International Journal of Research in AYUSH and Pharmaceutical Sciences (IJRAPS)
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The Effectiveness of Goksuradi Guggulu and Varunadi Kwath with Goksuradi Guggulu in the Management of Mutrasmari w.s.r. to Urolithiasis
Full text linkIntroduction: Mutrasmari is considered as Astamahagada in Ayurveda in which there is formation of stone in the Mutravaha srota. It is an ancient disease with global distribution. The symptoms of Mutrasmari are excruciating pain in urethra, ureter, urinary bladder and over umbilical region, haematuria etc and later that may lead to emergence by the obstruction in urination. Hence on the basis of pathology and its clinical presentation the disease is correlated with Renal calculus or Urolithiasis in modern Urology.
Methodology: 38 patients diagnosed as Mutrasmari were randomly divided in two groups as per the lottery system of randomization. The patients of Group A were given 1000mg Goksuradi guggulu twice a day for 45 days. The patients of Group B were given 1000 mg of Gokshuradi guggulu along with 45 ml of Varunadi kwatha twice a day for 45 days. The patients of both the groups were advised to follow the dietary regimen and lifestyle modification. The effect of the intervention was assessed before and after treatment.
Result: The treatment outcomes were statically analyzed and found that both treatment groups were significant in relieving the symptoms like abdominal pain, burning micturition, dysuria and expulsion of renal culculi. 100% relief noted on Surudhir mutrata (Hematuria) where only single patient complaint had been registered as Hematuria in Group B. In case of Mutradaha (Burning micturation) there was mild improvement in group A and moderate improvement in group B. Similarly there was complete remission in Mahati vedana (Dysuria and Pain in abdomen) case in both Group A and Group B after the treatment. Conclusion: Gokshuradi guggulu along with Varunadi Kwatha shows more significant result than Gokshuradi guggulu
Management of Vataja Kasa w.s.r. to Tropical Pulmonary Eosinophilia by Shringarabhra Rasa with Mridu Virechana
Full text linkThe clinical features of vataja kasa are oftenly compared to TPE are, Shushka kasa, Alpa kapha nishtivana, Swarabedha, shushka ura kantha vaktrata, Dourbalya etc. TPE is an occult form of filariasis and is characterized by dry cough, dyspnoea, nocturnal wheezing etc, and marked peripheral blood eosinophilia. This affects males and females at a ratio of 4:1 often during the 3rd decade of life. Keeping in view about the adverse effects of the modern sciences, an attempt was made to find an effective Ayurvedic treatment modality.
Methods: 15 subjects with classical signs and symptoms of Vataja kasa and raised esinophil count >500cells/cumm were selected. After Amapachana by Shunti churna with hot water, subjects were given Kantakari ghrita for Snehapana prior to Virechana with Eranda taila followed by Shringarabhra rasa for 21 days with follow up of 1 month.
Results: Shringarabhra Rasa with Mridu Virechana provided highly significant results in all parameters of assessment.
Conclusion: It is found that the relief was highly significant after Mridu Virechana. It is found that the effect of therapy was highly significant on Shushka kasa and Shushka urah kantha vaktra
Role of Takra (Ayurvedic Probiotic) in the Management of Gastrointestinal Disorders
Full text linkGastrointestinal disorders can be grouped as functional gastrointestinal disorders (FGIDs) without an organic cause based on the systems and part of the Gastrointestinal (GI) system affected. Probiotics are called "good" or "helpful" bacterias as they help keep our gut healthy. probiotics have been extensively studied in detail in infectious gastroenteritis, antibiotic-associated diarrhea etc., gastrointestinal disorders. As the probiotics are the fermented products, Takra can be considered as an Ayurvedic probiotic which is being used since centuries in Grahani etc., Rogas. The present study evaluates the effect of the Takra or the buttermilk in the management of gastrointestinal disorders. A detailed study of Takra is shown having multiple benefits and very effective in increasing the good bacterias of the gastrointestinal system, and thereby decreasing the bad bacterias and play a very important role in maintenance of the gastrointestinal health. Consumption of Takra, an Ayurevdic probiotic in our daily meals helps to promote the intestinal immunity and prevention of the gastrointestinal disorders
Concept of Ekal Dravya Chikitsa (Single Drug Therapy) in Sushrut Samhita
Full text linkAyurveda is a holistic health care system which, aims to offer the user an optimum health by alleviating diseases and helps in maintaining, promoting health by advising proper daily and seasonal regimen along with rationalized therapeutics when indicated. A good physician is one who uses minimum substances for desired effect or maximum results. From ancient past, it has been revealed that Ayurveda had a vast knowledge in the field of application of medicinal plants. Medicinal plants have significant importance in human life as it helps in maintaining human health and in improving the quality of life. Also this application in the form of single dravya has also been evidenced in many of Ayurveda texts.
Sushrut Samhita is one of the classical text of Ayurveda, basically a part of Brihatrayee, have been surviving from ancient time and considered to be an important treatise on medicine and surgery. It is one of the two foundational Hindi texts alongside the Charak Samhita, which includes knowledge about medicine as well as surgical training, instruments and procedures. Likewise in charak samita, use of EDC has been also mentioned in Sushrut Samhita for both inervention as well as surgical management of disease. Using Ekal Dravya for curing many disease has been mentioned in past by many of Aacharyas, considering Sushrut Samhita as the first Samhita of Ayurveda to use therapeutic interventions as well as surgical procedure for the management of clinical condition, It has been reviewed to assess the extent of use of EDC.
Using single herb for managing diseased condition has been evidenced at various instances in Sushrut Samhita in conceptual as well as in applied form. This provides an evidenced based proof that EDC was mentioned in our ancient Ayurvea texts which now need to be explored, so as to minimize the load on biodiversity for using minium herbs in a disease where it is sufficed
A Comparative Clinical Study in the Management of Vataja Kasa w.s.r. to Tropical Pulmonary Eosinophilia by Shringarabhra Rasa and Shwasakasa Chintamani along with Mridu Virechana
Full text linkVataja kasa vis-à-vis T.P.E is a disease of Swasanavaha samsthana, is one of the commonest problem in tropical countries like India. India being a tropical country the prevalence of TPE is remarkable. Vatajakasa presents with symptoms like Shuska kasa, Prasakta vega, Uraha shoola, Ksheena bala, Ksheena oja, Kshamana etc. In Ayurveda, researches have been done and Vataja kasa can be compared with TPE. TPE symptoms such as repeated bouts of dry cough, chest pain, weight loss, and Malaise etc may continue for weeks or months with remission and reoccurrence.
Methods: Classical signs and symptoms of Vataja kasa and raised esinophil count >500cells/cumm and 30 patients were selected and randomly allocated in two groups. Firstly, Shunti churna with hot water was given for Amapachana, later patients were given Kantakari ghrita for Snehapana prior to Virechana with Eranda taila in both the groups followed by Shringarabhra rasa in Group A and Shwasa kasa chintamani in Group B for 21 days with follow up of 1 month.
Results: Both Group A and Group B provided highly significant results in all parameters of assessment but group B showed better improvement in the symptoms of the disease Vataja kasa in the present study.
Interpretation and Conclusion: 15 subjects (50%) got marked relief, 5 subjects (16.66%) got moderate relief in subjective parameters; 20 subjects (66.66%) got mild relief and 5 (16.66%) subjects got moderate relief in objective parameter. Hence, the modalities of our treatment can be recommended to all the patients of Vataja kasa without any hesitation
A CLINICAL UTILITY OF PRAKRITI PARIKSHAN- AN AYURVEDIC DIAGNOSTIC TOOL: A BRIEF REVIEW
Full text linkAyurveda is science of life. Prevention and cure of disease is the aim of Ayurveda. Prakriti is one of the major Ayurvedic principles derived from the Veda, Purana, Upanishad, and Darshana. Prakriti in Ayurveda refers to an individual’s inherent nature; an inborn inclination that governs consciousness and activity. Prakriti is supposed to be fixed in every person. It is influenced by the status of Tridosha, at the time of union of ovum and sperm. Also, an individual\u27s Prakriti is determined based on the predominance of any single or a combination of two or three Dosha. Every individual, like genetic coding, has a different combination and is thus a distinct entity. In Ayurvedic texts different Acharyas have described different features of Doshaj, Manasa, Bhautika & Jatyadi Prakriti. For fulfilling the aim of Ayurveda and alleviating disorders in diseased states, knowledge of an individual\u27s constitution and status of Dosha is required, and with this knowledge, we can prevent and cure disease stages by managing the diet, physical activities, and psychological conditions of the individual. Prakriti also determine an individual\u27s reaction to environmental circumstances, lifestyle choices, medications, and illness susceptibility, making it one of the earliest known concepts in preventive and personalized or genomic medicine. To understand the pattern of susceptibility of an individual to different diseases, selection of drugs, their dose, drug reaction to the body, disease prognosis, course, and preventive measures, Prakriti analysis is performed first, followed by Vikriti analysis. Hence, Prakriti emphasizes uniqueness and plays a significant role in disease prevention and cure, as well as maintaining a healthy body throughout one\u27s life
The Effectiveness of Taalishadi Churna Compared with Sitopaladi Churna in the Management of Kasa
Full text linkIntroduction: Kasa is a Vata-kapha pradhana disease, caused due to Vata vimargagaman and Pranavaha shrotodusti. Due to the various similarities in its clinical presentation, Kasa can be correlated with cough (bronchitis). According to National center for health statistics, 62 million cases of common cold and cough occurs each year.
Methodology: A total of 44 patients diagnosed as Kasa were randomly divided as per the lottery system of randomization. The patients of Group A were given 5 gram of Sitopaladi Churna twice a day for 30 days. The patients of Group B were given 5 gram of Taalishadi Churna twice a day for 30 days. The patients of both the groups were supposed to follow the dietary and behavioural advices. The response of the drug was assessed at pre-treatment and post-treatment time.
Results: There was equal significant change in all of the Roga bala, Agni bala and Deha bala parameters by both Sitopaladi and Taalishadi Churna. It was revealed that all other blood parameters except Hb, TLC and Neutrophil count used in the study were not significant in both the groups. Both drugs were found equally highly significant (p< 0.0001) in Sushka kasa and Swarabheda. Sitopaladi churna was more effective in relieving Hritparswashool (p=0.002) whereas Taalishadi churna is more effective in reducing Pitanisthivanam (p=0.007). In case of Nirghosh, Sitopaladi churna was more effective (p<0.0001). On the other hand, Taalishadi churna was more effective in relieving Peenasa (p<0.001).
Conclusion: Both Sitopaladi Churna and Taalishadi Churna were found to be equally effective in the treatment of Kasa
Development and Evaluation of Controlled Release Formulations of Esomeprazole
Full text linkThe present work was aimed to development of controlled release formulations of Esomeprazole to improve bioavailability. Esomeprazole is the proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing gastric acidity. Construction of calibration curve of Esomeprazole and to investigate the drug and polymer interaction studies by FTIR and DSC. To prepare the different controlled release formulations of Esomeprazole tablets with different polymers like Polymethacrylates such as Eudragit-S100, Eudragit-L100, Eudragit-RSPO, Eudragit-RS100, Eudragit-RL100 and Eudragit RLPO by Direct Compression method. Evaluation of Esomeprazole pre compression parameters such as Bulk density, Tapped density, Hausner’s ratio, Carr’s index, Angle of repose. Evaluation of post-compression parameters of Esomeprazole controlled release tablets such as Weight variation, Hardness, Friability test, Thickness, Drug Content and In-vitro dissolution studies. Evaluation of in-vitro dissolution uniqueness of all the formulations of Esomeprazole by using USP dissolution apparatus type-II (paddle). To study the mechanism of drug dissolution by applying kinetic parameters. To perform the stability studies of optimized formulations of Esomeprazole as per ICH guidelines
AN OVERVIEW OF PROBLEMS ASSOCIATED WITH USE OF MODERN INVESTIGATORY TECHNIQUES FOR DIAGNOSIS OF DISEASES IN AYURVEDA
Full text linkĀyurveda science has a very scientific methodology for diagnosing disease but the skill to adopt that methodology is vanishing day by day. Though various modern diagnostic techniques are evolved in modern medical science, all of them cannot be directly adopted for diagnosis in Āyurveda. In this article, problems associated with use of modern investigatory techniques for diagnosis of diseases in Āyurveda has been discussed. Physiology and Pathology of Āyurvedaare quite different from that of modern medical science. In diagnosing pathologies associated with anatomical abnormalities, these modern investigatory techniques can be adopted easily but the diagnostic tools based on biochemical changes in body cannot be adopted in Āyurveda unless one has proper understanding of basic principles of Āyurveda
PHYSICO-CHEMICAL ANALYSIS OF SHADGUNA KAJJALI AND SHADGUNA BALIJARITA RASASINDURA)
Full text linkAnalytical study of any drug is essential to standardize it. Analytical study is carried out to check drug quality. For this purpose some analytical tests are performed and their results are compared with standard parameters. The drug fulfilling these criteria can be taken as standard drug and can be used for therapeutic purpose. Percentage of total mercury in Shadguna Kajjali and Shadguna balijarita rasasindur was 40.03%, and 84.17%. Total Sulphur in Shadguna Kajjali and Shadguna balijarita rasasindur was 43.07% and 11.16%. Percentage of free sulfur in Shadguna Kajjali and Shadguna balijarita rasasindur was 22.11%. XRD of Shadguna balijarita Rasasindur were identified as Cinnabar (Hgs) with Hexagonal Crystal Structure having primitive lattice. In this paper Physico-Chemical Analysis of Shadguna Kajjali and Shadguna balijarita rasasindura is done