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Pain interference in maintenance hemodialysis: a single-center cross-sectional study using the Pain Effects Scale (PES)
No full textChanges in the gill and gut microbiota of koi infected with carp edema virus
No full textCarp edema virus (CEV) is a contagious pathogen affecting mostly the gills of common carp (Cyprinus carpio) and impairing the functions of this organ. Moreover, CEV was reported to cause stress activation and modulation of the hosts immune system. Last but not least, secondary bacterial infections often occur during CEV infection. In this study, we assessed the impact of CEV infection on the microbiota in the gills, foregut, and hindgut of koi. Moreover, we studied expression of genes encoding antiviral proteins, proinflammatory cytokines, mucins, and tight junction proteins. We observed increased levels of cortisol and glucose in the blood plasma of CEV-infected fish, suggesting activation of stress response. Histopathological analysis of the gills showed occlusion of the intralamellar space with the presence of apoptotic cells in CEV-infected fish, while in the gut only minor histopathological changes were recorded. Microbiota of the gills was significantly altered during infection with increased absolute abundance of several bacteria genera, including opportunistic bacteria e.g. Chryseobacterium, Flavobacteria, Aeromonas, and Pseudomonas. In the foregut, we did not observe changes in the absolute bacterial abundance between control and CEV-infected fish, while in the hindgut only absolute abundance of Aeoromonas was increased in infected fish. Moreover, CEV infection differentially altered expression of studied genes, including for example upregulation of expression of mxa, vig, il-1b, and cldn 7 in studied organs. Our study explores the effect of CEV infection on the host microbiota, which may partly explain the occurrence of secondary bacterial infections during infection with this virus
No full textThe microbial cell wall is a dynamic structure responsible for maintaining the shape and integrity of the cell. It is involved in the processes of cell growth, reproduction and division, protection against environmental stress factors, bidirectional selective transport of various molecules, and interactions with other microorganisms inhabiting a particular ecological niche. The cell surface of microorganisms pathogenic to humans is also responsible for constant and direct contact with the host during the initiation and further development of the infection, and proteins exposed on the surface play a key role in this phenomenon. The set of proteins exposed on the cell surface is collectively referred to as the surfaceome. In surfaceome studies, the cell surface shaving technique is increasingly used while maintaining cell integrity, which, in addition to providing insight into the composition of surface proteins, also makes it possible to track the interactions of pathogen molecules with host molecules. This experimental approach will be described in this review with examples of the most relevant groups of identified microbial proteins involved in the host–pathogen interactions
cIPMA : an R package for combined importance-performance map analysis
No full textCombined importance–performance map analysis (cIPMA) extends partial least squares structural equation modeling (PLS-SEM) by integrating importance as sufficiency estimates with bottleneck diagnostics necessity thresholds from Necessary Condition Analysis (NCA). While conceptually powerful, the current workflow for cIPMA is fragmented, typically requiring commercial software, manual data rescaling, and external spreadsheet transformation and visualization, which increase the risk of human error and reduce reproducibility. This article introduces cIPMA, an open-source R package that automates the complete cIPMA workflow on top of seminr for PLS-SEM and NCA for necessary condition analysis. The package implements the rescaling and weighting procedures required for importance–performance maps, calls NCA’s CE-FDH ceiling technique to obtain necessity effect sizes and bottleneck tables, and provides publication-ready visualization. Using the cIPMA package, researchers can perform a full cIPMA analysis in a single reproducible script and reduce the likelihood of specification and transcription errors. The package provides a transparent, open-source implementation that enables researchers to explore the interplay between probabilistic sufficiency and necessity logics in behavioral research while adhering to the established methodological requirements of cIPMA
The psychiatric comorbidities in adolescents with atopic dermatitis : a real-world study of propensity-matched cohorts
No full textDoes Poland need compulsory military service?
No full text2 lutego 2026 r. na na platformie internetowej radiokrakow.pl i antenie PR KRAKÓW z rekomendacji UJ ukazał się kolejny wywiad z prof. dr. hab. Dariuszem Kozerawskim, pracownikiem naukowym Katedry Bezpieczeństwa Narodowego (Instytut Nauk Politycznych i Stosunków Międzynarodowych, Wydział Studiów Międzynarodowych i Politycznych) Uniwersytetu Jagiellońskiego, w którym ujęte zostały między innymi opinie dotyczące: kwalifikacji wojskowej prowadzonej w Polsce, która daje wiedzę ewidencyjną, ale nie buduje realnych zdolności obronnych państwa; konieczności wprowadzenia powszechnego szkolenia wojskowego ze względu na brak wystarczającej liczby wyszkolonych rezerwistów; możliwości skorzystania z rozwiązań i doświadczeń organizacyjnych Finlandii i Ukrainy, które potwierdzają kluczowe znaczenie obowiązkowej służby wojskowej oraz konieczności skoncentrowania wysiłków władz RP nad budowaniem realnych zasobów wojskowych rezerw osobowych oraz rozwijaniem struktur dowodzenia.On February 2, 2026, on the online platform radiokrakow.pl and on PR Kraków, another interview with Professor Dariusz Kozerawski, a researcher at the Department of National Security (Institute of Political Science and International Relations, Faculty of International and Political Studies) of the Jagiellonian University, was published on the Jagiellonian University's radiokrakow.pl website and radio station PR Kraków. His interview included, among other things, opinions on: the military qualifications conducted in Poland, which provide evidence-based knowledge but do not build the country's real defense capabilities; the need to introduce universal military training due to the lack of a sufficient number of trained reservists; the possibility of drawing on the organizational solutions and experiences of Finland and Ukraine, which confirm the crucial importance of compulsory military service; and the need for the Polish authorities to focus their efforts on building real military reserve resources and developing command structures
Europe must learn to defend itself : Prof. Kozerawski on NATO and Trump's words
No full text27 stycznia 2026 r. na antenie Radia Kraków oraz na platformie internetowej radiokrakow.pl z rekomendacji UJ ukazał się kolejny wywiad z prof. dr. hab. Dariuszem Kozerawskim, pracownikiem naukowym Katedry Bezpieczeństwa Narodowego (Instytut Nauk Politycznych i Stosunków Międzynarodowych, Wydział Studiów Międzynarodowych i Politycznych) Uniwersytetu Jagiellońskiego, w którym ujęte zostały między innymi opinie dotyczące: interpretacji słów Donalda Trumpa o zaangażowaniu sojuszników z NATO w operacje stabilizacyjne USA w Iraku i Afganistanie „gdzieś z tyłu”; znaczenia więzi transatlantyckich i tego dlaczego nie wolno traktować ich jak politycznej transakcji; faktycznego znaczenia artykułu 5. Traktatu Waszyngtońskiego i tego dlaczego jego uruchomienie nie było i nie jest automatyczne; wpływu nowej Strategii Bezpieczeństwa Narodowego USA na potrzebę budowania prze Europę własnego systemu dowodzenia i większej samodzielności obronnej; konieczności zmiany przekonania w Europie i Polsce, że „NATO nas obroni”, i potrzeby realnego budowania zdolności obronnych i odporności całego społeczeństwa.On January 27, 2026, on Radio Kraków and on the online platform radiokrakow.pl, another interview with Prof. Dr. hab. Dariusz Kozerawski, a researcher at the Department of National Security (Institute of Political Science and International Relations, Faculty of International and Political Studies) of the Jagiellonian University, was published at the recommendation of the Jagiellonian University. The interview included, among other things, opinions on: the interpretation of Donald Trump's words about NATO allies' involvement in US stabilization operations in Iraq and Afghanistan "somewhere behind the scenes"; the importance of transatlantic ties and why they should not be treated as a political transaction; the actual significance of Article 5 of the Washington Treaty and why its activation was not and is not automatic; the impact of the new US National Security Strategy on Europe's need to build its own command system and greater defense independence; the need to change the belief in Europe and Poland that "NATO will defend us", and the need to actually build defense capabilities and the resilience of the entire society
