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Metallic trace elements in wild and farmed fish from the Aveiro Region (Portugal)
No full textInternational audienceThis study assessed the concentrations of 11 metallic trace elements (MTEs: As, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, Se, Zn) in fish muscle from eight wild and farmed species collected in the Aveiro region of Portugal, an area historically affected by industrial pollution. A total of 66 samples were analyzed by ICP-MS. Mean concentrations (mg/kg ww), arranged in ascending order, were: Ni (0.0001), Cd (0.0015), Co (0.0020), Pb (0.0023), Cr (0.0179), Mn (0.0862), Cu (0.2500), Se (0.2964), Fe (1.9236), As (1.9260, total As), and Zn (3.3701). Significant differences were observed among species and between wild and farmed fish, particularly in Dicentrarchus labrax and Sparus aurata. Although Cd and Pb concentrations remained below current European maximum levels, risk assessment based on safe consumption limits (SCLnc) identified total Se, Cd, and Pb as the most restrictive elements for daily intake, especially in children. For arsenic, only total concentrations were considered, as inorganic As could not be distinguished in this study. No significant non-carcinogenic risks were identified at current national average fish consumption levels; however, the potential cumulative and synergistic effects of multiple metals in chronic exposure warrant further investigation. The Metal Pollution Index (MPI < 1 for all samples) confirmed low overall contamination. These findings underscore the importance of ongoing monitoring of trace elements in fish to ensure food safety and protect vulnerable populations
Situations de vulnérabilités en contexte plurilingue dans les espaces francophones
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Effects of deep brain stimulation on non motor fluctuations in Parkinson’s disease (assessed with the NMF severity scale)
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Les Monts d'Or lyonnais : écrin paysager, écran bourgeois
No full textInternational audienceOn the outskirts of Lyon, the Monts d'Or is a small massif of golden stone villages offering panoramic views from the Saône valley to the Alps. Nestled in a lush green setting, the Monts d'Or are a haven for the region's wealthy. Indeed, the bourgeoisie asserted its social distinction through the protection of the landscape, notably by the Syndicat Mixte Plaines Monts d'Or (SMPMO). Environmental amenities in this privileged area of western Lyon are as much a source of income for investors as they are a marker of territorial identity for residents.This article examines the way in which landscape enhancement acts as a screen for the strategies deployed by the bourgeoisie to maintain its dominant position. The Monts d'Or is not a social monolith; the distribution of social groups in the area reveals a layering of domination. What's more, the power of the bourgeoisie has its limits in the Monts d'Or. An analysis of the commune of Saint-Germain shows that this power is partly being challenged by the new ecologist municipality, which is seeking to place the value of the landscape at the service of the common good.Aux portes de Lyon, les Monts d’Or sont un petit massif occupé par des villages en pierres dorées qui offrent un panorama de la vallée de la Saône jusqu’aux Alpes. Lovés dans un écrin de verdure, les Monts d’Or font figure d’entre-soi des possédants de la région. En effet, la bourgeoisie affirme sa distinction sociale par l’intermédiaire de la protection du paysage mise en place notamment par le Syndicat Mixte Plaines Monts d’Or (SMPO). Les aménités environnementales dans cet espace privilégié de l’Ouest lyonnais sont autant une rente pour les investisseurs qu’un marqueur d’identité territoriale pour les habitants.L’article questionne la façon dont la valorisation du paysage fait écran aux stratégies déployées par la bourgeoisie pour maintenir sa position dominante. Les Monts d’Or ne sont pas un monolithe social, la répartition des groupes sociaux du territoire révèle un étagement de la domination. De plus, le pouvoir de la bourgeoisie rencontre des limites dans les Monts d’Or. L’analyse de la commune de Saint-Germain montre que ce pouvoir est partiellement remis en cause par la nouvelle municipalité écologiste qui cherche à mettre la valeur paysagère au service du commun
DOP016 Monitoring serum αvβ6 antibodies during induction vedolizumab therapy is a strong and drug-selective predictor of sustained clinical remission in UC at one year
No full textDigital Oral PresentationInternational audienceBackground Antibodies against the integrin αvβ6 has been detected in the serum from inflammatory bowel disease (IBD) patients treated with vedolizumab (VDZ). We aimed to assess the impact of serum αvβ6 antibodies on the pharmacokinetics and the effectiveness of VDZ in IBD. Methods Real-world data were collected from two multicentric, prospective, observational studies, one including patients with IBD treated with VDZ the (VEDOPREDIRESP) and the second one including UC patients treated with intensified golimumab (GOLILOR). Serum αvβ6, antibodies titers were measured prior starting VDZ therapy (baseline) and at week (w)6 (ELISA assay). All clinical datasets and laboratory results were blinded to disease outcomes. Predictors for sustained clinical remission were assessed using univariate tests and multivariate logistic regression. Results During VEDOPREDIRESP, 115 IBD patients (UC, n = 67) were included. At the end of follow-up (W52), 49% of IBD patients (54% for UC) achieved clinical remission. At baseline, abnormal serum αvβ6 antibodies titers (>9.1µg/mL based on the median titers + 3 SD from controls) were significantly more frequent in UC than in CD patients (94% vs 19%, respectively; p < 0.001) and the median titers were significantly higher in UC patients (271 µg/mL (38-884) vs 5.2 µg/mL (2.5-10); p < 0.001). Using a ROC curve analysis, the best threshold value to distinguish UC from CD was 15µg/mL (AUROC : 0.95; Sen : 0.92, Spe : 0.95). In UC, the median serum αvβ6 antibodies titers from patients starting VDZ significantly drop over time between W0 and W6 (243 vs 190 µg/mL, respectively; p = 0.04). During induction regimen with VDZ in UC patients, a reduction of the αvβ6 antibodies titers of more than 30% between W0 and W6 predicted further sustained clinical remission at W52 (AUROC: 0.79; Se: 0.78, Sp : 0.80) (Fig 1). Using multivariate analysis, the only independent factor associated with clinical remission was the reduction of the αvβ6 antibodies titers of more than 30% between W0 and W6 (0R : 5.36, IC95 : 1.12- 8.54; p :0.04). In contrast to VDZ, when using an independent cohort of UC patients treated with golimumab, the median αvβ6 antibodies titers did not differ over time between responders and non-responders to drug intensification. Conclusion Serum αvβ6 antibodies are novel accurate markers to discriminate UC from CD. In UC patients, monitoring serum αvβ6 antibodies titers during induction with VDZ is a strong and drug specific predictor associated with sustained clinical remission at one year and might be of paramount interest to guide clinician’s decision. Conflict of interest: Roblin, Xavier: MSD, Abbvie, Amgen, Celltrion, Galapagos, Janssen, Takeda, Ferring, Theradiag, Lilly, Pfizer Nancey, Stéphane: Abbvie, Janssen, Pfizer, Celltrion, Takeda, Amgen Fresenius Kabi, Sandoz, Lilly XR: MSD, Abbvie, Amgen, Biogen, Celltrion, Galapagos, Janssen, Takeda, Ferring, Theradiag, Lilly Mechi, Fatma: Fumery, Mathurin: Grant: Pfizer Personal Fees: Abbvie, Janssen, Takeda, MSD, Biogen, Amgen, Sandoz, Fresenius, Gilead, Celgene, Galapagos, Mylan, Tillots, Ferring, Pfizer, Hospira, CTMA, Boehringer, Lilly, Arena Non-financial Support: Abbvie, Janssen, Takeda, MSD, Galapagos, Ferring, Pfizer Hebuterne, Xavier: Xavier Hébuterne reports clinical research funding from AbbVie, Abivax, Alphasigma, Arena Pharmaceuticals, Celgene, Eli Lilly, Enterome, Gilead, Janssen, InDex Pharmaceuticals, Pfizer, Roche, Salix, Sangamo, Takeda, Theravance, serving on advisory boards for AbbVie, Abivax, Arena Pharmaceuticals, Gilead, Janssen, Pfizer, Roche, Takeda, and participating in lectures and educational activities for AbbVie, Amgen, Baxter, Fresenius Kabi, Janssen, MSD, Mylan, Nutricia, Pfizer, Tillots, and Takeda. Altwegg, Romain: Abbvie, Celltrion, Janssen, Takeda, MSD, Pfizer Barrau, Mathilde: Abbvie, Celltrion, Takeda, Janssen, Pfizer Paul, Stephane: MSD, Takeda, Abbvie, Amgen, Theradiag, Janssen, Celltrio
Novel CNNM2 variant causing hypomagnesemia and early-onset calcium pyrophosphate deposition disease: A case report
No full textInternational audienceCalcium pyrophosphate deposition (CPPD) disease is a common crystal arthropathy in the elderly, but its early-onset forms are rare. While secondary hypomagnesemia is a recognized contributor to CCPD, inherited renal magnesium-wasting syndromes remain underdiagnosed. Here we performed a whole exome sequencing (ES) in order to detect pathogenic variants in a 58-year-old male patient with early and severe, refractory CPPD disease. We conducted a comprehensive clinical, biochemical, radiological, and genetic evaluation of the patient. ES was performed and filtered for rare, likely pathogenic variants following ACMG/AMP criteria. Cascade genetic testing was performed in family members. Hypomagnesemia with inappropriate renal magnesium loss was found. Radiographs revealed diffuse chondrocalcinosis ES identified a novel heterozygous Cyclin and CBS Domain Divalent Metal Cation Transport Mediator (CNNM2) missense variant (c.319G>C; p.Gly107Arg), absent from population databases and predicted deleterious (REVEL 0.82). This variant affects a highly conserved residue in the extracellular β-barrel domain. Family screening revealed two additional carriers with isolated hypomagnesemia, consistent with autosomal dominant inheritance. CNNM2 encodes a basolateral magnesium transporter in the tubule. This is the first reported case of CPPD linked to a CNNM2 variant through persistent hypomagnesemia. Its variants have been linked to renal hypomagnesemia, neurological comorbidities, but no link to CPPD has been described. This expands the phenotypic spectrum of CNNM2-related disorders and highlights the relevance of genetic testing in CPPD cases with unexplained hypomagnesemia. Building on published functional studies and domain-level protein modeling, we propose a simplified three-tier classification scheme that organizes CNNM2 variants into clinically meaningful categories
Anchor-proofness in Voting
No full textThis work contributes to a foundational question in economic theory: how do individual-level cognitive biases interact with collective choice mechanisms? We study a setting where voters hold intrinsic preference rankings over a set of alternatives but cast approval ballots to determine the collective outcome. The ballots are shaped by an anchoring bias: alternatives are presented sequentially by a social planner, and a voter approves an alternative if and only if it is acceptable and strictly preferred to all alternatives previously encountered. We first analyze which approval-based voting rules are anchor-proof, in the sense that they always select the same winner regardless of the presentation order. We show that this requirement is extremely demanding: only very restrictive rules satisfy it. We then turn to the potential influence of the social planner. On the upside, when the planner has no information about the voters' intrinsic preferences, she cannot manipulate the outcome
BrGDGT-based palaeothermometer in drylands: the necessity to constrain aridity and salinity as confounding factors to ensure the robustness of calibrations
No full textInternational audiencePast temperature reconstructions offer valuable insights into the impact of climate change on the global climate-human-vegetation system. Branched glycerol dialkyl glycerol tetraethers (brGDGTs) are recognized as effective temperature proxies, particularly in lakes and peatlands, where they are well preserved. However, their reliability as palaeothermometers can be compromised by factors beyond air temperature, especially in drylands. This study investigates the recently compiled Arid Central Asian (ACA) brGDGT surface Data Base, a regional dataset consisting of 753 surface samples from the drylands of ACA. The distribution of brGDGTs in relation to climate and environmental variables was analysed to explore their potential as reliable temperature proxies, mainly focusing on brGDGTs methylation (MBT), cyclisation (CBT), and isomer (IR) indices. The brGDGT-based palaeothermometer is a promising tool for understanding past climates, but our comparison between an ACA-centred database and a worldwide continental surface sample database reveals several challenges. Drylands exhibit extreme climate and soil/lacustrine properties, amplifying the impact of confounding factors on brGDGT-based relationships with mean annual air temperature. Salinity emerges as the dominant factor influencing brGDGT variance, followed by sample type, pH, and aridity, all of which contribute significantly. These factors interact in complex ways, with the salinity effect varying between soil and lacustrine deposits. For sample physicochemical conditions, the IR6+7Me′ index is best for salinity, and IR6Me is most suitable for pH reconstruction. Thus, the MBT5Me′-temperature relationship is limited in ACA, particularly for lacustrine samples, and MBT6Me′ does not offer a better solution under hyper- to semi-arid conditions. Sub-calibrating models for specific environmental conditions such as salinity and aridity improves the accuracy of temperature reconstructions. Furthermore, the difference between MBT5Me′ and MBT6Me′ provides a promising proxy to assess aridity. Although the brGDGT signal in drylands is influenced by multiple controlling factors, it remains a valuable tool for understanding past climate and environmental conditions, especially when accounting for the complex interactions between these factors based on each study's unique physicochemical and bioclimatic context. Further research, incorporating a broader range of surface samples alongside comprehensive soil and climate data, holds the potential to enhance the accuracy of brGDGT-based climate reconstructions
De la conception à l’institutionnalisation d’un dispositif de promotion de la santé en milieu scolaire : vers un modèle autonome et pérenne
No full textInternational audienceCadre théorique : La recherche interventionnelle en santé publique doit produire des interventions non seulement efficaces, mais aussi réalisables, transférables et généralisables dans des conditions réelles (Moore et al., 2015). La phase post-expérimentale est critique pour la pérennisation : l’intervention doit dépasser le cadre expérimental optimisé pour s’adapter aux conditions réelles, tout en maintenant un degré suffisant de fidélité pour préserver son essence même (Dusenbury et al., 2003, Villeval, 2018, Cambon et al., 2014). Problématique : Cette communication présentera le processus d’autonomisation du dispositif ALLIANCE. Initialement conçu et testé dans un cadre expérimental, l’enjeu était de produire un dispositif autonome (indépendant de l’équipe de recherche) et pérenne.Méthode : Le processus d’autonomisation a fait l’objet d’une co-construction associant chercheurs, professionnels de terrain (formatrices ALLIANCE, équipes de circonscription de l’Éducation nationale) et partenaires institutionnels (parlementaires, représentants départementaux et académiques de l’Éducation nationale). La démarche était donc fondée sur l'intégration de connaissances académiques, professionnelles et expérientielles. Entre avril 2025 et janvier 2026, plusieurs réunions collectives et sous-groupes thématiques ont permis : 1) d’identifier les modalités d’adaptation des ingrédients essentiels du dispositif afin de garantir leur fonctionnement autonome et pérenne, et 2) organiser les conditions pratiques de ce déploiement autonome. Résultats : La co-construction a permis d’adapter trois volets essentiels du dispositif :1) Diagnostic des besoins de santé (étape initiale de la démarche de projet utilisée en formation) : simplification des outils initiaux et création d’une « boîte à outils » intégrable aux démarches existantes.2) Formation et accompagnement : transfert des missions de formation aux conseillers pédagogiques de circonscription, selon des stratégies différenciées selon les territoires (co-animation, formations collectives, formation de formateurs académiques en appui).3) Les ressources : constitution d’un « kit ALLIANCE » clé en main (supports de formation, fiches-actions), facilitant l’appropriation et l’autonomie des formateurs et des bénéficiaires. Ce travail illustre l’institutionnalisation (conformément à la volonté des partenaires de l’Éducation nationale) du dispositif ALLIANCE comme un levier d’autonomisation et de pérennisation. Toutefois, dans le cadre d’une extension à d’autres territoires, caractérisés par des ressources, des acteurs et des contextes différents, d’autres leviers que l’institutionnalisation pourraient être mobilisés. L’enjeu est de concevoir des stratégies adaptées aux réalités locales, condition essentielle pour assurer à la fois la transférabilité (Cambon et al., 2012) et l’ancrage durable du dispositif