Manisa Celal Bayar Üniversitesi Akademik Arşiv Sistemi
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Dyspnea: perfus?on ?ndex and tr?age status
No full textPurpose: To determine the relationship between perfusion index and the emergency triage classification in patients admitted to the emergency department with dyspnea. Methods: Adult patients who presented with dyspnea and whose perfusion index values were measured with Masimo Radical-7 device at the time of admission, at the first hour and the second hour of admission were included in the study. The PI and oxygen saturation measured by finger probes were compared and the superiority of their effects on the emergency triage classification was compared. Results: For the 0.9 cut- off value of the arrival PI level according to the triage status; sensitivity 79.25%; specificity 78.12%; positive predictive value is 66.7 and negative predictive value is 87.2. A statistically significant correlation was found between the triage status and the 0.9 cut- off value of the admission PI level. We can say that the ODDS rate of red triage is 13.63 times (95% CI: 5.99-31.01) times higher in cases with a PI level of 0.9 and below. In the ROC analysis, the cut-off value of 1.1 and above the admission PI level was determined as the most appropriate point for discharge. Conclusion: The perfusion index can help to determine the triage classification in emergency departments for dyspnea
Reduction of [CP2*Mo2O5] by thioglycolic acid in an aqueous medium
No full textCompound [CP*2Mo2O5] reacts with thioglycolic acid, HSCH2COOH, in an acidic (CF3COOH) mixed water-methanol solvent, to yield compound [{Cp*Mo(mu-SCH2CO2)}(2)(mu-S)]. During this reaction, the thioglycolic acid acts as a reducing agent, as a ligand, and provides a sulfide ion for the Mo-S-Mo bridge. The molecular structure of the product can be described as containing two four-legged piano stools that share three legs. The Mo-Mo distance of 2.792(7) angstrom indicates metal-metal bonding, in agreement with the compound diamagnetism. (c) 2005 Elsevier B.V. All rights reserved
The effects of gender and menopause on serum lidocaine levels in smokers
No full textit has been established that human cytochrome P450 (CYP) enzymatic activity is affected by gender, or by hormonal factors such as the menopause in women. Gender differences have a more pronounced effect on cytochrome (CYP) 3A4 isoenzyme activity, whereas cytochrome (CYP) 1A2 isoenzyme activity is mainly induced by chronic smoking. Lidocaine is frequently used in the treatment of hemodynamic changes following laryngoscopy and tracheal intubation during general anesthesia, and is metabolized by CYP3A4 and CYP1A2 isoenzymes in the liver. The aim of this study was investigate the effects of gender and menopause on serum lidocaine levels in smokers under general anesthesia. Six men, six premenopausal women and six postmenopausal women were enrolled in the study and received i.v. lidocaine (1 mg/kg) 1 minute before they underwent general anesthesia. Serum lidocaine concentrations were measured using the EMITO method at 1, 5, 10, 20, 40 and 60 minutes post-administration. Statistical analyses were performed using the Mann-Whitney U-test. No statistically significant differences were found regarding the area under curve (AUC((0-60)) mu g/mL/min), elimination half-life (t(1)/(2) [min]) of lidocaine and in the measured levels of serum lidocaine at any time point between the study groups (p > 0.05). These results suggest that gender and menopause may have no significant effect on serum lidocaine levels in smokers
Docetaxel in combination with octreotide shows synergistic apoptotic effect by increasing SSTR2 and SSTR5 expression levels in prostate and breast cancer cell lines
No full textDocetaxel (DTX) is widely used for the treatment of metastatic prostate and breast cancers. Despite the clinical success of DTX, drug-related cumulative toxicity restricts its clinical use in cancer therapy. Thus, there is an urgent need for new therapeutic options. Octreotide (OCT) is a synthetic somatostatin analog that induces apoptosis in different cancer cell lines in vitro. In this study, we investigated the possible synergistic apoptotic effects of DTX in combination with OCT in prostate and breast cancer cell lines. The XTT cell viability assay was used to determine cytotoxicity. Apoptosis was evaluated by Cell Death Detection ELISA(Plus) Kit. The expression levels of apoptotic proteins were assessed by human apoptosis antibody array. Levels of SSTR2 and SSTR5 proteins were determined by western blot analysis. DTX and OCT combination induced apoptosis in both breast and prostate cancer cells in a concentration- and time-dependent manner. Moreover, combination treatment resulted in inhibition of anti-apoptotic proteins such as Bcl-2 and Bcl-xL and induction of pro-apoptotic proteins Bax, Cytochrome c and IAPs in all of the tested cancer cell lines. SSTR2 and SSTR5 protein levels were induced as compared to any agent alone. These results indicate that this combination treatment is a significant inducer of apoptosis in a synergistic manner in breast and prostate cancer cells. This strong synergism helps to lower the dose of DTX in both types of cancers, thus letting DTX to be used for longer periods by delaying resistance development and lesser side effects
The Probable Effects of the Modernization of the Customs Union Upon the International Road Transportation Sector: Izmir Region Example
No full textThis study aims to detect the probable effects of the modernization of the European Union (EU) - Turkey Customs Union upon the international road transportation sector Izmir region has been selected as a research area Izmir is located in the Aegean region, which is the third biggest city and second biggest port of Turkey. With its developed industry due to the region's raw material resources, qualified labor force, and wide range of transportation opportunities, Izmir is one of the important trade centers, ranking second after the Marmara Region in terms of industry. Closeness to the landlocked centers with high processing capacities such as Manisa, Denizli, Aydin, Mugla, Bursa, Usak, Kutahya, and the presence of around 1,700 companies with international capital makes Izmir more critical for the logistics sector. Thus, it is considered an acceptable sample area for the research. A semi-structured interview technique has been used in the investigation. According to the results of interviews with 19 international road transporters in Izmir, the modernization of the Customs Union will increase Turkey's competitiveness of trading in goods and services with the EU countries. Removing the obstacles like visa problems, limitations on the free movement of drivers and transportation services, transit tolls that the Turkish road transport companies face in the EU member states, the modernization of the Customs Union will benefit both Turkish road transporters and exporters, as well as increase trade volume between the sides
Apoptotic effects of Corchorus olitorius L. leaf extracts in colon adenocarcinoma cell lines
No full textCorchorus olitorius L. is a highly consumed plant in Cyprus and other Eastern Mediterranean countries and known as a medicinal food in many cultures. The aim of the study is to determine in vitro anticancer and apoptotic induction effects of dichloromethane (DCM) and aqueous Con-horus olitorius L. leaf extracts in primary (Colo-320) and metastatic (Colo-741) colon adenocarcinoma cell lines.. Cell growth and cytotoxicity were measured with MTT assay with five different concentrations of extracts in Colo-320 and Colo-741 cell lines. Apoptotic activities of Corchorus olitorius L. were investigated by immunocytochemistry using antibodies directed against to caspase-3, cytochrome-c and FasLigand (FasL). TUNEL assay was used to detect DNA fragmentation in both cell lines. Both DCM and aqueous phase of extracts at 50 mu g/ml concentration were more effective at inhibiting Colo-320 and Colo-741 cell growth when compared with other dilutions. The number of TUNEL positive cells was significantly higher in Colo-741 cells when compared with both control group and Colo-320 cell line. DCM phase extract significantly increased caspase-3 immunoreactivity while aqueous phase extract significantly increased cytochrome-c and FasLigand (FasL) immunoreactivities in Colo-320 cell lines. Both extracts were able to significantly increase caspase-3, cytochrome-c and FasL immunoreactivity in Colo-741 cells showing that both apoptotic pathways were triggered. Overall, Corchorus olitorius L. extracts induced apoptosis in both cancer cell lines while being more effective in metastatic colon adenocarcinoma cell lines suggesting that the extracts might have potential anticancer effects and possibility to be used as precursor to phytomedicinal colon cancer treatment as oppose to chemotherapy
On the Developable Mannheim Offsets of Timelike Ruled Surfaces
No full textIn this paper, using the classifications of timelike and spacelike ruled surfaces, we study the Mannheim offsets of timelike ruled surfaces in the Minkowski 3-space. First, we define the Mannheim offsets of a timelike ruled surface by considering the Lorentzian casual character of the offset surface. We obtain that the Lorentzian casual character of the Mannheim offset of a timelike ruled surface may be timelike or spacelike. Furthermore, we give characterizations for developable Mannheim offsets of a timelike ruled surface
Improvement in Corrosion Resistance of Tantalum Oxide and Tantalum Oxide with Diethanolamine Sol-Gel Coated Magnesium Alloys
No full textIn this study, corrosion resistance was developed to ensure that AZ91 Mg alloy remains stable in the body for longer periods. For this purpose, tantalum oxide and tantalum oxide with diethanolamine coatings were made by sol-gel method on AZ91 magnesium alloy surfaces. The structural analyses of tantalum oxide and tantalum oxide with diethanolamine obtained by sol-gel method were carried out. By using the dip coating method, coatings with different concentrations of solutions and different dipping numbers were applied on AZ91 Mg alloy surfaces. Thus, the effects of dipping numbers and chemical content of the solution on the coating thicknesses, surface roughnesses, morphologies and corrosion resistances of coating layers were examined. As a result, it was determined that the coating thicknesses increased with the dipping number. The low number of dipping could not provide sufficient protective layer formation on the surface. Better results were obtained in samples with a high dipping numbers. It was observed that needle-like structures were formed in the solution using diethanolamine. As the amount of diethanolamine increased, a more homogeneous and dense coating layer was observed. Accordingly, an increase in corrosion resistance has been observed. It was determined that the corrosion rate of AZ91 Mg alloy has decreased by 86% with increasing dipping number and diethanolamine amount
Cracking during cold forming process of rear brake component
No full textThe root cause for cracking of rear brake components occurred during cold forming process was investigated. Optical micrographs showed the abundance of extended inclusions with several rounded ones in the steel. SEM image revealed the fracture surface which contained many extended cavities formed by extended inclusions and dimples all indicating a ductile rupture. EDS analysis confirmed that the extended inclusions were MnS type while the rounded ones were formed as a result of Ca-treatment. The crack propagation along with inclusions was clearly observed on the polished planes and on the fracture surface. It was determined that MnS type inclusions were the root cause for the cracking phenomena. The abundance of extended MnS inclusions indicated insufficient inclusion modification through Ca-treatment and insufficient removal of these inclusions in failed steel. (C) 2007 Elsevier Ltd. All rights reserved