigates the use of digital portfolios as an alternative form of assessment in mathematics modelling education. The publication presents both the practical implementation of a teaching unit with modelling tasks in schools and the integration of the concept into a university seminar for pre-service teachers. The aim is to comprehensively assess modelling competencies and to explore innovative methods of performance evaluation. In addition, accompanying scientific studies are described that analyze the effectiveness of the seminar concept, the perspectives of teachers and learners, and factors influencing the portfolio grade
A 5-min paradigm to evoke robust emotional reactivity in neuroimaging studies
No full textThe advent of the Research Domain Criteria (RDoC) approach to funding translational neuroscience has highlighted a need for research that includes measures across multiple task types. However, the duration of any given experiment is quite limited, particularly in neuroimaging contexts, and therefore robust estimates of multiple behavioral domains are often difficult to achieve. Here we offer a “turn-key” emotion-evoking paradigm suitable for neuroimaging experiments that demonstrates strong effect sizes across widespread cortical and subcortical structures. This short series could be easily added to existing fMRI protocols, and yield a reliable estimate of emotional reactivity to complement research in other behavioral domains. This experimental adjunct could be used to enable an initial comparison of emotional modulation with the primary behavioral focus of an investigator’s work, and potentially identify new relationships between domains of behavior that have not previously been recognized
Computed tomography hypoperfusion-hypodensity mismatch vs. automated perfusion mismatch to identify stroke patients eligible for thrombolysis
No full textBackground and purpose: Automated perfusion imaging can detect stroke patients with unknown time of symptom onset who are eligible for thrombolysis. However, the availability of this technique is limited. We, therefore, established the novel concept of computed tomography (CT) hypoperfusion-hypodensity mismatch, i.e., an ischemic core lesion visible on cerebral perfusion CT without visible hypodensity in the corresponding native cerebral CT. We compared both methods regarding their accuracy in identifying patients suitable for thrombolysis. Methods: In a retrospective analysis of the MissPerfeCT observational cohort study, patients were classified as suitable or not for thrombolysis based on established time window and imaging criteria. We calculated predictive values for hypoperfusion-hypodensity mismatch and automated perfusion imaging to compare accuracy in the identification of patients suitable for thrombolysis. Results: Of 247 patients, 219 (88.7%) were eligible for thrombolysis and 28 (11.3%) were not eligible for thrombolysis. Of 197 patients who were within 4.5 h of symptom onset, 190 (96.4%) were identified by hypoperfusion-hypodensity mismatch and 88 (44.7%) by automated perfusion mismatch (p < 0.001). Of 22 patients who were beyond 4.5 h of symptom onset but were eligible for thrombolysis, 5 patients (22.7%) were identified by hypoperfusion-hypodensity mismatch. Predictive values for the hypoperfusion-hypodensity mismatch vs. automated perfusion mismatch were as follows: sensitivity, 89.0% vs. 50.2%; specificity, 71.4% vs. 100.0%; positive predictive value, 96.1% vs. 100.0%; and negative predictive value, 45.5% vs. 20.4%.
Conclusion: The novel method of hypoperfusion-hypodensity mismatch can identify patients suitable for thrombolysis with higher sensitivity and lower specificity than established techniques. Using this simple method might therefore increase the proportion of patients treated with thrombolysis without the use of special automated software. The MissPerfeCT study is a retrospective observational multicenter cohort study and is registered with clinicaltrials.gov (NCT04277728)
Development of a soft X-ray spectrometer for fluorescence photons emitted during laser cooling at SIS100 and of a fast high voltage divider for CRYRING@ESR
No full textDiese Arbeit behandelt Experimente mit hochgeladenen relativistischen Ionen am GSI Helmholtzzentrum und an der FAIR-Anlage mit dem SIS100. Im ersten Teil wird das Laser-Cooling-Projekt vorgestellt, in dessen Rahmen ein Spektrometer für Fluoreszenzstrahlung im weichen Röntgenbereich entwickelt wurde. Mithilfe dieses Systems lässt sich die Ionengeschwindigkeit über die Wellenlänge der Photonen rekonstruieren und der Kühlprozess überwachen. Zusätzlich wird eine Laserkühl-Teststrahlzeit am ESR mit 12C3+-Ionen beschrieben, bei der der Einsatz gepulster Laser zum Laserkühlen demonstriert wurde. Im zweiten Teil wird die Arbeit an dem schnellen Hochspannungsteiler FC20 beschrieben, der zur exakten Bestimmung der Elektronenenergie im CRYRING dient. Diese Energie ist entscheidend für die Kühlung und für Experimente zur dielektrischen Rekombination. Bei Spannungsmessungen während einer Strahlzeit mit Ne3+-Ionen konnte eine Genauigkeit von unter 5,8 ppm innerhalb von 10 ms erreicht werden.This thesis focuses on experiments involving highly charged relativistic ions conducted at the GSI Helmholtz Centre and the FAIR facility with the SIS100. The first part presents the laser cooling project, for which a fluorescence photon spectrometer operating in the soft X-ray range was developed. This system can be used to reconstruct the ion velocity via the wavelength of the photons and to monitor the cooling process. In addition, a laser cooling test beam time at the ESR with 12C3+ ions is described, during which the use of pulsed lasers for laser cooling was demonstrated. The second part describes the work on the fast high-voltage divider FC20, which is used to precisely determine the electron energy in the CRYRING. This energy is crucial for cooling and for experiments on dielectric recombination. Voltage measurements performed during a beam time with Ne3+ ions achieved an accuracy of less than 5.8 ppm within 10 ms
De toekomst van de wereld begint in Europa:30 Jaar Haus der Niederlande
No full textAls Hauptredner trug Robert Menasse diesen Text beim Festakt zum 30-jährigen Bestehen des Hauses der Niederlande am 15. Mai 2025 in der Stadtbücherei Münster vor. Im Haus der Niederlande sind seit 1995 die drei Einrichtungen der Universität Münster untergebracht, die sich mit dem niederländischen Sprach- und Kulturraum beschäftigen: das Institut für Niederländische Philologie (INP), das Zentrum für Niederlande-Studien (ZNS) und die Bibliothek im Haus der Niederlande (BHN). Gemeinsam haben diese drei Institute das Haus in den letzten 30 Jahren als einen Ort der universitären Lehre und Forschung sowie des grenzüberschreitenden Austausches etablieren können. Es ist der Ort an dem Deutsche, Niederländer, Belgier und andere über die Gestaltung der gemeinsamen Zukunft in Europa nachdenken und diskutieren
Digitalisierungen in Schule und Bildung als gesamtgesellschaftliche Herausforderung:Perspektiven zwischen Wissenschaft, Praxis und Recht
No full textDigitalisierung ist ohne Zweifel eines der bestimmenden Zukunftsthemen der frühen 2020er-Jahre und als solches sowohl gesamtgesellschaftlich als auch für die am Bildungswesen beteiligten Akteur*innen von hoher praktischer Relevanz. Der Sammelband verbindet Beiträge aus Erziehungswissenschaft und Bildungsforschung, Schulpraxis, Recht und Bildungspolitik. Ziel ist es, eine Orientierung zu Fragen der Digitalisierung(en) sowie deren Implikationen im schulischen Kontext anhand der schulgestalterischen Bereiche Organisationsentwicklung, Unterrichtsentwicklung und Personalentwicklung zu geben. Dabei zeigen wissenschaftliche Beiträge aktuelle Diskurs- und Forschungslinien auf; Fokusbeiträge werfen kaleidoskopartige Schlaglichter auf virulente Themenfelder jenseits des Diskurses (wie z. B. ethische Fragen im Umgang mit Algorithmen)
Employer attractiveness in the Chemical Industry: Investigating the impact of product novelty, product relevance, and work meaningfulness
No full textWhile research on employer attractiveness has traditionally focused on external employer branding, less is known about what attracts employees to stay. This study examines how product-related factors—specifically perceived novelty and societal relevance—relate to internal employer attractiveness, and whether these relationships are mediated by meaningful work. We develop and test a mediation model using two-wave survey data from 138 employees of a global chemical company. Results show that
perceived product novelty has a significant positive relationship with employer attractiveness, partially mediated by meaningful work. Perceived product relevance, however, does not show a direct relationship, but an indirect one via meaningful work. These results highlight that perceived product characteristics - beyond traditional HR instruments - can contribute to how employees evaluate their employer. The study extends the internal employer branding literature by integrating product-driven perceptions and meaningfulness into the understanding of organizational attractiveness
Engineering of a chitin deacetylase to generate tailor-made chitosan polymers
No full textChitin deacetylases (CDAs) emerge as a valuable tool to produce chitosans with a nonrandom distribution of N-acetylglucosamine (GlcNAc) and glucosamine (GlcN) units. We hypothesized before that CDAs tend to bind certain sequences within the substrate matching their subsite preferences for either GlcNAc or GlcN units. Thus, they deacetylate or N-acetylate their substrates at nonrandom positions. To understand the molecular basis of these preferences, we analyzed the binding site of a CDA from Pestalotiopsis sp. (PesCDA) using a detailed activity screening of a site-saturation mutagenesis library. In addition, molecular dynamics simulations were conducted to get an in-depth view of crucial interactions along the binding site. Besides elucidating the function of several amino acids, we were able to show that only 3 residues are responsible for the highly specific binding of PesCDA to oligomeric substrates. The preference to bind a GlcNAc unit at subsite −2 and −1 can mainly be attributed to N75 and H199, respectively. Whereas an exchange of N75 at subsite −2 eliminates enzyme activity, H199 can be substituted with tyrosine to increase the GlcN acceptance at subsite −1. This change in substrate preference not only increases enzyme activity on certain substrates and changes composition of oligomeric products but also significantly changes the pattern of acetylation (PA) when N-acetylating polyglucosamine. Consequently, we could clearly show how subsite preferences influence the PA of chitosans produced with CDAs
