Asian Pacific Journal of Health Sciences
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A Review on Curcumin and its Use as Novel Drug Delivery System
Get PDFCurcumin is a principle compound obtained from turmeric, that is, Curcuma longa which is Indian rhizomatous medicinal plant from the family Zingiberaceae. Curcumin is yellow pigment commonly used as a spice in food processing industry. Curcumin, Demethoxycurcumin, and Bisdemethoxycurcumin are the major active constituents of the turmeric and are collectively known as curcuminoids. In recent studies, it has been demonstrated that curcumin has a variety of biological activities, pharmacological performances, provide protection, and promotion of health. This paper reviews the current research progress on its versatile bioactivity, such as antioxidant, anti-inflammatory, and immune-regulatory activities, cancers, diabetes, liver, and cardiovascular systems. The curcumin belongs to biopharmaceutical classification system Class IV that indicates low solubility and low permeability. The systemic bioavailability of orally administered curcumin is low in humans and only traces of it have been found in the liver. Here, we emphasized its broad therapeutic activity in treating life-threatening diseases by improving solubility as well as permeability with the help of novel drug delivery system
A Case of Gilbert Syndrome and Uncontrolled Diabetes Mellitus with Elevated HbA1C Improved with Individualized Homeopathic Medicine
Get PDFDiabetes mellitus is one of the most common metabolic disorders in the present era from altered lifestyle. Glycosylated hemoglobin (HbA1C) is the most reliable blood parameter for diagnosis and prognosis of diabetes mellitus. Gilbert syndrome in diabetic patients lowers the prevalence of microvascular complications of diabetes mellitus. Even though Gilbert syndrome is a fortunate factor in this patient, progressive weight loss is the raising concern. From proteolysis and diuresis, kidneys can get damaged in course of time. Uncontrolled HbA1C again can increase the risk of complications of diabetes mellitus. In this case, HbA1C and weight loss with diabetes mellitus improved with an individualized homeopathic approach. Natrum Muriaticum was selected on a constitutional basis, and it was administered on an LM scale which helped the patient in bringing down blood parameters and managing weight loss of Diabetes
Effect of Lowering the pH of Sodium Hypochlorite on Control of Pseudomonas aeruginosa in Maintenance of Pharmaceutical Water System
Get PDFDrinking water or potable water is a common source for generation of purified water or demineralized water which is used for processing of medicinal products such as tablets, capsules, syrups, and nasal sprays. Before allowing for purification, it is manufacturer’s responsibility to ensure the microbial load control in the source water to get good quality product water and to avoid biofilm formation in waterlines. The current research involves the study of an effectiveness of sodium hypochlorite (NaOCl) at various concentrations of water pH on microbial control by following pour plate technique. The aim of this study was to examine the effect of lowering the pH on the recovery of Pseudomonas aeruginosa. Three groups were tested by challenging known population of P. aeruginosa by varying the pH of 5.0, 7.0 and 9.0. No significant difference was observed at pH 5.0 and 7.0 and the recovery increased when the pH increased at 9.0. Effective microbial control was obtained at neutral pH. The increase of pH resulted decrease of effectiveness of NaOCl
A Review on Pharmacognosy, Phytoconstituents, Pharmacological Activities of Murraya koenigii Plant
Get PDFNature is the main source of supplements that one human needs. Some of the traditional medicines systems such as Ayurveda, Siddha, Unani, and Chinese belong to the medicines that obtained from natural sources and all human may depend upon that medicines from the ancient times. Murraya koenigii is herbal plant belongs to the family Rutaceae. It is commonly known as curry leaves. There is a large range of the plant M. koenigii and mostly found in tropical and subtropical regions in the world. The leaves of plants are used in treating piles, inflammation, itching, fresh cuts, dysentery, bruises, and edema. Roots of the plants are purgatives. They are used to stimulate the body and body aches. The bark is used in treating snakebites. The essential oils are extracted from M.koenigii leaves that are used in anti‐oxidative, hepatoprotective, antimicrobial, antifungal, anti‐inflammatory, and nephroprotective activities. The various medicinal properties of M. koenigii are depend on their chemical constituents like terpenoids, flavonoids, phenolics, carbohydrates, carotenoids, vitamins, and nicotinic acid from various parts of the M. koenigii plant. This review leads to show the various activities, uses, phytoconstituents, description of plant, and preclinical investigations which occurs instead of the studied plant
Comparative Pharmaceutico Analytical Study of Madhyama Paka and Khara paka in Sneha Paka WSR to Katupila Taila
Get PDFIntroduction: Different types of Snehapaka have been mentioned in Sarangdhar Samhita such as Mrudu Paka, Madhyama Paka, Khara Paka, Dagdha Paka, Ama Paka, and Gandha Paka. Further, different uses of sneha according to its paka had been mentioned in which Madhyama Paka and Khara Paka are stated to be used for internal (Pana) and external (Abhyang), respectively. Aim: The present study was carried out to discriminate type of paka in Katupila taila on the basis of classical and modern parameters, namely, Paka pariksha, organoleptic-physicochemical parameters, and chromatography. Results: Average 934.8 g (93.48% yield) and 845.33 g (84.53% yield) of Katupila Taila madhyama paka (KPTM) and Khara paka, respectively, was obtained from batch size of, 1 L of Tila Taila with 212 g of Kalka dravya and 4 L of Kwatha of Katupila stem. Temperature reached up to 92°C and 97°C, respectively, for completion of Madhyama Paka and Khara Paka. Heating was carried out for 3 consecutive days for both Paka. Discussion: Average duration between initiation of Madhyama Paka and end of Khara Paka was 1 h and 44 min. Here, temperature and duration of heating play a major role in the type of Paka. It showed difference in the values of physicochemical parameters of both Paka. KPTM and Khara paka were having specific gravity (0.9179 ± 0.0050 and 0.9294 ± 0.0067), refractive index (1.449 ± 0.009 and 1.474 ± 0.015), acid value (2.908 ± 0.0538 and 1.809 ± 0.0472), iodine value (108.075 ± 2.9793 and 72.875 ± 3.2548), saponification value (169.66 ± 8.9132 and 226.64 ± 6.1567), and BTTT value (19.6 ± 0.3, 28.5 ± 0.5), respectively
Development and Validation RP-HPLC Method for Simultaneous Estimation of Bilastine and Montelukast in Bulk and Pharmaceutical Dosage Form
Get PDFA simple, precise, sensitive, and rapid reverse phase high-performance liquid chromatography method was developed and validated for simultaneous estimation of bilastine and montelukast in bulk as well as in tablet formulation according to ICH guidelines. The chromatographic phase consisted by methanol and acetonitrile (70:30) at pH 3 adjusted by 0.1% orthophosphoric acid. The flow rate was adjusted to 1 ml/min and ultraviolet detection was carried out at 260 nm. The retention time for of bilastine and montelukast were found to be 3 and 7 min, respectively. The detector was showed linear responses over the concentration range 25–150 μg/ml for bilastine and 5–30 μg/ml for montelukast a good correlation coefficient of 0.999. This proposed method is highly sensitive, precise, and accurate which reduces cost of analysis, hence recommended for routine quality analysis in laboratories
Advent Through the Traditional Medicine Regime for Kshata Guda, that is, Parikartika: A Case Series
Get PDFOne of the most common symptoms in anorectal diseases which encounters in routine clinical practice is Kshata guda, that is, Parikartika, mentions in Ayurved Samhitas. Parikartanam means excessive cutting pain around the anus. Pain is the most important clinical symptoms in this disease. Anal fissure is one of the eloquent causes of pain with per rectum bleeding, sphincter spasm in the anal region at times. Fissure is a crack or a split in the lower end of anal canal. Bailey and Love (1968) have described fissure-in-ano as an elongated ulcer in long axis of anal canal. It is mostly due to constipation. Exact etiology is obscure, one theory is that the fissure-in-ano is caused by overstretching of the epithelial lining of the anal canal by the pressure of a hard fecal mass during defecation against the posterior wall of anorectal junction which is relatively poor supported by musculature on this aspect of the rectum and anal canal. In this case series, the cases are observe symptomatically for the drug healing properties and the objective of the hypothetical parameters shows fruitful results with the application of Yashtimadhu tail (medicated oil) in the management of Parikatika (Fissure-in-ano), leading to non-surgical management of Parikatika (Fissure-in-ano) in very cost-effective way
Quality and Content of Online Information Related to “Immunity Boosting”
Get PDFIn this era of “infodemic,” online health information has become a prime concern, and therefore, an analysis of studies on online health information, the reasons for which people seek online health information, its strengths and shortcomings, and the concept of E-health literacy has been done in this paper. Various tools to assess online health information and recent papers on assessment using DISCERN tool have been discussed. The concern for immunity boosting and its significance in the COVID era has grown manifold, especially for providers and consumers of health information. Online health information has become a vital part of healthcare in modern times; however, its quality seems to differ across domains. Online information on immunity boosting also seem to be misleading the people. This article provides an insight into the sphere of online health information and throws light over the hurdles that people come across face while retrieving health information online
Point of Care Microbiological Tests in Periodontology
Get PDFPeriodontal diseases involve a complex inflammatory response of the periodontal tissues against various micro-organisms leading to destruction of the tooth supporting structures. Laboratory investigations have remained the mainstay for analytical processes of a large number of samples involving various disciplines. However, due to the limitations regarding health-care budgets, there has been a paradigm shift from central laboratories to point of care tests (POCT). Newer diagnostic tests can prove to be beneficial in evaluation of patient’s response to periodontal therapy. Oral fluid-based POCT used selectively are now being utilized as the potential “chairside” tests for determination of oral diseases
“A Descriptive Study to Assess the Knowledge Regarding Ebola Virus Disease among Nursing Students in Selected College of Nursing, Haridwar, Uttarakhand in a View to Develop Information Booklet”
Get PDFOne of the true tests of headship is the skill to identify a problem before it becomes an emergency. Ebola virus also called Ebola hemorrhagic fever is rare but fatal illness. Ebola is named after the Ebola River in Zaire. It earliest emerged in Sudan and Zaire. These viruses are to be found in sun- Saharan Africa. This spreads through human to human transmission. It is transmitted to human population from wild animals such as fruit bats, chimpanzees, and monkeys. Often blood or body fluids of infected animals contains this virus and contact with it makes human vulnerable to Ebola virus disease (EVD). No vaccine as such available to combat this deadly disease. On the other hand, early detection of case and symptomatic treatment aid in fast recovery. The aim of the study was (1) to assess the knowledge regarding Ebola virus among nursing students, (2) to find association between knowledge score and demographic characteristics, and (3) to develop an information booklet on EVD based on knowledge of nursing students. Quantitative approach and descriptive design were used in the study. The study was conducted in Arihant College of Nursing, Haridwar. Convenient sampling technique was used to collect data from 60 subjects. Based on findings of the study, it was concluded that the mean knowledge score was 07.42 ± 2.28. A majority of subjects, 54 (90%) were having poor knowledge and 6 (10%) were having average knowledge regarding EVD. No subjects were having good knowledge regarding EVD. This study concluded that there is a need of upgrading knowledge and awareness regarding EVD among nursing students. Although it is not a disease of Asian region, chances of international spread are always there