International Journal of Research in AYUSH and Pharmaceutical Sciences (IJRAPS)
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Concept of Urastha Hridaya (Heart) According to Ayurveda
Full text linkHridaya (heart) is considered as one of the vital organ of the body by Ayurveda. Since it is one among the Trimarams and is regarded as Dasha prana ayatana, any injury to the Hridaya results in causation of grave diseases, severe complications or and even death. A vigilant study reveals that, two organs share approximately equal claims to put themselves identical with the term Hridaya which denotes an organ controlling the passage of Prana by collecting, distributing in a rhythm. At one end is the notion that Hridaya refers to brain, at the other end of the scale, it is the view that Hridaya is heart. As per Ayurvedic text, Hridaya is not only an organ that pumps blood, but also something with much wide area of action. Ayurvedic classic mentions that Hridaya is that which controls body, mind and senses, in addition is a seat of the intellect and vitality. Therefore it is essential to understand this organ thoroughly; however, Acharya Charak and Acharya Sushruta considered Hridaya as one among the Kosthangas and one among Kosthas respectively. These descriptions certainly indicate Hridaya as the ‘Urastha hridaya’. The present review article draws attention towards the concept of Urastha hridaya i.e., heart considered in Ayurveda
Simultaneous Estimation of Metformin and Teneligliptin in Pharmaceutical Formulation by Using UV Spectroscopy
Full text linkThree new UV spectrophotometric methods namely simultaneous equation, absorbance ratio and dual wavelength methods were developed and validated for simultaneous estimation of Metformin and Teneligliptin in bulk drug and tablet formulation which were simple, rapid, sensitive, precise and accurate. In simultaneous equation method, absorbance was measured at 233nm for Metformin and 241nm for Teneligliptin. In absorbance ratio method, absorbance was measured at 244nm for Metformin and 233nm for Teneligliptin. In dual wavelength method, two wavelengths were selected for each drug, the absorbances was measured at 225 and 251nm for Metformin and 240 and 221nm for Teneligliptin. Developed methods were validated according to ICH guidelines including parameters viz., specificity, linearity and range, precision, accuracy, limit of detection and limit of quantification. All the three methods showed linear response in the concentration range of 2-10µg/mL for Metformin and 0.5-2.5µg/mL for Teneligliptin with a low correlation coefficient. Results of method validation parameters follows ICH guideline acceptable limits. Methods were found to be simple, rapid, sensitive, economical and hence can be useful for simultaneous estimation of Metformin and Teneligliptin in pure drug and commercial tablet formulation for routine quality control analysis
Pharmacognostic and Phytochemical Evaluation of Bellente Gida (Mussaenda Belilla Buch.Ham.) A Folklore Claim
Full text linkTraditionally used medicinal plants have recently received the attention of the pharmaceutical and scientific committees. Hence there is a need to develop new effective traditional drugs with scientific validation. One such plant is Mussaenda belilla Buch-Ham which belongs to Rubiaceae family locally called as Bellante gida in south canara district Karnataka. It is a climbing shrub. Local people use the leaf juice as shampoo for hair as it is good for hair.
The present study deals with the pharmacognostic and phytochemical study, analytical parameters, organoleptic tests, macroscopic and microscopic study,p hysical tests. Taste with tongue method showed kashaya madhura rasa.The drug contains carbohydrates, proteins, alkaloids, tannins and phenolic compounds in Aqueous and alcoholic extracts. HPTLC study showed total 9 peaks at 254nm and 10 peaks at 366nm. It also contains calcium, iron, sulphates, chlorides like In-organic compounds.
It contains the mucilage which is soothing to eyes, hairs. It contains proteins, tannins, phenol, calcium, iron acts as Raktha sthambhaka, Raktha vardhaka, Vrana roopana, and Tvak prasadaka. So it need further experimental and clinical study
Role of Ayurveda in Public Health: A Critical Review
Full text linkThe healthcare system in India and Nepal has various indigenous systems like Ayurveda, Yoga, naturopathy, Siddha, Unani, and Homeopathy, which are widely accepted and practiced parallel to allopathy. In both countries, a large section of the population belonging to different strata of society practices these traditional medicine systems to improve their health. Being an ancient holistic system of medicine, Ayurveda deals with each individual and at the community level in its entirety. The social impact of ill health is increasing, with some diseases affecting the health of individuals and that of a nation\u27s economy with their increasing healthcare costs. The Ayurvedic system of medicine has its advantages: it also fulfills the social health demands. One of the most vital and unique aspects of Ayurvedic medicine is Swastavritta, or health promotion. Ayurveda emphasizes two points, i.e., how to keep a healthy person healthy & how to prevent the patient\u27s illness, and public health also has similar objectives to prevent diseases, cure diseases, and longevity by improving the quality of life of the individuals. Many theories related to public health, such as infectious diseases, immunity, nutrition, etc., have been described in the classical texts of Ayurveda. Various texts associated with Ayurveda, relevant modern medical science books, research/review articles, and websites have been used as source materials for this study. The aim of Ayurveda and Public Health is mainly the same. In this growing world, most diseases are related to daily lifestyle, and these diseases can be prevented by following the principles of Ayurveda, and if anyone suffers from an illness, then Ayurveda will also help get rid of these diseases. Ayurveda has the potential to improve the worsening global health status, and it also would be one of the best options to promote public health
Concept of Kshetrikarana - Process to Get Best Result of Rasa Aushadhi and Rasayana- A Review
Full text linkThe process of Kshetrikarana (purification to body) is mentioned in different Rasasastra texts like Ayurveda Prakasha, Rasatarangini, etc in the context of Parada Sevanavidhi (intake of mercurial preparations). Kshethrikarana includes the therapies like Pachana, Snehana, Swedana, Vamana and Virechana. While in Rasashastra ,Shodhana procedures are described before intake of Rasaaushadhi and Rasayana. According to Ayurveda the Shareera is considered as the Kshetra and Atma as Kshetragya. The health condition of an individual depends upon their and Kshetra (Shareera) and Kshetragya (Atma). To bring our body and Atma in pure harmonic balanced stage complete purification of body is required. Without this there is no effect of taking Rasaaushadhi and Rasayana. This unique concept is described in Ayurveda Prakasha of Acharya Sri Madhava. The method of doing purification procedures in prior to administration of Rasaaushadhi and Rasayana therapy is called as Kshethrikarana. Concept of Kshetrikarana was studied in detail and conclusion was drawn. This unique approach of Kshethrikarana can be used in Swastha person before Rasayana therapy to prepare the body and also in diseased person it can be given to get the maximum benefits of the medicine in the shortest duration of time. The procedures for Kshethrikarana can be seen imbibed within Panchakarma therapy but all Panchakarma procedures are not adopted for Kshethrikarana. Kshethrikarana includes the therapies like Pachana, Snehana, Swedana, Vamana and Virechana. Kshethrikarana presents a unique approach in Ayurveda with specially designed procedures for purification of the body. Kshethrikarana is not merely a Shodhana therapy but also, allows the biological system to return to its homeostasis & to rejuvenate rapidly & also facilitates the desired Pharmacotherapeutic effects of medicine administered thereafter
SYZYGIUM CUMINI DEPARTS THE NEGATIVES OF THE ALLOXAN INDUCED DIABETES IN SWISS ALBINO MICE
Full text linkBackground: Because of the unfavorable side effects and higher cost of synthetic anti-diabetic medicines, an alternative approach to manage diabetes mellitus from an herbal source would be safe and within the affordability of the common people. Hence we investigated the hypoglycemic and pancreatic islets restoration effect of Syzygium cumini seed extract using glibenclamide as positive control.
Methods: Six (06) normal control mice and eighteen (18) alloxan induced diabetic mice grouped as diabetic control, Syzygium cumini and standard drug, were used for this experiment. In comparison to a reference drug-glibenclamide (@600μg/kg body weight), Syzygium cumini seed ethanolic extract (@500mg/kg body weight) was given orally once daily for thirty days to counteract alloxan induced alteration in blood glucose level and pancreatic cells morphology. Fasting blood glucose (FBG) level was evaluated at 15 days intervals, whereas mice were ethically sacrificed to collect pancreas at the completion of the experiment and processed for histological examination.
Results: Research results revealed that in both the Syzygium cumini and standard drug treated groups, FBG level were significantly lower than the diabetic control group (P < 0.05). Histologically, smaller islets and necrosis, present in the pancreas of diabetic mice were returned to normal following treatment with Syzygium cumini seed extract and standard anti-diabetic drug.
Conclusion: Syzygium cumini seed extract could be recommended as anti-diabetic for humans and animals especially in developing and under developed countries where this plant is readily available and affordable
An Ayurvedic Approach to Yonisopha in Puerperal women: A Case Report
Full text linkSutika is very delicate stage of women life. She needs to be given special care during this stage. Acharya Sushruta and Vagbhat have said that after one and half months of regulated or restricted specific dietics and mode of life the women becomes free from epithet of Sutika roga developing due to use of direct air, dietics and mode of life likely to aggravates dosas, incompatible food and indigestion are very serious. Kashyapa has described puerperal disorders at 2 places once in dusprajata chikisaadhaya without giving exact number but numbering 35 and again 64 disorders in sutikoprakramaniya adhaya. Among the described disorders yoni sopha (inflammation) was one which noted in this case. In this case a primi patient had underwent full-term normal delivery with right mediolateral episiotomy without any obvious complications. Thenafter Yonisopha (inflammation) was noted noted in right side of episiotomy which could have been converted to Rakta Vidhradhi (Haemotoma) which has been explained by our classics Indu and Vhagbhat- “external and internal Rakta Vidhradhi can be seen in women after childbirth during sutikakala. A married women G1P0A0L0 came with POG 39 weeks 4 days since 7 pm 17/04/2021. We received her in NIA PTSR IPD at 1am on 18/04/2021. There was no history of leaking and bleeding p/v. Patient was admitted and further evaluation was assessed. Then, FTND with RMLE as vertex presentation an alive male child of weight 3.25 kg delivered at 4:20 am on 18/04/2021. Patient stood the procedure well. When the patient was taken for perineal care at 5pm in the evening on the same day, sign of inflammation (reddish bluish in colour) was noted on the right lateral side of episiotomy wound. On examination, severe tendernesss was noted with raised temperature locally. Oral drugs were prescribed as Triphala guggulu, Jwarhara Kashya, Kaishore Guggulu. Ice fomentation was done. Perineal care was done with Panchvalkala kwatha churna. Shatdhouta Ghrita was applied. Then the wound was completely resolved
Kharaliya Rasayana used in clinical Ayurveda Practice- A Conceptual Review
Full text linkIn Ayurveda different herbs, metals and minerals are used in day to day clinical practice. Parad (Mercury) is commonly used ingredient of number of Rasa Aushadhi. The certain procedures are to be followed to make the Mercury fit for administering it into the body, by which all the physical and chemical impurities of Mercury are mitigated. The numbers of these procedures to purify Mercury are eighteen which is known as Parad Ashtadash Samskar. Kharaliya Rasayana is one of most frequently used Parad Murchhita Aushadha Vargikarana in Ayurveda. References regarding Kharaliya Rasayana were collected and studied in detail and conclusion was drawn. The Kharaliya Rasayana stands foremost in comparison with Parpati, Pottali & Kupipakwa Rasayana in terms of its popularity, wide range of therapeutic utility & ease of preparation. Kharaliya Rasayana are innumerable and most indicated in majority of disease condition. Bhavana & Mardana Samskara are the main principle behind the preparation of Kharaliya Rasayana by which its therapeutic safety and efficacy is determined
A comparative Clinical Evaluation of Amritadya Guggulu with and without Yavamalaki choorna in the management of Dyslipidemia
Full text linkAs a result of confronting challenges of modernization, man has adapted himself to the fast paced life by modifying his dietary and lifestyle preferences to suit the modern era. This has resulted in a state of discrepancy between the external environment and his internal mechanism causing multitudes of diseases which referred as “lifestyle diseases”. Dyslipidemia is a condition in which the level of lipoproteins (cholesterol, triglycerides or both) is raised in the plasma. For this “Amritadya Guggulu” mentioned in Chakradatta and “Yava Amalaki Choorna” mentioned in Charaka sutra sthana is selected. The ingredients of Amritadya Guggulu like Guduchi, Truti, Vella, Vatsaka, Triphala are Medohara and Tiktarasa pradhana which is Kapha vata hara, Laghu, Kapha shoshaka effective in case of Dyslipidemia on the other hand Yava Amalaki choorna is also having Medohara property. In the present study, 40 patients of Dyslipidemia were registered and were randomly placed and observed in two groups, treated with Amritadya Guggulu and Amritadya Guggulu with Yavamalaki Choorna for 30 days. Each disease feature was scored according to the assessment criteria and each patient was assessed and scored with respect to his/her presenting complaints. Respective scores were subjected for statistical analysis using paired student ‘t’ test for the individuals groups and unpaired student ‘t’ test to compare both the groups
Artificial Intelligence: Applications in Healthcare Industry
Full text linkArtificial intelligence (AI) is becoming a core part of the digital health systems to shape and support modern medicine. The situations such as pandemic COVID-19 pressing health systems to consider technology, such as artificial intelligence powered clinical decision support for faster and more informed decisions. AI utilises machine learning models to search medical data and uncover insights to improve health outcomes and patient experiences. AI is mainly used for clinical decision support and imaging analysis. Clinical decision support tools help the physician to take decisions about treatments, medications, physical and psychological health and other patient needs by providing quick access to information or research that\u27s relevant to their patient. In medical imaging, AI tools are used to analyze CT scans, X-rays, MRIs and other images/ findings that a human radiologist might miss. Many healthcare organizations around the world started field-testing new AI-supported technologies to overcome the challenges like COVID-19 pandemic created. Various healthcare applications with AI are presented in this article