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Linearization of Multi-band RF Transmitters Based on Direct Learning Architecture for LTE/5G Applications
No full textInternational audienc
Livre blanc de la pharmacologie biologique
No full textNational audienceEn 2024, le groupe de travail « Suivi thérapeutique pharmacologique et personnalisation des traitements de la Société française de pharmacologie et de thérapeutique » a élaboré un livre blanc dont l’objectif est de présenter l’état des lieux de la sous-discipline de la pharmacologie biologique, de décrire les compétences attendues pour exercer le métier de pharmacologue biologiste, de définir le périmètre de l’activité professionnelle, d’identifier les forces et les points d’amélioration actuels de la sous-discipline dans l’objectif final de proposer les évolutions du métier de pharmacologue biologiste. Ce document se compose de plusieurs parties : un préambule visant à rappeler le panorama de la pharmacologie biologique en France ; un état des lieux rappelant ce qu’est un pharmacologue biologiste, ses missions, les forces et faiblesses de la profession et les pré-requis en termes de formation ; un référentiel de compétences du pharmacologue biologiste et enfin les perspectives et nouvelles missions du pharmacologue biologiste. Ce document a pour vocation de servir de référentiel, d’aider à définir la profession de pharmacologue biologiste et de structurer la discipline afin de pouvoir la faire évoluer vers une profession d’interface entre biologie et clinique
Non-dietary personal pesticide exposure using silicone wristbands across 10 European countries
No full textEdition: 20250814International audienceIndividuals are exposed to pesticides via dietary and non-dietary exposure routes. There is a growing need for aggregated exposure estimates across occupationally and non-occupationally exposed populations. Exposure to current-use and legacy pesticides was studied using silicone wristbands worn by farmers, residents living close to treated fields (neighbors), and the general population (consumers), in total, 641 participants across 10 European countries. Wristband extracts were analyzed for 193 pesticides by targeted Liquid and Gas Chromatography-Mass Spectrometry. Information on exposure predictors, such as frequency of cleaning, was collected by questionnaire. Logistic regressions and multivariable generalized least squares models were used to study predictors of pesticide occurrence and concentrations, respectively. We detected 173 out of 193 pesticides (89 %) across all samples. Per wristband 9 - 74 (median of 36) pesticides were detected in conventional farmers (FC), 8 - 66 (median of 20) in organic farmers, 3 - 66 (median of 20) in neighbors and 2 - 54 (median of 17) in consumers. Insecticides, like permethrin and chlorpyrifos, were commonly detected across all groups (\textgreater85 %). Concentrations varied significantly across groups, with the highest levels often observed in FC. We identified pesticide use and having pets as important predictors of personal non-dietary exposure. Mixture analysis revealed one major combination (in 72 % of all samples) of three insecticides, namely permethrin, chlorpyrifos, DDE p,p', and the synergist piperonyl butoxide. This study highlights that farm workers using a conventional farming system are a highly exposed group. It is unclear what the identified prevalent mixtures mean for cumulative exposure and resulting health risks
Versatile luminescence macroscope with dynamic illumination for photoactive systems
No full textInternational audienceLuminescence imaging is invaluable for studying biological and material systems, particularly when advanced protocols that exploit temporal dynamics are employed. However, implementing such protocols often requires custom instrumentation, either modified commercial systems or fully bespoke setups, which poses a barrier for researchers without expertise in optics, electronics, or software. To address this, we present a versatile macroscopic fluorescence imaging system capable of supporting a wide range of protocols, and provide detailed build instructions along with open-source software to enable replication with minimal prior experience. We demonstrate its broad utility through applications to plants, reversibly photoswitchable fluorescent proteins, and optoelectronic devices.</div
Ce que disent les familles plurielles de l’évolution de la parenté et de la parentalité : le beau-parent vulnérable
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Multimaterial fibers interfaced with ZnO for photoelectrochemical detection
No full textInternational audienceThe development of miniaturized, remotely addressable sensing devices is crucial in a variety of fields, including healthcare, environmental monitoring, and security. This study introduces an optrode sensor comprising a multimaterial fiber composed of a phosphate glass cladding and a continuous Zn wire core, interfaced with a photoactive ZnO coating on its tip, deposited by anodization. It is shown that this optrode can promote photoelectrochemical reactions under illumination with UV light when immersed in an aqueous electrolyte. Proof-of-principle experiments demonstrate that these optrodes produce a glucose-responsive photocurrent, opening the way to biomedical applications. This optical sensor shows promise, as it would ultimately allow the decoupling of input stimuli, i.e., potential and light excitation, over a long distance. Due to its advantages in terms of integration, detection speed, and ease of use, these ZnO/Zn/phosphate optrodes hold significant potential for remote analysis and implantable sensors.</p
Polynomial solutions for general linear polynomial ordinary integro-differential systems
No full textInternational audienceIn this article, we consider the problem of computing polynomial solutions of general linear systems of ordinary integro-differential equations with polynomial coefficients. This algorithmic problem is a key step for many computations with matrices having linear integro-differential operator entries such as the computation of left/right syzygies, left/right inverses, left/right factorizations, and thus, for the development of an effective algebraic analysis approach for linear systems of ordinary integro-differential systems using effective elimination methods and effective homological algebra. The linear systems that appear in the above problems are generally rectangular and inhomogeneous. The contribution of this paper is to provide the first algorithm for computing polynomial solutions of inhomogeneous rectangular systems of linear integro-differential equations with polynomial coefficients. Our algorithm is implemented in the freely available Maple package Bavula
Comparative assessment of early neointimal formation: P8RI-coated Silk Vista versus Pipeline Vantage (Shield) in a rabbit model using optical coherence tomography
No full textInternational audienceBackground Several coating strategies have been recently introduced to reduce thrombogenicity of flow diverters (FDs), while the P8RI coating focuses on stimulating endothelial cells for faster arterial healing. This study aims to evaluate early neointimal growth over the FD struts by comparing these two strategies in an animal model. Methods Bare Silk Vista (bare-SV), P8RI Silk Vista (P8RI-SV), and Pipeline Vantage with Shield technology (Shield-PV) were implanted in rabbits to treat elastase-induced aneurysms (n=6, 10, and 7, respectively) and in the aorta (n=6, 7, and 4, respectively). At 5 and 28 days, the devices were imaged with optical coherence tomography (OCT) to evaluate the stent-coverage ratio. Conventional histology and multiphoton microscopy were also performed. Results The aneurysm occlusion rate was similar in all three groups (P=0.577). On OCT images, the stent-coverage ratio on day 5 and day 28 (overall and at each location) was significantly higher with P8RI-SV compared with both bare-SV and Shield-PV (Kruskal-Wallis P<0.0001, Dunn post-test P<0.001 for both timepoints). Histological and multiphoton microscopy evaluations confirmed that the struts of P8RI-SV were covered by well-organized neointima expressing a high rate of collagen at the aneurysm neck and in the aorta, compatible with an advanced stage of tissue remodeling and stabilized neointima. Conclusion P8RI-SV demonstrated higher rates of neointimal formation covering the FD struts compared with bare-SV and Shield-PV at day 5 and day 28 in rabbits. These results confirm faster and improved arterial healing with P8RI coating; however, further studies are needed to evaluate the clinical benefits in patients
Complications following curative brain arteriovenous embolization: a 12-year single-center cohort study with MRI-monitored adverse events
No full textInternational audienceOBJECTIVE Advancements in endovascular devices and techniques have improved cure rates for selected brain arteriovenous malformations (AVMs). However, data on angiographic and treatment-related complications remain limited. This study presents a 12-year single-center experience with curative endovascular treatment (EVT), along with comparative insights from previously published cohorts. METHODS Data from all brain AVMs treated with curative intent EVT between 2010 and 2022 were reviewed for baseline demographic characteristics, angioarchitectural features, treatment techniques (single arterial, double arterial, venous, arterial and venous, and transvenous embolization with selective temporary flow arrest [TFATVE]), complications, and clinical and angiographic outcomes. Hemorrhagic and ischemic complications were assessed with postprocedural MRI. Ischemic volumes were semiautomatically calculated on apparent diffusion coefficient maps using regions of interest segmentation by two independent readers. Univariate and multivariate analyses were performed to identify predictors of cure and complications. RESULTS A total of 193 patients (54% male, mean ± SD age 38.7 ± 15.9 years) with 193 AVMs (60.6% ruptured) were included. The following techniques were included: single arterial (37.8%), double arterial (26.4%), arterial and venous (19.7%), TFATVE (8.3%), and single venous (7.8%). Intraprocedural complications occurred in 10.4% of cases. Both hemorrhagic and symptomatic ischemic complications occurred in 15.5% of patients. Mean ischemic volume was 9.4 ± 15.1 cm 3 and was significantly higher in symptomatic cases. Overall minor and major complications rates were 14% and 3.1%, respectively. The mortality rate was 4.7% and was lower in unruptured AVMs though these had a higher complication rate. The overall angiographic cure rate was 80.3%, increasing to 93%–100% in cases treated with advanced approaches. On multivariate analysis, AVM in an eloquent brain location was associated with lower cure rates (OR 0.3, p = 0.023), while advanced techniques involving TVE were associated with higher cure rates (OR 7.9, p < 0.001). CONCLUSIONS This large, single-center experience adds to the growing evidence that curative EVT can be a valuable option, especially when advanced techniques are used for low-grade and ruptured deep AVMs. At the same time, higher complication rates in unruptured or higher grade (Spetzler-Martin [SM] grade IV–V) lesions highlight the importance of cautious patient selection. Larger, multicenter prospective studies in high-volume centers are needed to better define the role of curative EVT