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Basic helix-loop-helix transcription factor DEC2 functions as an anti-apoptotic factor during paclitaxel-induced apoptosis in human prostate cancer cells
Get PDF弘前大学博士（医学）掲載誌 International Journal of Molecular Medicine, 38, p.1727-1733, 201
脳卒中片麻痺者における後ろ歩きの動作解析に関する研究
Get PDF弘前大学博士（保健学）[Chapter 1] Review of backward walking
Purpose: The purpose of this study was to review existing literature on gait analysis and physical therapy related to backward walking (BW).
Methods: English language and Japanese language studies were identified through
searches of CiNii, PubMed and the Internet.
Results: Fifty-five studies were identified.
Conclusion: While some studies concluded that the joint movement patterns in BW and forward walking (FW) are similar, several studies reported that these patterns in BW and FW are different.
[Chapter 2-1]
Comparison of forward walking and backward walking in healthy young adults
Purpose: The purpose of this study was to compare the characteristics of BW and FW in healthy young adults.
Subjects: Fourteen healthy young adults.
Methods: Subjects were required to walk over a 5-m walkway at a self-selected pace.
Results: Walking speed, stride length, and cadence were significantly lower in BW than in FW. The peak hip extension, knee flexion, ankle plantar flexion, and the peak hip and 77 knee joint moments were also significantly lower in BW.
Conclusion: We conclude that BW is not a simple reverse reproduction of FW.
[Chapter 2-2]
Effects of ankle push-off during backward walking on ankle and hip joints
Purpose: The purpose of this study was to investigate the differences in the kinetic and kinematic factors of different ankle push-offs during BW.
Subjects: Fourteen healthy young adults.
Methods: Subjects were required to walk over a 5-m walkway at a self-selected pace
under three conditions: Natural Push-off BW, Increased Push-off BW, and Decreased
Push-off BW.
Results: Walking speed and stride length increased in the order of Decreased Push-off
BW, Natural Push-off BW, and Increased Push-off BW. The peak value of the hip
extension angle was higher in Increased Push-off BW than in Decreased Push-off BW.
Conclusion: Ankle push-off can help increase the walking speed and improve the
propulsive force of the ankle joint in BW. Hip joint movement plays an important role in BW to accommodate for the disadvantage ankle strategies have in this type of walking.
[Chapter 3]
Motion analysis of backward walking in stroke patients with hemiplegia
Purpose: The purpose of this study was to investigate the features of BW in stroke
patients with hemiplegia.
Subjects: Nine stroke patients.
Methods: Participants performed FW and BWalong a 5-m walkway. Walking speed and stride length were self-selected.
Results: On the paretic side, walking speed, stride length, and cadence were significantly
lower in BWthan in FW. Peak hip extension was significantly lower in BW, and peak hip flexion moment, knee extension moment, and both ankle dorsiflexion and plantar flexion 78 moments were lower in BW.
Conclusion: Unlike FW, BW requires conscious extension of the hip joint, which is
difficult for stroke patients with hemiplegia. Therefore, the range of hip joint movement
was smaller in BW, and walking speed and stride length were decreased. The peak ankle plantar flexion moment was significantly lower in BW than in FW, and it was difficult to generate propulsion power in BW. These difficulties also affected the walking speed
Novel method of assessing ascending aorta with a stenotic bicuspid aortic valve
Get PDF弘前大学博士（医学）掲載誌 The Journal of heart valve disease, 24, p.554-9, 201
Influence of Distance from Home to Hospital on Survival among Lung Cancer Patients
Get PDF弘前大学博士（医学）掲載誌 Asian Pacific journal of cancer prevention, 17, p.5025-30, 201
Association between Higher Serum Cortisol Levels and Decreased Insulin Secretion in a General Population
Get PDF弘前大学博士（医学）掲載誌 PLoS One, 11(11), e0166077, 201
Detecting asymptomatic recurrence after radical cystectomy contributes to better prognosis in patients with muscle-invasive bladder cancer
Get PDF弘前大学博士（医学）掲載誌 Medical Oncology, 34, p.90, 201
Association between regional cerebral blood flow and Mini-Mental State Examination score in patients with Alzheimer's disease
Get PDF弘前大学博士（保健学）アルツハイマー病患者の脳血流は早期段階から減少している。現在、アルツハイマー病の脳血流は、統計解析を用いたZ-scoreで評価されている。しかしながら、Z-scoreは、脳血流の障害領域を考慮していない。本研究では、脳表面領域とZ-scoreを考慮したΣzSを定義し、アルツハイマー病患者の認知障害の重症度示すミニメンタルステート検査を使用して測定した局所脳血流との関連性を調べた。本研究において、後部帯状回のΣzSとミニメンタルステート検査の下位項目1、2、5で負の相関が認められた。さらに、ミニメンタルステート検査の合計スコアと脳の細分化された領域のブロードマン領野30で負の相関が認められた。本研究の結果は、局所脳血流代謝の指標として有用であり、アルツハイマー病患者の認知機能の解釈を深めることができるかもしれない
