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Leveraging multi-omics integration to uncover childhood traumarelated mechanisms in bipolar disorder
No full textInternational audienc
Continuous investment for sustainable third-party logistics performance: a system dynamics approach
No full textInternational audience3PL providers must regularly deploy sustainable investments to improve their environmental, social and economic performance. However, gaps between expected and actual global performance are often observed, leading firms to regulate this policy of continuous investment. To meet this objective, we propose a system dynamics model that simulates the control of investment levels using balancing and reinforcing loops involving non-linear relationships between certain variables. Based on a realistic data set, the simulations help to understand the behaviour of a steering system in response to fluctuations in various endogenous factors (stakeholders’ performance objectives, funding threshold decided by shareholders) and exogenous factors in favour of sustainable logistics (3PL market trends, government and societal pressures). An original result shows that in the event of a gradual increase in the average level of competitive performance, the level of investment self-regulates and reaches a stable equilibrium after transient instabilities in response to this exogenous disturbance
EPS à l'école primaire : un état des pratiques d'enseignement
No full textInternational audienceL’activité physique (AP) est aujourd’hui reconnue comme un pilier fondamental d’unebonne santé, et sa pratique en est recommandée à tous les âges, selon des modalités variées.Ces habitudes d’AP prennent une importance particulière chez l’enfant puisqu’elle en conditionnera en partie sa pérennité à l’âge adulte. A ce titre, l’Education Physique et Sportive(EPS) à l’école primaire y joue un rôle primordial, l’école étant parfois le lieu unique dela pratique d’une AP chez l’enfant. Les modalités de son enseignement y revêtent doncun rôle fondamental. Bien qu’aucune enquête n’ait été menée au niveau national, des rapports parlementaires au début des années 2010 ont cependant souligné que l’EPS constituaitune ” variable d’ajustement horaire ” en regard de matières sujettes à ” pression ” commele français ou les mathématiques. Pour cerner plus objectivement les contours de l’EPS `al’école primaire, nous avons lancé un questionnaire en ligne à l’intention des Professeurs desEcoles (PE) dans 6 départements français (Pas-de-Calais, Nord, Vienne, Seine-Saint-Denis,Seine-et-Marne et Val-de-Marne) afin de connaître leurs usages d’enseignement d’EPS, maiségalement, le cas échéant, les freins pouvant les limiter. L’analyse des 1967 réponses retenuesmontre que la durée hebdomadaire d’EPS est inférieure à celle imposée par les programmes,et qu’elle est impactée par divers paramètres relatifs aux PE (sexe, âge, ancienneté d’exercice,pratique personnelle d’une AP) mais également au contexte de l’école (milieu urbain, nombre d’habitants, nombre de classes, présence d’une association sportive scolaire). Les freinsprincipaux évoqués sont le manque de temps, les conditions météorologiques et le manqued’infrastructures
Correlation between computed electric dose maps and early post-operative MRI for the evaluation of irreversible electroporation
No full textInternational audienceObjective. To correlate numerical simulations of the electric dose distribution with early post-operative MRI following irreversible electroporation (IRE) treatment of hepatocellular carcinoma (HCC).Approach. A standard linear electrostatic model was employed to simulate the three-dimensional electric field (EF) distribution using real electric pulses and geometrical characteristics and intraoperative cone-beam CT (CBCT) data. Spatial registration between intraoperative CBCT and post-operative MRI was performed using both rigid and deformable methods, ranging from simple global translations based on anatomical landmarks to advanced deformable image registration (DIR) techniques accounting for elastic tissue deformations.Main Results. The proposed approach was retrospectively evaluated using data from 22 patients who underwent IRE liver ablation (one patient underwent two distinct IRE procedures), resulting in a total of 23 procedures. The most accurate correspondence between predicted and observed ablation zones was achieved using a dose threshold of approximately 350 V/cm, yielding a median Dice Similarity Coefficient (DSC) around 0.74, indicative of substantial spatial overlap. Although elastic DIR approaches applied to segmented liver regions provided the highest registration accuracy, the simpler translational registration based on manually selected landmarks demonstrated surprisingly robust performance in localizing the simulated EF within the actual ablation zone.Significance. These findings contribute to the standardization of IRE efficacy assessment on MRI and highlight the significant potential EF simulations to predict the extent of tissue ablation in IRE procedures for HCC. This approach may offer a valuable tool for improving intraoperative decision-making and post-operative assessment
Challenges to Adolescent Pre-exposure Prophylaxis (PrEP) Uptake: an Exploration of Black and Latino American Parents’ Beliefs, Attitudes, and Receptivity to PrEP
No full textTashuna Albritton, Karna Coulibaly, and Paulo Pina contributed equally.International audienc
The impact of allogeneic hematopoietic stem cell transplantation on pulmonary complications in adults with inborn errors of immunity
No full textInternational audienceBackgroundPulmonary involvement (repeated lung infections, lung parenchymal inflammation, scarring, and malignancies) is frequent in patients with inborn errors of immunity (IEIs) and accounts for a significant proportion of the disease burden. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) can cure most severe IEIs. The indications for allo-HSCT have recently been extended to adults.ObjectiveWe sought to assess the impact of allo-HSCT specifically on respiratory status.MethodsWe retrospectively analyzed data of 50 patients with IEIs who underwent a first allo-HSCT after the age of 16 at 3 expert centers in France.ResultsThe median length of follow-up was 4.8 years (interquartile range: 1.6-9.2) before allo-HSCT and 3 years (interquartile range: 1.4-6.0) after allo-HSCT. Ten patients died as a result of allo-HSCT–related complications. Four patients developed bronchiolitis obliterans syndrome. After 1-year posttransplantation, the mean annualized rate of severe respiratory infections (0.14 [95% CI: 0.04 to 0.24]) was lower than the value recorded before transplantation (0.54 [95% CI: 0.25 to 0.82]; P = .003 for paired comparisons of equivalent durations). Lung function was declining before allo-HSCT (mean FEV1: −2.09% predicted/year [95% CI: −7.27 to 3.09]) but increased afterward (+2.44% predicted/year [95% CI: −4.79 to 9.69], P = .0034 for paired comparisons). On computed tomography scans of the chest, bronchial disorders and lung parenchyma cavities were the most frequent abnormal findings. The bronchial thickening and bronchiolar micronodules regressed after allo-HSCT, whereas bronchiectasis and residual parenchymal cavities were stable.Conclusionsallo-HSCT seems likely to protect the long-term pulmonary prognosis of adults with IEIs; it is associated with a significantly lower incidence of severe respiratory infections, better lung function, and radiologic stabilization of lung damage
The Evolution of Innovation Policy: Two Promising Directions for Tackling Societal Challenges
No full textInternational audienceThis article explores how public innovation policies can address today’s Grand Challenges − complex societal and environmental problems such as climate change and AI transformation. It presents two approaches: mission-oriented policies and local, procedural “small-wins” strategies. Mission-oriented innovation policies emphasize proactive state involvement in steering large-scale transformations, as seen in ecological and AI-focused initiatives in Europe and France. These policies aim to shape markets and foster long-term technological breakthroughs. In contrast, small-wins strategies prioritize localized, iterative innovations driven by stakeholder engagement, flexibility, and experimentation. While mission-oriented policies set broad national directions, small-wins initiatives offer bottom-up, adaptive responses tailored to specific contexts. The article argues for a complementary use of both approaches to foster sustainable and inclusive innovation. This dual framework could enable public actors to tackle systemic uncertainty, promote green and digital transitions, and build resilient innovation ecosystems across scales
Fine-structure resolution of SiV color centers in CVD nanodiamonds via HPHT annealing
No full textInternational audienceDiamonds and nanodiamonds (NDs) containing quantum color centers, such as nitrogen-vacancy (NV) centers, have been widely studied in recent years for their promising applications across various fields, including cryptography and telecommunications, medical sciences, and sensing. In the context of sensing, recent studies on color centers such as silicon-vacancy (SiV) and germanium-vacancy (GeV) centers have shown great potential for measuring physical quantities like magnetic fields, temperature, and strain. This is due to their intense zero-phonon line (ZPL) optical signal, which accounts for about 80% of their total luminescence and is characteristic of group-IV color centers (G4V) [1]. In our recent papers, we demonstrated that as-grown CVD NDs containing SiV and GeV centers, featuring luminescent ZPLs and excellent photostability at room temperature, can function effectively as nanosensors under high stress and pressure conditions (up to 180 GPa) [2, 3]. To advance our research, in this work we investigate the optical properties of SiV centers in as-grown NDs at cryogenic temperatures. For SiV centers, which have spin 1/2, the fine structure should become accessible through the Jahn-Teller effect, which lifts the degeneracy at cryogenic temperatures (< 20 K). However, experiments on our as-grown NDs reveal significant spectral broadening even at around 9 K, caused by lattice strain, which prevents access to the optically addressable electronic spin states of the SiV center. To overcome this limitation, we propose an original post-treatment involving high-pressure and high-temperature (HPHT) annealing using the Paris–Edinburgh press. This approach allows the gradual increase of temperature and pressure allows for control over the undesired diamond-to-graphite phase transition. HPHT annealing experiments were conducted at the PSICHE beamline of Synchrotron SOLEIL [4], where X-ray diffraction and tomography analyses enabled precise monitoring of P-T parameters and made it possible for the first time to access single fine-structure transitions of SiV centers in such NDs.References[1] C. Bradac, et al., Nat. Commun. 10, 1 (2019). [2] B. Vindolet, et al., Phys. Rev. B 106, 214109 (2022).[3] M. De Feudis, et al., Adv. Mater. Interfaces 7, 1901408 (2019).[4] L. Henry et al., J. Synchrotron Rad. 29 (2022)
Une autonomie sous contrainte administrative et temporelle [Introduction à la 3e partie : "Rendre autonome"]
No full textCollectif MINA93 = Bonnet Doris, Bouagga Yasmine, Destremau Blandine, El Qadim Nora, Long Julien, Zougbédé EmelineInternational audienc
