19826 research outputs found
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The Rediscovery of Ma Sicong's Cello Concerto in A: A Scholarly Performance Edition
No full textThesis (DM) – Indiana University, Music, 202
Notes on Geometry: Incidences
No full textLecture Notes about incidence geometry suitable for an undergraduate clas
Personal, Social, and Historical Applications of the Family Photo Archive
No full textFamily photographs can aid in memory recall and have personal value, but the historical and social information that can be found in them is just as invaluable
The Influence of Parental Money Management on Children’s Financial Literacy Development
No full textWinner of the "Chancellor's Award for Achievement for an Oral Presentation"Have you ever wondered how your parents’ money management affected yours? This research project aims to explore how parental money management influences financial literacy skills in children. In addition to a review of selected scholarly literature, an original survey was conducted to measure the impacts of parental money management on children’s financial literacy skills. Preliminary findings show that parental money management has both positive and negative impacts. For instance, good parental money management modeling leads to good financial literacy in their children, and vice versa
What Are You Afraid Of?: Examining Student Fears with Money to Better Inform Curriculum Development
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EVALUATING PHOSPHATIDYLINOSITIDE AS LIPID BIOMARKERS FOR HYPERGLYCEMIA-RELATED TRIPLE-NEGATIVE BREAST CANCER AGGRESSIVENESS
No full textThesis (M.S.) - Indiana University, Department of Biochemistry and Molecular Biology, 2025Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, marked by limited treatment options and poor patient outcomes. Clinical and epidemiological studies suggest that systemic metabolic conditions, particularly high blood glucose associated with Type 2 Diabetes, may worsen TNBC progression. However, there are no current biomarker for detecting TNBC, especially in hyperglycemic patients.
This thesis investigates how elevated glucose levels influence TNBC behavior and whether lipid signaling molecules at the cell membrane, known as phosphatidylinositol lipids (PIs), can serve as biomarkers of disease progression. To address this, we combined functional assays that measure key cancer traits, including cell migration, attachment to the extracellular matrix (ECM), and cell accumulation, with lipidomic analyses of cell membranes under normal and high-glucose conditions.
Our findings demonstrate that hyperglycemia enhances aggressive traits in TNBC cells, promoting increased movement and growth, but no effect on ECM attachment. In parallel, lipid profiling revealed alterations in PI molecules that regulate growth and survival pathways, with differences observed across cell models. These results highlight a direct connection between metabolic stress and cancer progression. By linking systemic metabolic dysregulation to cell signaling in TNBC, this work identifies PI4P, PI(4,5)P2 and PIP3 lipids as potential biomarkers and points toward new strategies for risk stratification and therapeutic intervention
