Manisa Celal Bayar Üniversitesi Akademik Arşiv Sistemi
Not a member yet
26853 research outputs found
Sort by
Changes in distribution patterns of integrins in endometrium in copper T380 intrauterine device users
No full textIntrauterine contraception is the most cost-effective reversible method of contraception today, but its mechanism of action is not well understood. Our objective was to investigate immunohistochemical. distribution patterns of xv, x3, beta 1 integrins in women using a copper T380 intrauterine device (IUD) for different periods of time to obtain insight into the rote of integrins in intrauterine contraception. Endometrial biopsies were obtained from patients using T Cu380A IUD in follicular and luteat phases and in menopausal women grouped according to the period of time of IUD use (group 1: = 3 years). Each group consisted of 10 patients, with a total number of 60 patients. Labelling intensity of at integrins, except for beta 1 which increased in the follicular phase, were decreased in women who used IUD for >= 3 years when compared with group 1 in the follicular and luteat phases and in the menopause. We conclude that long-term use of IUD affects integrin expression in endometrium not only in follicular and luteat phases of premenopausal women but also in postmenopausal women. Copper IUD can inhibit binding of integrins to the extracellular matrix and it may cause inhibition of the implantation stage, which is crucial for pregnancy. (c) 2005 Elsevier GmbH. All rights reserved
The Mediating Role of Autobiographical Memory in the Relationship Between Narcissism and Rejection Sensitivity
No full textBoth grandiose and vulnerable narcissistic individuals perceive a threat to the self when they face real or imaginary rejection. The sensitivity to rejection may affect them differently. Thus, this research examines the role of grandiose and vulnerable narcissism in the retrieval of self-threatening memories. The study aims to test the mediating role of autobiographical memory (AM) in the relationship between rejection sensitivity (RS) and two dimensions of narcissism. A total of 369 university students (ages between 18 and 32) participated in the study. The Rejection Sensitivity Questionnaire was applied to the participants, triggering the memory of positive and negative autobiographical rejection. Then, the Autobiographical Memory Characteristics Questionnaire and the Pathological Narcissism Inventory were applied. The results showed that the autobiographical memory characteristics differ depending on the dimension of narcissism when they face rejection. This changes depending on having positive or negative content as well as recalling the sensory details especially emotional characteristics of the AM. The use of AM as a mediator in the relationship between narcissism and rejection sensitivity has provided a viewpoint beyond experimental and relational studies. The results have shed light on the role of narcissism and RS in the processing of autobiographical memories
Investigation of Bond Strength of Spray Dried Hydroxyapatite-Wollastonite Composite Powder After Plasma Spray
No full textHydroxyapatite (HA) is one of the most significant calcium phosphate bio-ceramic which is used commercially in biomedical application due to its similar structure with natural bone, bioactivity, and stability in body fluid. HA has excellent biological properties, while plasma sprayed HA coatings have poor bond strength which makes it difficult to use HA coated implants under mechanical stress. Wollastonite (CS) is a calcium silicate based bioactive ceramic which is used in thermal spraying due to its higher bond strength than HA coatings, however it dissolves quicker than HA in simulated body fluid (SBF). The aim of this work is to produce HA-CS composite powder in order to increase bond strength of the coating. In this study, commercial CS and precipitated HA mixture suspension which involved wt. 20% CS was prepared for spray drying (SD) application. HA-CS composite microspheres were granulated by spray drying to supply homogeneity of coating and carry powders to the plasma easily. Afterwards, HA and HA-CS composite microspheres were coated by plasma spraying on carbon steel. Results showed that HA-CS composite coatings have higher adhesion strength, while it decomposes easier to other calcium phosphates than pure HA coating. Additionally, HA-CS coating has higher rate of porosity and un-melted particles
The Role of Proteins in Apoptosis of Somatic and Germ Cells in the Mouse Ovary
No full textIn this study, to determine the mechanisms of cell death in developing follicles, we investigated whether expression of Bcl-2, p53 and Bax play a role throughout the growth of follicles in the mice. Ovarian tissues and oocytes were obtained from 30 Mus Musculus type mouse. The immunostaining of ovarian tissue sections and oocytes was performed using anti-Bcl-2, anti-Bax and anti-p53 antibodies and terminal deoxynucleotidyl transfrase (TdT) assay (TUNEL) were also used for detection of internucleosomal DNA fragmentation. In ovarian tissue section evaluation, granulosa cells in antrum of secondary and Graaf follicles were positive with TUNEL staining. Immunoreactivity of Bcl-2 was moderate in primary and secondary follicles of granulosa cells. While immunostaining of p53 was moderate in granulosa cells of Graaf follicles, Bax immunoreactivity was moderate and strong in secondary and Graaf follicles, respectively. When granulosa cells were break off from zona pellucida, there were TUNEL positive cells. In unfertilised oocytes evaluation, TUNEL positive cells were observed in the granulosa cells which were free from zona pellucida. When the granulosa cells were attached with zona pellucida, they were TUNEL negative. While immunoreactivity of Bcl-2 was detected in both oocytes and granulosa cells which were attached with zona pellucida, immunostaining of p53 were only detected in granulosa cells which break off from zona pellucida. In conclusion, regulation of apoptosis in granulosa cells may be controlled by Bax expression and when the granulosa cells were not attached with zona pellucida, they may go into the apoptotic cascade. Therefore; we suggest that, the death of granulosa cells may control signals from intrinsic pathways in the Graaf follicule or from extrinsic pathways after ovulation. However, we consider of further studies to be necessary
The molecular mechanism of etanercept, an anti-tumour necrosis factor-a receptor-fusion protein, in the treatment of acute generalized exanthematous pustulosis
No full textIntroduction: Acute generalized exanthematous pustulosis (AGEP) is one of the severe adverse cutaneous drug reactions. In its pathophysiology, releasing of tumour necrosis factor-alpha (TNF-) is very important. Therefore, treatment with an anti-TNF- receptor-fusion protein, such as etanercept, may be effective. Objective: To present a case and evaluate the molecular mechanism of etanercept in the treatment of AGEP. Case: A 53-year-old woman with multiple disseminated pustules and a rash on the upper part of her back, which was progressively worsening and spreading to approximately 60-70% of the skin on her back, and fever (38.7 degrees C), was admitted to our department. After etanercept treatment, all the symptoms were rapidly improved and the patient's skin practically cleared within 5 days. Biopsy samples taken from this patient with AGEP before and after etanercept treatment were stained immunohistochemically with p53 and bcl-2 antibodies and also an apoptosis detection kit. Results: In epidermis, increasing p53 expression-related apoptosis and decreasing bcl-2 expression was detected. However, after etanercept treatment, p53 expression-related apoptosis decreased and bcl-2 expression increased. Conclusion: Because TNF- stimulated inflammation and also p53-related apoptosis occurs in AGEP, a TNF- blocking agent such as etanercept may be effective for quick treatment
Drug-using behaviors of the elderly living in nursing homes and community-dwellings in Manisa, Turkey
No full textAim: The study aimed to investigate drug-taking behaviors of the elderly living in a nursing home or community dwelling and to determine the factors affecting their behaviors. Materials and methods: This cross-sectional study was conducted on the elderly living at homes (n = 106) or in nursing homes (n = 220) in the city center of Manisa located in the Aegean region of Turkey. The study data were collected between February 2011 and May 2011. For data collection, three survey forms were used: the socio-demographic questionnaire, the standardized mini mental test and the questionnaire which enquires drug-using behavior. The data were evaluated with SPSS for 15.00 Windows statistical package program. Data descriptive statistics were evaluated with the chi-square test, Student's t-test and logistic regression analysis. Results: The mean age of the whole group was 73.4 +/- 6.3 (65-94). In the study group, the mean numbers of chronic diseases and medications used were 1.2 +/- 0.9 (0-5) and 2.6 +/- 1.8 (0-10), respectively. According to the survey results, those living in nursing homes, males and those with education higher than primary school education displayed better drug-taking behaviors than those living at home, females and those with less than primary school education, respectively. Conclusion: The appropriate use of medicine is a major problem in old age. Living at home or in a nursing home, gender and education are important factors affecting the correct use of medicine in old age. (C) 2011 Elsevier Ireland Ltd. All rights reserved
IL-2R, IL-6 and IL-8 Levels in Behcet's Disease
No full textBackground and Design: Immunological factors are considered to have an important role in the multifactorial ethiopathogenesis of Behcet's disease (BD). Especially, Th1 cells function by expressing proinflammatory cytokines and neutrophil-attracting chemokines. Levels of IL-2R, IL-6 and IL-8 were evaluated in patients with BD in this study. Material and Method: Sixty-six patients with BD (36 with inactive and 30 with active) composed the study group and 22 subjects the control group. Cytokine analyses were done with ELISA method by using commercial kits. ESR and CRP levels were also measured. Results: IL-2R, IL-6 and IL-8 levels in all patients, including the inactive ones, were not different from those in controls. CRP and ESR levels in patients were higher than in controls. IL-8 and CRP levels were increased in patient with active BD (p<0.05) when compared to those with inactive BD. Conclusion: Our study demonstrated elevated levels of serum IL-8, a chemokine activating monunuclear cells and neutrophils, in patients with active BD. IL-8 may be considered as an activity marker for BD. (Turkderm 2010; 44: 213-5
Comparative adsorption of Ni(II) and Cd(II) ions on epichlorohydrin crosslinked chitosan-clay composite beads in aqueous solution
No full textRemoval of Ni(II) and Cd(II) by adsorption on epichlorohydrin crosslinked chitosan-clay composite beads was examined in solutions representative of contaminated solutions containing heavy metals. Several important parameters influencing the adsorption of Ni(II) and Cd(II) ions such as contact time, pH, temperature and effect of metal concentration were investigated systematically by batch experiments. Langmuir and Freundlich adsorption models were used to describe adsorption isotherms and constants. The obtained results showed that the equilibrium adsorption behavior of Ni (II) and Cd (II) on epichlorohydrin crosslinked chitosan-clay composite beads could be applied to Langmuir and Freundlich models respectively. Maximum adsorption capacities for Ni(II) and Cd(II) ions were found as 32.36 mg g(-1) and 72.31 mg g(-1) respectively. The recovery of the metal ions after adsorption and the regeneration of the adsorbent was carried out by treatment of the loaded beads with either 0.1 M HNO3, or 0.01 M EDTA. The adsorbents were characterized by FTIR, SEM and TGA analysis. (C) 2012 Elsevier B.V. All rights reserved
Microstructural Evolution and Mechanical Properties of Cold-deformed Al-5Cu Alloy Samples After Isothermal Heat Treatments
No full textIn this paper, the microscopic morphology of a semi solid Al5Cu alloy by strain induced melt activated (SIMA) process were investigated, and the effects of predeformation, microstructural evolution, aging response and hardness changes were determined. The microstructural observation shows that while the grain boundaries started to appear after 620 degrees C, globular grains surrounded wet boundaries needed for SSP were obtained at 650 degrees C. The grain sizes exhibited ununiformity from the outer surface to the center of the sample because of ununiform predeformation. Although isothermal heat treatments reduced hardness, age hardening gave back the hardness loss
Measurement of the Semileptonic CP Asymmetry in B0-(B)over-bar0 Mixing
No full textThe semileptonic CP asymmetry in B-0-(B) over bar (0) mixing, a(s1)(d), is measured in proton-proton collision data, corresponding to an integrated luminosity of 3.0 fb(-1), recorded by the LHCb experiment. Semileptonic B-0 decays are reconstructed in the inclusive final states D-mu(+) and D*(-)mu(+), where the D- meson decays into the K+pi(-)pi(-) final state and the D*(-) meson into the (D) over bar (0)(-> K+pi(-))pi(-) final state. The asymmetry between the numbers of D-(*()-)mu(+) and D-(*()+)mu(-) decays is measured as a function of the decay time of the B-0 mesons. The CP asymmetry is measured to be a(s1)(d) = (-0.02 +/- 0.19 +/- 0.30)%, where the first uncertainty is statistical and the second systematic. This is the most precise measurement of a(s1)(d) to date and is consistent with the prediction from the standard model