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Raga Therapy An Effective Treatment for Stress Management
Get PDFDelayed encounters with stress are identified with poor individual well-being and related to significant monetary expenses for the general public. Accordingly, the advancement of cost-effective stress prevention or stress management tactics has turned into a vital attempt at recent research endeavors. Music has been appeared to influence physiological, cognitive, and emotional stress-related procedures advantageously. Subsequently, the utilisation of tuning in to music as a financial, non-intrusive, and profoundly acknowledged mediation apparatus has gotten uncommon enthusiasm for the administration of stress and stress-related medical problems. “Raga is the grouping of chosen notes (swaras) that loan suitable ‘temperament’ or feeling in a specific blend. “Raga therapy means healing through the raga. It’s a yoga framework with the help of resonant sounds. Ragatherapy implies curing through the raga. It is the information on the most proficient method to utilise raga for curing [1]”. Symphonies of raga ensure a calming influence on the mind and body. Researchers have found the role of raga therapy in treating stress. In the present research, raga therapy was administered to 74 subjects suffering from stress as an intervention plan. The ISMA questionnaire was administered to them before and after the intervention. Different sequences of ragas were directed to them for 30 min. A significant effect of raga therapy established on stress management
Panel of Regulatory miRNAs for Blood Coagulation under Normoxic and Hypoxic Conditions
Get PDFAbnormal blood coagulation may lead to venous thromboembolism (VTE), a complex multifactorial disease. Hypoxia (oxygen deprivation) is a major factor disturbing the blood hemostasis and predisposing the body towards coagulation and VTE. Pathophysiology of VTE can be attributed to post-transcriptional gene regulation by microRNAs (miRNAs). The present study identified regulatory miRNAs involved in causing blood coagulation under normoxic and hypoxic conditions. Meta-analysis was performed, following PRISMA guidelines, for identifying miRNAs involved in blood coagulation pathway. Studies evaluating miRNAs from circulating blood as potential biomarkers of VTE were selected. A total of 16 studies met selection criteria and 8 having complete statistical information were selected for analysis. Study of blood coagulation mechanism under hypoxic conditions involved in-silico search within highly cited databases to identify miRNAs commonly regulating genes of hypoxia-inducible factor (HIF) family and coagulation pathway. Further bio-informatics approaches were employed to identify potential biomarker candidates. Meta-analysis revealed a panel of 12 miRNAs; two members of miR-27 family, hsa-miR-27a and hsa-miR-27b; two members of miR-320 family, hsa-miR-320a and hsa-miR-320b, hsa-miR-1233, hsa-miR-134, hsa-miR-424-5p, hsa-miR-221, hsa-miR-28-3p, hsa-miR-136-5p, hsa-miR-374-5p and hsa-miR-338-5p involved in blood coagulation under normoxic conditions. Besides these, present in-silico analysis identified a set of 5 miRNAs including hsa-miR-4667-5p, hsa-miR-6815-3, hsa-miR-4433a-3p, hsa-miR-6735-5p and hsa-miR-6777-3p which predominantly regulate genes that facilitate both coagulation and response to hypoxic stress. The present study generated a panel of regulatory miRNAs potentially involved in the process of blood coagulation under both normoxic and hypoxic conditions, which may serve as putative epigenetic biomarkers for coagulation
Technology Trends and Future Opportunities in Development of NBC Protective Clothing
Get PDFThis article reviews a detailed and timely evolution of Nuclear Biological Chemical (NBC) protective clothing. The increased threat of NBC weapons underlines the need for NBC protective clothing for first responders, service personnel as well as civilians. The material selection criteria for protective clothing have been changed considerably with the development of advance technical fibers to sustain the threat of CWA and fulfill precisely need for the NBC suits. Because of advancement, in the use and delivery of Chemical Warfare Agent (CWA), the evolution of the NBC suit is presented. The chemical protection of NBC protective clothing needs to be precisely evaluated and thereby related standard test methods are also duly accommodated. This review documented the journey of the NBC suit right from charcoal based to activated carbon spheres (ACS), and recent developments on the materials aspects of various protective clothing
In vitro Anti Diabetic Potential of Loranthacean Hemi Parasite Helicantes elasticus Desv Danser Collected from Six Different Hosts
Get PDFIn vitro anti-diabetic potential of methanolic extract of Helicantheselasticus(Desv.) Danser growing on six different hosts and thereby comparing the host’s influence on this parasitic plant for this efficacy was studied and statistically analysed. The results showed that Hemiparasite collected from Heveabrasiliensis, Citrus maxima, Anacardiumoccidentale and Saracaasoca were found highly effective in this regard. Highest inhibition on α-amylase was shown by H.elasticuscollected from Heveabrasiliensis where as inhibition of α-glucosidase was found to be highest in hemiparasite obtained from Citrus maxima. The host plants selected under study was also found good in reducing the blood glucose level. The study clearly reveals the fact that, anti-diabetic potential of H.elasticus have significantly influenced by the host trees
Therapeutic Approach and Characterisation of Watermelon (Citrullus lanatus) Rind against Acrylamide Toxicity
Get PDFWatermelon (Citrullus lanatus) is a cheap and easily available fruit in the local markets of India. The rind, which is the outer layer of watermelon, is completely edible. It is the only fruit with 90 per cent of water, and is fully edible including its rind and seeds as they contains different types of nutrients which are needed by our body in day to day life. The benefits in our body, includes reduced blood pressure, presence of different types of vitamins, such as vitamin A, B & C, as well as different types of minerals required by our body. The present study aims in evaluating the presence of different secondary metabolites in the watermelon rind. The therapeutic efficacy of watermelon rind against acrylamide toxicity in the lymphocyte cell line is studied. As selenium is an important micronutrient, an attempt has been made to prepare the selenium nanoparticles followed by its characterisation
Quantification of Mental and Physiological Workload Associated with two Specialised Military Running Events on Different Terrains
Get PDFIntense training regimes are practiced across military facilities to develop soldiers’ mental and physical abilities to meet the demands of modern-day warfare. Two short-duration military runs through the jungle and flat natural tracks were selected to quantify their mental and physiological workloads and explore track-specific differences. Two groups of healthy Indian soldiers (n=43 and 30; similar age, height, and weight) participated in time-bound 2.4 km runs on the jungle and flat natural tracks. Physiological variables, speed, and elevation with environmental parameters like temperature and humidity were recorded throughout the exercises. Subjective responses through NASA-TLX questionnaires were collected after the exercises. Mann-Whitney ‘U’ test was applied to find out the level of significance between groups.Physiological demands of runs on the jungle and flat natural track were similar (heart rate- 178.9 and 178.4 b/min; breathing rate- 42.0 and 46.6 breaths/min respectively; body temperature- 37.6℃ for both groups). The run on the jungle track needed a lower peak acceleration of 2.5 g (2.9 g on the flat track) and a higher variation in speed (4-16 knots). Participants expressed significantly high responses after the run on the jungle track. Run on the jungle track was physically intense, required adjustments in speed and acceleration to negotiate with the natural obstacles like uneven terrain and slippery surfaces. Besides this, environmental heat and higher humidity probably led to an increase in mental workload. The run on the flat natural track needed steady physical effort, fewer mechanical adjustments, and showed lower subjective responses
Determination of Antioxidant and Anti quorum Sensing Activity of Aegle marmelos Picrorrhiza kurroa and Swertia chirayita
Get PDFFrom the ancient period, humans have been fighting pathogenic microorganisms for survivalpurposes and in this context, man has developed antibiotics as a powerful weapon to treat various infections caused by pathogens. Nevertheless, the need to discover new antimicrobial agents is increasing at an alarming rate. This is because the microorganisms have developed various mechanisms to resist the action of antibiotics. One such mechanism is the production of biofilm. Infections caused by biofilm-forming pathogenic microorganisms are very difficult to treat, even using potent antibiotics. However, in folk medicine, many plants are found to be helpful to treat certain infectious diseases. This is because of the synthesis of a variety of bioactive compounds by plants with high medicinal value. Hence, in the present study, three different plants were used viz Aegle marmelos, Picrorrhiza kurroa, and Swertia chirayita to determine their antioxidant and anti-quorum sensing activities. According to the literature, antioxidants delay the oxidation process and nullify the effect of free radicals that cause damage and accelerate aging. Quorum sensing is the chemical way of communication between biofilm-forming microorganisms. Among the alcoholic extracts, the methanolic extract of P. kurroa showed the highest DPPH radical scavenging activity of 82.11%. All the plant extracts under investigation exhibited anti-quorum sensing activity against the standard culture of Chromobacterium violaceum MTCC 2656; however, the plant extracts of A. marmelos were found to be more potent as compared to P. kurroa and S. chirayita. Plant extracts P. kurroa and S. chirayita showed almost similar anti-quorum sensing activity. This confirms the pharmaceutical importance of plant materials of interest, which might prove to be useful to treat damage caused by free radicals and biofilm-related infections, after due consideration of clinical trials for safety issues
Biochemical and Ultrastructural Studies for Toxicity of Kaempferol Derivative Recovered from the Plant Lysimachia Ramosa
Get PDFLeaves of Lysimachia ramosa are used by various tribes of Meghalaya to cure intestinal helminth infections. Preliminary investigations disclosed impressive anthelmintic effects of the kaempferol derivative, an active component of the plant, however, toxic effects on its consumers, if any, are not known. Therefore, the present study has been undertaken to investigate the acute and sub-acute toxic effects of kaempferol derivative, of the plant, taking Wistar rats as a model. Following OECD 407, 250 mg, 500 mg, and 1000 mg/kg body weight doses of the active component have been selected to treat the animals for 28 days. On the 29th day, the animals have been sacrificed to assess different toxicological effects on animals. The LD50 value of the anthelmintic component was found to be more than 5000 mg/kg body weight of rats. Histological, ultrastructural, haematological, biochemical, andorgano-somatic (HSI and RSI) studies demonstrate changes in surface characteristics of various cellular organelles of different vital organs such as the liver, kidney, and intestine. Alterations were also recorded in different vital enzymes such as AST, ALT, and ALP in the phytochemical exposed rats at higher doses. The results revealed that treatment with the active component at a higher concentration may lead to toxicological effects if treatment persists for a longer period
Molecular Interplay between Vitamin D and Immunity can Aid Antitubercular Treatment Vitamin D in Immunomodulation of TB
Get PDFTuberculosis (TB) causes maximum mortality and morbidity worldwide. 25 per cent of the global population harbour Mycobacterium tuberculosis (Mtb) and therefore are at risk of developing active disease. Of late, the disseminated diseases of TB are on the increase. Nearly one-third of all TB infections can be classified as extrapulmonary-TB (EPTB). TB can spread to the bone, brain, intestine, peritoneum, genitourinary system, and female genital sites leading to problems of conception. Therefore undoubtedly, TB has turned out to be a tremendous public health problem globally. The emergence of drug-resistant bacteria calls for new anti-tuberculous drugs to enhance response to antimicrobial therapy for active TB. However, discoveries of very effective anti-TB new medicines have not materialised yet. Thus, nutritional anti-TB intervention is highly important. In the pre-antibiotic era, Vitamin D was used for the treatment of TB. Its active component 1,25-dihydroxy-vitamin D3 was shown to display anti-TB activity in vitro. Vitamin D deficient humans display greater susceptibility to TB. Vitamin D deficiency induces worse disease progression in TB cases as observed in many clinical trials. The efficacy of the addition of vitamin D supplements in TB treatment has also been estimated. Thus, by now, the role of vitamin D in TB prevention and treatment is well established. Knowledge of the molecular mechanism of vitamin D is crucially vital for new anti-TB drug design. This review article discusses the recent advancement regarding the molecular mechanism of vitamin D-related anti-TB action. Further elucidation of this area may help novel anti-TB drug development