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Występowanie i zmienność niedosłuchu pseudopercepcyjnego w schorzeniach ucha środkowego
Full text link"Similar to legal companies" : vendor brands and other aspects of marketing communication in the darknet drug trade
Full text linkThe darknet or illicit online drug trade has expanded significantly in recent years. Vendors’ marketing communication strategies remain underexplored,however, as researchers focus on well-identified methods such as product quality, delivery times, or stealth shipping techniques. This study aims to show the multifaceted nature of sellers’ marketing practices on the dark web, including nonstandard approaches such as discounts, free samples, sales,contests, and lotteries. The article presents a case study of Cebulka, the largest Polish-language darknet market, using qualitative content analysis, natural language processing, descriptive statistics, and in-depth interviews. On Cebulka, vendors build relationships with buyers and maintain their trust through "marketing as promise management," which includes feedback and review systems. The multi-method research approach reveals the nuanced nature of marketing on darknet platforms, drawing parallels and distinctions with traditional drug marketing. Additionally, this study contributes to understanding the darknet drug trade within the context of local markets, another underexplored topic
Biogenesis of Au nanoparticles from plant-derived metabolites - <i>in vitro</i> and <i>in vivo</i> studies
No full textBiomimetic gold nanoparticles (Au NPs) were synthesized via a sustainable approach without any additional toxic chemical reagents and fully characterized. It was proven that only whole aqueous extracts of Rosa damascene (RD) and Rosa rugosa (RR) are powerful enough to reduce, graft, and stabilize metallic nanostructures, resulting in the formation of stable, monodisperse nanocolloids (Au@RD NPs and Au@RR NPs) whereas individual constituent molecules were insufficient to yield stable metal NPs. The biological study conducted, both in vitro and in vivo, revealed no acute cytotoxicity (in HaCaT cell lines and zebrafish larval models) but bacteriostatic activity at equivalent doses with potent inhibition of biofilm formation (for a MRSA strain). Noteworthy, the additive antibacterial activity of rose extracts when combined with rifampicin promotes that these attractive inorganic–organic hybrids could be suitable alternatives to combat the acquisition of antimicrobial resistance. This huge application potential was also emphasized by the presence of insignificant changes in the expression of pro-inflammatory cytokine genes (IL-1β, IL-6, and CXCL8) and apoptotic/autophagic associated genes (TP53, MAP1LC3B, and SQSTM1) in treated HaCaT cells at antimicrobial doses. In addition, at the studied doses, the survival of Danio rerio larvae and their proper development (i.e., lack of deformities) endorsed biocompatibility in vivo
Study of the effect of tyrosine kinase inhibitors on vascular endothelial function in mice in vivo
No full textDemonstration of in vitro-in vivo relationship (IVIVR) and virtual bioequivalence (VBE) between progesterone intravaginal rings using physiologically based pharmacokinetic (PBPK) modelling
No full textAn international, expert-based, multispecialty Delphi Consensus document on stroke risk stratification and the optimal management of patients with asymptomatic and symptomatic carotid stenosis
No full textSafety and efficacy of 6% hydroxyethyl starch in patients undergoing major surgery : the randomised controlled PHOENICS trial
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