Defence Life Science Journal
Not a member yet
454 research outputs found
Sort by
Extraction and Formulation of Lip Tint from Natural Dye Extracted from Celosia Cristata Linn Flower
Get PDFThe escalating utilisation of synthetic dyes across diverse industries, including textiles, cosmeceuticals, food, and pharmaceuticals, is projected to witness a notable 6.5 % surge by 2027, notwithstanding the well-documented drawbacks associated with their usage. Synthetic dyes have been linked to adverse effects such as skin irritation, necrosis, genotoxicity, and hyperactivity in children. Acknowledging the imperative need to transition towards safer alternatives, this study investigates the extraction and formulation of a lip tint employing a dye derived from Celosia cristata Linn as a natural substitute for synthetic dyes. The aqueous extraction of Celosia cristata Linn flower unveiled the presence of various phytochemical constituents, including flavonoids, tannins, phenols, steroids, terpenoids, quinones, cellulose, starch, and saponins. Particularly noteworthy is the betalain constituent in the flower extract, which imparts the dye with nutraceutical, antioxidant, and anti-inflammatory properties. The formulated lip tint underwent a comprehensive evaluation encompassing dye stability, spreadability, melting point, skin irritation, surface anomalies, homogeneity, perfume stability, pH, short-term stability, and colorant yield. The study concludes that the lip tint formulated from Celosia cristata Linn dye represents a viable and safe alternative for various cosmeceutical applications, providing a natural solution to the adverse effects associated with synthetic dyes
Effect of Packaging Material on Moisture Migration and Textural Attributes of Bread During Storage
Get PDFBread as a commodity is included in the special inventory of Defence Forces, particularly as a morning or evening snack item. The present investigation pertains to the studies on the effect of various packaging materials, e.g. metalized polyester (MP-99.8 µm), low-density polyethylene with lower thickness (LDPE-1-78.33 µm), multi-layer flexible pouches (MLFP-106.2 µm), low-density polyethylene with higher thickness (LDPE-2-125.12 µm), and paper foil polyethylene (PFP-124.6 µm) on textural attributes of bread. Textural properties were significantly influenced by the change in moisture content which was clearly shifted from crumb to crust to the extent varying from -25.89% to +24.90% in LDPE-2; -29.11% to +29.77% in MP; -22.22% to +21.11%; in MLFP; -19.46% to +19.67% in PFP; -20.42% to +20.55% in LDPE-1 at the end of its expected shelf-life i.e. five days. Though overall bread moisture content was not much affected in PFP and MP, the marked difference was primarily observed in the case of bread packed in LDPE-2, LDPE-1, and MLFP. This difference may be attributed to the thickness and permeable properties of the packaging material used for the study. The hardness and resilience of samples depicted opposite trends, respectively, during their storage. The current study gives insight into physicochemical changes occurring in the bread system when variety commonly practiced packaging materials is used and a perspective strategy for its extended life during varied field conditions.
Prevalence of Cancer in India with Respect to Leukaemia and their Factorial Relations
Get PDFCancer is a growing burden on the healthcare system. Leukaemia is one such commonly reported cancer. In the United States, leukaemia is thought to account for roughly 3.5 percent of all cancer cases and 4 percent of cancer-related deaths. The present article examines the responsible factors for leukaemia cases in India. For the study, trends of cancer incidence (new cases per year), death, and DALYs (Disability-adjusted life years) attributable to all cancers combined and distinct kinds of malignancies. DALYs were selected as the primary measure for disease burden because it accounts for both death and morbidity and is recommended by India’s National Health Policy for illness monitoring. The preserved blood samples of prior knowledge of cases were taken for study and analysis. The article highlights the total burden of all cancers in terms of DALYs from 1990 to 2020, followed by incidence and fatalities. Patterns of 10 cancer types that account for the majority of cancer-related and leukaemia DALYs important disparities in cancer distribution between men and females in India have been discussed in the paper. Six more cancer types that are in the top ten most common incident cancers in Indian women and men but are not among the top ten cancers generating the most DALYs are also reported from the study. The age-standardised incidence rate of the major kinds of malignancies like leukaemia showed significant inter-state variability, ranging from 3.3 to 11.6 times for the four most common malignancies (lip and oral, breast, lung, and stomach). Leukaemia CML mortality has been steadily declining over the last 20 years, but AML fatalities have been steadily increasing. In conclusion, total cancer incidence did not rise as quickly as previously anticipated among aging Americans; nonetheless, myeloid leukaemia and Chronic Lymphocytic Leukaemia (CLL) rates dramatically surpassed those of other malignancies. In this paper, we have given a brief overview of the factors responsible for leukaemia and compared to other cancer cases in India, and a major portion is waited for future research
Commercialisation of Innovations: A Case Study of Liposomal Formulations
Get PDFLiposomes are the potential drug delivery systems for various therapeutic categories. During the past 60 years, researchers have explored this drug delivery system which has resulted in a large pool of documents in terms of patents and publications. The paper’s objective is to understand why after 60 years of extensive research with more than 50,000 patent documents and 35,000 research publications, only 17 products based on liposomes are commercially available. After detailed analysis, the authors found that the research publications and patent documents are primarily focused on the basic research aspects and have limited participation from the industry. Therefore, in this paper, it has been emphasised how the research projects on liposomes must re-orient its focus so that it leads to the commercialisation of liposomes. This paper also provides a comprehensive analysis of challenges and opportunities for researchers concerning various research areas of liposomes like manufacturing techniques, characterisations, stability, storage, pre-clinical and clinical evaluations, regulatory requirements as well as pharmaco-economic analysis
Antifungal Potential of Seabuckthorn (Hippophae Rhamnoides L.) Against Rhizopus Azygosporus: An in-silico Approach to Combat Mucormycosis
Get PDFRhizopus species are opportunistic fungal pathogens from the Mucorales order, commonly found in soil, decaying organic matter, and indoor environments. While generally harmless, they can cause life-threatening infections in immunocompromised individuals, leading to mucormycosis. During the COVID-19 pandemic, mucormycosis cases surged, particularly in India, due to immune suppression caused by diabetes (present in66.1 % of cases) and widespread corticosteroid use (80.3 % of cases). Standard treatments include antifungal agents like Amphotericin B, Posaconazole, and Isavuconazole, along with surgical debridement. Mucorales exhibit resistance to many antifungals due to their unique cell wall composition, making azoles like itraconazole and voriconazole ineffective, while echinocandins show minimal activity. Seabuckthorn (Hippophae rhamnoides L. ), rich in bioactive compounds, exhibits antioxidant, anti-inflammatory, and antimicrobial properties, making it a promising candidate against Rhizopus infections. This study employs molecular docking using iGEM Dock to evaluate the binding affinity of Seabuckthorn bioactive compounds against ergosterol biosynthesis in Rhizopus azygosporus, a major causative agent of mucormycosis. ADMET analysis is performed to assess the pharmacokinetic profiles of the compounds, ensuring their suitability for therapeutic applications. The present study identifies futuristic novel drug targets and efficient antifungal agents to effectively address mucormycosis
Biological Enrichment of Hippophae rhamnoides L. (Seabuckthorn) Through Microbial Interventions and Exploring the Probable Role of Plant Growth-Promoting Bacteria from Termite Mounds
Get PDFSeabuckthorn (Hippophae rhamnoides L.) is an economically significant shrub, renowned for its oil, containingover 100 bioactive compounds. Phytochemical studies have reported numerous constituents for biomedical applicationshaving nutraceutical and therapeutic properties. However, oil content in the current cultivars is below optimal level.Traditional methods of breeding, employed to reach optimal level are resource-intensive and time-consuming. Asustainable alternative, organic farming has resurfaced with its integration with beneficial soil micro-fauna whichprovides an eco-friendly approach in enhancing crop quality and productivity conventional agricultural practices.Amidst these, Plant Growth-Promoting Bacteria (PGPB) is one promising option. PGPB enhance phytohormoneproduction, nutrient uptake, and secondary metabolites by activating plant’s natural immune response. Few bacteriahave been explored in the rhizospheric soil of Hippophae sp. to enhance its metabolite production. This paperreviews researches done on the PGPB associated with Hippophae sp. and explores the novel idea of using termitemound or termite gut bacteria that could catalyse the production of bioactive content. Termites and their moundsfoster a diverse and underexplored microbiota of PGPB which could promote production of phytohormones andact as a biocontrol agent against pathogens of Hippophae sp. The role of such microbes being used as bio-fertiliserin several plant species gives a new prospect in improving the livelihood of high-altitude farmers, simultaneouslycontributing to sustainable agricultural practice
Isolation and Characterisation of Microorganisms from Rhizospheric Soil of Seabuckthorn from Garhwal Region of Uttarakhand
Get PDFA plant with significant nutritional and therapeutic value, Seabuckthorn (common name: Badrifal and Family: Elaeagnaceae) is recognised for its abundance of bioactive substances, including vitamins, flavonoids, polyphenols, and vital fatty acids, and possesses various health benefits and has the potential to cure diabetes and cardiovascular disorders. Seabuckthorn is a drought-resistant shrub that flourishes in harsh environments, as climate change is a major driver of biodiversity loss. In India, it is primarily found in high altitudes of the Indian Himalayan Region (IHR), such as Uttarakhand, Himachal Pradesh, Sikkim, and Arunachal Pradesh. In the present study, 9 rhizospheric microorganisms have been isolated from a soil sample of Seabuckthorn from Garhwal region of Uttarakhand. Out of 9 isolates, 4 were fungal isolates, 4 were bacterial isolates, and the remaining 1 was an actinobacteria. Furthermore, isolated microbes were investigated for biochemical tests including, catalase, oxidase, siderophore production and phosphate solubilisation assay. The analysis shows that all isolates (bacteria, fungi and actinobacteria) were positive for catalase and oxidase test. The two fungal isolates (GEU_SBT03 and GEU_SBT04) and two bacterial isolates (GEU_SBT05 and GEU_SBT06) were found positive for siderophore production. In addition, three fungal isolates (GEU_SBT01, GEU_SBT02, and GEU_SBT04) and two bacterial isolates (GEU_SBT05 and GEU_SBT06) showed positive response for phosphate solubilisation. These results conclude that isolated microbes (both bacteria and fungi) from the rhizosphere of Seabuckthorn possess plant growth-promoting activity, which can be further applied as biofertilizers for promoting high yield of Seabuckthorn plant and other biotechnological applications
Seabuckthorn Hippophae rhamnoides: A Miracle Shrub to Combat Environmental Shift
Get PDFA native of northwest Europe and central Asia, including the northern Himalayas and portions of China, Seabuckthorn (Hippophae rhamnoides) is a member of the Elaeagnaceae family. Seabuckthorn is a plant that grows well in arid, cold areas; its components, fruit, and leaves are utilised in traditional Asian medicine. Seabuckthorn, which is well-known for its nutrient-dense, tasty berries, has a wide range of bioactive substances, such as polyphenols like flavonoids, phenolic acids, tannins, fatty acids, vitamins, and phytosterols, which support its culinary, cosmetic, and therapeutic applications. The plant is highly valued in traditional medicine, offering a wide range of health benefits having rich antioxidant properties and stress-relief. Seabuckthorn is highly included in daily diets for preventing diet-related diseases. It is especially advantageous for land reclamation and reforestation in vulnerable mountain regions because of its capacity to stop soil erosion, encourage nitrogen fixation, and enhance soil fertility. Seabuckthorn is perfect for agroforestry in climate-vulnerable areas since it grows well in harsh environments.It aids in carbon capture and boosts resilience to climate change. Despite global expansion, improved varieties with higher yields, disease resistance, and enhanced medicinal and culinary traits are still needed for broader, more effective cultivation. The current review describes nutritional, medicinal, and ecological significance of Seabuckthorn (Hippophae rhamnoides) as a factor in health, soil fertility, and climate stability. It also expounded and stressed why better varieties were necessary to promote sustainable cultivation
Harnessing the Power of Seabuckthorn in Green Synthesis of Nanoparticles : Opportunities and Challenges
Get PDFNanoparticles (NPs) have extended substantial popularity in everyday care products owing to their unique physicochemical features. However, traditional synthesis routes typically involve dangerous chemicals and high-energy processes that are a threat to the environment and safety. Green synthesis is a sustainable strategy for nanoparticle (NP) synthesis that takes advantage of plant-based reducing agents as substitutes for harsh chemicals. Seabuckthorn (Hippophae rhamnoides) extract is a prime candidate with an excellent list of bioactive compound profile that includes flavonoids, phenolics, and vitamins. Such natural components provide the possibility of using a cleaner, greener, and sustainable route for the formation of nanoparticles. This review paper explores the potential role of Seabuckthorn extract in the green synthesis protocols of NPs (NPs) based on its exceptional antioxidant, anti-inflammatory, and antimicrobial activities. A critical analysis of the synthesis procedure highlights the benefits of using Seabuckthorn extract over conventional approaches in terms of increased biocompatibility and eco compatibility. In addition, this review discusses the variety of nanoparticles that may be synthesised with Seabuckthorn extract. In addition, we critically evaluate the current research scenario, competition in scaling up the synthesis process, and the directions for enhancing the use of Seabuckthorn extract-mediated nanoparticles in diverse applications. The results highlight the significance of sustainable methods in nanotechnology, opening the door for eco-friendly innovations in personal care products
Harnessing Seabuckthorn (Hippophae rhamnoides) Surfactants for Human Metapneumovirus (HMPV): A Computational Approach
Get PDFHuman metapneumovirus (HMPV) is a highly mutating respiratory virus that ruses the immune system with frequent mutations, creating a major health challenge. Lacking approved vaccines or treatments, there is a pressing need for effective antiviral therapies. Seabuckthorn (Hippophae rhamnoides) has many antioxidants, anti-inflammatory and antimicrobial activity, and might be the key to bridging this gap. In this research, we employed sophisticated computational molecular docking methods to investigate how some of the bioactive compounds of Seabuckthorn-palmitic acid, oleic acid, and palmitoleic acid-bound to the viral proteins of HMPV. We found that these compounds dock strongly to major viral protein targets, helping to indicate that these compounds might inhibit the functioning of the virus. These observations open the exciting possibility of therapeutic development of Seabuckthorn-derived compounds as safe and natural antiviral agents with the potential to overcome viral mutations, thus providing a new therapeutic avenue against HMPV infections