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A randomized fractional modeling of pest management dynamics for tea plant (Camellia sinensis) with parameter adaptation to Turkish data
No full textFractional differential equations offer a detailed analysis of modeling problems. Many pest management models have been investigated by using fractional calculus and although these models provide a generalized approach, the inability to handle uncertainty highlights the need to incorporate probabilistic elements. In this study, a model of pest management is used to show that using randomized components along fractional derivatives provides an approach that handles the random nature of pest spread. The new model is thoroughly analyzed to validate the generalization achieved with the fractional-random approach. Results show that a 10% uncertainty in model components leads to 10 times more deviation in pest population. Similar findings on variation show that the fractional-random model is more competent in capturing the variability that is more significant for tea plant biomass. These results, which cannot be achieved with the deterministic model, indicate that the fractional-random model provides extensive findings that represent the variability in farmer awareness and pest spread tendencies
Advanced Methods in Classification
No full textData Minin Dersi 12. Hafta Ders Notu Konusu : Advanced Methods in Classificatio
Life-threatening presentation of pulmonary hydatid cyst with hemoptysis and hydatoptysis
No full text..
Triazole-substituted pyrazole–pyrimidine hybrids as anticancer agents: synthesis, cytotoxicity, apoptosis mechanisms, and JAB1-targeted structure-based design
No full textIn this study, twelve new triazole substituted pyrazole-pyrimidine hybrid compounds were synthesized through click reaction and evaluated for their cytotoxic activity against pancreatic, breast, and gastric cancer cell lines. Among the tested compounds, 4e demonstrated the most potent cytotoxic activity, with IC₅₀ values below 10 μM across all evaluated cancer cell lines: Breast cancer cell lines MCF-7 (5.6 ± 1.01 μM), MDA-MB-231 (8.18 ± 1.26 μM), and gastric cancer cell line HGC-27 (5.68 ± 0.45 μM). Furthermore, RT-qPCR analysis revealed that 4e significantly modulated the expression of apoptosis-related genes, notably inducing a marked downregulation of BIRC3, implicating the activation of the mitochondria-mediated intrinsic apoptotic pathway. Flow cytometry confirmed apoptosis induction. Furthermore, computational metabolomic pathway analysis indicated that 4e altered glucose metabolism, notably affecting genes and metabolites associated with glycolysis and fatty acid biosynthesis. These results highlight compound 4e as a promising anticancer candidate with dual action on apoptotic signaling and metabolic pathways. Given the potent biological activity of 4e , further optimization was pursued through a structure-based drug design strategy targeting the oncogenic regulator JAB1, 4e was designed as a scaffold for targeting JAB1. A virtual library of analogues was generated, and all derivatives were docked against the JAB1 crystal structure (PDB ID: 5JOG). Several compounds showed higher docking scores than the co-crystallized ligand (CSN5i-3), suggesting enhanced binding affinity. In parallel, binary QSAR models were developed using the MetaCore/MetaDrug platform to predict anticancer activity. Based on the combined docking and QSAR analyses, several promising analogues were identified and proposed for synthesis and subsequent biological evaluation in future studies
Bone health and fracture risk in diabetes: A multicenter study
No full textSummary: We assessed bone health in over 2500 adults with diabetes across Türkiye. T1DM patients had lower BMD, while T2DM patients showed higher fracture risk despite higher BMD. Several modifiable factors were linked to osteoporosis. These findings support personalized bone assessments in diabetic populations. Background: Diabetes mellitus (DM) is a recognized risk factor for bone fragility. While type 1 DM (T1DM) is typically associated with low bone mineral density (BMD), type 2 DM (T2DM) often presents with higher BMD despite increased fracture risk. Large-scale comparative studies remain limited. Objective: To evaluate bone health, including osteopenia, osteoporosis, and fracture risk, in adults with T1DM and T2DM. Methods: This multicenter, cross-sectional study included 2562 patients (224 with T1DM, 2338 with T2DM) from 27 centers across Türkiye. BMD was assessed using dual-energy X-ray absorptiometry (DXA) and fracture risk was estimated via the Turkish-adapted FRAX® algorithm in patients aged ≥ 40 years. Multinomial logistic regression was used to identify independent predictors of low BMD. Results: Osteoporosis prevalence was 5.5% in T1DM and 9.6% in T2DM (femoral neck T-score). Adjusted BMD was significantly lower in T1DM at all skeletal sites, while FRAX-based fracture risk and fall-related fractures were higher in T2DM. Independent predictors of osteoporosis included older age, female sex, lower BMI, reduced calcium levels, corticosteroid use, albuminuria, hypertension, and less frequent sodium-glucose cotransporter-2 (SGLT2) inhibitor use. T1DM was independently associated with osteopenia but not osteoporosis. Conclusion: This multicenter study demonstrates distinct patterns of BMD and fracture risk across diabetes subtypes and supports individualized bone health assessment in routine diabetes care
Theoretical foundations of energy finance: a multidimensional framework
No full textEnergy has moved beyond its traditional role as a factor of production to become a central arena of financial activity, connecting global markets, investment practices, and policy design. This chapter reviews the conceptual and theoretical foundations of the energy–finance nexus, highlighting how financialization, systemic risks, and emerging green and digital finance mechanisms shape both market behavior and institutional responses. By drawing on neoclassical, Keynesian, behavioral, and complexity-based traditions, it develops a multidimensional framework that integrates economic, financial, technological, and political perspectives. The review shows that financialization tends to heighten volatility and market interconnectedness, while crises intensify the transmission of shocks across energy, carbon, and financial systems. Climate, geopolitical, and policy risks compound these vulnerabilities, influencing investment behavior, risk management, and governance structures. At the same time, green finance instruments, ESG investing, carbon markets, and digital platforms are beginning to transform the financial architecture that underpins the energy transition—although their effectiveness depends critically on consistent policy, strong governance, and inclusive frameworks. This synthesis demonstrates that the energy transition is inseparable from a financial transition. Effective policy design, risk mitigation, and equitable capital allocation are critical to aligning investment with sustainability objectives. By integrating theoretical perspectives and policy considerations, this chapter offers a roadmap for understanding the energy–finance nexus and informs future research and policymaking in the evolving global energy landscape
Çay Bitkisinin Kimyasal-Biyokimyasal İçeriği ve Bu İçeriğe Etki Eden Faktörler
No full textÇay Tarımı Dersi 13. Hafta Ders Notu Konusu : Çay Bitkisinin Kimyasal-Biyokimyasal İçeriği ve Bu İçeriğe Etki Eden Faktörle
Core characteristics of the social studies teacher from stakeholder perspectives: A comparative analysis
No full textThe primary aim of this study is to identify the core qualities that social studies teachers in Türkiye are expected to possess, based on stakeholder perspectives. Designed as a qualitative case study, the research sought to address the question: “What kind of teacher?” Data were collected from academics, graduate and undergraduate students, and in-service social studies teachers who participated in the International Social Studies Education Symposium held in June 2022. A total of 97 participants contributed their views and experiences during the stakeholder workshops conducted as part of the symposium. The data were analyzed using both deductive and inductive thematic analysis approaches. The findings indicate that, despite notable variations among stakeholder groups, common qualities emphasized for social studies teachers include subject matter knowledge, pedagogical competence, and technological proficiency. A smaller number of participants highlighted qualities such as having a project-oriented mindset and maintaining high motivation. The study offers important implications for the development of undergraduate social studies teacher education programs and highlights the potential role of the Social Studies Educators Association, along with other associations and civil society organizations with similar aims, in collaboratively establishing field-specific standards
Effects of a puppet-assisted house-tree-person test on fear and anxiety in children receiving chemotherapy and associated influencing factors: A projective, quasi-experimental study
No full textObjectives: This study investigated the effect of the puppet-assisted House-Tree-Person Test (HTP-T) on fear and anxiety levels in children undergoing chemotherapy treatment and the factors influencing these outcomes. Methods: The study employed a one-group pretest-posttest quasi-experimental design combined with HTP-T analysis. The study was conducted with 29 children aged 5-12 years receiving chemotherapy at the pediatric hematology-oncology outpatient clinics of a university hospital in the Eastern Black Sea Region of T & uuml;rkiye during the 2022-2024 years. Data were collected using "the Demographic Information Form for Children and Parents, the Children's State Anxiety Scale (CSA), the Children's Fear Scale (CFS), and HTP-T". Data analysis was performed using descriptive statistics, repeated measures ANOVA, and HTP-T analysis. Results: Statistically significant differences were observed in children's mean CSA (F = 3.898, p = 0.026, eta 2 = 0.122) and CFS (F = 5.313, p = 0.008, eta 2 = 0.159) scores across the pre-treatment, during-treatment, and post-treatment measurements. The HTP-T analysis revealed that children had difficulty regulating anxiety and fear, expressed concerns about family and environmental events, reported feelings of loneliness, and exhibited strong emotional attachment to their families. Conclusion: The study demonstrated that incorporating puppet-assisted HTP-T during chemotherapy contributed to reducing children's fear and anxiety and offered a useful approach for identifying influencing factors. Implications for nursing practice: HTP-T, a therapeutic play technique incorporating puppetry and projective methods, may be effective in reducing fear and anxiety among children undergoing chemotherapy. (c) 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies
Comparative analyses of drilling force, temperature, and damage in natural and glass fiber-reinforced al–epoxy composites
No full textThis study examined the drilling performance of five polymer composite systems: three natural fiber (jute, flax, hemp) composites with aluminum particle-reinforced epoxy, one glass fiber-reinforced composite with the same matrix, and an unreinforced aluminum particle-filled epoxy (Al–epoxy). Drilling experiments were performed at spindle speeds of 1500 and 3000 rpm with feed rates of 50, 75, and 100 mm/min in order to evaluate the effect of cutting parameters on the drilling performance. Cutting zone temperatures were measured using thermocouples embedded within the drill bit’s cooling channels, while thrust forces were recorded with a dynamometer. Additionally, hole exit damage and inner hole surface roughness were evaluated to assess machining quality. The results showed that increasing spindle speed reduces thrust forces due to thermal softening of the matrix, whereas natural fiber-reinforced composites generally exhibit higher thrust forces and slightly rougher inner hole surfaces compared to synthetic counterparts. During drilling, the measured thrust forces ranged from 320 to 693 N for the glass fiber-reinforced specimen and from 335 to 702 N for the Al–epoxy specimen, while for natural fiber-reinforced composites the thrust force values were 352–679 N for hemp, 241–719 N for jute, and 571–732 N for flax specimens. Synthetic specimens (glass fiber and Al–epoxy) exhibited comparable cutting temperature ranges (288–371 °C and 248–327 °C, respectively), whereas natural fiber-reinforced composites showed higher and broader temperature ranges of 311–389 °C for hemp, 368–374 °C for jute, and 307–379 °C for flax specimens. The overall results indicated that lower forces were generated during the drilling of synthetic glass fiber-reinforced composites, while among natural fiber-reinforced plastics, flax fiber-reinforced composites stood out by exhibiting a balanced machining response