Manisa Celal Bayar Üniversitesi Akademik Arşiv Sistemi
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LIMPRINT Study: The Turkish Experience
No full textBackground: Lymphedema and chronic edema is a major health care problem in both developed and nondeveloped countries The Lymphoedema Impact and Prevelance - International (LIMPRINT) study is an international health service-based study to determine the prevalence and functional impact in adult populations of member countries of the International Lymphoedema Framework (ILF). Methods and Results: A total of 1051 patients from eight centers in Turkey were recruited using the LIMPRINT study protocol. Data were collected using the core and module tools that assess the demographic and clinical properties as well as disability and quality of life (QoL). Most of the Turkish patients were recruited from specialist lymphedema services and were found to be women, housewives, and having secondary lymphedema because of cancer treatment. The duration of lymphedema was commonly <5 years and most of them had International Society of Lymphology (ISL) grade 2 lymphedema. Cellulitis, infection, and wounds were uncommon. The majority of patients did not get any treatment or advice before. Most of the patients had impaired QoL and decreased functionality, but psychological support was neglected. Although most had social health security access to lymphedema centers, nevertheless access seemed difficult because of distance and cost. Conclusion: The study has shown the current status and characteristics of lymphedema patients, treatment conditions, the unmet need for the diagnosis and treatment, as well as burden of the disease in both patients and families in Turkey. National health policies are needed for the prevention, diagnosis, and treatment in Turkey that utilize this informative data
Morphological and Anatomical Studies on Arum nickelii Schott and Arisarum vulgare O.Targ.-Tozz Species
No full textIn this study, aimed to investigate the morphology and anatomy of Arum nickelii Schott (Yilan yastigi) and Arisarum vulgare O.Targ.-Tozz (Yilancikotu) belong to Araceae family. The plants are separated from each other according to whether spathe is united or divided. Anatomical sections were prepared using paraffin method and painted by double staining series safranin-fast green. It is observed that, plants containing typically feature, of monocotyl have distinguish features from other types of Araceae. These differences are illustrated with original drawings and photographs
Synthesis of new 1,2,3-triazolo-nucleoside analogues with 2-propargylamino pyrimidines via click reactions
No full textIn this study, it was reported that twelve nucleoside analogues were synthesized by click reactions. The reactions were carried out between the azide derivatives of D-glucopyranose, D-galactopyranose, D-ribofuranose and 2-propargylamino pyrimidine derivatives (5 and 7) that are synthesized via a different route for the first time. In the first step, N-propargyl guanidine was obtained with the reaction of 1H-pyrazole-1-carboxamidine hydrochloride and propargyl amine, then condensation of N-propargyl guanidine and beta-diketone (4 and 6) resulted in 2-propargylamino pyrimidines (5 and 7) for the first time in good yields (85%). Finally, click reactions were performed with azidosugars (8a-8f) and 2-propargylamino pyrimidine derivatives and produced twelve new nucleoside analogues in good yields. (9a-9f, 10a-10f, 65-73% yields). The chemical structures of the new derivatives were elucidated spectroscopic techniques, such as FT-IR, H-1 NMR, F-19 NMR, C-13 NMR and TOF-ESI-MS
Low levels of urinary epidermal growth factor predict chronic kidney disease progression in children
No full textUrinary epidermal growth factor (uEGF) has recently been identified as a promising biomarker of chronic kidney disease (CKD) progression in adults with glomerular disease. Low levels of uEGF predict CKD progression and appear to reflect the extent of tubulointerstitial damage. We investigated the relevance of uEGF in pediatric CKD. We performed a post hoc analysis of the Cardiovascular Comorbidity in Children with CKD (4C) study, which prospectively follows children aged 6-17 years with baseline estimated glomerular filtration rate (eGFR) of 10-60 ml/min/1.73 m(2). uEGF levels were measured in archived urine collected within 6 months of enrollment. Congenital abnormalities of the kidney and urinary tract were the most common cause of CKD, with glomerular diseases accounting for <10% of cases. Median eGFR at baseline was 28 ml/min/1.73 m(2), and 288 of 623 participants (46.3%) reached the composite endpoint of CKD progression (50% eGFR loss, eGFR < 10 ml/min/1.73 m(2), or initiation of renal replacement therapy). In a Cox proportional hazards model, higher uEGF/Cr was associated with a decreased risk of CKD progression (HR 0.76; 95% CI 0.69-0.84) independent of age, sex, baseline eGFR, primary kidney disease, proteinuria, and systolic blood pressure. The addition of uEGF/Cr to a model containing these variables resulted in a significant improvement in C-statistics, indicating better prediction of the 1-, 2- and 3-year risk of CKD progression. External validation in a prospective cohort of 222 children with CKD demonstrated comparable results. Thus, uEGF may be a useful biomarker to predict CKD progression in children with CKD
Evaluation of species distribution and risk factors of candidemia: a multicenter case-control study
No full textThe application of Migration of Armenians around Trabizond according to Turkish and German Sources
No full textThere has not been any detailed study, based on Turkish and German sources, on Forced migration of Armenians from Trabizond. This study aims to fulfill this gap. Based on Turkish documents and reports of German diplomats, this article examines forced migration of Armenians from Trabizond. Reports of German diplomats both serve the understanding of the Armenian migration and prove that there has not been any Armenian Massacre. Turkish sources, too, show that Ottoman State had no bad intentions in migration policies. As a result, both Turkish and German sources indicate show that. There has not been any Armenian massacres around in Trabizond
An advanced method with convergence analysis for solving space-time fractional partial differential equations with multi delays
No full textThis study considers the space-time fractional partial differential equations with multi delays under a unique formulation, proposing a numerical method involving advanced matrix system. This matrix system is made up of the matching polynomial of complete graph together with fractional Caputo and Jumarie derivative types. Also, the derivative types are scrutinized to determine which of them is more proper for the method. Convergence analysis of the method is established via an average value of residual function using double integrals. The obtained solutions are improved with the aid of a residual error estimation. A general computer program module, which contains few steps, is developed. Tables and figures prove the efficiency and simplicity of the method. Eventually, an algorithm is given to illustrate the basis of the method
Calibration of gamma-ray detectors using Gaussian photopeak fitting in the multichannel spectra with a LabVIEW-based digital system
No full textThis paper reports on the development of a gamma-ray spectroscopic system for the (i) recording and (ii) processing of spectra. The utilized data read-out unit consists of a PCI digital oscilloscope, personal computer and LabVIEW (TM) programming environment. A pulse-height spectra of various sources were recorded with two NaI(T1) detectors and analyzed, demonstrating the proper usage of the detectors. A multichannel analyzer implements the Gaussian photopeak fitting. The presented method provides results which are in compliance to the ones taken from commercial spectroscopy systems. Each individual hardware or software unit can be further utilized in different spectrometric user-systems. An application of the developed system for research and teaching purposes regarding the design of digital spectrometric systems has been successfully tested at the laboratories of the Department of Experimental Physics
Nonlinear Mathematical Models for Paths Maintaining Constant Normal Accelerations
No full textNew path equations maintaining constant normal accelerations with arbitrary tangential decelerations for a moving object is derived. The case of tangential deceleration proportional to the square of velocity is treated in detail. It is assumed that in this special case, the vehicle is under the influence of drag force only. The equation is cast into a dimensionless form first. Numerical solution of the resulting nonlinear third order differential equation is contrasted with the perturbation solution. When the perturbation parameter is small, the match is excellent. The derived paths may found applications in the motion of land, marine and aerial vehicles
Synthesis and thermoluminescence study of Eu doped novel LaBO3 phosphor: Heating rate, dose response, trapping parameters
No full textIn this study, LaBO3, one of the Lanthanum-based perovskites-type oxides, and a series of LaBO3:Eu3+ phosphor samples were synthesized by solid state reaction technique. By using XRD, samples of the synthesized samples were analysed to identify a compound that indicates orthorhombic cells belonging to the Pmcn (62) space group. After 5 Gy of beta irradiation, the sample doped with 0.5 mass % Eu showed the highest integrated thermoluminescence intensity (TL). To evaluate the dose response, samples were irradiated with beta radiation from 0.1 to 100 Gy. The studied sample exhibits linear behaviour up to doses up to 5 Gy, while above this (up to 100 Gy) shows quasi-linear behaviour before reaching saturation. The peak number, trap structure, and kinetic parameters of Eu-doped LaBO3 thermoluminescence curves were determined using an initial rise method combined with TM-Tstop experiments, various heating rates (VHR), and Glow Curve Deconvolution (GCD) method. TM-Tstop calculations suggest nine plateaus of activation with energies of 1.21 eV, 0.98 eV, 1.03 eV, 1.32 eV, 1.43 eV, 0.68 eV, 1.98 eV, 1.83 eV and 1.92 eV which constitute the main radiation storage contributions. The GCD method was used to calculate trap depths and frequency factors ranging from 0.68 to 1.95 eV and from 106 to 1015 s-1, respectively. In VHR method, one of the high temperature glow peaks exhibited unusual behaviour which was attributed to a competition between radiative and non-radiative transitions