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LONG-TERM SURVIVAL OF THE FIRST BIOLOGIC TREATMENT IN PSORIATIC ARTHRITIS AND THE EFFECT OF THE SELECTED TREATMENT ON DRUG SURVIVAL; TURKBIO REGISTRY
No full textAnnual European Congress of Rheumatology (EULAR) -- JUN 03, 2020 -- ELECTR NETWORKAkkoc, Nurullah/0000-0002-3718-171XWOS: 000555905003497[No abstract available
Evidence-based Practices in the Prevention of Central Venous Catheter Infections: Knowledge of Intensive Care Nurses
No full textWOS: 000540039600005Objective: This study aimed to determine the knowledge level of intensive care nurses regarding evidence-based practices in the prevention of infections related to the Central Venous Catheter (CVC). Materials and Methods: This descriptive study was conducted in the adult intensive care units of a research and practice hospital and a private hospital in September-November 2018. the written consent of the participants and the approval of the ethics committee and necessary institutions were obtained. in data collection, a "data collection form regarding the demographic features of the participants" and "information form oriented to preventing infections regarding CVC" were used. Results: the study was completed with 126 nurses, 52.4% of whom were aged 19-28 and 50.0% had been working in intensive care units for 1-38 months. Their knowledge regarding the prevention of CVC-related infections was low. the total mean scores of nurses aged 29-43 were statistically significantly higher than those aged 19-28 (p=0.045). the total mean scores of the nurses who had worked as a nurse for 7-24 years were statistically significantly higher than those who had worked for 1-6 years (p=0.003), and the total mean scores of the nurses who had worked as intensive care unit nurses for 40-288 months were statistically significantly higher than those who had worked for 1-38 months (p<0.001). Conclusion: This study found that nurses had a low level of knowledge regarding evidence-based practices in the prevention of CVC-related infections, and as age and experience of working as a nurse in intensive care units increased, knowledge levels also increased
Does low body mass index constitute a risk of damage to the soft tissues during reaming for proximal femoral nailing? a cadaveric study
No full textPubMed: 32458128Background: the purpose of this cadaveric study was to evaluate the damage to the gluteus medius muscle, tendon and superior gluteal nerve in low BMI patients during the reaming of the greater trochanter tip for proximal femoral nailing. Materials and methods: the study used 19 femurs of 10 fresh femur intact cadavers [mean BMI: 22.79 (17.60–28.70)]. A guidewire was placed in the tip of greater trochanter under C-arm fluoroscopy, and a 17-mm reamer was advanced over the wire. After the reaming was completed, the hips were dissected and the gluteus medius muscle, tendon and superior gluteal nerve were inspected to evaluate the amount of injury. Results: BMI was < 18.50 in 3 cadavers. the gluteus medius muscle was injured in all hips. the superior gluteal nerve was intact in all hips, but the thickness of gluteus medius muscle mass that remained intact was thicker in the cadavers with a higher BMI (3.86 mm for low BMI, 9.08 mm for high BMI group). the percentage of the tendon insertion disrupted by the reamer was an average of 36.20% in the low BMI group and an average of 26.93% in the high BMI group. the percentage of the tendon insertion disrupted by the reamer showed a statistically significant difference between low and high BMI cadavers. Conclusion: the injury to the gluteus medius muscle and tendon after proximal femoral nailing through the greater trochanter tip may be higher in patients with low BMI. It must be kept in mind that gluteal muscle could be damaged during proximal femoral nailing and this could result in limping. © 2020, Springer-Verlag France SAS, part of Springer Nature.None of the authors of this manuscript received funding, grants, or in-kind support in support of this research or the preparation of this manuscript. the authors have no financial relationships with any company. Each author certifies that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article
A novel id-iri score: development and internal validation of the multivariable community acquired sepsis clinical risk prediction model
No full textEl-Sokkary, Rehab/0000-0002-8135-7671; Uysal, Serhat/0000-0002-4294-5999WOS: 000520706000011PubMed: 31823148We aimed to develop a scoring system for predicting in-hospital mortality of community-acquired (CA) sepsis patients. This was a prospective, observational multicenter study performed to analyze CA sepsis among adult patients through ID-IRI (Infectious Diseases International Research Initiative) at 32 centers in 10 countries between December 1, 2015, and May 15, 2016. After baseline evaluation, we used univariate analysis at the second and logistic regression analysis at the third phase. in this prospective observational study, data of 373 cases with CA sepsis or septic shock were submitted from 32 referral centers in 10 countries. the median age was 68 (51-77) years, and 174 (46,6%) of the patients were females. the median hospitalization time of the patients was 15 (10-21) days. Overall mortality rate due to CA sepsis was 17.7% (n = 66). the possible predictors which have strong correlation and the variables that cause collinearity are acute oliguria, altered consciousness, persistent hypotension, fever, serum creatinine, age, and serum total protein. CAS (%) is a new scoring system and works in accordance with the parameters in third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). the system has yielded successful results in terms of predicting mortality in CA sepsis patients
Outcomes of Carotid Sparing Radiotherapy For Early Stage Glottic Cancer: Turkish Society For Radiation Oncology Group (TROD) Retrospective Study
No full text62nd Annual Meeting of the American-Society-for-Radiation-Oncology (ASTRO) -- OCT 25-28, 2020 -- ELECTR NETWORKWOS: 000582521502657[No abstract available]Amer Soc Radiat Onco
A familial Mediterranean fever patient with double homozygous mutations treated with anakinra after kidney transplantation
No full textsevinc, mustafa/0000-0003-2804-4884; Hasbal, Nuri Baris/0000-0002-2229-5140WOS: 000581011100010PubMed: 31201047[No abstract available
The cerebral blood flow deficits in Parkinson's disease with mild cognitive impairment using arterial spin labeling MRI
No full textYildirim, Zerrin/0000-0002-5128-1784; Eryurek, Kardelen/0000-0003-0482-3963; Gurvit, Hakan/0000-0003-2908-8475; Arslan, Dilek Betul/0000-0002-1124-3695WOS: 000545915200001PubMed: 32632889Parkinson's disease (PD) with mild cognitive impairment (PD-MCI) is currently diagnosed based on an arbitrarily predefined standard deviation of neuropsychological test scores, and more objective biomarkers for PD-MCI diagnosis are needed. the purpose of this study was to define possible brain perfusion-based biomarkers of not only mild cognitive impairment, but also risky gene carriers in PD using arterial spin labeling magnetic resonance imaging (ASL-MRI). Fifteen healthy controls (HC), 26 cognitively normal PD (PD-CN), and 27 PD-MCI subjects participated in this study. ASL-MRI data were acquired by signal targeting with alternating radio-frequency labeling with Look-Locker sequence at 3 T. Single nucleotide polymorphism genotyping for rs9468 [microtubule-associated protein tau (MAPT) H1/H1 versus H1/H2 haplotype] was performed using a Stratagene Mx3005p real-time polymerase chain-reaction system (Agilent Technologies, USA). There were 15 subjects withMAPTH1/H1 and 11 subjects withMAPTH1/H2 within PD-MCI, and 33 subjects withMAPTH1/H1 and 19 subjects withMAPTH1/H2 within all PD. Voxel-wise differences of cerebral blood flow (CBF) values between HC, PD-CN and PD-MCI were assessed by one-way analysis of variance followed by pairwise post hoc comparisons. Further, the subgroup of PD patients carrying the riskyMAPTH1/H1 haplotype was compared with noncarriers (MAPTH1/H2 haplotype) in terms of CBF by a two-samplettest. A pattern that could be summarized as "posterior hypoperfusion" (PH) differentiated the PD-MCI group from the HC group with an accuracy of 92.6% (sensitivity = 93%, specificity = 93%). Additionally, the PD patients withMAPTH1/H1 haplotype had decreased perfusion than the ones with H1/H2 haplotype at the posterior areas of the visual network (VN), default mode network (DMN), and dorsal attention network (DAN). the PH-type pattern in ASL-MRI could be employed as a biomarker of both current cognitive impairment and future cognitive decline in PD.Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [1001, 115S219]; Istanbul University Scientific Research Projects Unit Project [1567/42362]This study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) 1001 Grant #115S219 and Istanbul University Scientific Research Projects Unit Project #1567/42362
Erken Dönem Uyumsuz Şemaları ile Savunma Düzenekleri Arasındaki İlişkilerin Çocukluk Çağı Travmaları Açısından İncelenmesi
No full textAmaç: Çalışmanın amacı savunma düzenekleri ve erken dönem uyumsuz şemalar arasındaki ilişkilerin çocukluk çağı travmaları açısından incelenmesidir. Yöntem: Çalışmaya, İstanbul’daki çeşitli vakıf üniversitelerinden 308 kadın ve 192 erkek öğrenci olmak üzere 500 öğrenci alınmıştır. Katılımcılara Demografik Bilgi Formu, Savunma Biçimleri Testi, Young Şema Ölçeği Kısa Formu-3 ve Çocukluk Çağı Travmaları Ölçeği uygulanmıştır. Sonuçlar: Bu çalışmada Savunma düzenekleri, erken dönem uyumsuz şemalar ve çocukluk çağı travmaları arasında anlamlı ilişkiler bulunmuştur. Travma deneyimi olup-olmama durumunun, savunma düzenekleri ve erken dönem uyumsuz şemaların oluşumu üzerinde istatistiksel açıdan anlamlı bir etkisi olduğu bulunmuştur. Tartışma: Çocukluk çağı travmalarının psikoterapisinde savunma düzenekleri ve erken dönem uyumsuz şemaların incelenmesi faydalı olacaktır. (Anadolu Psikiyatri Derg 2020; 21(3):237-244
Long Term Outcomes of Freestyle Stentless Aortic Bioprosthesis: A Single Center Experience
No full textEZELSOY, MEHMET/0000-0002-8423-5071WOS: 000518864700007PubMed: 32118540Background: the study is presenting our long-term clinical results after freestyle stentless aortic root bioprosthesis replacement in patients with severe aortic insufficiency with ascending aortic aneurysm. Methods: Seventy-seven patients with ascending aortic aneurysms and aortic valve insufficiency underwent a total root replacement procedure using a stentless "Freestyle" valve (Medtronic Inc., Minneapolis, Minnesota). There were 50 (64.9%) men and 27 (35.1%) women. Mean age was 68.7 +/- 11.1 years. the surgical procedure used a complete root replacement. Concomitant procedures included coronary artery bypass grafting in 15 (19.5%) patients. Results: the mean cardiopulmonary bypass time was 130.3 +/- 26.4 minutes and total aortic cross clamp time was 99.5 +/- 23.6 minutes. Hospital mortality was 2.6%. the median follow-up time was 11.2 years. the 5- and 10-years freedom from aortic valve reoperation were 97.4 +/- 1.2% and 93.4 +/- 4.9%, respectively. During 10 years follow up, there were 14 late deaths; 4 deaths were cardiac, and 10 deaths were noncardiac. Valve-related deaths were attributable to thromboembolism in 1 patient, endocarditis in 2 patients, and congestive heart failure in 1 patient. Conclusion: the freestyle stentless aortic root bioprosthesis offered good clinical outcomes, in terms of survival and structural valve deterioration. the Freestyle valve is a viable option for use in patients undergoing bioprosthetic aortic valve replacement and expected desire for long-term durability
Mode of delivery does not have a relationship with high-risk HPV positivity
No full textWOS: 000560762700016Objective: This study aims to evaluate the delivery room data for patients who give birth with standard vaginal delivery and caesarean section (C/S), to estimate whether high-risk (HR) HPV status affected the mode of delivery. Methods: Between January 2014 and January 2018, 8,376 pregnant women gave birth in our hospital. of 8,376 patients, 1,039 pregnant women were aged 30 years and older and had HPV results known. They had a singleton pregnancy and no contraindications for standard delivery. Results: C/S rates for all HR HPV groups were lower than for all HPV-negative groups. However, no statistically significant difference was found between HR HPV-positive and HPV-negative patients for C/S rates got all 987 patients (18.75% vs. 24.39%) (p = 0.463), 245 primiparous patients (50.0% vs. 59.83%) (p = 0.629) and 742 multiparous patients (11.53% vs. 12.56%) (p = 0.876). Conclusion: HR HPV positivity does not affect normal vaginal labour progress and does not statistically increase C/S rates at the labour ward. Therefore, HR HPV positivity should not be regarded as a negative risk factor for normal vaginal labour progress