238455 research outputs found
Sort by
Quantitative Ultrasound Radiomics for Predicting and Monitoring Neoadjuvant Chemotherapy Response in Breast Cancer: A Systematic Review of Clinical Cohorts
No full textThis systematic review aims to aggregate clinical studies using QUS radiomics to predict or monitor NAC response in breast cancer. It will catalog acquisition settings, calibration/normalization strategies, ROI and peritumoral definitions, feature families (MBF/SS/SI, scatterer metrics, textures/derivatives), learning frameworks, validation schemes, and performance metrics at pre-treatment and early on-therapy timepoints. Among secondary aims are to highlight signal trajectories (such as early MBF/SI rises in responders), examine subtype-conditioned performance, and summarize translational signals (associations with recurrence-free outcomes when available). The review is intended to provide a transparent template for multicenter standardization and to inform the design of adaptive trials that test whether early QUS-guided escalation/de-escalation improves patient-centered outcomes
Characteristics of Nurse-Led Interventions to Minimize Physical Restraints in ICUs: A Scoping Review protocol
No full textThis project aims to conduct a scoping review to map and describe nurse-led interventions designed to minimize the use of physical restraints in adult intensive care units (ICUs). Physical restraint is frequently used in ICUs to prevent device removal and ensure patient safety; however, its use has been associated with adverse outcomes such as delirium, functional decline, and post-intensive care syndrome. Although clinical guidelines and policy statements emphasize restraint minimization, the implementation and characteristics of nurse-led interventions remain heterogeneous and have not been comprehensively synthesized.
This scoping review will be conducted in accordance with the JBI Manual for Evidence Synthesis, and the completed review will be reported in accordance with the PRISMA Extension for Scoping Reviews (PRISMA-ScR) guidelines. Using the Population–Concept–Context (PCC) framework, the review will include studies involving adult ICU patients, focusing on non-pharmacological, nurse-led, or nurse-involved interventions aimed at reducing or minimizing the use of physical restraints. Eligible sources will consist of experimental and observational studies, qualitative research, quality improvement initiatives, and practice reports.
The review will systematically search multiple electronic databases, including MEDLINE (PubMed), CINAHL (EBSCOhost), the Cochrane Library, Ichushi-Web, and J-STAGE. Three reviewers will independently screen studies and extract data. Extracted information will be descriptively mapped to summarize intervention characteristics, targeted patient behaviors or conditions, and clinical contexts in which these interventions are implemented.
The findings of this review will provide an overview of existing evidence and identify knowledge gaps to inform future research and the development of nurse-led strategies to support restraint minimization in adult ICUs
Understanding spatial distribution of Coquillettidia peturbans relative to Crow Island Portsmouth Township, Bay County, Michigan
No full textMosquito surveillance is a valuable tool when inferring species habitat preferences and entomological characteristics of a given area. However, entomological surveillance is incomplete for appropriate analysis of the Coquillettidia peturbans in and around the Crow Island area of Bay County, Michigan where significant habitat for this unique mosquito is present
Prereg: Humor Similarity among Friendship Quads
No full textThis project examines humor style similarity among each dyad in a four-person friend group. We predict that friends will have both actual and perceived similarities in humor style. We also predict that perceived humor style similarity will be stronger than actual humor style similarity.
This project also intends to examine whether humor style similarity is related to relationship satisfaction and conflict among the friend dyads. These research questions are largely exploratory
The Role of Work-Life Balance in Mediating The Relationship Between Job Satisfaction and Perceived Career Opportunities in Generation Z
No full textThis study examines whether work–life balance can serve as an effective mediator between job satisfaction and perceived career opportunities among Generation Z
伝統的メディアやSNSの情報が有権者の政治印象に与える影響に関する実験
No full text＜問い＞
政治的なメッセージは、執筆者の属性（記者 vs. 個人）や、発表プラットフォーム（新聞 vs. SNS）によって、その説得力が変化するか
Harmful Healing: Iatrogenic Fragility in Psychological Safety Interventions
No full textTrigger warnings, content warnings, and related psychological safety interventions have proliferated across educational, digital, and clinical
environments with the explicit goal of protecting vulnerable individuals from emotional harm. Meta-analytic evidence demonstrates these
interventions fail to reduce distress upon content exposure while reliably increasing anticipatory anxiety beforehand. This paper proposes
that safety interventions are not merely ineffective but potentially iatrogenic, causing the psychological fragility they claim to prevent.
I introduce “iatrogenic fragility” as a theoretical framework explaining how well-intentioned protective measures may construct vulnera-
bility through three interacting mechanisms. First, nocebo priming: warnings function as verbal suggestions of negative outcomes, activating
anticipatory anxiety through neurobiological pathways documented in clinical nocebo research. Second, institutionalized avoidance: warn-
ings legitimize safety-seeking behaviors that prevent the inhibitory learning necessary for resilience, functioning as institutional-scale safety
signals that maintain rather than extinguish anxiety. Third, identity consolidation: warnings reinforce trauma-centered identity by implic-
itly communicating that recipients require protection, increasing the centrality of past adversity to self-concept in ways that are directly
countertherapeutic for trauma recovery.
These mechanisms interact to produce a self-reinforcing cycle: safety interventions increase fragility, which generates demand for ex-
panded protections, which further increases fragility. The framework synthesizes findings from clinical psychology, health psychology, and
social cognition that have not previously been integrated. By identifying the causal pathways through which protective intentions produce
harmful outcomes, the iatrogenic fragility framework generates testable predictions and suggests that resilience-focused alternatives may
better serve the populations these interventions were designed to help
