Manisa Celal Bayar Üniversitesi Akademik Arşiv Sistemi
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Tibiofemoral instability in primary total knee replacement: A review, Part 1: Basic principles and classification
No full textTibiofemoral instability following total knee replacement has received little attention. However it is a cause of early and late failure and usually requires revision surgery. Several factors may be implicated including improper soft tissue balancing, flexion -extension gap mismatch and acute ligamentous injuries. Meticulous surgical technique and proper prosthetic selection at the primary procedure avoids this complication. (C) 2005 Elsevier B.V. All rights reserved
Cross validation of the Turkish version of dermatology life quality index
No full textBackground The aim of this study was to test the linguistic validation of the Turkish version of the Dermatology Life Quality Index (DLQI) for Turkish speaking dermatology patients. Methods The DLQI is a 10-item dermatology specific index developed originally in English. The methodology of this study consists of four consecutive sections: Translation, cognitive debriefing, field testing and statistical analysis. Translation steps: (a) Two forward independent translations into Turkish, (b) reconciliation of these translations by a dermatologist, (c) backward translation of the consensus Turkish version by a bilingual person into its original language (English), (d) and comparing the original questionnaire with the backward translated one. Cognitive debriefing: Sessions were performed on five patients from each of the seven different dermatological diagnosis groups. Field testing: The final Turkish version on which the face validity was approved by specialists on a total of 79 inpatients/outpatients with various dermatological diagnoses treated at Celal Bayar University Hospital. Statistical analysis: Internal consistency (using Cronbach a) and item-total score correlations (Pearson correlation) were used for reliability analysis. Validity analysis was carried out by construct testing (principal components factor analysis), convergent (Pearson correlation) and (discriminate Student's t-test and Mann-Whitney U-test) validity, and SF-36 was used in parallel with DLQI in order to test convergent validity. The data were analyzed by the SPSS version 10.0 (SPSS Inc., Chicago, IL, USA) statistical package. Results The mean age of the patients in the study was 30.77 +/- 15.91 years; the mean score of DLQI was 7.61 +/- 6.12. The median of item-total correlation coefficient was found to be 0.66, within a range of 0.48-0.81. The internal consistency of the index was found to be highly sufficient (alpha = 0.85). The DLQI was found to be highly related to the physical domain of SF-36. Life quality score was found to be significantly low for the inpatients compared with outpatients (differential validity). Conclusion It was found that the Turkish version of the DLQI was an acceptable index for dermatologists and dermatology patients and, moreover, to be valid and reliable in a cross-sectional level. The responsiveness of the Turkish version of the DLQI needs to be tested further on a variety of dermatological conditions with different severities
Characterization of L. tropica secreted exosomes and development of exosome-based preventive vaccine against L. tropica induced cutaneous leishmaniasis
No full textPreparation and mineralization of 13-93 bioactive glass-containing electrospun poly-epsilon-caprolactone composite nanofibrous mats
No full textIn this study, silicate- based 13-93 bioactive glass (BG) /poly-epsilon-caprolactone (PCL) nanocomposite fiber mats were fabricated through electrospinning. To prepare composites, amorphous electrospun bioactive glass nanofibers (BGFs) or melt-derived microscale bioactive glass particles (BGPs) were incorporated into the PCL matrix. In vitro mineralization ability of the prepared fibrous mats was assessed in simulated body fluid under static conditions. The results revealed that it is possible to prepare bead-free continuous nanofibers using PCL-acetone solution at specified PCL concentrations (8 and 10 wt%). Nanofibers with almost uniform diameters were produced using 10 wt% PCL solution. Incorporation of BG in the form of particle or fiber into the PCL matrix was made between 1 wt% and 10 wt%. The results showed that the diameter of BGP-containing composite fibers was higher compared to BGF-containing composite scaffolds. The addition of BG to the PCL matrix both in the form of powder and fiber enhanced hydroxyapatite formation in the fibrous scaffolds. The amount of calcium phosphate-based material formation was higher in glass particle-containing samples compared to glass fiber-containing PCL scaffolds. Additionally, the degradation rate in phosphate buffer and silicium ion release amount of BGP-containing PCL fibers was higher compared to BGF-containing PCL fibers. It was concluded that fibrous composite scaffolds prepared in this study could have potential in tissue engineering applications
Cardiac phenotype in familial partial lipodystrophy
No full textObjectives LMNA variants have been previously associated with cardiac abnormalities independent of lipodystrophy. We aimed to assess cardiac impact of familial partial lipodystrophy (FPLD) to understand the role of laminopathy in cardiac manifestations. Study design Retrospective cohort study. Methods Clinical data from 122 patients (age range: 13-77, 101 females) with FPLD were analysed. Mature human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) from a patient with an LMNA variant were studied as proof-of-concept for future studies. Results Subjects with LMNA variants had a higher prevalence of overall cardiac events than others. The likelihood of having an arrhythmia was significantly higher in patients with LMNA variants (OR: 3.77, 95% CI: 1.45-9.83). These patients were at higher risk for atrial fibrillation or flutter (OR: 5.78, 95% CI: 1.04-32.16). The time to the first arrhythmia was significantly shorter in the LMNA group, with a higher HR of 3.52 (95% CI: 1.34-9.27). Non-codon 482 LMNA variants were more likely to be associated with cardiac events (vs. 482 LMNA: OR: 4.74, 95% CI: 1.41-15.98 for arrhythmia; OR: 17.67, 95% CI: 2.45-127.68 for atrial fibrillation or flutter; OR: 5.71, 95% CI: 1.37-23.76 for conduction disease). LMNA mutant hiPSC-CMs showed a higher frequency of spontaneous activity and shorter action potential duration. Functional syncytia of hiPSC-CMs displayed several rhythm alterations such as early afterdepolarizations, spontaneous quiescence and spontaneous tachyarrhythmia, and significantly slower recovery in chronotropic changes induced by isoproterenol exposure. Conclusions Our results highlight the need for vigilant cardiac monitoring in FPLD, especially in patients with LMNA variants who have an increased risk of developing cardiac arrhythmias. In addition, hiPSC-CMs can be studied to understand the basic mechanisms for the arrhythmias in patients with lipodystrophy to understand the impact of specific mutations
Nonlinear vibrations and stability analysis of axially moving strings having nonideal mid-support conditions
No full textIn this study, nonlinear vibrations of an axially moving string are investigated. The main difference of this study from other studies is that there is a nonideal support between the opposite sides, which allows small displacements. Nonlinear equations of motion and boundary conditions are derived using Hamilton's principle. Equations of motion and boundary conditions are converted to nondimensional form. Thus, the equations become independent from geometry and material properties. The method of multiple scales, a perturbation technique, is used. A harmonically varying velocity function is chosen for modeling the axial movement. String as a continuous medium is investigated in two regions. Vibrations are investigated for three different cases of the excitation frequency . Stability analysis is carried out for these three cases, and stability boundaries are determined for the principle parametric resonance case. Thus, differences between ideal and nonideal boundary conditions are investigated
Determination of Active Life Constraints in Adults
No full textThe Active Life Constraints Scale (ALCS) (Heath, 2009) total 5010 participants selected by simple random sampling method. In the original version, there are 21 items and 7 subscales, and it is in four-point likert type; however, in the Turkish adaptation, it is seen after confirmatory factor analysis that the scale has 7 subscales and 20 items. As a result of the confirmatory factor analysis conducted to test the reliability of the scale, the cronbach alpha value of the 20-item scale was found 0.819. For the subscales, the reliability scores were found as follows: lack of time 0.981, social effect 0.921, lack of energy 0.854, lack of will 0.773, fear of injury 0.862, lack of skill 0.875 and lack of resources 0.816. Independent variables were evaluated using MANOVA analysis which revealed that the main effect of the variable age is significant in all subscales of ALCS, the main effect of the variable gender is significant in social effect, lack of will and lack of skill subscales, the main effect of the variable bodymass index is significant only in lack of energy subscale. It is determined that 45-54 years of age group has the highest scores from the subscales lack of time, lack of energy and lack of will of ALCS in terms of age variable. When gender variable is considered, it is determined that both women and men have high scores from lack of energy subscale. When body mass index variable is considered, overweight participants have the high scores from lack of energy subscale. Finally, it could be suggested that the most important factors that constrain adults from an active life are lack of energy, lack of time and lack of wil
HALP Score as a New Prognostic Factor for Patients with Metastatic Bladder Cancer
No full textObjective: To investigate the effect of the haemoglobin, albumin, lymphocyte, and platelet (HALP) score (Haemoglobin, Albumin, Lymphocyte, Platelet count) on survival as a new prognostic factor in metastatic bladder cancer. Place and Duration of the Study: Department of Medical Oncology, Celal Bayar University, Manisa, Turkey, and Adnan Menderes Methodology: The medical charts of patients with metastatic bladder cancer were reviewed retrospectively. Prognostic value of the HALP score as a marker of overall survival was examined through a receiver operating characteristic (ROC) curve analysis. Results: The cut-off value for the HALP score in the ROC curve analysis was 29. The median overall survival (OS) was 19 months when the HALP score was less than 29, and the median OS was 40 months when the HALP score was 29 or greater, and this finding was statistically significant (p = 0.003). Conclusion: The HALP score is closely related to prognosis in metastatic bladder cancer. A high HALP score is associated with better survival outcomes
Is there an association between clinical symptoms and intestinal parasitic infections?
No full textIntestinal parasitic infections are major causes of childhood diseases in rural regions. The significant causes of this problem are the insufficient resources to improve the infrastructure in these regions and inadequate health services in both the diagnosis and treatment of diseases, The aim of this study was to assess the association between intestinal parasitic infections and clinical symptoms of infected children. Cellophane tape and stool samples of 100 children, aged between 7-10 years, from two villages of Manisa city, were examined for intestinal parasites and their symptoms were recorded. Although some symptoms, such as abdominal pain, anorexia and fatigue were found to be common in infected children, no significant relationship was found between symptoms and intestinal parasitic infections
Neural extension of experimental data to investigate using phosphogypsume in light brick production
No full textIn this study, usability of wastes produced in phosphoric acid plants in structural brick manufacture has been investigated. There are several parameters involved in using these wastes in brick production namely the rate of added waste, firing speed and firing temperature. The performance of these parameters can be measured by several criteria such as natural drying shortening, water absorption and weight loss. Therefore, so many experiments are needed to investigate the effects of these parameters on the bricks produced with these wastes. The result of a series of experiments were utilized to achieve this end. The results have shown that the industrial wastes considered improve the performance of the bricks in terms of the criteria mentioned above. However, the results have also shown that further investigations are needed to explore the effects of interim values on the performance of the bricks. To achieve that end, a neural experimental study is adopted. For this purpose, the results of the experiments conducted were used to construct an artificial neural network. The trained and tested network was then used to check the effects of 280 different combinations for each type of material mixtures mentioned. The outcome of these artificial tests have provided the optimal values for the waste addition rate, firing speed and firing temperature based on the four criteria mentioned previously. (c) 2008 Elsevier Ltd. All rights reserved