International Journal of Advances in Pharmaceutics
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Recent research on liquisolid technology for solubility enhancement- A review
Get PDFLiquisolid system is a novel and promising approach to enhance aqueous solubility, dissolution rate as well as bioavailability of water insoluble solid drugs or liquid lipophilic drugs by conversion of liquid drugs, drug suspensions or drug solution in non-volatile solvents, into dry, non-adherent, free flowing and compressible powder mixtures by simple blending with selected carriers and coating materials. This technology is based on a new mathematical model proposed by Spireas et al . The three main proposed mechanisms by which bioavailability of drug is increased that are increased surface area of drug, increase aqueous solubility of drug and improved wettability of the drug
Formulation and Evaluation of microsphere of Rebiprazole Sodium
Get PDFMicrospheres include microparticles and microcapsules (having a core of the drug) of 1-1000?m in diameter and consisting either entirely of a bioadhesive polymer or having an outer coating of it.In this work, an effort was made to formulate microsphere of Rabeprazole sodium by using different polymers. Prepared formulations are evaluated for bulk density, tapped density, percent mucoadhesion, Percent compressibility, Hausner's ration, percentage yield, size and surface morphology, interaction study by Differential scanning calorimeter and in vitro drug release. Formulation which passed all the evaluation parameters were considered as best formulation of Rabeprazole sodium
Vital role of quality assurance as a backbone in pharmaceutical industry
Get PDFThe overview on the vital role of a Quality Assurance department in a pharmaceutical industry and how it is related to other departments as an important factor is well discussed in each subsection. It also explains on how Quality Assurance can increase the revenue of the industry and it also explains on the work flow from the raw material till the finished product and the role of Quality Assurance in each flow. It gives a clear picture on how the Quality Assurance is manage and gives ideas on how to enhance the flow. The role of Quality Assurance in regulatory affairs and also business development is explained
HPTLC fingerprint profile of methanol extract of the marine red alga Portieria hornemannii (Lyngbye) (Silva)
Get PDFThe present study was aimed to develop the high performance thin layer chromatography (HPTLC) fingerprint profile of methanol extracts of marine red alga Portieria hornemannii (Lyngbye) (Silva). A HPTLC method for the separation of the active constituents in extracts has been developed and TLC of these extracts on silica gel pre-coated aluminum plates of Merck by the automatic TLC applicator and using the solvent system n-hexane:ethyl acetate (60:40 v/v) was performed. HPTLC profiling of the extract confirm about the presence of various phytochemicals. HPTLC finger print scanned at 490 nm for methanol and ethyl acetate algal extracts revealed 13 peaks with Rf values in the range of 0.16 to 0.99 respectively. The HPTLC method for routine quality control of present species can be carried out using this method for extracts of plant and serve in qualitative, quantitative and was appropriate for standardization of the extract
Formulation and Development of Bilayer Floating Tablet of Nifedipine using surface solid dispersion technique
Get PDFThe aim of the present work was to develop formulation of Nifedipine in the form of bilayer floating sustained release tablet. Bilayer consist of a two layers, immediate release layer and second sustained release layer, compressed in single unit dosage form. Immediate release layer contains surface solid dispersion of Nifedipine and Floating sustained release layer also contain surface solid dispersion of Nifedipine by using HPMC K100M and HPMC K15M as sustained release polymer. Nifedipine is an antihypertensive drug. Surface solid dispersion of Nifedipine was prepared by solvent evaporation method with different super disintegrant as a polymer for improvement of solubility resulting in improved bioavailability. In the present study Nifedipine bilayer floating controlled release tablet were prepared with the help of direct compression method, using sodium bicarbonate and citric acid which generate gas upon contact with gastric fluid. Immediate release layer releases the drug immediately and floating sustained release layer floats on gastric fluid for upto12 hours and releases the drug in sustained manner, subsequently it prolongs duration of action. The tablets were evaluated for various physical parameters, buoyancy studies, dissolution studies and drug released mechanisms. The batch number F5 formulation showed minimum disintegration time of immediate release layer (24 sec) and gave maximum swelling index of the sustained release layer (82.8%) and also maximum drug release duration of Nifedipine spread over 12 hours
In vitro antibacterial effects of red alga Champia parvula (C. Agardh) of various solvents against human pathogenic bacteria
Get PDFThe aim of the present study is to evaluate the antimicrobial inhibitory effect of Champia parvula (red alga) of various solvents at the concentration 100 g/mL, on pathogenic bacteria like Klebsiella pneumoniae, Proteus vulgaris, Bacillus cerus, Bacillus subtilius, Staphylococcus aureus, and Salmonella typhii were studied by the disc diffusion method. The present study reveals that a higher zone of inhibition against Salmonella typhii (15.4 0.2), Bacillus subtilius (13.8 0.1) , Staphylococcus aureus (10.7 0.2) and Proteus vulgaris (10.6 0.1) in the methanol extract alone, followed by acetone, benzene, chloroform, and ethyl acetate extracts showed moderate activity against most of the pathogens, whereas chloroform extract is inactive only against Bacillus cerus. The positive control streptomycin shows inhibitory action against all the pathogens studied. This study shows the potential of marine active compounds from Champia parvula as an antimicrobial agent for a disease free environment
FORMULATION AND IN-VITRO CHARACTERIZATION OF LORNOXICAM TRANSDERMAL MATRIX PATCH
Get PDFTransdermal therapeutic systems are defined as self-contained, discrete dosage forms which, when applied to intact skin, deliver drug(s), through skin, at a controlled rate to systemic circulation. In the present study transdermal patches of Lornoxicam were prepared using hydrophilic polymer and hydrophobic polymer. Transdermal drug delivery system has the potential advantages of avoiding hepatic first pass metabolism, maintaining constant blood levels for a longer period of time, resulting in a reduction of dosing frequency, improved bioavailability, and decreased gastrointestinal irritation that occur due to local contact with gastric mucosa and improved patient compliance. Lornoxicam is a newer NSAID of the oxicam class for the treatment of anti-inflammatory properties in a range of painful and inflammatory conditions, including Rheumatoid arthritis and postoperative pain. Lornoxicam Patch was prepared by the solvent casting method using HPMC various grade and Eudragit RS 100 as a polymer, PEG-400 and Tween 80 uses as plasticizer, Methanol and Dichloromethane used as solvent. LXTMP1 showed desired % Drug Content, Thickness, Folding Endurance, Flatness, Diffusion Study, Sensitivity Study on animal and Kinetic Model Study and better than other seven batches so, it is selected optimized batch
Formulation and evaluation studies of BSA loaded chitosan nanoparticles by polymerization technique.
Get PDFAim: To prepare BSA loaded chitosan nanoparticles by polymerization technique and to study the effect of initiator concentration upon particle size, product yield, entrapment efficiency, loading capacity and drug release from the formulation. Methodology: In the present study BSA loaded chitosan nanoparticles were prepared by polymerization technique. Three formulations were prepared by varying the concentration of Initiator. The concentration of Initiator (Ammonium per sulphate) was maintained 1%, 2% 3% in formulation 1, Formulation 2 and Formulation 3 respectively. The effect of initiator concentration on Mean particle diameter, Drug content, entrapment efficiency, loading capacity, electrophoretic mobility and zeta potential was studied. Results and discussion: Best nanoformulations were obtained with Ammonium per sulphate 2 % concentration with Mean particle diameter of 441.7 nm. Electrophoretic mobility and Zeta potential value (-3.304 and -42.1) was also more among all chitosan formulations indicating greater stability. Conclusion: Hence Formulation 2 was considered to be the best Formulation for the preparation of BSA loaded Chitosan nanoparticles
Development of UV spectrophotometric methods and validation for estimation of furosemide in bulk and tablet dosage form by absorbance maxima and Area Under the Curve method
Get PDFThe present work was to develop two simple UV spectrophotometric methods for simultaneous estimation of furosemide (FUR) in bulk and tablet dosage form and validate as per ICH guidelines. Method A is absorption maxima method in which ?max was found to be 277 nm. Method B is area under the curve (AUC) in which area in the wavelength range of 258.40 nm 293.80 nm was selected for analysis of furosemide .Linearity was observed in the concentration range 5-25?g/ml (r2 =0.999) for both the methods. The % assay for the marketed formulation for absorption maxima and area under the curve method was found to be 99.16%, and 99.20% respectively. The methods were validated with respect to linearity, precision and accuracy studies. Recovery studies for absorption maxima, and area under the curve was found to be 100.46%, and 100.86% respectively. The developed methods were validated for linearity, precision, accuracy, LOD and LOQ as per ICH guidelines. Both the methods were found to be linear within the conc. Range of 5-25?g/ml for furosemide. The present methods were found to be simple, linear, precise, accurate and sensitive and can be used for routine quality control analysis for the estimation of furosemide in bulk and tablet dosage form
Formulation and evaluation of atenolol oro dispersable tablets by co-processed super-disintegration process
Get PDFOral disintegrating tablet (ODT) is defined as A solid dosage form containing medical substances or active ingredient which disintegrates rapidly usually within a matter of seconds when placed upon the tongue. The aim of the present research is to formulate Atenolol oral disintegrating tablets.Atenolol is ?1- cardio selective adrenergic receptor blocker, widely used in the treatment of hypertension, angina pectoris, arrhythmias and myocardial infarction. It works by slowing down the heart and reducing the work load of the heart.Atenolol was specifically developed so as to pass the blood brain barrier and overcome theside effects such as depression and nightmares.It has been reported that atenolol undergo extensive hepatic first pass metabolism following oral administration and has shorter biological half-life of 6 7 hours with oral bioavailability of 50%. The conventional tablets of atenolol are reported to exhibit fluctuations in the plasma drug levels after administration. Atenolol ODTs are prepared by novel co-processed super-disintegration process using Cross Povidone and Cross carmellose sodium, as the super disintegrants. The prepared tablets were characterized for their hardness, weight variation, disintegration time, wetting time, water absorption ratio friability, and in vitro dissolution studies.he ability of the tablet to release the drug faster depends on the concentration and type of super disintegrant. In this study the oral disintegrating tablets containing Cross carmellose sodium and Cross Povidone as the super disintegrant in the ratio of 1:1 shows better release of drug. About 99.5% of the drug was released from the tablets in 6 mins. Therefore, based on the physico chemical properties, in vitro drug release profile and mouth feel formulation F 1 containing 1:1 of Cross carmellose sodium and crospovidone is optimised as the best formulation