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Effect of Urtica dioica Seed Extract on Aquaporin 1 and 7, Caspase-3 and Oxidant/Antioxidant Status in Diethylnitrosamine-induced Kidney Damage in Rats
No full textDiethylnitrosamine (DENA) is known to have a carcinogenic effect on the liver by stimulating oxid ative stress and inflammation. There are few studies on the negative effects of DENA on kidney tissue, and the therapeutic effect of Urtica dioica Seed Extract (UDSE) against the negative effects of DENA is investigated for the first time in this study. Th is study investigated the protective effect of UDSE on kidney tissues of rats administered DENA. The rats were divided into four groups (n=8): control, UDSE (1 mL/kg/daily for 16 weeks), DENA (200 mg/kg/first day), DENA+UDSE (200 mg/kg/first-day single dose, and 1 mL/kg/daily for 16 weeks). At the end of the experiment, blood and kidney tissues were taken for biochemical and pathological analysis. DENA administration has been shown to increase oxidative stress in the kidneys and reduce antioxidant levels. Moreover, compared to the DENA group, DENA decreased the level of aquaporin (AQP)-1 in kidney tissue, while UDSE treatment increased both AQP-1 levels in kidney tissue and AQP-1 and 7 levels in the serum samples. Histopathological examination of the kidney revealed significant coagulation necrosis, especially in proximal tubular epithelial cells, hyperemia in capillaries, mononuclear cell infiltration between tubular area s, atrophy in the glomerular cluster, and adhesions with Bowman's capsule. In addition, there was a decrease in both caspase-3 (immunohistochemically) expression and TOS levels in the DENA+UDSE group compared to the DENA group, while an increase was seen in antioxidant levels. These findings indicated that UDSE may be an essential therapeutic agent against DENA-induced kidney injury. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved
Evaluating the attractiveness of architectural destinations with content analysis method and artificial intelligence: the case of Ankara
No full textDetermining the attractiveness of architectural destinations is important in revealing why visitors prefer these places. The study will help to identify the positive and negative aspects of buildings in terms of tourism in a wide scope and will also guide architects and designers in building design. From this point of view, the sample area of this study was determined as the city of Ankara. Ankara is a potential tourism destination as it is both the country’s capital and home to many historical buildings that shed light on the Republican era. The study method is based on content analysis of the comments of domestic and foreign tourists on architectural structures in the city on Tripadvisor, one of the leading digital travel platforms. The study is limited to eight (8) architectural structures. By analyzing the comments on the travel platform, the prominent themes in the attractiveness elements of architectural structures were identified. Although the numerical values obtained with artificial intelligence are different, the prominent contents are the same. The ability of artificial intelligence to interpret and analyze concepts constitutes an important method for qualitative analysis. As a result, the study found that the most attractive elements of architectural destinations for visitors are historical, cultural, and architectural values. © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group
Silver and ruthenium complexes with anthracene functionalized N-heterocyclic carbene ligands: catalytic and cytotoxicity properties
No full textIn this study, we have synthesized two Ag (2a and 2b) and two Ru (3a and 3b) complexes with anthracene substituted N-heterocyclic carbene (NHC) ligands. Ag?NHC complexes have been synthesized by the interaction of corresponding benzimidazolium chloride and Ag2O. Ru?NHC complexes have been synthesized by the transmetalation reaction between corresponding Ag?NHC and [RuCl2(p-cymene)]2 dimer. The synthesized complexes have been characterized by elemental analysis, NMR (1H and 13C NMR), and mass (high resolution mass spectroscopy, HRMS) spectroscopic techniques. In order to assess the catalytic potential of the Ru?NHC complexes, we have conducted experiments involving the hydrosilylation of terminal alkynes. Both complexes have exhibited a moderate level of catalytic activity, achieving conversions ranging from 70 to 90%, along with a substantial ?-(Z) selectivity within the range of 80–90%. Furthermore, we have also subjected the benzimidazolium chlorides (1a and 1b), Ag?NHCs and Ru?NHCs to cytotoxicity testing using human breast cancer cells (MCF-7) and human colorectal cancer cells (Caco-2). The results of these assays have demonstrated that all compounds strongly inhibit the proliferation of both cell lines. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024
Evaluation of the effect of local Bovine Amniotic Fluid on Osseointegration of Titanium Implants: A Histologic and Histomorphometric Study
Get PDFThe aim of this study was to histologically and histomorphometrically investigate the effect of locally applied bovine amniotic fluid (BAF) on osseointegration levels in implants. Adult female Sprague-Dawley rats weighing 300-350 g were used as subjects. The rats were divided into two groups: the sham-operated control group (n=10) and the local BAF group (n=10). Implant cavities were created in the tibias of all subjects under sterile saline cooling with rotating instruments. Local BAF was applied to all implant sockets before the implants were placed. Rats were sacrificed after a four-week osseointegration period. Histological staining was performed using hematoxylin and eosin staining to analyze the osseointegration. Examinations of the bone implant connection (BIC) and peri-implant bone formation (PBF) were performed using a light microscope and an image analyzer. As a result of the analysis, the mean BIC value was 40.3 +/- 4.9 for the sham-operated control group and 45.2 +/- 7.7 for the local BAF group. The mean PBF was 39.9 +/- 6.3 for the sham control group and 40.5 +/- 5.7 for the local BAF group. A statistically significant difference was found between the sham control group and the local BAF group for the BIC and PBF values (P>0.05; P >0.05; P : 0.11; P : 0.83). The application of local BAF to the implant socket did not have a clear positive effect on implant osseointegration. More studies are needed to clarify the association between local BAF and osseointegration.The authors wish to thank Implance Dental Implant Systems, AGS Medical, Istanbul, Turkiye for the manufacturing of the implants which used in this study
Determination of some environmental factors on milk yield traits and milk components in Simmental cows
Get PDFThe aim of the study was to determine the effects of various environmental factors on milk yield and milk components in Simmental cows. In the present study, 33,813 milk yield records from 1631 cows and milk samples from 233 cows were used for milk component analysis. Lactation milk yield (LMY) and 305 -day yield (305-DMY) were the milk yield characteristics studied. Environmental factors considered for milk yield characteristics included province, calving year, calving month, parity, age, and lactation length. Milk components analyzed were fat percentage (FP), protein percentage (PP), lactose percentage (LP), somatic cell count (Log(10)SCC), and dry matter (DM). Environmental factors considered for milk components were province, birth year, control month, calving month, and parity. The results indicated that all environmental factors significantly influenced milk yield characteristics (p < 0.01). Specifically, province and birth year significantly affected FP and Log(10)SCC (p < 0.01), whereas calving month, control month, and parity did not significantly affect FP. Province, birth year, and control month significantly influenced PP and DM (p < 0.01), while calving month and parity did not significantly affect PP. Province was the only significant factor for LP (p < 0.01). Considering all data, the averages of traits were as follows: LMY (5628.1 +/- 12.80 kg), 305-DMY (5309.2 +/- 11.80 kg), total dry matter yield (TDMY) (22.58 +/- 0.51 kg), DM (12.43 +/- 0.08%), Log10SCC (2.29 +/- 0.04, equivalent to 226239 cells/mL), FP (3.78 +/- 0.06%), PP (3.57 +/- 0.02%), and LP (4.72 +/- 0.01%)
Examination of motivation to participate in sports, loneliness and hopelessness levels of hearing impaired athletes
Get PDFSosyal Bilimler Enstitüsü, Beden Eğitimi ve Spor Ana Bilim Dalı, Beden Eğitimi ve Spor Bilim DalıBu çalışmada işitme engelli sporcuların spora katılım motivasyonu, yalnızlık ve umutsuzluk düzeylerinin incelenmesi amaçlanmaktadır. Çalışma genel tarama modeli kapsamında betimsel olarak planlanmıştır. Araştırmanın örneklemi ise gönüllü katılım dikkate alınarak, 70'i kadın, 196'sı erkek olmak üzere toplamda 266 işitme engelli sporcudan oluşmaktadır. Veri toplama araçları olarak birinci kısımda Kişisel Bilgi Formu, ikinci kısımda "Engelli Bireylerde Spora Katılım Motivasyonu Ölçeği", üçüncü kısımda "UCLA Yalnızlık Ölçeği" ve dördüncü kısımda "BECK Umutsuzluk Ölçeği" kullanılmıştır. Verilerin normal dağılıma uygunluğu kolmogorov smirnov normallik testiyle sınanmış ve verilerin parametrik olmayan testlere uygun olduğu tespit edilmiştir. Bağımlı ve bağımsız değişkenler arasındaki ilişkide Spearman korelasyon testi uygulanmıştır. İki kategorili değişkenlerde Mann-Withney U testlerinden, ikiden çok kategorili değişkenlerde Kruskal Wallis-H testi uygulanmıştır. Ayrıca aritmetik ortalama, standart sapma, frekans/yüzde hesaplamaları yapılmıştır. Araştırma sonucunda İşitme engelli sporcuların spora katılım motivasyonu ile işitme kaybı zamanı arasında yapılan analizde içsel motivasyon ve dışsal motivasyon boyutlarında anlamlı fark olduğu, spora katılım motivasyonu ile spor branşı arasında tüm alt boyutlarda anlamlı fark olduğu, spora katılım motivasyonu ile müsabaka kategorisi değişkeni arasında içsel motivasyon alt boyutunda anlamlı fark olduğu, spora katılım motivasyonu ile uluslararası dereceye girme değişkeninde dışsal motivasyon ve motivasyonsuzluk boyutlarında anlamlı fark olduğu, spora katılım motivasyonu ile işitme kaybı zamanı değişkeninde motivasyonsuzluk boyutunda anlamlı fark olduğu, spora katılım motivasyonu ile eğitim durumu değişkeninde dışsal motivasyon boyutunda anlamlı fark olduğu, spora katılım motivasyonu ile algılanan sosyal çevre değişkeninde dışsal motivasyon ve motivasyonsuzluk boyutlarında anlamlı fark olduğu görülmektedir. İşitme engelli sporcuların yalnızlık düzeyleri ile sadece spor branşı değişkeni arasında anlamlı fark olduğu tespit edilmiştir. İşitme engelli sporcuların umutsuzluk düzeyleri ile cinsiyet değişkeni arasında motivasyon kaybı ve gelecekle ilgili beklentiler alt boyutları arasında anlamlı fark olduğu, İşitme engelli sporcuların umutsuzluk düzeyleri ile medeni durum değişkeni arasında gelecekle ilgili duygular alt boyutu arasında anlamlı fark olduğu, İşitme engelli sporcuların umutsuzluk düzeyleri ile işitme kaybı zamanı değişkeni arasında motivasyon kaybı alt boyutu arasında anlamlı fark olduğu, İşitme engelli sporcuların umutsuzluk düzeyleri ile spor branşı değişkeni arasında gelecekle ilgili duygular alt boyutları arasında anlamlı fark olduğu, İşitme engelli sporcuların umutsuzluk düzeyleri ile uluslararası dereceye girme değişkeni arasında gelecekle ilgili beklentiler alt boyutu arasında anlamlı fark olduğu, İşitme engelli sporcuların umutsuzluk düzeyleri ile eğitim durumu değişkeni arasında motivasyon kaybı ve gelecekle ilgili duygular alt boyutları arasında anlamlı fark olduğu tespit edilmiştir. Sonuç olarak; sporun engelli bireyler üzerinde olumlu sonuçlar ortaya çıkardığı, umutsuzluk ve yalnızlık düzeylerini azalttığı ve sporla bireylerin olumsuz duygulardan uzaklaşarak motivasyonlarının arttığı söylenebilir.In this study, it is aimed to examine the motivation to participate in sports, loneliness and hopelessness levels of hearing impaired athletes. The study was planned descriptively within the scope of the general survey model. The sample of the study consists of a total of 266 hearing impaired athletes, 70 of whom are female and 196 of whom are male, taking into account voluntary participation. As data collection tools, Personal Information Form was used in the first part, "Motivation to Participate in Sports in Individuals with Disabilities Scale" in the second part, "UCLA Loneliness Scale" in the third part and "BECK Hopelessness Scale" in the fourth part. The suitability of the data for normal distribution was tested with the Kolmogorov Smirnov normality test and it was determined that the data were suitable for nonparametric tests. Spearman correlation test was applied for the relationship between dependent and independent variables. Mann-Withney U test was applied for variables with two categories and Kruskal Wallis-H test was applied for variables with more than two categories. In addition, arithmetic mean, standard deviation, frequency/percentage calculations were made. As a result of the research, there was a significant difference in intrinsic motivation and extrinsic motivation dimensions in the analysis between the motivation of hearing impaired athletes to participate in sports and the time of hearing loss, there was a significant difference in all sub-dimensions between the motivation to participate in sports and the sport branch, and there was a significant difference in the intrinsic motivation sub-dimension between the motivation to participate in sports and the competition category variable, It is seen that there is a significant difference in the extrinsic motivation and amotivation dimensions in the motivation to participate in sports and the variable of international ranking, there is a significant difference in the amotivation dimension in the motivation to participate in sports and the time of hearing loss, there is a significant difference in the extrinsic motivation dimension in the motivation to participate in sports and the educational status variable, there is a significant difference in the extrinsic motivation and amotivation dimensions in the motivation to participate in sports and the perceived social environment variable. It was determined that there was a significant difference between the loneliness levels of hearing-impaired athletes and only the sport branch variable. There is a significant difference between the hopelessness levels of hearing impaired athletes and the sub-dimensions of loss of motivation and expectations about the future between the gender variable, There is a significant difference between the hopelessness levels of hearing impaired athletes and the marital status variable between the sub-dimension of feelings about the future, There is a significant difference between the hopelessness levels of hearing impaired athletes and the time of hearing loss variable between the sub-dimension of loss of motivation, It was determined that there was a significant difference between the hopelessness levels of hearing-impaired athletes and the sub-dimensions of feelings about the future between the variable of sport branch, there was a significant difference between the hopelessness levels of hearing-impaired athletes and the sub-dimension of expectations about the future between the variable of international ranking, there was a significant difference between the hopelessness levels of hearing-impaired athletes and the sub-dimensions of loss of motivation and feelings about the future between the variable of educational status. As a result, it can be said that sports have positive results on individuals with disabilities, reduce their levels of hopelessness and loneliness, and increase their motivation by getting away from negative emotions
Review of the Environmental Performance Index (EPI): Methods, Constraints and Recommendations
Get PDFDuring the formation of composite index constructs, some constraints are encountered with respect to considerations such as the availability or accessibility of indicators, weights of such indicators, sub-indicators or variables to be used for reaching the indicators, data pertaining to such variables, and the determination of the most convenient method to be used for arranging the data set. In addition, it is required for the methods to be used to comply with the aim of the index to be formed. Researchers who want to develop a composite environmental index are required to consider all these considerations. This study aims to indicate and discuss the composite environmental index formation process through the examination of the EPI, which is a global composite index. One might argue that it contributes to the explanation of the composite index construction process, which has been examined, albeit limitedly, in the literature. Eventually, the methods that may be used in the index formation process by the researchers who want to form a composite index were discussed, and suggestions that may improve the methodological strength of the indices to be developed by them were presented. Our findings indicate the absence of an established theoretical methodology for composite sustainability indices. The creation of these indices has depended entirely on the expertise of the involved researchers
Hz. in contemporary tafsir the prophet's ummilism: The example of Muhammed Abi·d al-Jabiri
Get PDFSosyal Bilimler Enstitüsü, Temel İslam Bilimleri Ana Bilim DalıTezimiz, Hz. Muhammed ümmiliği meselesinin çağdaş tefsirlerde, özellikle Muhammed Abid el-Câbirî özelinde nasıl ele alındığı ile ilgilidir. Hz. Muhammed'in ümmîliği meselesi klasik dönemden itibaren müfessirler tarafından ele alınmıştır. Bu döneme ait tefsirler incelendiğinde, Hz. Muhammed özelinde kavram ile ilgili tespit edilen anlam, onun okur-yazar olmadığı şeklindedir. Müfessirlerin genel görüşleri incelendiğinde, ayetlerde ve sözlüklerdeki mevcut anlamlarına paralel olarak, Hz. Muhammed'in okur-yazarlığı dışında bazı farklı anlamların da söz konusu olduğu görülmektedir: "Kendilerine daha önce vahiy ve peygamber gönderilmemiş ve Kur'an'ın ilk muhatabı Arap toplumu"; "İlahi kitap gönderilmemiş, vahye muhatap olmamış herhangi bir toplum/millet"; "Ehl-i Kitab'ın kendilerinden olmayan kişileri tanımlama şekli" gibi bazı farklı anlamlar da karşımıza çıkmaktadır. Çağdaş dönemde de müfessirlerin genel kanaati Hz. Muhammed'in okuma yazma bilmediği yönündedir. Ancak bu görüşte olmayan tek müfessir, Muhammed Âbid el-Câbirî'dir. O, kendinden önce ortaya konmuş görüşleri etraflıca ele alarak Hz. Muhammed'in ümmi olmadığı sonucuna varmıştır.Our thesis, Hz. It is about how the issue of Muhammad's illiteracy is handled in contemporary commentaries, especially in the case of Muhammad Abid al-Jabiri. Hz. The issue of Muhammad's illiteracy has been addressed by commentators since the classical period. When the commentaries of this period are examined, Hz. The meaning of the concept in the case of Muhammad is that he was not literate. When the general views of the commentators are examined, in parallel with the existing meanings in the verses and dictionaries, Hz. It seems that there are some different meanings other than Muhammad's literacy: "The Arab community to whom no revelation or prophet had been sent before and the first addressee of the Quran"; "Any society/nation that has not been sent a divine book and has not received revelation"; We also encounter some different meanings such as "the way the People of the Book define people who are not among them." The general opinion of commentators in the contemporary period is that Hz. It is said that Muhammad could not read or write. However, the only commentator who does not hold this view is Muhammad Âbid al-Câbirî. He examined in detail the views put forward before him and Hz. He concluded that Muhammad was not illiterate
The Effect of Phenotypic and Genotypic Factors on Some Yield Traits in Holstein Friesian Cows with High Milk Yield Reared in Türkiye
Get PDFThis study was carried out to determine the effects and phenotypic relationships of some environmental factors (first calving age, calving year, and calving season) on Lactation period, dry period, milk yield and Milkability traits. The material of the study was the lactation records of 1079 Holstein cows raised in a private dairy farm. As a result of analyses, the values of 305-DMY yield (305 DMY), the lactation period (LP), dry period (DP), time to reach peak yield (Tmax), peak yield (Ymax), average daily milk yield (ADMY), total lactation milk yield (ATMY) and age at first calving (AFC) were determined as 9926.3±178.1 kg, 318.1±1.4 days, 60.05±0.9 days, 95.2±2.1 days, 42.3±0.3 kg, 32.2±0.3 kg, 10248.7±94.1, and 26.7±0.2 months, respectively. The study found the average milk flow rate (MFR) and the average milking time (MT) as 2.0±0.0 kg min-1 and 360.9±4.7 seconds, respectively. In addition, estimates of the 305-day mature equivalent milk yield (ME 305-d) and MFR were also found to be 0.41±0.24 and 0.51±0.30, respectively. As a result, this dairy farm can be recommended as an example to breeders who have just started their dairy farm in Türkiye and countries with similar environmental conditions and are looking for a model
Investigation of the effect of physical activity program adapted on some motor skills and quality of life in young individuals with smile intellectual disability
Get PDFSosyal Bilimler Enstitüsü, Beden Eğitimi ve Spor Ana Bilim DalıBu çalışmada hafif zihinsel engeli bulunan 14-18 yaş arasındaki bireylere uygulanan 12 haftalık uyarlanmış fiziksel aktivite programının bazı motor beceriler ile yaşam kalitesi üzerindeki etkisi incelendi. Deneysel tarama yöntemi ile gerçekleştirilen araştırmaya deney grubu olarak Elazığ Abdullah-Hakan Tangülü Özel Eğitim Meslek Okulundan 36 (17 kadın, 19 erkek), kontrol grubu olarak ise Elazığ Mavi Kardelen Rehabilitasyon Merkezinden 30 (14 kadın, 16 erkek) olmak üzere toplam 66 (31 kadın, 35 erkek) birey iştirak etti. 12 haftalık bir süreç olarak planlanan araştırmada, katılımcıların boy uzunluğu, vücut ağırlığı, denge, kuvvet, reaksiyon zamanı ve esneklik özellikleri ön test, son test ve kalıcılık testi ile belirlendi. Ayrıca sürecin başında ve sonunda yaşam kalitesinin seyrine dönük değerlendirmeler katılımcıların ebeveynleri tarafından yapıldı. Ölçümlerden elde edilen verilerin istatistiksel analizlerinde SPSS 22.0 paket programı kullanılmış olup, istatistiksel işlemler öncesi verilerin çarpıklık ve basıklık değerleri ile dağılımlarındaki normallik değerleri dikkate alınmak sureti ile grup içi, gruplar arası ve tekrarlı ölçümlerde farklılıkları belirlemeye yönelik t testi ile ANOVA testi kullanıldı. Yapılan ölçümler sonucunda uyarlanmış fiziksel aktivite programı sonrasında deney ve kontrol grupları arasında, boy uzunluğu, vücut ağırlığı, vücut kitle indeksi, denge, kuvvet, esneklik değerlerinde anlamlı farklılık tespit edilirken (p0,05). Anlamlı değişimler genellikle deney grubunda kaydedilirken, kontrol grubundaki değerlerin çoğunlukla benzer seyrettiği tespit edildi. Dört alt boyuttan oluşan yaşam kalitesi ölçeğinin sadece "okul işlevselliği" alt boyutunda deney grubu lehine anlamlı bir farklılığın bulunması, uyarlanmış fiziksel aktivite programının okul veya okul ortamının etkinliğine pozitif yönde bir katkı sağladığı söylenebilir. Bilişsel anlamda özel eğitim alan bireylerin aynı zamanda motor becerilerinin de belli bir program kapsamında desteklenmesi, onların yaşam kalitesinin bir bütünlük içerisinde yükseltilmesini muhtemelen daha mümkün hale getirecektir.In this study, the effect of a 12-week adapted physical activity program applied to individuals aged 14-18 with mild intellectual disabilities on some motor skills and quality of life was examined. The research was conducted with the experimental screening method, with a total of 66 (31) participants, 36 (17 women, 19 men) from Elazığ Abdullah-Hakan Tangülü Special Education Vocational School as the experimental group, and 30 (14 women, 16 men) from Elazığ Mavi Kardelen Rehabilitation Center as the control group (31 women, 35 men) individuals participated. In the research planned as a 12-week period, participants' height, body weight, balance, strength, reaction time and flexibility characteristics were determined by pre-test, post-test and permanence test. In addition, evaluations of the quality of life at the beginning and end of the process were made by the participants' parents. SPSS 22.0 package program was used in the statistical analysis of the data obtained from the measurements, and ANOVA test with T test was used to determine the differences within the group, between the groups and in repeated measurements, taking into account the skewness and kurtosis values of the data and the normality values in the distributions before the statistical operations. As a result of the measurements, after the adapted physical activity program, a significant difference was detected between the experimental and control groups in height, body weight, body mass index, balance, strength and flexibility values (p0.05). While significant changes were generally recorded in the experimental group, it was determined that the values in the control group were mostly similar. The fact that there is a significant difference in favor of the experimental group only in the "school functionality" sub-dimension of the quality of life scale, which consists of four sub-dimensions, can be said that the adapted physical activity program makes a positive contribution to the effectiveness of the school or school environment