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Does understanding others help children to be more social and less lonely? : relations among theory of mind, social skills and loneliness
No full textWe examined longitudinal (three waves across two years) relationships among advanced theory of mind (AToM), social skills and loneliness in young children, while controlling for verbal abilities, executive functions, and parents’ education level. At T1, 750 typically developing primary-school-age children (340 boys and 410 girls; Mage at T1 = 7.44 years, SD = 0.50) participated in the study. Across the sample, AToM abilities developed over time, but social skills and levels of loneliness remained stable. The cross-lagged relationships revealed that early social skills were linked with later AToM. However, these associations diminished over time, particularly from the second to the third grade. In contrast, loneliness did not show significant cross-lagged effects on either social skills or AToM in later grades. Among girls, earlier social skills were a systematic predictor of later AToM skills and loneliness, whereas among boys, only social skills at T1 were a predictor of AToM and loneliness at T2 while AToM at T1 was a predictor of social skills at T2. We regard social skills as the most important element in the analysed relationships, and recommend that enhancement of children’s social skills be continuously encouraged
Mechanistic modelling of lidocaine and prilocaine absorption from EMLA cream upon topical application using physiologically based pharmacokinetic modelling
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How water models influence the interfacial organization of oxysterol epimers : a comparative simulation study using TIP3P and OPC
No full textPosterior pole of dermapteran oocytes houses a single aggregate of organelles reminiscent of endolysosomal vesicular assemblies described in mouse oocytes
No full textOocytes of derived dermapterans (the Eudermaptera), in addition to “conventional” organelles, i.e. mitochondria, elements of endoplasmic reticulum, Golgi complexes, lysosome-like bodies and reserve materials (yolk spheres, lipid droplets), contain unexpectedly rich set of noncanonical organelles. It includes assemblies of endoplasmic reticulum and fine granular "nuage" material, ribosome-associated vesicles, and extensive arrays of parallel arranged endoplasmic reticulum cisternae. During vitellogenesis (yolk formation), all lysosome-like bodies are gradually translocated towards the posterior oocyte pole, where they form relatively large, morphologically distinct compartment that we termed the posterior pole lysosomal compartment. This compartment is not surrounded by a limiting membrane and stains positively with Proteostat, a dye used to detect proteins implicated in the formation of biomolecular condensates. In the light of these results, we hypothesize that posterior pole lysosomal compartment is reminiscent of endolysosomal vesicular assembly/ies participating in the sequestration/degradation of aggregated proteins in mammalian oocytes
Retrospective multicenter study on childhood kaposiform hemangioendothelioma (2007-2024) : report of the Section of Childhood Vascular Anomalies of the Polish Society of Pediatric Oncology and Hematology
No full textPost-infection and post-vaccination anti-COVID-19 antibody levels in relation to physical condition
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