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Using game-based research approaches to gauge children's perceptions: insights from a food education project
No full textInternational audienceThis paper provides insight into how gaming can be used to explore the children's experience of food, and to envision possible future transitions in their eating habits. The case study presented is part of the ERMES project, an interdisciplinary initiative funded by the French National Research Agency (ANR-23-CE36-0009), focused on primary school children aged 9-10 in the Îlede-France region. The project aims to develop scientific understanding on how children engage with and relay "food messages" in their daily lives, and how these messages influence their attitudes and eating habits. The paper presents and discusses the use of research game-based workshops to capture children's attitudes, preferences, and understanding of nutrition in a playful and engaging manner. These activities not only facilitate data collection but also foster trust and active participation among children. Additionally, the case study highlights the challenges of conducting action-oriented research in school settings, including minimizing researcher influence and addressing scientific bias. Findings suggest that game-based approaches are effective in exploring complex topics like sustainable eating, offering insights into children's peer culture and food-related behaviors. However, the study emphasizes that game-based activities should complement, rather than replace, traditional methods such as observations and surveys. By integrating games into research, the study provides a novel framework for understanding children's food perceptions, contributing to the development of effective food education strategies
Chaetoceros socialis extract triggers apoptosis in oral and colorectal cancer cells through PI3K/AKT/mTOR pathway modulation
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Association between red blood cell transfusion and adverse clinical outcomes is Independent of cardiac history: a multicenter observational InPUT study analysis
No full textInternational audiencePurpose Red-blood-cell (RBC) transfusion is one of the most frequent interventions in critical care patients. While patients with acute cardiac conditions are more likely to receive transfusions at higher haemoglobin thresholds than other critically ill patients, data on RBC transfusion practice for critically ill patients with pre-existing cardiac conditions are scarce.Methods Using the International Point-Prevalence Study of Intensive-Care Unit Transfusion Practices cohort, weighted logistic regression investigated the association between the RBC units transfused and the primary composite outcome of 28-day mortality, new-onset acute kidney injury or ventilatory weaning failure. Interactions with cardiac history (acute coronary syndrome and/or heart failure) were tested. ResultsCardiac history was present in 746 of 3643 patients (20%) and 894 of 3643 (25%) received at least one RBC unit. Transfusion rates were similar in patients with and without cardiac history (25% vs. 24%; p = 0.51). Among transfused patients, median nadir haemoglobin during ICU stay was slightly higher in those with cardiac history (7.6 g/dL vs. 7.4 g/dL respectively; p = 0.007), whereas stated haemoglobin transfusion threshold did not statistically</div
The Non-Coding RNome Landscape in Erythropoiesis: Pathophysiological Implications
No full textInternational audienceErythropoiesis is a multistage process critical for red blood cell production and systemic oxygen transport. It is tightly regulated, and recent advances have highlighted the pivotal regulatory roles of non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), in governing both physiological and pathological erythropoiesis. These ncRNAs have roles in the fine-tuning of the classical transcriptional and post-transcriptional control. This review explores the complex landscape of the non-coding RNome in erythroid differentiation, maturation, and function. We summarize how specific miRNAs influence erythroid lineage commitment, hemoglobin switching, iron metabolism, and cellular morphology, as well as their modulation by environmental and pathological cues. We also discuss emerging evidence on lncRNAs regulating chromatin remodeling, alternative splicing, apoptosis, enucleation, and erythroid-specific gene expression. These insights suggest that ncRNAs are instrumental orchestrators of erythropoiesis and accordingly, potential biomarkers and therapeutic targets in anemia and related hematologic disorders
Microwave spectroscopy of ultracold-sodium least-bound molecular states
No full textInternational audienceWe have performed microwave spectroscopy of sodium least-bound molecular states, improving the precision of the knowledge of their energies at zero magnetic field by almost three orders of magnitude. Our experimental observations give us access also to states submitted to predissociation, a phenomenon where a bound molecular state can naturally decay into the continuum. Our findings are compared to numerical calculations based on the latest interpolation of sodium interaction potentials and show good agreement, with slight discrepancies in the zero-field energy of the molecular states, suggesting a need for small adjustment of the interaction potentials
Urge to eat and Body Mass Index: exploring the association with diffuse and defined emotions
No full textInternational audienceObjective Emotional eating is more common in individuals with obesity and is a predictor of increased Body Mass Index (BMI). This study aimed to identify the types of emotions associated with the urge to eat in subjects with varying BMI levels. Methods Adult participants were recruited as part of a validity study for a new questionnaire designed to assess an individual’s relationship with their body. The Emotional Eating Scale of the Dutch Eating Behavior Questionnaire (DEBQ), as well as questions on past and current eating disorders, body weight status and history, health, and socio-demographic data, were assessed through an online questionnaire. Results Six hundred participants were included, comprising 80.5% women. 27.0% were living with overweight and 21.2% with obesity. The urge to eat was significantly more frequent in response to diffuse emotions than to defined emotions, independent of sex and BMI level. The frequency of emotional eating was positively associated with BMI for all emotions explored by the DEBQ. The defined emotion “depressed/discouraged” induced an urge to eat more often in individuals with obesity. “Feeling abandoned” was the diffuse emotion most associated with obesity (53.5% of subjects with obesity ate often or very often versus 28.6% of subjects with normal weight). Conclusion This study highlights the need to explore diffuse emotions in subjects with obesity
Contributions aux problèmes des suites à somme nulle pondérées et classiques
No full textIn this thesis, we study problems related to zero-sum sequences over finite abelian groups, both in the classical and the weighted settings. In our framework, sequences are elements of the free abelian monoid over the group G; that is, the order of terms in the sequence is not taken into account. We begin by investigating the basic algebraic properties of these monoids, then proceed to analyze in detail certain classical arithmetic invariants associated with these structures. We prove that, for a broad class of weights, the unions of sets of lengths form intervals, and we obtain various results concerning the elasticity of these monoids. More detailed results are established for the special case of plus-minus weighted sequences. We conclude by showing that our results not only provide a natural generalization of existing work, but also have concrete applications. In particular, we present an arithmetic application by demonstrating that these monoids arise in the study of norm monoids of algebraic integers. Finally, for classical zero-sum sequences, we determine the number of minimal zero-sum sequences of a given length over a finite abelian group. Using an inclusion-exclusion type argument, we obtain exhaustive results for the case where the length does not exceed five .Dans le cadre de cette thèse, nous étudions des problèmes liés aux suites à somme nulle sur les groupes abéliens finis, qu'elles soient de nature classique ou pondérée. Soulignons que, dans notre contexte, les suites sont des éléments du monoïde abélien libre sur le groupe G, c’est-à-dire l’ordre de termes de la suite n’est pas pris en compte. Nous commençons par étudier les propriétés algébriques de base de ces monoïdes, puis analysons en détail certains invariants arithmétiques classiques associés à ces structures. Nous démontrons que, pour une large classe de poids, les unions d'ensembles de longueurs sont des intervalles, et nous obtenons divers résultats concernant l'élasticité de ces monoïdes. Des résultats plus détaillés sont obtenus pour le cas particulier des suites plus-moins pondérées. Nous concluons en montrant que nos résultats ne constituent pas seulement une généralisation naturelle de travaux existants, mais qu'ils possèdent également des applications concrètes. En particulier, nous fournissons une application arithmétique en démontrant que ces monoïdes interviennent dans l'étude des monoïdes des normes des entiers algébriques. Enfin, pour les suites à somme nulle classiques, nous déterminons le nombre de suites à somme nulle minimales d'une longueur donnée sur un groupe abélien fini. Avec un argument de type inclusion-exclusion, nous obtenons des résultats exhaustifs pour le cas où la longueur ne dépasse pas cinq
Étudiants haïtiens en France : parcours migratoires et contraintes d’intégration socioprofessionnelle
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The Critical Role of Adipocytes in Leukemia
No full textInternational audienceThe bone marrow microenvironment is a dynamic and complex niche that plays a central role in the development, progression, and therapeutic resistance of leukemia. Among the various stromal and immune cells that compose this microenvironment, adipocytes are increasingly recognized as active participants rather than passive bystanders. These cells contribute to leukemia pathophysiology by supplying leukemic cells with vital metabolic fuels such as free fatty acids and glutamine, which support cellular bioenergetics and biosynthesis. Furthermore, adipocytes secrete adipokines—including leptin, adiponectin, and others—that influence leukemic cell proliferation, apoptosis, and chemoresistance. Leukemic cells, in turn, are not merely recipients of these signals, but actively remodel the marrow niche to their advantage. They can suppress adipogenesis, inhibit the differentiation of mesenchymal stem cells into adipocytes, or reprogram existing adipocytes to adopt a tumor-supportive phenotype. These transformed adipocytes may enhance leukemic cell survival, dampen immune responses, and create a metabolic sanctuary that enables resistance to standard chemotherapies. This reciprocal and dynamic interaction between leukemic cells and adipocytes contributes significantly to minimal residual disease and relapse, posing a major challenge for durable remission. Recent advances in tissue engineering—such as organ-on-chip and 3D co-culture systems—offer promising platforms to recapitulate and study these leukemia–adipocyte interactions with high fidelity. These models facilitate mechanistic insights and provide a foundation for developing novel therapeutic strategies aimed at disrupting the metabolic and paracrine crosstalk within the leukemic niche. Targeting the adipocyte–leukemia axis represents a compelling and underexplored avenue for improving leukemia treatment by sensitizing malignant cells to existing therapies and overcoming the protective influence of the bone marrow microenvironment