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Hashimoto Tiroiditinde Görsel Uyandırılmış Potansiyeller
No full textObjective: Hashimoto’s thyroiditis (HT) is an autoimmune disease in which neurological involvement is not uncommon. This study aimed to explore the presence of visual evoked potential (VEP) changes as an indicator of subclinical central nervous system involvement in euthyroid HT patients without obvious neurologic findings. Methods: Thirty HT patients with normal neurological examination and thirty healthy controls were included. VEPs were recorded by using pattern?reversing black and white checkerboard with monocular testing. P100, N75 and N135 (ms) peak latencies, and P100 amplitudes of right (R) and left (L) eyes in each group were compared. Results: There was no significant difference between the groups for age. The mean of the P100 (R: 108.13±4.3, L: 108.2±4.4 ms), N75 (R: 79.23±6.03, L: 80.2±5.78 ms) and N135 (R: 141.8±11.2, L: 142.4±10.2 ms) latencies, and the P100 amplitude (R: 6.71±4.16, L: 6.6±3.9 µV) in the HT group were not significantly different from P100 (R: 107.2±3.8, L: 107.7±4.36 ms), N75 (R: 79.9±5.5, L: 78.9±6.17 ms), N135 (R: 140.3±8.4, L: 141.9±9.7 ms) latencies and P100 amplitude (R: 8.20±3.32, L: 6.9±2.9 µV) in the control group. Also, there was no significant correlation between P100 latencies and thyroid specific antibody levels in the HT group. Conclusion: This result may be due to the fact that HT does not significantly affect the optic nerve and visual pathways, or that VEP is an inadequate technique to demonstrate possible involvement.Amaç: Hashimoto tiroiditi (HT), nörolojik tutulumun eşlik edebildiği otoimmün bir hastalıktır. Söz konusu tutulumun ötiroid hastalarda subklinik olarak ortaya çıkabileceği öne sürülmektedir. Bu çalışmada, objektif nörolojik bulgusu olmayan ötiroid HT hastalarında merkezi sinir sisteminin (MSS) olası tutulumunun bir göstergesi olarak, görsel uyarılmış potansiyellerdeki (VEP) değişikliklerin varlığı incelenmiştir. Yöntemler: Nörolojik muayenesi normal olan 30 HT ve 30 sağlıklı kontrol çalışmaya dahil edilmiştir. VEP kaydı dama taşı “patern reversal” kullanılarak yapılmış, her iki grubun, sağ ve sol göz P100, N75 ve N135 dalgalarının tepe latansları ve P100 amplitüd değerleri karşılaştırılmıştır. Bulgular: Gruplar arasında yaş açısından anlamlı fark bulunmamıştır. Dahil etme kriterlerine uygun erkek hasta mevcut olmadığından, kontrol grubu da sadece kadınlardan oluşturulmuştur. HT grubunun P100 (R: 108.13±4.3, L: 108.2±4.4 ms), N75 (R: 79.23±6.03, L: 80.2±5.78 ms), N135 (R: 141.8±11.2, L: 142.4±10.2 ms) tepe latansları ve P100 amplitüdü (R: 6.71± 4.16, L: 6.6±3.9 µV) ile kontrol grubunun P100 (R: 107.2±3.8, L: 107.7±4.36 ms), N75 (R: 79.9±5.5, L: 78.9±6.17 ms), N135 (R: 140.3±8.4, L: 141.9±9.7 ms) tepe latansları ve P100 amplitüdü (R: 8.20±3.32, L: 6.9±2,9 µV) arasında anlamlı fark bulunmamıştır. Tiroid spesifik antikorlar ile P100 tepe latansları arasında da anlamlı bir korelasyon saptanmamıştır. Sonuç: HT ve kontrol gruplarına ait VEP değerleri arasında anlamlı bir fark bulunmamasının, HT’nin optik sinir ve görsel yolakları belirgin şekilde etkilememesinden, yahut VEP tekniğinin hastalardaki olası MSS tutulumunu göstermede yeterli hassasiyete sahip olmamasından kaynaklanıyor olabileceği düşünülmüştür
RISK FACTORS, MANAGEMENT AND INPATIENT OUTCOMES OF PNEUMONIA AFTER ACUTE STROKE
No full textWOS:000587365200311[No Abstract Available]0037
Comparison of the effects of intraoperative morphine, fentanyl or paracetamol administration on postoperative pain level and analgesic consumption in patients with synchronous intraoprative remifentanil infusion
No full textObjective: We aimed to compare the effects of morphine, fentanyl or paracetamol applied for anesthesia induction and at the end of the surgery for postoperative pain control and analgesic consumption in patients who have undergone pelvic and lower abdominal surgery. Material and Methods: Patients with the American Society of Anesthesiologists (ASA) score I-II and aged between 18-70 years were given intravenous remifentanil intraoperatively. Fentanyl was administered in doses of 1.5 mcg / kg during anesthesia induction and 10 min before the end of the surgery. In fentanyl group, morphine was administered in doses of 0.1 mg / kg during induction and 0.5 mg/kg 30 min before the end of the surgery and paracetamol was administered in doses of 10 mg/kg during induction and 5 mg/kg 30 min before the end of the surgery. Morphine was administered for patient-controlled analgesia. Results: The mean verbal pain scores of the paracetamol group were significantly higher when compared to the pain scores of the other groups at the 0, 1, 2, 3, 4, 8, 12, and 16 hours (p <0.01 , p = 0.02). Postoperative morphine consumption in the paracetamol group was significantly higher (p = 0.02). Conclusion: The addition of intraoperative paracetamol to the remifentanil infusion, may not be sufficient in postoperative analgesia in gynecologic cancer surgery
'Trifecta' outcomes of robot-assisted partial nephrectomy: Results of the 'low volume' surgeon
No full textReis, AlessanRSS/0000-0001-8486-7469WOS: 000560788000006PubMed: 32822123Objective: There is limited data regarding surgeon volume and partial nephrectomy outcomes. the aim of this study is to report trifecta outcomes of robot-assisted partial nephrectomy (RAPN) performed by the low volume surgeon. Materials and Methods: Thirty-nine patients with clinical T1-2 renal tumors who underwent RAPN between 2012 and 2018 were included in this study. Trifecta was defined as negative surgical margins, warm ischemia time <= 20 minutes, and no operative complications. Patient demographics, R.E.N.A.L. nephrometry score, operation time, estimated blood loss, warm ischemia time, length of hospital stay, renal functions, and oncological outcomes were analyzed retrospectively. Complications were graded based on the modified Clavien-Dindo classification system. Results: the median R.E.N.A.L. nephrometry score was 6 (4-10). RAPN was successfully performed in all but one patient. the median operation time was 180 (90-240) minutes. Warm ischemia was performed only by segmental renal artery control in 35 and, by main renal artery control in three patients. the off-clamp technique was used in two patients. the median warm ischemia time was 16 (0-31) minutes. Seven patients had a warm ischemia time of longer than 20 minutes. Three patients had postoperative complications. the surgical margin was positive in one patient. As a result, the trifecta was achieved in 30 of the 39 patients (77 %). Conclusion: RAPN is a safe and effective minimally invasive alternative in the treatment of renal masses. the present study suggests that reasonable trifecta rates can be achieved even by low volume surgeons
Prevalence and Characteristics of Atrial Fibrillation in Turkish Patients Undergoing Hemodialysis
No full text34th National Congress of Nephrology -- OCT 18-22, 2017 -- Antalya, TURKEYHasbal, Nuri Baris/0000-0002-2229-5140WOS: 000547335800006Objective: Atrial fibrillation (AF) is one of the most common and cumulatively important cardiac arrhythmias. Prevalence of AF is much higher in patients with chronic kidney disease (may be up to 27%). We aimed to study the prevalence and clinical features of AF in hemodialysis centers. Materials and Methods: Patients who had been under chronic in-center hemodialysis for at least 6 months and were >= 18 years of age were included in this cross-sectional study conducted at five hemodialysis centers across Istanbul between May 2017 and July 2017. Medical history, clinical (including medications and echocardiography), and laboratory data were obtained using a standardized study form. Results: the data of 632 prevalent patients undergoing in-center hemodialysis (mean age 62.7 +/- 13.9 years, males 350 and females 282) were included in the analysis. AF was present in 92 (14.5%) of the patients. the prevalence of AF was lowest in patients = 2 or less. Conclusion: AF is highly prevalent in patients undergoing hemodialysis, and warfarin was used in nearly 5% of the patients with AF undergoing hemodialysis in this study, which suggests that the current knowledge is unconvincing to proceed for the treatment with anticoagulation. Further studies are needed to guide the management for prevention of strokes in patients with AF undergoing dialysis
Investigation of the biochemical and apoptotic changes in breast cancer cells treated with leaf extract from tea (Camellia sinensis L.) grown with added boric acid
No full textWOS: 000568991100001Tea obtained from the leaves of Camellia sinensis L., a medicinal plant, is a widely popular beverage. Deficiency in boron, a micronutrient for C. sinensis, affects the growth as well as the quality of tea. the aim of this study was to explore whether boric acid at various concentrations added to soil improves the quality of C. sinensis and also whether it changes the apoptotic, anti-proliferative, and anti-oxidative effects of C. sinensis leaf extract on breast cancer (MCF-7) cells. C. sinensis was grown in Rize-Turkey. Boric acid at concentrations of 100 (group B), 300 (group C), and 500 (group D) mg/m(2) in sodium tetraborate buffer was administered as a single dose to the soil; group A (no boric acid) was the control. Boron, glutathione (GSH), malondialdehyde and protein carbonyl levels in the C. sinensis leaves were measured. C. sinensis leaf extracts at different concentrations was applied to MCF-7 cells for 24 and 48h Cytotoxicity, proliferation, and apoptosis were examined. the highest TUNEL+ cell percentage was in MCF-7 cells treated with D group leaf extract compared to the control group (p<0.001 at concentrations of 2.3, 2.6 and 3mg/mL). Moreover, the GSH level increased in the MCF-7 cells under the same conditions (p<0.001 for each concentration). Leaf extracts from C. sinensis grown in soil with boric acid have more anti-proliferative, apoptotic and anti-oxidative effects on the MCF 7 cells.Scientific Research Projects Coordination Unit of Marmara UniversityMarmara University [FEN-A-040712-0277]This work was supported by the Scientific Research Projects Coordination Unit of Marmara University. Project No: FEN-A-040712-0277
Did Syrian refugees increase the rate of measles in Turkey?
No full textPubMed: 32442676[No abstract available
Quercetin-loaded nanoparticles enhance cytotoxicity and antioxidant activity on C6 glioma cells
No full textErdemir, Aysegul/0000-0002-6099-4903; Mansuroglu, Banu/0000-0001-8440-9118;WOS: 000524166500001PubMed: 32192406Quercetin (Qu) is a natural flavonoid present in many commonly consumed food items. the dietary phytochemical quercetin prevents tumor proliferation and is a potent therapeutic cancer agent. the purpose of this study was to synthesize and characterize quercetin-loaded poly(lactic-co-glycolic acid) nanoparticles (Qu(1)NP, Qu(2)NP, and Qu(3)NP) with different size and encapsulation properties and to evaluate their in vitro activity on C6 glioma cells. Nanoparticles were synthesized by single emulsion solvent evaporation method. Then, particle size, zeta potential, polydispersity index and encapsulation efficiency of nanoparticles were determined. Particle size of Qu(1)NP, Qu(2)NP, and Qu(3)NPs were determined as 215.2 +/- 6.2, 282.3 +/- 7.9, and 584.5 +/- 15.2 nm respectively. Treating C6 glioma cells with all nanoparticle formulations effectively inhibited the cell proliferation. Qu(1)NPs were showed the lowest IC50 value in 48 h with 29.9 mu g/ml and achieved higher cellular uptake among other nanoparticles and Qu. Additionally, 48-h treatment with Qu(1)NPs significantly decreased MDA level (14.90 nmol/mu g protein) on C6 glioma cells which is related to reduced oxidative stress in cells. Findings of this study revealed that quercetin's cellular uptake and anti-oxidant activity is improved by small-sized Qu(1)NPs in C6 glioma cells.Research Foundation of Yildiz Technical UniversityYildiz Technical University [FKG-2017-3067]This work was supported by the Research Foundation of Yildiz Technical University under Grant [FKG-2017-3067]
Intercontinental study on pre-engraftment and post-engraftment Gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: Risk factors and association with mortality
No full textPubMed: 33186673Objectives: We present here data on Gram-negative rods bacteremia (GNRB) rates, risk factors and associated mortality. Methods: Data on GNRB episodes were prospectively collected in 65 allo-/67 auto-HSCT centers in 24 countries (Europe, Asia, Australia). in patients with and without GNRB, we compared: demography, underlying disease, HSCT-related data, center` fluoroquinolone prophylaxis (FQP) policy and accreditation status, and involvement of infection control team (ICT). Results: the GNRB cumulative incidence among 2818 allo-HSCT was: pre-engraftment (pre-eng-allo-HSCT), 8.4 (95% CI 7–9%), post-engraftment (post-eng-allo-HSCT), 5.8% (95%CI: 5–7%); among 3152 auto-HSCT, pre-eng-auto-HSCT, 6.6% (95%CI: 6–7%), post-eng-auto-HSCT, 0.7% (95%CI: 0.4–1.1%). GNRB, especially MDR, was associated with increased mortality. Multivariate analysis revealed the following GNRB risk factors: (a) pre-eng-allo-HSCT: south-eastern Europe center location, underlying diseases not at complete remission, and cord blood source; (b) post-eng-allo-HSCT: center location not in northwestern Europe; underlying non-malignant disease, not providing FQP and never accredited. (c) pre-eng-auto-HSCT: older age, autoimmune and malignant (vs. plasma cell) disease, and ICT absence. Conclusions: Benefit of FQP should be explored in prospective studies. Increased GNRB risk in auto-HSCT patients transplanted for autoimmune diseases is worrying. Infection control and being accredited are possibly protective against bacteremia. GNRB are associated with increased mortality. © 2020 the British Infection AssociationGilead Sciences Meso Scale Diagnostics, MSDHA declares receiving a research grant from MSD; speaker grant from Gilead, MSD, Pfizer. Other co-authors have no conflicts of interest to declare relevant to this study
Papaverine Has Therapeutic Potential for Sepsis-Induced Neuropathy in Rats, Possibly via the Modulation of HMGB1-RAGE Axis and Its Antioxidant Prosperities
No full textWOS: 000562629900001PubMed: 32842806Aim Our aim was to investigate the possible neuroprotective properties of papaverine in sepsis-induced critical illness neuropathy (SCIN) through the evaluation of various inflammatory biochemical markers, including interleukin 6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-alpha), and oxidative stress biomarkers, such as malondialdehyde (MDA) and lactic acid. Additionally, evaluation of the HMGB1/RAGE interactions in SCIN was another target of this research. Method To create a sepsis model, a procedure involving intraperitoneal injection of feces was performed on 48 rats. the rats were divided into four equal groups: sham operated, controls and those receiving 20 and 40 mg/kg/day papaverine. After five-day treatments, compound muscle action potential (CMAPs) with electroneuromyography (ENMG) was recorded in all rats. Following ENMG evaluations, the plasma levels of sRAGE, HMGB1, TNF-alpha, IL-6, CRP, MDA and lactic acid were measured. Results TNF-alpha, CRP, IL-6, HMGB1, MDA, and lactic acid levels were significantly elevated in the SCIN group, and sRAGE levels were significantly decreased. in recipients of papaverine (20 and 40 mg/kg) treatment, these biochemical findings were improved. Furthermore, electrophysiological findings also showed significant improvement in both 20 and 40 mg/kg papaverine treated groups. Conclusion Papaverine demonstrates neuroprotective effects in a rat model of SCIN. Considering its anti-inflammatory and antioxidant properties, papaverine's neuroprotective effects possibly stem from the suppression of the RAGE-HMGB1 axis