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Accuracy of Dexcom One+ in patients with diabetes or stress hyperglycemia hospitalized in cardiac intensive care unit
No full textAcute kidney injury in the course of tubulointerstitial nephritis related to novel oral anticoagulants
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Effect of the porosity of the palladium shell in Au-core Pd-shell bimetallic nanoparticles for the radiosensitizing properties in simulated anticancer proton radiotherapy
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Stroke mechanism and severity after left atrial appendage occlusion : insights from the LAAOS III randomized clinical trial
No full textDistribution of gunshot residue particles of a submachine gun fired at cotton fabric from the nearest vicinity : a study by means of SEM-EDX technique
No full textChemical and bioactivity profiling of extractives from tropical wood residues : Ipe, Merbau, and Jatoba
No full textNovel amphiphilic copolymers as stabilizers for glyceryl monooleate-based lipid–polymer hybrid nanoparticles
No full textAmphiphilic copolymers represent a primary class of stabilizers for lipid–polymer hybrid nanoparticles. Among them, lyotropic liquid crystalline nanoparticles (LLCNPs) have some significant advantages, such as controlled release, targeted delivery and protection of active compounds, towards their use as potential carriers of active substances or drugs. The aim of this work is to study a series of linear amphiphilic block copolymers for stabilization of glyceryl monooleate [1-(cis-9-octadecenoyl)-rac-glycerol]-based lipid–polymer hybrid nanoparticles. For this purpose, poly(ethylene glycol)-b-poly(benzyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate), poly(ethylene glycol)-b-poly(9,9-dimethyl-2,4,8,10-tetraoxaspiro[5.5] undecan-3-one), and poly(ethylene glycol)-b-poly(trimethylene carbonate) were synthesized using anionic ring opening polymerization and poly[oligo(ethylene glycol) methacrylate]-b-poly(ethyl methacrylate) was synthesized by atom transfer radical polymerization. The chemical structures of copolymers were confirmed by , while the molar masses were determined by SEC measurements. Lipid–polymer nanosystems were prepared by the top-down method. Their physicochemical and morphological characteristics were assessed through dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), fast Fourier transform (FFT) analysis and microcalorimetry (mDSC). Varying the molar ratios of GMO to copolymers resulted in nanoparticles with different sizes and internal organization, with these properties being influenced by the type of hydrophobic block used in the copolymer, as can be expected and observed for other LLCNPs stabilized with amphiphilic block copolymers. This study introduces a broader group of amphiphilic polymeric stabilizers for the development of LLCNPs and highlights how variations in copolymer composition affect the structural characteristics and properties of emerging nanosystems