137262 research outputs found
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Nuovi moduli di sicurezza integrata. Il controllo delle attività produttive e commerciali
No full textI servizi di verifica presso le attività commerciali e produttive, svolti dalle Forze di Polizia a competenza sia nazionale che locale nell’ottica di
un effettivo contrasto all’immigrazione irregolare ed allo sfruttamento della manodopera clandestina, garantiscono significativi margini di
efficacia nella misura in cui si attui un intervento multifattoriale capace di coinvolgere tutti i soggetti a vario titolo deputati al contrasto delle
illegalità in question
Le sfide di INSITE
No full text“INSITE” Integrated Shared Knowledge from Geo-Paleontological Heritage to Present Territorial Challenges è un progetto di ricerca di rilievo nazionale (PRIN) finanziato nel 2022 dal Ministero dell’Università e della Ricerca (MUR). Il progetto è stato sviluppato dalla unità di ricerca del DICEA (capofila) dell’Università degli Studi di Napoli Federico II, coordinata da R.A. La Rocca e dall’unità di ricerca del DST dell’Università degli Studi del Sannio di Benevento, coordinata da F.O. Amore. Questo gruppo di lavoro ha lavorato in costante sinergia nell’affrontare il tema della rigenerazione territoriale, ponendosi l’obiettivo di esplorare strategie e metodologie per valorizzare un patrimonio culturale che sembrava essere ad esclusivo uso di esperti del settore, assegnando alla pianificazione territoriale un ruolo guida per una governance integrata.
Il volume raccoglie i contributi presentati in occasione del convegno “Le sfide di INSITE”, presso La Scuola Politecnica e delle Scienze di Base dell’Università di Napoli Federico II. L’occasione del convegno è parsa opportuna per operare un ulteriore confronto e provare a trarre alcune prime conclusioni sulla possibilità di trasformare il patrimonio geopaleontologico da semplice eredità passiva a risorsa attiva e propulsiva di qualità della vita e attrattività territorial
Metafisiche del riflusso. Campanella personaggio in Fortezza
No full textIl saggio ricostruisce il rapporto di Giovanni Giudici con l'opera di Tommaso Campanella, soffermandosi in particolare sulla sezione conclusiva della raccolta "Fortezza", con richiami puntuali ai testi e ai materiali d'archivio conservati presso il Fondo d'autore del Centro Apice di Milano
Inteligencia artificial e innovación didáctica universitaria: aplicaciones, experiencias y perspectivas pedagógicas
No full textImpact of changes in diabetes care models and advanced technologies on two-year glycemic control after COVID-19 lockdown in adults with Type 1 Diabetes
No full textAims: The COVID-19 pandemic led to significant shifts in lifestyle and clinical management for individuals with Type 1 Diabetes (T1D) that, during the COVID-19 lockdown, showed an improved glycemic control, characterized by increased time-in-range (TIR) and reduced glucose variability. This study aimed to assess the long-term trends and factors influencing glycemic control over two years post-lockdown in adults with T1D. Methods: A longitudinal study was conducted on 207 adults with T1D (mean age 38 ± 13 years), with 50.2% using multiple daily insulin injections and 49.8% on continuous subcutaneous insulin infusion. Continuous glucose monitoring (CGM) metrics-including TIR, time-above-range (TAR); time-below-range (TBR), and coefficient of variation (CV)- were assessed before, during, and at 6, 12, and 24 months post-lockdown. Participants also completed an online questionnaire evaluating lifestyle habits before, during, and one year after lockdown. Results: The glycemic improvements observed during lockdown persisted for two years. TIR 70-180 mg/dl remained significantly higher, while TAR > 250 mg/dl and TBR < 54 mg/dl were significantly lower at all post-lockdown time points (p < 0.05 for all). These improvements were not attributed to lifestyle changes, which remained relatively stable one year after lockdown. Telemedicine was implemented being the prevalent model of care during this period. Notably, the improvement in glycemic control concerned the participants transitioning to advanced insulin delivery systems during the two-year observational period (p < 0.001). Conclusions: Glycemic control improvements in adults with T1D were sustained for two years post-lockdown and related to transitioning to more advanced insulin delivery systems
Novel cardiovascular metabolic risk factor mechanisms and therapeutic opportunities
No full text: Metabolic disorders such as obesity, type 2 diabetes, and dyslipidaemia are major drivers of cardiovascular risk and have reached epidemic levels in Western populations. Recent advances in clinical research have uncovered unexpected and often beneficial effects of pharmacological classes of metabolic drugs on cardiovascular outcomes, revealing complex interactions between metabolism and cardiac pathology. Despite their clinical efficacy, the molecular and cellular mechanisms through which many of these agents act remain only partially understood. This gap in knowledge underscores the urgent need for fundamental research that not only dissects the biology of metabolic disorders and cardiovascular disease but also reveals the mechanistic basis of existing and emerging therapies, thereby enabling rational therapeutic development. This scientific statement, developed by researchers from the European Society of Cardiology (ESC) Council on Basic Cardiovascular Science and several ESC Working Groups, provides a state-of-the-art overview of the emerging molecular and cellular pathways linking metabolic abnormalities with vascular and cardiac disease. By illuminating these critical connections and unresolved questions, this article aims to catalyse innovation in the prevention and management of cardiovascular disease in the context of metabolic dysfunction and to suggest new directions for future research
Direttrice della Collana “Diritto e Religioni” edita dalla Luigi Pellegrini Editore, Cosenza.
No full textBrain organoids as models of extracellular vesicle–mediated human neural communication
No full text: Cellular communication orchestrates human brain development through complex interactions involving adhesion molecules, signaling ligands, extracellular matrix, and extracellular vesicles. While intrinsic genetic programs governing neural differentiation are well characterized, the roles of extrinsic, non-cell-autonomous signaling, particularly extracellularmediated communication, remain poorly understood. Here, we review recent advances in three-dimensional brain organoids derived from human pluripotent stem cells as physiologically relevant models that recapitulate key aspects of human neurodevelopment, enabling detailed study of extracellular vesicle-mediated intracellular signaling. We highlight how organoid systems facilitate the investigation of extracellular vesicle cargo dynamics and their influence on neural cell fate, migration, and circuit assembly, as well as their involvement in neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases. These insights show the potential of brain organoids to unravel complex cellular interactions and inform biomarkers discovery and therapeutic strategies for neurological diseases
Exploring Workers’ Experience in Public Administrations: Intergenerational Relations and Change as Difficulties and Potential
No full textBackground: In a context of profound transformationwithin PublicAdministration, the growing generational diversity of the workforce poses critical challenges to organisational wellbeing. While ageism is a known risk, the intersectionality of age and gender—manifesting as gendered ageism—remains an under-explored area that can significantly undermine job satisfaction and employee health. Objective: This study aimed to explore the subjective work experience of public sector employees, specifically focusing on intergenerational relations and the impact of gendered ageism. Methods: A qualitative study was conducted involving 30 employees of the Italian Public Administration, recruited via purposive sampling. Data were collected through semi-structured interviews lasting approximately 38 min and analysed using a thematic analysis of elementary contexts via T-Lab software. Results: The analysis revealed four distinct thematic clusters positioned along two main factor axes (Individual/Organisation and Difficulties/Potential). The results show a dichotomy: while positive relationships with colleagues (Cluster 1) and the drive for change (Cluster 4) act as potential resources, the experience is marred by significant difficulties. These include organisational imbalances (Cluster 3) and, crucially, specific experiences of gendered ageism (Cluster 2), manifesting as stereotypes, pressure on women’s physical appearance, and exclusionary dynamics. Conclusions: The findings highlight that gendered ageism is a distinct stressor impacting workforce sustainability. Combating intersectional discrimination represents a strategic priority to safeguard well-being, retain skills, and build a healthy, resilient, and productive working environment
ASAH2 deficiency affects sphingolipid homeostasis and neuromotor control, causing a progressive neurological disorder
No full text: Sphingolipids are integral components of cell membranes and modulate cell survival, proliferation, and apoptosis. ASAH2 is a brain- and gut-enriched gene encoding the neutral N-acylsphingosine amidohydrolase 2, a poorly characterized member of the human ceramidase family. This enzyme plays a pivotal role in maintaining the sphingolipid homeostasis, which is crucial for neurogenesis and synaptic function in central and peripheral nervous system. In fact, a dysregulated sphingolipid metabolism is associated with progressive neurological conditions, including Alzheimer's disease and Parkinson's disease. Here, we report the identification of biallelic ASAH2 variants in an individual with a neurodevelopmental condition featuring cognitive impairment, neuropathy, ophthalmoplegia, and progressive cerebellar and extraocular muscles atrophy. Through exome sequencing, we identified very rare missense ASAH2 variants, predicted to be deleterious by in silico analyses. Muscle biopsy histopathologic evaluation revealed features suggestive of neuropathic damage. Lipidomic profiling revealed a hyper-accumulation of glucosylceramide in the subject's cells. Then, the functional investigation of the ASAH2 variants in Drosophila showed the production of an unstable protein and consistent loss-of-function neuromotor phenotypes. Our findings support ASAH2 as a candidate gene for a previously uncharacterized neurodevelopmental disorder with neuropathic features and progressive cerebellar atrophy, underscoring the important role of this ceramidase in human nervous system