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Context normalization: A new approach for the stability and improvement of neural network performance
No full textInternational audienc
Pour une expertise scientifique et technique impartiale en vue de la maîtrise des expositions professionnelles aux pesticides en milieu agricole.Rapport final de la formation spécifique de Commission nationale de la déontologie et des alertes en matière de santé publique et d’environnement (cnDAspe), présenté lors de la séance plénière du 16 novembre 2023.
No full textPour une expertise scientifique et technique impartiale en vue de la maîtrise des expositions professionnelles aux pesticides en milieu agricoleRapport final de la formation spécifique de Commission nationale de la déontologie et des alertes en matière de santé publique et d'environnement (cnDAspe), présenté lors de la séance plénière du 16 novembre 2023 Composition de la formation spécifique Isabelle BALDI (épidémiologiste et expologue) Aurélie BERTHET (toxicologue et expologue) Alain GARRIGOU (ergonome) Nathalie JAS (historienne et sociologue des sciences) Jean Noël JOUZEL, président (sociologue) Pierre LEBAILLY, vice-président (épidémiologiste et expologue) Annie MARTIN (juriste) Viviane MOQUAY (vétérinaire biologiste) Giovanni PRETE (sociologue) Ludovic TUDORI (chimiste)</div
Patrimoines alimentaires en Amérique latine. Faire face aux inégalités et aux changements globaux : introduction.
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L'Ami Melquiadès ou l'âne qui brait jamais ne se tait: Saynète de moeurs madrilènes en un acte et trois tableaux, musique des maîtres Valverde et Serrano
No full textTraduction collective de l'atelier de traduction théâtrale du CREC (UR2292, Sorbonne Nouvelle). Il s'agit d'une édition bilingue, publiée aux éditions UGA (Grenoble).Carlos Arniches, El amigo Melquíades o por la boca muere el pez, Teatro Completo, Madrid, Aguilar, 1948Dans les quartiers populaires de Madrid, au début du XXe siècle, Blanche rêve d’amour et de belles tenues et se laisse séduire par Séraphin le Gandin qui lui promet monts et merveilles. Benita, sa sœur, aussi consciente des réalités que Blanche est naïve, aidée par son chevalier servant Avelino, décide de la sauver d’un déshonneur certain et d’un avenir très malheureux. De stratégies de séduction en retournements cocasses, cette pièce – musicale en partie – fait défiler les habitants du quartier qui chantent, dansent et évoquent leur quotidien avec drôlerie et tendresse.Représentée pour la première fois à Madrid en 1914, cette saynète est emblématique de l’œuvre comique de Carlos Arniches, un dramaturge que Federico García Lorca considérait comme doté d’une véritable poétique tant son inventivité verbale est prodigieuse. Son œuvre n’a jamais été traduite en France
Using multiomic integration to improve blood biomarkers of major depressive disorder: a case-control study
No full textInternational audienceBackground Major depressive disorder (MDD) is a leading cause of disability, with a twofold increase in prevalence in women compared to men. Over the last few years, identifying molecular biomarkers of MDD has proven challenging, reflecting interactions among multiple environmental and genetic factors. Recently, epigenetic processes have been proposed as mediators of such interactions, with the potential for biomarker development.Methods We characterised gene expression and two mechanisms of epigenomic regulation, DNA methylation (DNAm) and microRNAs (miRNAs), in blood samples from a cohort of individuals with MDD and healthy controls (n = 169). Case-control comparisons were conducted for each omic layer. We also defined gene coexpression networks, followed by step-by-step annotations across omic layers. Third, we implemented an advanced multiomic integration strategy, with covariate correction and feature selection embedded in a cross-validation procedure. Performance of MDD prediction was systematically compared across 6 methods for dimensionality reduction, and for every combination of 1, 2 or 3 types of molecular data. Feature stability was further assessed by bootstrapping.Findings Results showed that molecular and coexpression changes associated with MDD were highly sex-specific and that the performance of MDD prediction was greater when the female and male cohorts were analysed separately, rather than combined. Importantly, they also demonstrated that performance progressively increased with the number of molecular datasets considered.Interpretation Informational gain from multiomic integration had already been documented in other medical fields. Our results pave the way toward similar advances in molecular psychiatry, and have practical implications for developing clinically useful MDD biomarkers.</div
Un historien, des images, l’Algérie
No full textInternational audienceParmi mes nombreux travaux historiques consacrés à l’histoire de l’Algérie, j’ai à la fois utilisé des sources écrites, et aussi des images qui racontent des histoires, construisent une mémoire visuelle. Dans cet article, ce ne sont pas les images fixes (les photographies) qui sont étudiées, mais les images en mouvement, celles du documentaire et de la fiction, à propos de la séquence de la guerre d’Algérie. Comme on le verra, ce fonds d’images est très riche alors que certains se plaignent encore d’un manque, d’une absence, qui n’est véritable que dans quelques cas très précis. Pour le reste, c’est plutôt pléthore : il faut alors faire du tri, analyser, et c’est de cela qu’il est question dans l’article (en particulier via l’inventaire des films de fictions et des documentaires)
Lumière sur l’interprétation des statuts d’une union de syndicats, note sous Cass. soc., 4 juin 2025, no 23-60.116
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Quelle place pour le transfert conventionnel du contrat de travail ?
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Experimental and modeling study of single-crystal diamond CVD growth on etch pits
No full textInternational audienceSingle crystal diamond synthesized by chemical vapor deposition (CVD) is a promising material for advanced applications, particularly in power electronics and quantum technologies.However, crystalline defects, especially dislocations, can have a significant negative influence on performance.To improve the film quality, several surface treatment techniques have been developed, among which H2/O2 plasma etching is widely used [1]. This treatment creates etch pits with a typical inverted pyramidal structures that can be used as markers for dislocation detection in diamond [2].Achieving higher crystalline quality requires optimizing growth conditions to effectively fill these etch pits [3] .This study investigates the formation and filling dynamics of etch pits in CVD single crystal diamond. Etch pits were generated using H2/O2 plasma etching and characterized by Scanning Electron Microscopy (SEM) and Differential Interference Contrast Microscopy (DICM) to determine their crystallographic orientation.According to previous studies2, the observed etch pits are formed by (113) planes.Controlled deposition experiments were then performed and the imaging techniques were used to study the evolution of the etch pits as a function of deposition time. A comparative analysis was finally made with a 3D geometric growth model [4] After 45 hours of deposition, the (100) surface rate is lower than the (100) rate at the etch pit flat bottom, influencing the filling dynamics.Both the surface and depth evolution follow a linear trend over time.The 3D geometric growth model accurately reproduces the observed evolution of the surface and its linear evolution in time (Fig.1).This approach improves our understanding of the etch pit filling mechanisms to improve the crystalline quality of CVD diamond.[1] F. Silva et al., Diamond and Related Materials 5 (1996) 338[2] H. Umezawa et al., Diamond and Related Materials 40 (2013) 56-59[3] J. Achard et al.,Phys. Status Solidi A 206, No.9(2009) 1950[4] F.Silva et al., Diamond and Related Materials 17 (2008) 1067-107
Enhanced 3D nanocrystalline diamond coatings for titanium implants using distributed antenna microwave systems: advancing growth processes and biocompatibility
No full textInternational audienceBiomaterials are designed to interact with biological systems to treat or replace any damaged tissue or organ of the body. Among the metals used in biomaterials research, titanium alloys offer the optimal balance of mechanical and biocompatible properties. However, the performance of titanium-based biomaterials can still be enhanced, as titanium implants may fail to properly integrate with the surrounding bone tissue, loosen, or trigger inflammatory responses. To address this issue, titanium surfaces can be treated to improve cellular behaviour on the biomaterial. In particular, due to its unique properties, including very high hardness, chemical inertness, biocompatibility, and low friction coefficient, diamond is considered as one of the best candidates for coating titanium implants and prostheses. NanoCrystalline Diamond (NCD) films, characterized by their nanometric grain size and low surface roughness, are promising for applications requiring smooth, as-grown surfaces. In this work, we investigate the suitability of a Distributed Antenna Array (DAA) reactor, consisting of 16 plasma sources arranged in a 2D matrix, operating at low pressure and low temperatures, for growing NCD films on 2D and 3D complex-shape Ti and TA6V substrates. The results demonstrate the development of continuous, good quality and uniform 200 nm-thick NCD coatings on these substrates, exhibiting superior mechanical and biological properties. Indeed, the hardness and adhesion of NCD/Ti and NCD/TA6V systems, along with no sign of cytoxicity, allowing cell adhesion and proliferation while enhancing osteointegration, are particularly suitable for the intended applications. Moreover, a satisfactory three-dimensional growth using the DAA reactor demonstrates the feasibility of applying this NCD coating process to complex-shaped implants and prosthesis with curvatures and right angles, which could provide significant benefits for the long-term success of medical devices