4053 research outputs found
Sort by
Validity and reliability study of the turkish version of the eye care clinical competence questionnaire related to eye care of intensive care patients by nurses
No full textAim: This methodological study was conducted to determine the validity and reliability of the Turkish version of the Eye Care Clinical Competence Questionnaire, which evaluates the clinical competence of nurses regarding eye care in intensive care patients. Design: A methodological study. Methods: The study included 175 nurses working in the ICUs of the hospitals where the study was conducted. Results: Following factor analysis, based on the tetrachoric correlation matrix for the information sub-dimension, eight items were excluded from the questionnaire. As a result of the confirmatory factor analysis conducted for the questionnaire, the error variance value of item 26 was removed from the questionnaire. The final questionnaire adapted for the Turkish cultural context consisted of 26 items. Cronbach’s alpha value for the attitude sub-dimension was 0.87; the Cronbach alpha value for the application sub-dimension was 0.85, and the Cronbach alpha value for the questionnaire as a whole was 0.84. Conclusion: It was found that the Turkish version of the Eye Care Clinical Competence Questionnaire was a valid and reliable measurement tool. This measurement tool can be used in studies to evaluate the clinical competence of intensive care nurses regarding eye care. © 2021 Central European Journal of Nursing and Midwifery
UTERİN SERVİKAL LEİOMYOMU TAKLİT EDEN DEV EKSTRAVEZİKAL MESANE LEİOMYOMU: 8 YILLIK POSTOPERATİF TAKİBİ VE LİTERATÜRÜN GÖZDEN GEÇİRİLMESİ
No full textThe incidence of bladder leiomyoma is estimated at only 0.43% because most bladder tumors arise from the urothelium. Moreover, 30% of them are the extra-vesical type. The symptoms include urinary tract obstruction, bladder irritation, and dysuria, with the possibility of dyspareunia or hematuria depending on the size and location of the tumor. Bladder leiomyomas cannot be diagnosed solely by combining symptoms and imaging techniques. We present a rare case of giant sized extravesical-type bladder leiomyoma with a diameter of 15.5x14.5x14 cm, which was misdiagnosed as a uterine cervical leiomyoma. It caused unilateral ureteral distension without related symptoms. During the 8-year postoperative follow-up, the patient had two healthy full-term pregnancies and no recurrence was observed. We reviewed the literature of the most recent five years and discussed the characteristics of 22 bladder leiomyoma cases. Unlike the literature, the present case is unique due to the giant size of the bladder leiomyoma, its ureteral complications, and long follow-up period. Bladder leiomyomas are rare bladder tumors which should be borne in mind during the differential diagnosis of a pelvic mass. Surgical excision is the most useful procedure for diagnosis and treatment.Mesane leiomyomunun insidansı sadece %0,43 olarak tahmin edilmektedir; çünkü mesane tümörlerinin çoğu üroepitelyumdan kaynaklanmaktadır. Bunun yanı sıra, mesane leiomyomlarının sa?dece %30’u ekstra-vezikal tiptedir. Üriner sistem obstrüksiyonu, mesane irritasyonu, dizüri, disparoni veya hematüri gibi semp?tomlar kitlenin boyut ve yerine göre değişebilir. Yalnızca semp?tom ve görüntüleme tekniklerine dayanarak mesane leiomyomu tanısı konulamayabilmektedir. Preoperatif uterin servikal leiom?yom ön tanısı düşünülen, 15,5x14,5x14 cm çapında tek taraflı üreteral distansiyona yol açan, nadir görülen bir ekstravezikal tip mesane leiomyomu olgusunu sunuyoruz. Sekiz yıllık postope?ratif takip boyunca, hastanın iki sağlıklı term gebeliği mevcuttu ve nüks izlenmedi. Son beş yılın literatürü gözden geçirilerek 22 mesane leiomyomunun özellikleri sunuldu. Literatürden farklı olarak, mevcut olgu mesane leiomyomunun büyüklüğü, üreteral komplikasyonları ve uzun takip süresi ile benzersizdir. Mesane le?iomyomları, pelvik kitlenin ayırıcı tanısında göz önünde tutulması gereken, nadir görülen mesane tümörleridir. Tanı ve tedavi için en faydalı prosedür cerrahi eksizyondur
The effects of vitamin D (Vit D) replacement on pathological complete response ( PCR) in breast cancer (BC) patients receiving neoadjuvant systemic chemotherapy (NAC).
No full text[No Abstract Availale
New Oral AntiCoagulants Use in REnal Disease and AF (NOACURE-AF)- Where do we stand?: An expert consensus view using the Delphi method
No full text[No Abstract Availale]BayerBayer AGThe Delphi panel meeting from which this publication was derived was supported by Bayer
Prevalence and clinical/molecular characteristics of PTEN mutations in Turkish children with autism spectrum disorders and macrocephaly
No full textBackground: Phosphatase and tensin homolog (PTEN) germline mutations are associated with cancer syndromes (PTEN hamartoma tumor syndrome; PHTS) and in pediatric patients with autism spectrum disorder (ASD) and macrocephaly. The exact prevalence of PTEN mutations in patients with ASD and macrocephaly is uncertain; with prevalence rates ranging from 1% to 17%. Most studies are retrospective and contain more adult than pediatric patients, there is a need for more prospective pediatric studies. Methods: We recruited 131 patients (108 males, 23 females) with ASD and macrocephaly between the ages of 3 and 18 from five child and adolescent psychiatry clinics in Turkey from July 2018 to December 2019. We defined macrocephaly as occipito--frontal HC size at or greater than 2 standard deviations (SD) above the mean for age and sex on standard growth charts. PTEN gene sequence analysis was performed using a MiSeq next generation sequencing (NGS) platform, (Illumina). Conclusion: PTEN gene sequence analyses identified three pathogenic/likely pathogenic mutations [NM_000314.6; p.(Pro204Leu), (p.Arg233*) and novel (p.Tyr176Cys*8)] and two variants of uncertain significance (VUS) [NM_000314.6; p.(Ala79Thr) and c.*10del]. We also report that patient with (p.Tyr176Cys*8) mutation has Grade 1 hepatosteatosis, a phenotype not previously described. This is the first PTEN prevalence study of patients with ASD and macrocephaly in Turkey and South Eastern Europe region with a largest homogenous cohort. The prevalence of PTEN mutations was found 3.8% (VUS included) or 2.29% (VUS omitted). We recommend testing for PTEN mutations in all patients with ASD and macrocephaly.PTEN Research [IBU-17-001]PTEN Research, Grant/Award Number: IBU-17-001
Comparison of obstetric and infectious results among Syrian pregnant women
No full textAim: We do not have enough information about the obstetric and fetal positions of migrant pregnant women.After the Syrian civil war in 2011, neighboring countries and Europe faced a wave of migration.The study aims at comparing the obstetric, fetal, and infectious outcomes of Turkish pregnant refugee women. Material and Methods: A total of 810 Syrian and 810 Turkish pregnant women who gave birth between January 1, 2020 and August 1, 2020 were included in the study. The demographic characteristics, obstetric, fetal, neonatal, TORCH (Toxoplasma gondii, others, rubella virus, cytomegalovirus and herpes simplex virus), HBsAg, anti-HBs, anti-HCV, and anti-HIV seroprevalences, and laboratory results of the women were compared. Results: Adolescent pregnancies were found to be higher among Syrian pregnant women (p<0.001). Normal birth rates were also higher in these women (p<0.001). The week of pregnancy at birth, age and Apgar scores were found to be lower compared to Turkish pregnancies (p<0.001). The rate of delivery below 2,500 grams was higher among Syrian women (p<0.001). Anti-HBs protection was not sufficient (p<0.05), and Toxoplasma gondii seropositivity seemed to be higher (p < 0.05). The rate of ARH + blood group in pregnant women from Syrian (28.5%) was lower than in Turkish pregnant women (34.9%) (p < 0.05). Discussion: It was observed that the rate of adolescent pregnancy was higher in refugee pregnant women. Adolescent pregnancies are at risk in terms of obstetric and neonatal outcomes. Therefore, efforts to prevent these pregnancies should be made. Syrian pregnant refugee women should be protected against adverse perinatal and infectious situations
Retrospective analysis of autologous stem celltransplantation outcomes in multiple myeloma patientswith renal insufficiency
No full textAim: The most seen complication of multiple myeloma (MM) is renal insufficiency (RI). Although MM is known as one of the causes of reversible end-stage renal disease, these patients are usually not suitable for autologous stem cell transplantation (ASCT). We aimed in this study to reveal the clinical course of MM patients with renal insufficiency that underwent ASCT.Materials and Methods: We included 25 MM patients with RI who has undergone ASCT in this study. Creatinine levels more than 2 mg/dL was defined as renal insufficiency at the time of diagnosis. For survival analysis, we included patients with a minimum 100 days post-transplantation follow-up.Results: Median age was 56.6±7.9 (42-65) years. Melphalan was given 140 mg/m2. Nine patients (36%) required dialysis at the time of diagnosis. Six patients became dialysis-free with induction therapy. After ASCT, none of the patients needed dialysis. Cox regression analysis showed a significant increase in disease-free survival (DFS) and overall survival (OS) times compared to patients with very good partial response in patients with complete response on the 100th day of ASCT (for DFS; 15.7 months vs 63.7 months, p=0.009 and for OS; 37.9 months vs 97.3 months p=0.01, respectively). Conclusion: There are studies showing that ASCT performed with reduced dose of melphalan is a renal protective and effective method in patients with renal impairment. Our study confirms this thesis, as well as emphasizing the significant effect of CR on DFS and OS on the 100th day after transplantation in these patients
Prevalence of CYP2C19 Polymorphisms in Clopidogrel Treated Turkish Patients: Preliminary Results, 2017
No full textBackground: Clopidogrel is one of the most frequently prescribed antiplatelet agents to reduce the risk of atherosclerotic symptoms. CYP2C19 enzyme is involved in clopidogrel metabolism, and several genetic variations of CYP2C19gene are able to affect the clinical response of clopidogrel. Despite the lack of a fully accepted guideline for CYP2C19 pharmacogenetic testing before clopidogrel treatment by relevant communities, we believe that determination of the variant frequencies is important to predict the efficiency and possible clopidogrel related risks before the initiation of treatment on the basis of populations. Our aim was to determine the distribution of gene polymor-phisms affecting the enzyme activity in Turkish cardiac patients prescribed clopidogrel. Methods: 54 clopidogrel prescribed patients were included in the study. The presence of CYP2C19*2, *3, *4, *5, *6, *7, *8, *9, *10 and *17 polymorphisms were investigated using a microarray platform. Results: No variant allele was detected for *4, *5, *6, *7, *8, *9 and *10 polymorphisms. The geno-type frequencies were detected as 38.89% for *1/*1, 16.67% for *1/*2, 11.11% for *2/*17, 1.85% for *1/*3, 1.85% for *2/*3, 27.78% for *1/*17 and 1.85% for *17/*17. According to genotype analysis, 1.85% of the patients were recorded as poor and 29.63% intermediate; whereas 27.78% as rapid and 1.85% ultra-rapid metabolizers. Conclusion: Although our study population does not consist of a high number of patients, since the high frequency of intermediate, rapid and ultra-rapid metabolizer patients were detected in relatively high frequencies, CYP2C19 polymorphisms should be taken into account for efficiency and possible clopidogrel related risks in Turkish cardiac patients. © 2021 Bentham Science Publishers.Istanbul Kalkinma Ajansi: TR10/16/YNY/0030This study was supported by Istanbul Development Agency, Project No:TR10/16/YNY/0030, Turkey
GIANT SIZED EXTRAVESICAL BLADDER LEIOMYOMA MIMICKINGUTERINE CERVICAL LEIOMYOMA: A CASE REPORT WITH 8 YEARS’POSTOPERATIVE FOLLOW-UP AND A REVIEW OF THE LITERATURE
No full textThe incidence of bladder leiomyoma is estimated at only 0.43% because most bladder tumors arise from the urothelium. Moreover, 30% of them are the extra-vesical type. The symptoms include urinary tract obstruction, bladder irritation, and dysuria, with the possibility of dyspareunia or hematuria depending on the size and location of the tumor. Bladder leiomyomas cannot be diagnosed solely by combining symptoms and imaging techniques. We present a rare case of giant sized extravesical-type bladder leiomyoma with a diameter of 15.5x14.5x14 cm, which was misdiagnosed as a uterine cervical leiomyoma. It caused unilateral ureteral distension without related symptoms. During the 8-year postoperative follow-up, the patient had two healthy full-term pregnancies and no recurrence was observed. We reviewed the literature of the most recent five years and discussed the characteristics of 22 bladder leiomyoma cases. Unlike the literature, the present case is unique due to the giant size of the bladder leiomyoma, its ureteral complications, and long follow-up period. Bladder leiomyomas are rare bladder tumors which should be borne in mind during the differential diagnosis of a pelvic mass. Surgical excision is the most useful procedure for diagnosis and treatment