Borneo Journal of Pharmacy
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The Potential of Walnut Seeds (Canarium indicum L.) in Repairing The Genotoxicity Effect of Mercury on Mice Erythrocytes
No full textHydrargyrum (familiar as mercury) is a persistent transition metal element. They are known as bio-accumulative properties that are dangerous to the environment and has serious damaging effects on biota, including genetic changes or mutagenesis. Moreover, it can accumulate indirectly in the human body due to the consumption of products that have contaminated. Whereas, ellagic acid has reported as one of 13 flavonoid compounds that have potential as an anti-mutagen and anti-cancer in the walnuts seeds. This study was aimed to ensure the potential extent of ellagic acid extracts in walnut seeds to reducing and repairing the genotoxicity effects of mercury. Therefore, using the experimental method, this study was divided into several test treatments. Two controls treatment as a comparison of the presence of micronucleus with group tests that given a 20 ppm mercury dosage. Then continued with the addition of walnut seed extract with various dosage (10, 15, and 20 ppm) by oral injection continuously for two weeks as a recovery process to reducing and repairing the genotoxicity effect of mercury. The significant results showed that there are differences between pre and post-treatment. It indicated that the extract has the potential for improving and reducing the genotoxicity effect of mercury. The data were evaluated and obtained the total micronucleus from the smear of peripheral blood of mice by comparing the total micronucleus before and after giving of walnut extract
The Rationality of Antibiotics Use on Inpatient Department of Pediatric in One of the Hospital in Cimahi
No full textThe purpose of this study is to assess the rationality of the use of antibiotics from inpatients in one hospital in Cimahi, West Java. The research about rationality analysis of antibiotics at pediatric inpatient in one of the hospitals in Cimahi was done retrospectively use descriptive analysis design. The data source was the medical record of a patient who treated at the children's inpatient ward from January through March 2017. The result shows that 39% of infected patients were children under one-year-old. Three significant cases of diseases that occurred in the period were bronchopneumonia, typhoid fever, and typhoid fever+bronchopneumonia. Antibiotics therapy was given as single therapy as well as combination, where cefotaxime (51%) and ceftriaxone (42%) were the most antibiotics widely used as single therapy. Antibiotic use at children inpatient ward during the period January – March 2017 on bronchopneumonia, typhoid fever, and typhoid fever + bronchopneumonia patients was not 100% rational referring to criteria: correct diagnosis, correct indication, the correct drug of choice, correct dosage, correct method, and correct time interval of drug administration
Computational Drug Design against Ebola Virus Targeting Viral Matrix Protein VP30
No full textEbola viral disease (EVD) is a deadly infectious hemorrhagic viral fever caused by the Ebola virus with a high mortality rate. Until date, there is no effective drug or vaccination available to combat this condition. This study focuses on designing an effective antiviral drug for Ebola viral disease targeting viral protein 30 (VP30) of Ebola virus, highly required for transcription initiation. The lead molecules were screened for Lipinski rule of five, ADMET study following which molecular docking and bioactivity prediction was carried out. The compounds with the least binding energy were analyzed using interaction software. The results revealed that 6-Hydroxyluteolin and (-)-Arctigenin represent active lead compounds that inhibit the activity of VP30 protein and exhibits efficient pharmacokinetics. Both these compounds are plant-derived flavonoids and possess no known adverse effects on human health. In addition, they bind strongly to the predicted binding site centered on Lys180, suggesting that these two lead molecules can be imperative in designing a potential drug for EVD
Antibacterial Activity Test of Ethanol Extract Pineapple (Ananas comosus (L.) Merr.) Peel against Growth of Propionibacterium acnes
No full textPineapple peel (Ananas comosus (L.) Merr.) is waste from the pineapple fruit. The purpose of this study was to determine the content of pineapple peel extract and to antibacterial activity in various concentrations effective in inhibiting the growth of Propionibacterium acnes. The pineapple peel extract is made by using the extraction method in the form of maceration. The method used in the inhibitory test using the three replication samples in each treatment group. The sample consisted of 10 treatment groups ie pineapple peel extract concentration 12.5%, 25%, 37.5%, 50%, 62.5%, 75%, 87.5%, and 100%, as well as positive and negative control. The results obtained from pineapple peel screening contain flavonoid and saponin compounds. The data analysis shows that pineapple peel extract concentrations of 50%, 62.5%, 75%, 87.5%, and 100% had inhibitory zones with the medium-strong category while clindamycin as the control has a strong inhibition zone. The conclusion of this research proves that pineapple peel extract has antibacterial power to P. acnes with effective concentration is 100% with the strong category
Characterization and Identification of Allergen Protein in Shrimp Before and After Heated with SDS-PAGE Method
No full textFood allergies are one of the most common allergies in Indonesian society. Generally, when children aged 5-6 years food allergies will disappear, except peanut allergies and allergies to seafood, such as fish, shellfish and crustaceans. This study aims to determine the pattern of separation of allergen proteins in shrimp using anion exchange column chromatography method and identify allergen proteins in shrimp using the sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) method. Protein extraction from shrimp using Phosphate buffer saline (PBS) pH 7.2 and centrifuged at 10,000 rpm for 10 min at 4°C. Protein separation was carried out by anion-exchange column chromatography method, and the fraction obtained was measured at 280nm wavelength. The highest yield at absorbance was identified by using SDS-PAGE. Polyacrylamide gel electrophoresis was used to determine the protein profile and molecular weight of shrimp extract. Coloring of protein bands using silver staining. Data were analyzed descriptively based on the migration value of the sample protein bands compared to the marker protein band (Rf). The results of protein allergen profile analysis on shrimp using SDS-PAGE showed that the shrimp contained a protein band with a molecular weight of 37.77 kDa for cooked shrimp and 37.03 kDa for fresh shrimp
Antioxidant Activity of Ethanolic Extract from Tandui Leaves (Mangifera rufocostata Kosterm.) by DPPH Radical Scavenging Method
No full textTandui (Mangifera rufocostata Kosterm.) is a typical plant from South Kalimantan which belongs to the genus of Mangifera. Several species of Mangifera are known to have antioxidant activity. This study aimed to determine the antioxidant activity of ethanol extract of Tandui leaves. Tandui leaves that were obtained from the maceration method used 70% ethanol. Antioxidant activity was conducted quantitative using the DPPH (2,2-diphenyl-1-picrylhydrazil) method. The result of the antioxidant activity of Ethanol extract of Tandui leaves quantitatively obtained IC50 value was 60.7042 µg/mL. The ethanol extract of Tandui leaves has strong antioxidant activit
Tingkat Pengetahuan Siswi SMA Muhammadiyah Palangka Raya tentang Dysmenorrhea: Level of Knowledge of Female Students in Muhammadiyah Senior High School of Palangka Raya about Dysmenorrhea
No full textDysmenorrhea is one of the most common gynecological problems in women of all ages, the incidence of dysmenorrhea in the world is very large on average more than 50% of women in every world experience it. Muhammadiyah Senior High School is one of the best schools in Palangka Raya. Based on the observations that have been done by researcher the results are many students got dysmenorrhea with severe pain and certainly this condition will disrupt daily activity, especially when teaching and learning and so extracurricular activities. Therefore, research about the level of dysmenorrhea knowledge is needed. The research method was used in this research was a descriptive method with the technique of sampling purposive sampling with 10 statements questionnaire consist of 4 indicators there is the definition of dysmenorrhea, signs, and symptoms of dysmenorrhea, causes of dysmenorrhea and how to treat and prevent dysmenorrhea. Based on the results of the study was found that the level of dysmenorrhea knowledge female students Muhammadiyah Senior High School of Palangka Raya included in the sufficient category with percentage 66,67%, meanwhile based on knowledge indicators, definition of dysmenorrhea was 73.22% (sufficient category), signs and symptoms of dysmenorrhea was 58.93% (sufficient category), causes of dysmenorrhea was 63.69% (sufficient category) and how to treat and prevent dysmenorrhea was 68.75% (sufficient category). Based on the results of this study, it can be concluded that the level of dysmenorrhea knowledge female students Muhammadiyah Senior High School of Palangka Raya included in category sufficient to know with percentage 66.67%
Cover, Content, and Editorial Note from Borneo J Pharm Vol. 1 No. 1 May 2018
No full textAssalamu’alaikum Wr. Wb. Alhamdulillahirabbil ‘alamin. After a long wait for almost 12 years from the first stand, finally, the scientific journal of the Department of Pharmacy Universitas Muhammadiyah Palangkaraya can be published. This scientific journal we named Borneo Journal of Pharmacy (Borneo J Pharm), inspired by the rich treasures of traditional medicine from the Borneo island which further became the basis for the development of this periodical scientific publication. Borneo J Pharm published every 6 months (2 issues/year) every May and November. The aim of this journal is to publish high-quality articles dedicated to all aspects of the latest outstanding developments in the field but not limited to Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Pharmaceutical, Analytical Pharmacy-Medicinal Chemistry, Natural Product Development, Clinical-Community Pharmacy, Management Pharmacy, and other Pharmacy aspects. It was first published online in May 2018 using Open Journal System (OJS) 3.1 platform with e-ISSN 2621-4814 by URL http://journal.umpalangkaraya.ac.id/index.php/bjop. This edition contains 12 articles consisting of Pharmacognosy-Phytochemistry, Natural Product Development, Clinical-Community Pharmacy, and Management Pharmacy topics. Editorial boards are fully aware that there is still room for improvement in this edition, hence with all humility willing to accept constructive suggestions and feedback for improvements to the publication for the next editions. We hope that all parties, especially the contributors of the articles, could participate in the success of the publication in the next edition in November 2018. Wassalamu’alaikum Wr. Wb
Effect of Giving Celecoxib on Uric Acid Level on Mice
No full textCelecoxib is a breakthrough for pain relievers under the trade name Celebrex®, which is a Non-Steroid Anti-Inflammatory drug with its activity as an analgesic, antipyretic and anti-inflammatory. The purpose of this study was to find out the effect of celecoxib on blood uric acid levels of female white mice was induced with fresh cow liver extract. Experimental animals were divided into five groups, namely the control group (-), the control group (+) and the three dose groups, respectively 0.26, 0.52 and 1.04 mg/20 g. Observations were made on 7, 14 and 21 days with the Enzymatic Photometric method. The results showed that administration of celecoxib suspension at a dose of 0.26, 0.52 and 1.04 mg/20 g did not affect blood uric acid levels when compared with controls (P> 0.05)
Utilization of Catechins in Sunscreen Lotion Formulation
No full textSkin is the outermost part of the body which is susceptible to solar radiation. Excessive radiation from ultraviolet (UV) rays can harm the skin, such as premature aging effect, erythema, and even skin cancer. Antioxidant compounds are needed to protect the skin from excessive exposure of UV rays. The antioxidant can be useful as a defense system against free radicals, ultraviolet radiation, and air pollution. One source of antioxidant from nature is Catechins. Catechins are obtained from the isolation of gambir (Uncaria gambir Roxb). Besides being useful as an antioxidant, Catechins also has antibacterial, antiseptic and wound healing effect. The antioxidant activity of Catechins can absorb UV rays, provides protection against oxidative stress, inflammation, and skin cancer. Therefore, the research is necessary to utilize the catechins in sunscreen lotion formulation. Catechins are isolated from gambir by maceration with hexane and ethyl acetate (polar, nonpolar and residual fractions). The fraction which yields the most catechins is used as the active substance in the formulation. The formulation is divided into 4 lotion formulas, namely Formula 1 with 0.5% catechins concentration, Formula 2 with 7.5% catechins concentration, Formula 3 with 1% catechins concentration, and Formula 4 without catechins substance. Physical stability test and effectiveness of sunscreen formulation are carried out on 4 lotion formulas. Physical stability tests included organoleptic observation, homogeneity, pH, and assessment of the effectiveness of sunscreen formulation by using UV-Vis Spectrophotometer