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Transformation of 5-chloro- and 5-bromo-2-cyanopyridine to amides and iminonitriles at the Mo(IV) center
No full textThe reaction of complex with 5-chloro-2-cyanopyridine (5cl2py) and 5-bromo-2-cyanopyridine (5br2py), results in isolation of 4 new compounds, which were characterized by single X-ray crystal structure measurements, elemental analyses, IR and UV-Vis spectroscopy methods. Dimeric complex with the formula was isolated for the first time. The exchange of cyanido ligands for bidentate organic ligands, in this type of complexes, is largely pH dependent. Careful control of the reaction environment made it possible to obtain a modified organic ligand in which the nitrile group was hydrolyzed to the amide group (pH ca 8), or transformed, due to presence of cyanides in solution, to imino(5-chloropyridin-2-yl)acetonitrile (5cl2pya) or imino(5-bromopyridin-2-yl)acetonitrile (5br2pya), respectively. Two complexes with the formulas and (pH ca 10) were isolated. In these compounds, the 5cl2pya (or 5br2pya) was coordinated to the metal center as N,N-donating ligand, in which the modification of the nitrile group is discussed in detail in the paper
Factor VIIa - antithrombin complexes are increased in asthma : relation to the exacerbation-prone asthma phenotype
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Fingernail onychomycosis : a laboratory-based retrospective study with species profiling and antifungal susceptibility of yeasts
No full textClinical and anatomical perspective of the meningohypophyseal trunk : a comprehensive review
No full textConsolidative thoracic radiotherapy in the immunotherapy era for extensive-stage small cell lung cancer : a systematic review and meta-analysis with emphasis on brain and liver metastases
No full textChanges in the structure and thermal properties of feather keratin induced by L-Cys extraction followed by enzymatic hydrolysis
No full textFeather waste was valorised into bioactive peptides by extracting high-purity L-Cys–urea solution, followed by enzymatic hydrolysis with commercial proteases selected for their catalytic efficiency. The extraction reduced the α-helix content in favor of the β-sheet leading to less ordered crystal structures as ATR FT-IR and the XRD analyses revealed. These structural changes decreased keratin's thermal stability, resulting in its slower yet more gradual decomposition, as TGA and DSC results showed. The hydrolysis with trypsin, chymotrypsin, pepsin and subtilisin altered the secondary structure and thermal stability of extracted keratin, with changes depending on enzyme specificity. All hydrolysates showed the preserved amide features but reduced α-helix and β-sheet content and crystallinity. Subtilisin induced the most profound structural and molecular transformations, including the secondary structure loss, carboxylate group formation, and short peptide fragment generation, resulting in reduced structural order but enhanced thermal stability attributed to the stabilizing effect of sodium carboxylates
Polysaccharide derivatives-based nanotheranostics for selective interactions with specific types of cancer cells
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