Manisa Celal Bayar Üniversitesi Akademik Arşiv Sistemi
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Can maternal urinary and serum carbohydrate antigen 19-9 concentrations be utilized in the diagnosis of fetal hydronephrosis?
No full textObjective: Fetal hydronephrosis (FH) is the most common fetal renal pathology encountered in daily obstetric practice. Urinary and scrum carbohydrate antigen 19-9 (CA 19-9) concentrations are elevated in obstructive renal pathologies. Our aim was to assess maternal urinary and serum CA 19-9 concentrations in pregnancies with FH and compare results with controls. Material and Methods: Twenty pregnancies with severe FH, 20 pregnancies with mild-moderate FH, and 20 healthy singleton pregnancies were included in this descriptive, case-control study. The diagnosis and classification of FH was based on the anterioposterior diameter of fetal renal pelvis. Maternal urinary and serum CA 19-9 concentrations were measured and compared between groups. Results: Severe FH cases had significantly higher maternal urinary CA 19-9 concentrations compared to controls (median: 75 vs 24 U/mL; respectively; p= 0.014). Concentrations of CA 19-9 did not differ between the mild-moderate FH group and control group. No statistically significant difference was found between the groups with respect to maternal serum CA 19-9 concentrations. Conclusion: Our results show that maternal urinary CA 19-9 concentration is significantly higher in pregnancies with severe FH. However, no difference was detected in serum CA 19-9 concentrations between pregnancies with severe FH, mild-moderate FH and controls. If the mechanisms of transplacental passage and maternal urinary excretion are clarified, maternal urinary CA 19-9 may be a potential marker for indicating fetal kidney damage
Reliability of mechanical properties of induction sintered iron based powder metal parts
No full textReliability and safety are important for machine and construction elements. In this study, iron based powder metal parts (3% Cu, 0.5% Graphite and 1% Kenolube lubricant by weight) were sintered at 1200 degrees C by medium frequency induction sintering mechanism (30 KW powered and 30 kHz frequency). Mechanical property values of components were determined according to changing sintering time. Three point bending, % maximum strain, MicroVickers hardness (HV) and Rockwell-B hardness tests were applied. Statistical distribution functions were drawn and ultimate strength, ultimate strain, MicroVickers and Rockwell-B hardness values were determined depending on various reliability. As a result of the experiments, it was concluded that, the hardness of powder metal materials should not be based on MicroVickers hardness. (C) 2013 Elsevier Ltd. All rights reserved
Coordination entities of a pyrene-based iminopyridine ligand: Structural and photophysical properties
No full textA pyrene-based iminopyridine ligand L has been prepared and displays the absorption and emission properties expected for pyrene-based derivatives in solution. Ligand L, as well as two neutral and, one monocationic coordination entities, respectively formulated as [ZnLCl2] 1, [ReLCl(CO)(3)] 3 and [CuL2] (BF4) 2, have been crystallized and analyzed by single crystal X-ray diffraction analysis. The corresponding crystal structures indicate the formation of supramolecular architectures generated by offset pi...pi stacking between pyrene fragments and strong C-H center dot center dot center dot pi is interactions in coordination entity 1. For the cationic coordination entity 2, the crystal packing reveals the presence of C-H center dot center dot center dot F and C-H center dot center dot center dot pi interactions and numerous C-H center dot center dot center dot pi contacts interconnecting the molecules into a 3D network. As for coordination entity 3, hydrogen bonding and pi center dot center dot center dot pi stacking link the molecules in a three dimensional manner. Zinc(II) and copper(I) coordination entities have also been studied through isothermal titration calorimetry, which indicate a strong binding and a different stoichiometry for both coordination entities. Photophysical studies of the ligand and corresponding coordination entities show a monomer type pyrene emission and a higher fluorescence quantum yield for the zinc coordination entity 1 as compared with copper 2 and rhenium 3 coordination entities. (C) 2017 Elsevier Ltd. All rights reserved
Treatment of mild-to-moderate hypertension with calcium channel blockers: a multicentre comparison of once-daily nifedipine GITS with once-daily amlodipine
No full textBackground: Hypertension is one of the most important causes of cardiovascular disease, and treatment of hypertension leads to a significant reduction in cardiovascular mortality and morbidity. Although calcium channel blockers are regarded as an important part of the therapeutic armamentarium against cardiovascular diseases, and are among the most frequently prescribed anti hypertensive medications, concern has been aroused about these drugs, particularly the short-acting dihydropyridine derivatives. However, the value of nifedipine GITS (Adalat-Crono*), the long-acting dihydropyridine, is in need of being re-established. Objective: To compare the effectiveness, safety and tolerability of once-daily nifedipine and amlodipine treatment in patients with mild-to-moderate essential hypertension. Design: Randomised multicentre trial with an open comparison of treatments for 12 weeks, with a preceding placebo run-in period of 2 weeks (patients on beta-blockers at the time of enrolment entered a mandatory 2-week wash-out period before being allowed in the placebo run-in period; this wash-out period was one week for patients using any antihypertensive medication other than beta-blockers)
Angular analysis of the B0 → K*0 e+ e- decay in the low-q2 region
No full textAn angular analysis of the B-0 -> K(*0)e(+) e(-) decay is performed using a data sample, corresponding to an integrated luminosity of 3.0 fb(-1), collected by the LHCb experiment in pp collisions at centre-of-mass energies of 7 and 8TeV during 2011 and 2012. For the first time several observables are measured in the dielectron mass squared (q(2)) interval between 0.002 and 1.120 GeV2/c(4). The angular observables F-L and A(T)(Re) which are related to the K-*0 polarisation and to the lepton forward-backward asymmetry, are measured to be F-L = 0.16 +/- 0.06 +/- 0.03 and A(T)(Re) = 0.10 +/- 0.18 +/- 0.05, where the first uncertainty is statistical and the second systematic. The angular observables A(T)((2)) and A(T)(Im) which are sensitive to the photon polarisation in this q(2) range, are found to be A(T)((2)) = - 0.23 +/- 0.23 +/- 0.05 and A(T)(Im) = 0.14 +/- 0.22 +/- 0.05. The results are consistent with Standard Model predictions
Assessment of in vitro antitumoral and antimicrobial activities of marine algae harvested from the eastern Mediterranean sea
No full textAntitumoral activities of five algal extracts obtained from the marine algae Scytosiphon lomentaria, Padina pavonica, Cystoseira mediterranea (Phaeophyceae), Hypnea musciformis and Spyridia filamentosa (Rhodophyta) were assessed against the human breast adenocarcinoma cell line MCF-7 and the human prostate carcinoma epithelium like cell lines DU 145, LNCaP, PC3 using the cytotoxic assay, in vitro. The crude extract of S. filamentosa showed strong cytotoxic activity against the DU-145 cell line, and it showed less than 10% cell viability after treatment. Antimicrobial activities of the crude extracts of algae (with the exception of H. musciformis) were also tested by disc diffusion assay against three Gram positive and five Gram negative bacterial strains and against the yeast pathogen Candida albicans. Among the extraxts, S. lomentaria extract (prepared with methanol) inhibited highly Gram negative bacterium Salmonella typhimurium growth while C. albicans growth was only inhibited by C. mediterrranea extract
The Distinction between False Documents and Misleading Documents by the Critical Checkpoint Analysis
No full textThe most important financial source allowing the state to provide basic pubiic serviices such as boosting the general prosperity, supplying educational and medical service, providing security is taxes. The accurate collection of tax revenue is without doubt depends on a precise documentation. However, from time to time it occures that tax-payers attemp tax evasion by fake and misleading documents with different kinds of reasons. Altough the concepts of fake and misleading documents are described in taxation law, occasionally they are used instead of one for another. The regulation or use of this type of documents depending on the property is subject to penalties. For this reason, the difference between fake and misleading documents is described by the critical checkpoint analysis
Evaluation of the Effect of Body Position on Intraocular Pressure Measured with Rebound Tonometer
No full textObjectives: It is important to determine variables that influence intraocular pressure (IOP) measurement. This study aimed to evaluate the effect of body position on IOP. Materials and Methods: The study included 52 right eyes of 52 patients who presented to the ophthalmology department of our hospital and had no ocular disease except refractive errors. IOP was measured with an Icare PRO tonometer while patients were in sitting, standing, and supine positions, with intervals of 10 minutes between the positions. Correlations between the results were evaluated using Spearman's correlation analysis and Wilcoxon tests. Results: Thirty-six of the 52 patients were female, 16 were male. Mean age was 31.65 +/- 6.30 (23-47) years. Mean IOP values in the sitting, standing, and lying positions were 17.76 +/- 3.41 (12.70-25.60) mmHg, 17.10 +/- 3.27 (11.50-25.20) mmHg, and 18.46 +/- 4.67 (10.50-29.40) mmHg, respectively. There were no statistically significant differences between measurements taken in the different positions (p=0.112, p=0.472, p=0.071). We observed that there was no relationship between age and body position (p>0.45, p>0.79, p>0.77) or between gender and position (p>0.59, p>0.69, p>0.54). Conclusion: Gender and age had no effect on IOP measured in different body positions. There were also no significant differences between IOP values measured in the different positions. Therefore, we believe the portable Icare PRO tonometer can be used for patients who are confined to bed and will provide IOP measurements that are concordant with values obtained while sitting
Degradation of single lap adhesively bonded composite joints due to hot water ageing
No full textJoints, which are the most critical part of fibre-reinforced epoxy plastic structures, can be exposed to continuous hydrothermal action. In order to estimate their long-term performance, an accelerated ageing process was performed on adhesively bonded joints of glass-fibre-reinforced epoxy plastics with [0/90/45/-45](s) fibre orientations. Changes in the static tensile properties of single lap shear samples due to hot-wet exposure were investigated for one- and two-week immersion periods and at three different water temperatures (50 degrees C, 70 degrees C, and 90 degrees C). Both the ageing temperature and immersion time were found to be influential on load-displacement characteristics, maximum failure loads, and apparent failure modes of joints bonded with Loctite Hysol-9466 epoxy type adhesive. Due to the hydrothermal exposure, maximum failure loads, distance to failure values, and stiffness of joints decreased by a certain amount in proportion to the immersion time and temperature. While unaged samples and those aged at 50 degrees C and 70 degrees C exhibited mainly light fibre-tear (LFT) failures, the samples treated at 90 degrees C ruptured through the material cross section in stock-break (SB) failure mode
Quantitative liver magnetic resonance imaging: correlation between conventional magnetic resonance imaging, laboratory values, and prognostic indices in Budd-Ch iari syndrome
No full textPURPOSE In Budd-Chiari syndrome (BCS), unevenly distributed parenchymal changes and perfusion abnor-malities occur due to hepatic venous outflow obstruction. This study aimed to evaluate the changes in the liver parenchyma in BCS using the quantitative magnetic resonance (MR) techniques of MR elastography, T1 and T2 mapping, and diffusion imaging and correlate the quantitative MR param-eters through biochemical results and prognostic indices. METHODS Fourteen patients with BCS (seven men and seven women) were examined retrospectively. Liver stiffness (kPa), T1 relaxation times (ms) were achieved using the modified Look-Locker inversion recovery (MOLLI) 3(2)3(2)5 sequence and B1-corrected variable flip angle methods, T2 relaxation times (ms), and apparent diffusion coefficient (ADC) values (mm2/s) were measured using regions of interest placed in the same region in all quantitative methods. Measurements were repeated at the precontrast and postcontrast hepatobiliary phases. The reduction rate (RR; %) and adjusted post -contrast T1 (%) were calculated. The values obtained from different liver parenchyma areas (whole liver, caudate lobe, pathological T2 hyperintense tissue, and relatively preserved normal-appearing tissue) were compared using the Wilcoxon signed-rank test. Spearman's correlation coefficient was used to investigate the correlation between quantitative MR parameters and biochemical parame-ters/prognostic scores (Child-Pugh score, Clichy score, and Rotterdam index). RESULTS The parenchymal stiffness and precontrast T1 values of the caudate lobe were significantly lower than those of the remainder of the parenchyma, whereas the adjusted postcontrast T1 percentages (MOLLI) were significantly higher (P & LE; 0.027). The parenchymal stiffness value, T1 and T2 values, percentages of RR (MOLLI), and adjusted postcontrast T1 values for the pathological tissue and relatively normal tissue were significantly different (P < 0.028). No significant difference was found in terms of ADC values between any of the distinct regions of the liver. A strong correlation was detected between the Child-Pugh score, Clichy score, and precontrast T1 values obtained through the MOLLI sequence (r = 0.867, P = 0.012, r = 0.821, P = 0.023, respectively). No correlation was found between the whole liver stiffness values and the laboratory parameters, fibrosis markers, prognostic indices, or MR parameters. A significant correlation was identified be-tween creatinine levels and several T1 parameters and the T2 relaxation time (r & GE; 0.661, P & LE; 0.052). CONCLUSION Tissue stiffness and T1 relaxation values are high in the areas identified as fibrosis compared with those in the relatively preserved parenchyma. The T1 relaxation time can offer quantitative informa-tion for assessing segmental functional changes and prognosis in BCS