Oskar Bordeaux
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Biological features for a minimum conservation reference size revision – case of Ruditapes philippinarum in Arcachon Bay (French Atlantic coast)
No full textThe Minimum Conservation Reference Size (MCRS) for marine resources ensure that individuals can mature and reproduce at least once before being caught. For management purposes, MCRS should be revised for specific populations in given areas. In Arcachon Bay (southwest France), fishers have repeatedly requested a review of the MCRS for R. philippinarum. In 2020, a joint recommendation, supported by France, was addressed to the European Commission suggesting a possible reduction in the MCRS of R. philippinarum from 35 mm to 32 mm for Arcachon Bay. This paper provides an overview of the biological features that need to be considered to support such a review, primarily focusing on sexual maturity, individual growth and natural mortality. The reproductive cycle and size at first maturity, estimated at 26.7 mm for the Bay, were found to be similar to other locations in France and in Portugal. The greatest length at which growth slowdown occurred ranges between 24.0 and 31.5 mm with few differences among sites and no significant differences within each site (at hypsometric levels). The natural mortality coefficients were high with 0.67 yr−1 and 0.51 yr−1 for juveniles and adults, respectively. Regarding productivity (resulting from growth and mortality processes) and all methods combined, the optimal balance between individual growth and natural mortality above 30 mm was found at a mean length of 32.2 mm for the intra-lagoon sites and at a mean length of 36.8 mm for the oceanic sites. Based on available information, reducing the MCRS to 32 mm would not threaten population viability. However, the European Commission has raised warning points, which are discussed in light of current regulations in Arcachon Bay
Sci Rep
No full textProfessional foster families for dependent older adults are a housing model perceived as an alternative to nursing homes in the French West Indies. The clinical profile of older adults in foster families remains to be determined, particularly concerning neuropsychiatric symptoms (NPS) in the presence of major cognitive disorders. In this cross-sectional analysis from twin studies conducted in foster families (n = 107, mean age: 81.8 years, male/female ratio: 38/62) and nursing homes (n = 332; (mean age: 81.3 years, male/female ratio: 51/49), we compare the prevalence and severity of NPS, along with psychotropic drugs prescription, between older adults (≥ 60 years) living in both arrangements. The prevalence of major cognitive disorders and the total number of NPS (3.4 ± 2.7 in foster families vs. 3.4 ± 2.5; p = 0.946) were similar between the two groups. The prevalence of each NPS was similar except for apathy (20.0% in nursing homes vs. 8.5% in foster families, p = 0.006), aberrant motor behavior (22.1% in nursing homes vs. 36.2% in foster families, p = 0.004) and eating disorders and appetite (23.0% vs. 9.3%, respectively, p = 0.002). The use of antipsychotics was more frequent in nursing homes (36.7% vs. 26.2%, p = 0.046). This study suggests that the foster families' environment may be well suited for managing older adults with psycho-behavioral disorders. © 2025. The Author(s)
Retour sur la Rencontre Inter-Labos « Archéos en Transitions »
No full texthttps://bioarcheo.hypotheses.org/388
PBK-TD modelling of the gonadotropic axis: Case study with two azole fungicides in female zebrafish
No full textEndocrine disruptors (EDs) can disrupt the gonadotropic axis, which consists of the Hypothalamus-Pituitary-Gonads (HPG), notably by altering aromatase (cyp19a), a key enzyme regulating the endocrine system and reproductive function in fish. The effects of EDs can be predicted by integrating both toxicokinetic (TK) and toxicodynamic (TD) processes in order to relate adverse outcomes to external exposures. In this study, we developed a physiologically based kinetic-toxicodynamic model to simulate the disruption of the HPG axis (PBK-TD, hereafter named PBK-HPG) in female zebrafish exposed to either of two aromatase inhibitors, imazalil or prochloraz. The model was calibrated using Bayesian methods and supported by novel experimental data, including measurements of vitellogenin, 17β-estradiol, and 11-ketotestosterone levels, along with in vivo monitoring of the cyp19a1a gene in transgenic cyp19a1a-GFP ebrafish. Seamless integration of a PBK model within a TD model of the HPG-axis, provided the link between external exposure and internal levels of imazalil and prochloraz in key organs, allowing for mechanistic predictions of their inhibitory effects on gonadal aromatase. Our PBK-HPG model accurately predicted both baseline homeostasis and the effects of aromatase inhibition, with all endocrine endpoints including reproductive disruption, i.e., decreased egg production, falling within a twofold range of both experimental and literature data. Therefore, our PBK-HPG model could further support the development of a mechanistic qAOP with TK considerations. The model offers significant potential for improving environmental risk assessments of EDs and possibly other stressors across species
Face à la métropolisation : repenser l’enseignement de la pratique du projet au prisme des transitions
No full textEur J Clin Microbiol Infect Dis
No full textObese patients treated with daptomycin at 4 mg/kg have a 30% increased drug exposure, potentially raising the risk of adverse events (AEs) like rhabdomyolysis. Given limited data on the safety of higher doses (10 mg/kg) in this population, this study aimed to assess the safety of high-dose daptomycin in obese patients and to identify potential AEs risk factors. This multicenter, retrospective observational study was conducted from June 2021 to May 2022 using medical records. Patients with a BMI > 30 kg/m were classified as obese. AEs assessed included: CK elevation (> 5x upper limit of normal), severe elevation (> 10x upper limit), eosinophilic pneumonia, and elevated liver enzymes. Both univariate and multivariate analyses were conducted. A total of 1 303 patients were included: 970 non-obese and 333 Ob patients. These patients received an average daptomycin dose of 9.9 mg/kg based on actual body weight for an average treatment duration of 8.27 days. One-third of the patients had CK monitoring. AEs rates were 3.5% for the n-Ob group vs. 8.7% in the Ob group (p < 0.01). Ob patients had significantly higher CK levels (n-Ob, 9.5%; Ob, 20.3%; p = 0.001), and severe elevation (n-Ob, 5.2%; Ob, 10.9%; p = 0.03). Factors increasing AE risk included obesity, concomitant prescriptions of drugs with risk of rhabdomyolysis, eGFR 30-60 mL/min, and daptomycin duration (OR = 2.42; 4.34; 2.03 and 1.05, respectively, p < 0.001). On the opposite, consultation with an infectious disease specialist reduced risk (OR = 0.52, p = 0.024). This study highlights that obese patient has a significantly increased risk of AEs with high dose of daptomycin compared to non-obese patients. Adjusted body weight dosing may be considered to reduce AEs risk
« Procédure disciplinaire conventionnelle et maintien de la référence à la notion de garantie de fond : un premier indice »
No full textFront Immunol
Get PDFCytopenias occur frequently after kidney transplantation but posttransplantation thrombocytopenia (PTTCP) frequency has rarely been reported. This monocenter, retrospective study aimed to describe PTTCP frequency, causes, treatments and outcomes. PTTCP was defined as thrombocytopenia with ≥2 platelet counts <100×10/L after first month posttransplantation. Among 2118 kidney-transplant recipients between 2002 and 2018, 189 (8.9%) developed PTTCP. Their mean platelet-count nadir was 51×10/L [range 4-96×10]; nadir was <50×10/L for 87 (46.0%) patients. Main identified PTTCP etiologies were drugs (24.3%), or infectious diseases (20.1%; cytomegalovirus causing 79.4% of them), or unknown for 26 (13.7%). Bleeding rate was high (32.7%), with 40 (64.5%) severe episodes. During follow-up, 103 (54.5%) patients suffered graft loss or died at a median of 5.41 years post-PTTCP episode. Multivariate analyses retained a severe bleeding episode as being significantly associated with antiplatelet or anticoagulation therapy and pancytopenia, and age, creatininemia, transplantation-to-PTTCP interval and severe bleeding as significant risk factors for death or graft loss. PTTCP is frequently associated with severe bleeding, which is a risk factor for graft loss and death. Those findings suggest that the risk/benefit ratio of antiplatelet or anticoagulation therapies should be systemically evaluated for PTTCP patients
Des mers et des câbles, Géographie des Réseaux de Communications
No full textDans le cadre du label SAPS (Science Avec et Pour la Société) obtenu par l'Université Bordeaux Montaigne et dans le cadre d'un partenariat avec les Archives de Bordeaux Métropole, cette intervention à destination des professeur·es d'Histoire-Géographie de l'Académie de Bordeaux a porté d'une part sur le décryptage géo-audiovisuel d'un documentaire diffusé sur Arte "Les pionniers des câbles sous-marins, une révolution de la télécommunication" et d'autre sur les enjeux contemporains liés au déploiement des câbles sous-marins et des data centers