Oskar Bordeaux
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Eur J Nutr
No full textPurposeNutrition, as a modifiable exposure, seems relevant to prevent depression. Several nutrients have been associated with a lower risk of depression in older adults, but longitudinal studies examining nutrient combinations are lacking. Therefore, we investigated the association between a posteriori nutrient patterns and the odds of depressive symptomatology (DS) in older adults over time.MethodsThe sample included participants from the French Three-City cohort, a prospective population-based study focusing on adults >= 65 years. Nutrient intakes were assessed using a 24-hour recall in 2001 and Principal Component Analysis based on 40 nutrients, was performed to identify nutrient patterns. DS was assessed at each visit (up to eight visits until 2018) and defined by a Center for Epidemiologic Studies-Depression score >= 16 and/or antidepressant medication. Random effect logistic regression was performed to examine the association between nutrient patterns and DS over time controlled for potential confounding variables.ResultsThe study sample comprised 1,063 individuals (mean age 75.6y +/- 4.8) and 39.3% experienced DS at least once during a median follow-up of 11.5 years. Among 4 identified nutrient patterns, the first pattern characterised by high intake of magnesium, hydroxybenzaldehydes, stilbenes, dihydroflavonols, vitamin B6, lignans, tyrosols, folates, vitamins B3, B5, B1 and proanthocyanidins, was significantly associated with lower odds of DS over time (OR + 1 point = 0.85, 95% CI=[0.75;0.96]).ConclusionsIn this large sample of older adults, a mixed nutrient pattern was associated with lower odds of DS over time, offering valuable insights into nutrient potential role in mental health among older adults
BMC Infect Dis
No full textLinezolid and vancomycin are both recommended for the treatment of staphylococcal-associated central nervous system (CNS) infections. However, to date, no data are available comparing the outcomes of patients treated with vancomycin or linezolid for these infections. The aim of this study was to compare the incidence of treatment failure and adverse events (AEs) associated with vancomycin and linezolid in staphylococcal-associated CNS infections. This retrospective monocentric observational study was conducted between 01/01/2015 and 31/12/2023. All patients with a confirmed staphylococcal associated CNS infection and treated with vancomycin or linezolid were included. Failure of antimicrobial treatment was the primary outcome of interest, defined by a composite criteria: persistence of infection (i.e. positive culture after > 72 h of antimicrobial treatment active on the isolated bacteria), relapse of infection (i.e. new infection with the same bacteria involved in the initial episode) or infection related death. Second outcome of interest was AE incidence related to linezolid or vancomycin. Outcomes were analysed using survival analysis techniques and propensity score. Ninety one patients were included: 51 in vancomycin group and 40 in linezolid group. Infections were mainly meningitis (n = 71; 78%). Median duration of linezolid or vancomycin treatment was 7 days (IQR 4; 13). Treatment failure occurred in 18.6% (n = 17) of patients (infection persisted in 9.8% of patients (n = 9), infection relapsed in 6.6% (n = 6) and infection caused a fatal outcome in 4.4% (n = 4). In the Cox proportional hazards regression model, vancomycin was not associated with treatment failure (aHR 2.90; 95% CI [0.93-9.30]; p = 0.066). Using propensity score, vancomycin was associated with treatment failure (HR 3.28; 95% CI [1.02-10.54]; p = 0.045). Treatment with vancomycin was also associated with AE (HR 8.42; CI 95% [2.44;29.10]; p = 0.019). Patients treated with vancomycin for staphylococcal-associated CNS infections seems to have a higher risk of treatment failure and AE compared to those treated with linezolid. However, given the low statistical power and the observational nature of this study, further research is needed to confirm these findings
Récoltes intensives de biomasse et maintien de la fertilité des sols
No full textComment la biomasse et les nutriments sont distribués dans l’arbre ? Les résultats de la recherche montrent que, même si les rémanents ne représentent qu’une petite part de la biomasse totale de l’arbre en comparaison avec la biomasse du tronc, ils sont très riches ennutriments et contiennent souvent plus de nutriments que le tronc. Le chapitre « récolte des rémanents » fait le point sur une expérimentation initiée en 2009 sur la commune du Teich (33)
Isoler pour protéger ? La prison face à la transidentité
No full textLa prise en charge carcérale des femmes trans questionne la prison et perturbe l’un de ses principes structurants, à savoir la séparation des hommes et des femmes. La réponse de l’institution à la question de la transidentité repose sur leur mise à l’écart, principalement à l’isolement dans des maisons d’arrêt pour hommes. Cette approche sécuritaire révèle des représentations réductrices de la violence en détention, ainsi qu’une méconnaissance des réalités propres à la transidentité
J Alzheimers Dis
No full textWe argue that the provision of substantial dietary modifications to individuals who wish to maximize their brain health is ethically permitted, despite evidence for such an intervention being not yet fully conclusive. However, we argue that for a burdensome therapy with weak evidence and potential harms, balanced communication, informed consent and follow-up are necessary components of the ethical provision of such lifestyle changes. Moreover, health should be discussed as a value with individuals alongside non-health priorities to achieve balance and avoid brain healthism
Alcohol Clin Exp Res (Hoboken)
No full textBACKGROUND: Alcohol use is measured in diverse ways across settings. Harmonization of measures is necessary to assess effects of alcohol use in multi-cohort collaborations, such as studies of people with HIV (PWH). METHODS: Data were combined from 14 HIV cohort studies (nine European, five North American) participating in the Antiretroviral Therapy Cohort Collaboration. We analyzed data on adult PWH with measured alcohol use at any time from 6 months before starting antiretroviral therapy. Five cohorts measured alcohol use with AUDIT-C and others used cohort-specific measures. We harmonized alcohol use as grams/day, calculated using country-level definitions of a standard drink. For Alcohol Use Disorders Identification Test (AUDIT-C), we used Items 1 (frequency) and 2 (number of drinks on a typical day). Where alcohol was measured in categories, we used the mid-point to calculate grams/day. We used multivariable Cox models to estimate associations of alcohol use with mortality. RESULTS: Alcohol use data were available for 83,424 PWH, 22,447 (27%) had AUDIT-C measures and 60,977 (73%) recorded the number of drinks/units per week/day. Of the sample, 19,150 (23%) were female, 54,006 (65%) had White ethnicity, and median age was 42 years. Median alcohol use was 0.3 g/day (interquartile range [IQR] 0-4.8) and 0 g/day (IQR 0-20) for those with and without AUDIT-C. There was a J-shaped relationship between grams/day and mortality, with higher mortality for PWH reporting no alcohol use (adjusted hazard ratio [aHR] 1.46; 95% CI: 1.23-1.72) and heavier (>61.0 g/day) alcohol use (aHR 1.92; 1.41-2.59) compared with 0.1-5.5 g/day among those with AUDIT-C measures. Associations were similar among those with non-AUDIT-C measures. CONCLUSIONS: Grams/day is a useful metric to harmonize diverse measures of alcohol use. Magnitudes of associations of alcohol use with mortality may differ by setting and measurement method. Higher mortality among those with heavier alcohol use strengthens the case for interventions to reduce drinking
Front Psychiatry
Get PDFBipolar disorder (BD) and emotion dysregulation present substantial challenges for individuals and healthcare providers. Although pharmacological treatments remain the primary approach, psychosocial interventions show promise in addressing sub-threshold symptoms and deepening understanding of mood and emotion dysregulation mechanisms. The European Network for Bipolar Emotion Regulation (ENBER) aims to close the gap between research and clinical practice by offering practical insights for clinicians while contributing to scientific discourse on BD and emotion regulation (ER). This perspective paper identifies key questions for the field, suggesting directions for future research and highlighting promising interventions, such as Dialectical Behaviour Therapy (DBT), which have shown potential to reduce emotion dysregulation and improve personal recovery in BD. Future research should explore the flexibility and context-appropriateness of ER strategies, considering how current mood states significantly impact these dynamics. The commentary advocates for personalised treatment approaches that address individual differences in symptoms and ER capabilities, recommending innovative methodologies to better understand and apply ER in BD.Incorporating patient perspectives into research design is also a necessary focus for future research, having the potential to improve recovery and quality of life for individuals with BD. Copyright © 2025 Azevedo, Dodd, Weiner, M’Bailara, Pinto, Weibel, Lawlor, Koenders and Wright
Diabetes Metab
No full textDiabetes secondary to total pancreaticoduodenectomy (TP) is challenging to manage due to high glycemic variability and risk of hypoglycemia, in a frail population. We report the case of four patients with no prior diabetes who underwent TP. Three of four patients needed artificial nutritional support. Hybrid closed-loop (HCL) insulin therapy was initiated within 12 weeks of surgery. After 90 days of HCL treatment, continuous glucose measurement showed a 70.4 ± 11.8 % time in range (versus 43 ± 6.5 % before HCL); 0.2 ± 0.2 % time below range (versus 0.6 ± 0.5 % before HCL); 23.8 ± 9.1 % time above range 180-250 mg/dl (versus 22.9 ± 6.1 % before HCL); 4.2 ± 2.5 % time above range > 250 mg/dl (versus 33.8 ± 3.9 % before HCL). The glucose management indicator improved from 8.5 ± 0.6 % to 6.9 ± 0.6 %. There was no severe hypoglycemia or need for unplanned medical attention. Early post-operative use of HCL allowed our patients to achieve safely optimal glycemic control after TP
